MX2019006753A - Paquete de celda de flujo y metodo para fabricar el mismo. - Google Patents

Paquete de celda de flujo y metodo para fabricar el mismo.

Info

Publication number
MX2019006753A
MX2019006753A MX2019006753A MX2019006753A MX2019006753A MX 2019006753 A MX2019006753 A MX 2019006753A MX 2019006753 A MX2019006753 A MX 2019006753A MX 2019006753 A MX2019006753 A MX 2019006753A MX 2019006753 A MX2019006753 A MX 2019006753A
Authority
MX
Mexico
Prior art keywords
depressions
flow cell
cell package
interstitial regions
functionalized molecule
Prior art date
Application number
MX2019006753A
Other languages
English (en)
Inventor
Wei Wei
Li Edwin
Richez Alexandre
Tsay James
Huang Yuxiang
M Ramirez Sean
Prabhu Anmiv
Heiner David
M Beierle Jhon
Samiee Kevan
Munoz Kristina
malevanchik Leonid
Vincent Ludovic
Zhan Naiqian
Shieh Peyton
Yang Robert
Schmitt Samantha
Park Sang
Bailey Scott
Ahn Sunmin
Uzzell Valerie
Jamison Dill Tyler
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of MX2019006753A publication Critical patent/MX2019006753A/es

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B3/00—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products having particular features of form
    • B32B3/26—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layer; characterised by a layer with cavities or internal voids ; characterised by an apertured layer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N15/1436—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
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    • C09D133/26—Homopolymers or copolymers of acrylamide or methacrylamide
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
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    • H01L21/02—Manufacture or treatment of semiconductor devices or of parts thereof
    • H01L21/04—Manufacture or treatment of semiconductor devices or of parts thereof the devices having at least one potential-jump barrier or surface barrier, e.g. PN junction, depletion layer or carrier concentration layer
    • H01L21/18—Manufacture or treatment of semiconductor devices or of parts thereof the devices having at least one potential-jump barrier or surface barrier, e.g. PN junction, depletion layer or carrier concentration layer the devices having semiconductor bodies comprising elements of Group IV of the Periodic System or AIIIBV compounds with or without impurities, e.g. doping materials
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    • H01L21/3105—After-treatment
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    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
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    • H01L21/18—Manufacture or treatment of semiconductor devices or of parts thereof the devices having at least one potential-jump barrier or surface barrier, e.g. PN junction, depletion layer or carrier concentration layer the devices having semiconductor bodies comprising elements of Group IV of the Periodic System or AIIIBV compounds with or without impurities, e.g. doping materials
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    • H01L21/321—After treatment
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    • H01L21/02—Manufacture or treatment of semiconductor devices or of parts thereof
    • H01L21/04—Manufacture or treatment of semiconductor devices or of parts thereof the devices having at least one potential-jump barrier or surface barrier, e.g. PN junction, depletion layer or carrier concentration layer
    • H01L21/50—Assembly of semiconductor devices using processes or apparatus not provided for in a single one of the subgroups H01L21/06 - H01L21/326, e.g. sealing of a cap to a base of a container
    • H01L21/56—Encapsulations, e.g. encapsulation layers, coatings
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Abstract

Un paquete de celda de flujo incluye primera y segunda obleas modeladas de superficie modificada y una capa separadora. La primera oblea modelada de superficie modificada incluye primeras depresiones separadas por primeras regiones intersticiales, una primera molécula funcionalizada unida a un primer silano o derivado de silano en al menos algunas de las primeras depresiones, y un primer cebador injertado en la primera molécula funcionalizada en las al menos algunas de las primeras depresiones. La segunda oblea modelada de superficie modificada incluye segundas depresiones separadas por segundas regiones intersticiales, una segunda molécula funcionalizada unida a un segundo silano o derivado de silano en al menos algunas de las segundas depresiones, y un segundo cebador injertado en la segunda molécula funcionalizada en las al menos algunas de las segundas depresiones. La capa separadora une al menos algunas primeras regiones intersticiales a al menos algunas segundas regiones intersticiales, y define al menos parcialmente cámaras fluídicas respectivas del paquete de celda de flujo.
MX2019006753A 2016-12-22 2017-12-20 Paquete de celda de flujo y metodo para fabricar el mismo. MX2019006753A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662438316P 2016-12-22 2016-12-22
PCT/US2017/067645 WO2018119101A1 (en) 2016-12-22 2017-12-20 Flow cell package and method for making the same

Publications (1)

Publication Number Publication Date
MX2019006753A true MX2019006753A (es) 2020-01-30

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Application Number Title Priority Date Filing Date
MX2019006753A MX2019006753A (es) 2016-12-22 2017-12-20 Paquete de celda de flujo y metodo para fabricar el mismo.

