MX2019008347A - Secuenciamiento de canal bioptico, de una sola fuente de luz. - Google Patents
Secuenciamiento de canal bioptico, de una sola fuente de luz.Info
- Publication number
- MX2019008347A MX2019008347A MX2019008347A MX2019008347A MX2019008347A MX 2019008347 A MX2019008347 A MX 2019008347A MX 2019008347 A MX2019008347 A MX 2019008347A MX 2019008347 A MX2019008347 A MX 2019008347A MX 2019008347 A MX2019008347 A MX 2019008347A
- Authority
- MX
- Mexico
- Prior art keywords
- wavelength
- detector
- light source
- nucleotide
- light
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/159—Microreactors, e.g. emulsion PCR or sequencing, droplet PCR, microcapsules, i.e. non-liquid containers with a range of different permeability's for different reaction components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Se describe un sistema para determinar la secuencia de nucleótidos de polinucleótidos. El sistema puede comprender una fuente de luz, como un láser o un LED, configurado para generar luz a una longitud de onda predeterminada. Un detector del sistema puede detectar emisiones fluorescentes a una primera longitud de onda y una segunda longitud de onda. Un procesador del sistema identifica el nucleótido como un primer tipo si no es detectada emisión fluorescente por al menos un detector; identifica el nucleótido como un segundo tipo si es detectada una emisión fluorescente a la primera longitud de onda de luz por al menos un detector; identifica el nucleótido como un tercer tipo si es detectada emisión fluorescente a la segunda longitud de onda de luz por al menos un detector; e identifica el nucleótido como un cuarto tipo si son detectadas emisiones fluorescentes a la primera longitud de onda y la segunda longitud de onda de luz por al menos un detector.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762468242P | 2017-03-07 | 2017-03-07 | |
| PCT/US2018/021055 WO2018165099A1 (en) | 2017-03-07 | 2018-03-06 | Single light source, two-optical channel sequencing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019008347A true MX2019008347A (es) | 2019-10-21 |
Family
ID=61691591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019008347A MX2019008347A (es) | 2017-03-07 | 2018-03-06 | Secuenciamiento de canal bioptico, de una sola fuente de luz. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20200080142A1 (es) |
| EP (1) | EP3592865A1 (es) |
| JP (3) | JP7041684B2 (es) |
| KR (2) | KR102246285B1 (es) |
| CN (1) | CN110234771A (es) |
| AU (2) | AU2018231017B2 (es) |
| BR (1) | BR112019014683A2 (es) |
| CA (1) | CA3046015A1 (es) |
| IL (1) | IL267051A (es) |
| MX (1) | MX2019008347A (es) |
| RU (1) | RU2736384C1 (es) |
| WO (1) | WO2018165099A1 (es) |
| ZA (1) | ZA202106656B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11288576B2 (en) | 2018-01-05 | 2022-03-29 | Illumina, Inc. | Predicting quality of sequencing results using deep neural networks |
| JP6959364B2 (ja) | 2018-01-05 | 2021-11-02 | イルミナ インコーポレイテッド | シーケンシングシステムにおける試薬冷却器の不安定性およびフローセル加熱器の障害の予測 |
| SG11202104099VA (en) * | 2018-11-07 | 2021-05-28 | Egi Tech Shen Zhen Co Limited | Method for sequencing polynucleotides |
| WO2020191387A1 (en) * | 2019-03-21 | 2020-09-24 | Illumina, Inc. | Artificial intelligence-based base calling |