Country Status (16)

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US (2) US10955332B2 (es)
EP (1) EP3559982A4 (es)
JP (2) JP7236999B2 (es)
KR (1) KR102656824B1 (es)
CN (1) CN110382717B (es)
AU (1) AU2017379888B2 (es)
BR (1) BR112019013077B1 (es)
CA (1) CA3046659A1 (es)
IL (1) IL267446A (es)
MX (1) MX2019006753A (es)
MY (1) MY196044A (es)
PH (1) PH12019501507A1 (es)
RU (1) RU2754808C2 (es)
TW (1) TWI766922B (es)
WO (1) WO2018119101A1 (es)
ZA (1) ZA201903900B (es)

Families Citing this family (13)

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Publication number Priority date Publication date Assignee Title
US11739373B2 (en) * 2018-02-05 2023-08-29 G1 Sciences, Llc Systems and methods for multiplexed analyte detection using antibody-oligonucleotide conjugates
SG11201912113XA (en) 2018-06-29 2020-01-30 Illumina Inc Flow cells
JP2022513547A (ja) * 2018-12-17 2022-02-09 イルミナ インコーポレイテッド フローセルおよびシークエンシングキット
FR3090615B1 (fr) * 2018-12-20 2020-12-11 Soitec Silicon On Insulator Procédé de fabrication d’un dispositif comprenant une membrane surplombant une cavité
TW202100247A (zh) 2019-01-29 2021-01-01 美商伊路米納有限公司 流通槽
TW202045709A (zh) 2019-01-29 2020-12-16 美商伊路米納有限公司 流體槽
TW202043486A (zh) * 2019-01-29 2020-12-01 美商伊路米納有限公司 定序套組
TW202120693A (zh) * 2019-08-21 2021-06-01 美商伊路米納有限公司 偵測核苷酸之聚合酶併入的方法
CN114829368A (zh) 2019-12-18 2022-07-29 豪夫迈·罗氏有限公司 通过使用连续标记方案的合成进行测序的方法
JP2024518882A (ja) * 2021-04-30 2024-05-08 イルミナ ケンブリッジ リミテッド フローセル及び方法
CN117460836A (zh) * 2021-05-31 2024-01-26 伊鲁米纳公司 流通池和方法
WO2024064639A1 (en) 2022-09-19 2024-03-28 Illumina, Inc. Nanogel particles having dual functionality and temperature responsiveness for particle clustering in nucleic acid sequencing systems
WO2024081563A1 (en) 2022-10-10 2024-04-18 Illumina, Inc. Photo-switchable chemistry for reversible hydrogels and reusable flow cells

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US627435A (en) * 1899-06-20 Railway-rail
FR2726286B1 (fr) 1994-10-28 1997-01-17 Genset Sa Procede d'amplification d'acides nucleiques en phase solide et trousse de reactifs utile pour la mise en oeuvre de ce procede
US6130098A (en) * 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
JP3514908B2 (ja) 1995-11-13 2004-04-05 株式会社東芝 研磨剤
US6103479A (en) * 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
JPH10154673A (ja) * 1996-09-30 1998-06-09 Hitachi Chem Co Ltd 酸化セリウム研磨剤及び基板の研磨法
KR100775228B1 (ko) 1996-09-30 2007-11-12 히다치 가세고교 가부시끼가이샤 산화세륨 연마제 및 기판의 연마법
US6391937B1 (en) 1998-11-25 2002-05-21 Motorola, Inc. Polyacrylamide hydrogels and hydrogel arrays made from polyacrylamide reactive prepolymers
JP3951508B2 (ja) 1999-06-11 2007-08-01 松下電器産業株式会社 電子部品の製造方法
US6372813B1 (en) 1999-06-25 2002-04-16 Motorola Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
US6664061B2 (en) 1999-06-25 2003-12-16 Amersham Biosciences Ab Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
US7507579B2 (en) * 2002-05-01 2009-03-24 Massachusetts Institute Of Technology Apparatus and methods for simultaneous operation of miniaturized reactors
US7407601B2 (en) 2003-04-24 2008-08-05 Taiwan Semiconductor Manufacturing Co., Ltd Polymeric particle slurry system and method to reduce feature sidewall erosion
EP2789383B1 (en) 2004-01-07 2023-05-03 Illumina Cambridge Limited Molecular arrays
DE102004056980A1 (de) * 2004-11-25 2006-06-01 Clondiag Chip Technologies Gmbh Verfahren zur ortsspezifischen Synthese von Biopolymeren auf festen Trägern
US7737392B2 (en) * 2006-11-09 2010-06-15 The Board Of Trustees Of The University Of Illinois Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis
US8591764B2 (en) 2006-12-20 2013-11-26 3M Innovative Properties Company Chemical mechanical planarization composition, system, and method of use
EP2200931B1 (en) 2007-09-19 2017-06-07 The Charles Stark Draper Laboratory, Inc. Microfluidic structures with circular cross-section
EP2291533B2 (en) 2008-07-02 2020-09-30 Illumina Cambridge Limited Using populations of beads for the fabrication of arrays on surfaces
JP2012109287A (ja) * 2009-03-13 2012-06-07 Asahi Glass Co Ltd 半導体用研磨剤、その製造方法及び研磨方法
WO2010115122A2 (en) * 2009-04-03 2010-10-07 Illumina, Inc. Generation of uniform fragments of nucleic acids using patterned substrates
US20100298171A1 (en) * 2009-05-22 2010-11-25 Affymetrix, Inc. Apparatus for polymer synthesis
EP2500929B1 (en) * 2009-11-11 2018-06-20 Kuraray Co., Ltd. Slurry for chemical mechanical polishing and polishing method for substrate using same
WO2012170936A2 (en) 2011-06-09 2012-12-13 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
AU2012328662B2 (en) 2011-10-28 2015-12-17 Illumina, Inc. Microarray fabrication system and method
JP5907081B2 (ja) * 2012-02-02 2016-04-20 信越化学工業株式会社 合成石英ガラス基板の製造方法
US9012022B2 (en) * 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
US9512422B2 (en) * 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
DK2969479T3 (da) * 2013-03-13 2021-08-02 Illumina Inc Væskeanordninger i flere lag og fremgangsmåder til deres fremstilling
US8951716B2 (en) * 2013-03-15 2015-02-10 Taiwan Semiconductor Manufacturing Company, Ltd. Surface modification, functionalization and integration of microfluidics and biosensor to form a biochip
WO2014148399A1 (ja) * 2013-03-19 2014-09-25 株式会社フジミインコーポレーテッド 研磨用組成物、研磨用組成物製造方法および研磨用組成物調製用キット
AU2014284584B2 (en) * 2013-07-01 2019-08-01 Illumina, Inc. Catalyst-free surface functionalization and polymer grafting
TW201518488A (zh) * 2013-07-11 2015-05-16 Fujimi Inc 研磨用組成物及其製造方法
WO2015015913A1 (ja) * 2013-07-31 2015-02-05 株式会社 日立ハイテクノロジーズ 核酸分析用フローセル、及び核酸分析装置
EP3030682B1 (en) * 2013-08-05 2020-06-03 Twist Bioscience Corporation De novo synthesized gene libraries
US9352315B2 (en) * 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
EP3084523B1 (en) * 2013-12-19 2019-07-03 Illumina, Inc. Substrates comprising nano-patterning surfaces and methods of preparing thereof
US9533278B2 (en) * 2014-08-08 2017-01-03 Applied Materials, Inc. Patterned deposition of liquid films for biomedical devices
CN107108822B (zh) * 2014-10-31 2020-02-07 伊鲁米纳剑桥有限公司 聚合物以及dna共聚物涂层
CA2979194A1 (en) * 2015-03-13 2016-09-22 3M Innovative Properties Company Composition suitable for protection comprising copolymer and hydrophilic silane
US20160339428A1 (en) * 2015-04-21 2016-11-24 Texas Tech University System System and method for chemically patterned paper microfluidic devices
WO2016180944A1 (en) * 2015-05-13 2016-11-17 Atotech Deutschland Gmbh Method for manufacturing of fine line circuitry
US9895673B2 (en) * 2015-12-01 2018-02-20 Twist Bioscience Corporation Functionalized surfaces and preparation thereof
CN111093819B (zh) 2017-12-21 2022-04-05 伊鲁米纳公司 具有水凝胶涂层的流动池

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