| US11676685B2 (en) | 2019-03-21 | 2023-06-13 | Illumina, Inc. | Artificial intelligence-based quality scoring |
| NL2023314B1 (en) * | 2019-03-21 | 2020-09-28 | Illumina Inc | Artificial intelligence-based quality scoring |
| US11210554B2 (en) | 2019-03-21 | 2021-12-28 | Illumina, Inc. | Artificial intelligence-based generation of sequencing metadata |
| NL2023316B1 (en) * | 2019-03-21 | 2020-09-28 | Illumina Inc | Artificial intelligence-based sequencing |
| US11593649B2 (en) | 2019-05-16 | 2023-02-28 | Illumina, Inc. | Base calling using convolutions |
| KR102278015B1 (ko) * | 2019-12-06 | 2021-07-15 | 주식회사 뷰웍스 | 연속 광학 분석 시스템 및 광학 분석 방법 |
| EP4107735A2 (en) | 2020-02-20 | 2022-12-28 | Illumina, Inc. | Artificial intelligence-based many-to-many base calling |
| US20220195516A1 (en) * | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
| US20240012228A1 (en) * | 2020-12-28 | 2024-01-11 | Bioaces (Shanghai) Life Science Co., Ltd | Light source apparatus, microscopic device, optical detection device and optical detection method |
| US20220336054A1 (en) | 2021-04-15 | 2022-10-20 | Illumina, Inc. | Deep Convolutional Neural Networks to Predict Variant Pathogenicity using Three-Dimensional (3D) Protein Structures |
| US20220403450A1 (en) | 2021-06-03 | 2022-12-22 | Illumina Software, Inc. | Systems and methods for sequencing nucleotides using two optical channels |
| WO2023278184A1 (en) | 2021-06-29 | 2023-01-05 | Illumina, Inc. | Methods and systems to correct crosstalk in illumination emitted from reaction sites |
| WO2023034079A1 (en) | 2021-09-01 | 2023-03-09 | Illumina Software, Inc. | Amplitude modulation for accelerated base calling |
| WO2023107622A1 (en) | 2021-12-10 | 2023-06-15 | Illumina, Inc. | Parallel sample and index sequencing |
| WO2023175018A1 (en) | 2022-03-15 | 2023-09-21 | Illumina, Inc. | Concurrent sequencing of forward and reverse complement strands on separate polynucleotides |
| AU2023246772A1 (en) | 2022-03-29 | 2024-01-18 | Illumina Inc. | Chromenoquinoline dyes and uses in sequencing |
| WO2024003087A1 (en) | 2022-06-28 | 2024-01-04 | Illumina, Inc. | Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993019205A1 (en) * | 1992-03-19 | 1993-09-30 | The Regents Of The University Of California | Multiple tag labeling method for dna sequencing |
| US6436641B1 (en) | 2000-04-17 | 2002-08-20 | Visible Genetics Inc. | Method and apparatus for DNA sequencing |
| GB0112238D0 (en) * | 2001-05-18 | 2001-07-11 | Medical Biosystems Ltd | Sequencing method |
| JP2004177290A (ja) * | 2002-11-27 | 2004-06-24 | Sangaku Renkei Kiko Kyushu:Kk | 遺伝子解析データの処理方法 |
| WO2004063731A1 (ja) * | 2003-01-16 | 2004-07-29 | Olympus Corporation | 光検出装置 |
| EP2284278A1 (en) * | 2003-04-04 | 2011-02-16 | Roche Diagnostics GmbH | Improved system for multi color real time PCR |
| CA2525441A1 (en) * | 2003-05-13 | 2004-11-25 | Affymetrix, Inc. | System, method, and product for providing a wavelength-tunable excitation beam |
| CA2637974A1 (en) * | 2006-01-19 | 2007-07-26 | The Research Foundation Of State University Of New York | Methods and devices for detection and identification of encoded beads and biological molecules |
| US7776613B2 (en) * | 2006-08-07 | 2010-08-17 | President And Fellows Of Harvard College | Sub-diffraction image resolution and other imaging techniques |
| US8481259B2 (en) * | 2007-02-05 | 2013-07-09 | Intelligent Bio-Systems, Inc. | Methods and devices for sequencing nucleic acids in smaller batches |
| CN201313902Y (zh) * | 2008-12-09 | 2009-09-23 | 湖北师范学院 | 单一波长的dna测序装置 |
| JP5337676B2 (ja) * | 2009-06-25 | 2013-11-06 | 株式会社日立ハイテクノロジーズ | 蛍光分析装置および蛍光検出装置 |
| US8965076B2 (en) | 2010-01-13 | 2015-02-24 | Illumina, Inc. | Data processing system and methods |
| JP5834584B2 (ja) * | 2011-07-25 | 2015-12-24 | ソニー株式会社 | 情報処理装置、情報処理方法、プログラム及び蛍光スペクトルの強度補正方法 |
| US9193996B2 (en) * | 2012-04-03 | 2015-11-24 | Illumina, Inc. | Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing |
| US8754244B1 (en) | 2013-03-08 | 2014-06-17 | Illumina Cambridge Limited | Rhodamine compounds and their use as fluorescent labels |
| EP3080585B1 (en) * | 2013-12-10 | 2023-12-06 | Illumina, Inc. | Biosensors for biological or chemical analysis and methods of manufacturing the same |
| GB201508858D0 (en) * | 2015-05-22 | 2015-07-01 | Illumina Cambridge Ltd | Polymethine compounds with long stokes shifts and their use as fluorescent labels |
| CN205616889U (zh) * | 2016-04-06 | 2016-10-05 | 深圳市瀚海基因生物科技有限公司 | 基因测序光学装置 |
-
2018
- 2018-03-06 AU AU2018231017A patent/AU2018231017B2/en active Active
- 2018-03-06 US US16/468,269 patent/US20200080142A1/en not_active Abandoned
- 2018-03-06 CA CA3046015A patent/CA3046015A1/en active Pending
- 2018-03-06 EP EP18712067.0A patent/EP3592865A1/en active Pending
- 2018-03-06 RU RU2019118966A patent/RU2736384C1/ru active
- 2018-03-06 MX MX2019008347A patent/MX2019008347A/es unknown
- 2018-03-06 CN CN201880009537.0A patent/CN110234771A/zh active Pending
- 2018-03-06 KR KR1020197022368A patent/KR102246285B1/ko active IP Right Grant
- 2018-03-06 KR KR1020217012275A patent/KR102373741B1/ko active IP Right Grant
- 2018-03-06 JP JP2019541125A patent/JP7041684B2/ja active Active
- 2018-03-06 WO PCT/US2018/021055 patent/WO2018165099A1/en unknown
- 2018-03-06 BR BR112019014683-0A patent/BR112019014683A2/pt unknown
-
2019
- 2019-06-03 IL IL267051A patent/IL267051A/en unknown
-
2021
- 2021-09-09 ZA ZA2021/06656A patent/ZA202106656B/en unknown
- 2021-11-15 AU AU2021269291A patent/AU2021269291A1/en active Pending
-
2022
- 2022-03-11 JP JP2022038065A patent/JP2022088444A/ja active Pending
-
2023
- 2023-11-28 JP JP2023200836A patent/JP2024028778A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3592865A1 (en) | 2020-01-15 |
| IL267051A (en) | 2019-08-29 |
| US20200080142A1 (en) | 2020-03-12 |
| JP2024028778A (ja) | 2024-03-05 |
| AU2018231017B2 (en) | 2021-09-09 |
| KR102373741B1 (ko) | 2022-03-11 |
| NZ754255A (en) | 2021-05-28 |
| AU2021269291A1 (en) | 2021-12-09 |
| KR20210047980A (ko) | 2021-04-30 |
| KR102246285B1 (ko) | 2021-04-29 |
| AU2018231017A1 (en) | 2019-06-20 |
| WO2018165099A1 (en) | 2018-09-13 |
| ZA202106656B (en) | 2022-07-27 |
| JP2020507758A (ja) | 2020-03-12 |
| CN110234771A (zh) | 2019-09-13 |
| BR112019014683A2 (pt) | 2020-02-18 |
| CA3046015A1 (en) | 2018-09-13 |
| KR20190103267A (ko) | 2019-09-04 |
| JP7041684B2 (ja) | 2022-03-24 |
| JP2022088444A (ja) | 2022-06-14 |
| RU2736384C1 (ru) | 2020-11-16 |
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