MX2019006025A - Transcripcion controlable. - Google Patents

Transcripcion controlable.

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Publication number
MX2019006025A
MX2019006025A MX2019006025A MX2019006025A MX2019006025A MX 2019006025 A MX2019006025 A MX 2019006025A MX 2019006025 A MX2019006025 A MX 2019006025A MX 2019006025 A MX2019006025 A MX 2019006025A MX 2019006025 A MX2019006025 A MX 2019006025A
Authority
MX
Mexico
Prior art keywords
inducible
transcription
stem cells
pluripotent stem
genetic material
Prior art date
Application number
MX2019006025A
Other languages
English (en)
Inventor
Vallier Ludovic
Kotter Mark
Pawlowski Matthias
Bertero Alessandro
Ortmann Daniel
Original Assignee
Cambridge Entpr Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58073446&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019006025(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cambridge Entpr Ltd filed Critical Cambridge Entpr Ltd
Publication of MX2019006025A publication Critical patent/MX2019006025A/es

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)

Abstract

La presente invención se refiere a un método estable para introducir por lo menos un casete inducible en una célula, y permitir transcripción controlable desde adentro de ese casete inducible; el método puede usarse para cualquier tipo de célula, desde cualquier organismo eucariótico, pero tiene una aplicación particular en la introducción de casetes inducibles en células madre pluripotentes, tales como células madre pluripotentes animales o humanas (hPSC); el casete inducible se inserta de manera controlada de tal manera que asegure que el material genético que contiene no sea silenciado o sujeto a influencias negativas desde el sitio de inserción, y se controla la transcripción del material genético.
MX2019006025A 2016-11-24 2017-11-24 Transcripcion controlable. MX2019006025A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1619876.4A GB201619876D0 (en) 2016-11-24 2016-11-24 Controllable transcription
PCT/GB2017/053531 WO2018096343A1 (en) 2016-11-24 2017-11-24 Controllable transcription

Publications (1)

Publication Number Publication Date
MX2019006025A true MX2019006025A (es) 2019-11-25

Family

ID=58073446

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019006025A MX2019006025A (es) 2016-11-24 2017-11-24 Transcripcion controlable.

Country Status (22)

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US (3) US11697823B2 (es)
EP (3) EP3545079B1 (es)
JP (2) JP2020501533A (es)
KR (3) KR102500322B1 (es)
CN (3) CN117587067A (es)
AU (1) AU2017363950A1 (es)
BR (1) BR112019010692A2 (es)
CA (1) CA3044628A1 (es)
DK (1) DK3545079T3 (es)
EA (1) EA201991255A1 (es)
ES (1) ES2918013T3 (es)
GB (1) GB201619876D0 (es)
HR (1) HRP20220836T1 (es)
HU (1) HUE059163T2 (es)
IL (1) IL266832A (es)
LT (1) LT3545079T (es)
MX (1) MX2019006025A (es)
PL (1) PL3545079T3 (es)
PT (1) PT3545079T (es)
RS (1) RS63330B1 (es)
SI (1) SI3545079T1 (es)
WO (1) WO2018096343A1 (es)

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GB201619876D0 (en) 2016-11-24 2017-01-11 Cambridge Entpr Ltd Controllable transcription
CA3067872A1 (en) 2017-07-31 2019-02-07 Regeneron Pharmaceuticals, Inc. Cas-transgenic mouse embryonic stem cells and mice and uses thereof
MA52431A (fr) * 2018-03-02 2021-01-06 Generation Bio Co Identification et caractérisation de zones de sécurité du génome (gsh) chez les êtres humains et les génomes murins, et compositions de vecteurs viraux et non viraux pour une intégration ciblée au niveau d'un locus gsh identifié
AU2019239880B2 (en) 2018-03-19 2023-11-30 Regeneron Pharmaceuticals, Inc. Transcription modulation in animals using CRISPR/Cas systems
KR20210091226A (ko) * 2018-11-08 2021-07-21 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디. 부착 비의존성 세포 및 그 용도
WO2020264254A1 (en) * 2019-06-28 2020-12-30 Crispr Therapeutics Ag Materials and methods for controlling gene editing
CN110592014A (zh) * 2019-08-14 2019-12-20 广东美赛尔细胞生物科技有限公司 一种在nk细胞治疗中免辐照体外体内持续去除饲养细胞的方法
WO2021146627A1 (en) * 2020-01-17 2021-07-22 Sana Biotechnology, Inc. Safety switches for regulation of gene expression
JP2023516484A (ja) 2020-03-11 2023-04-19 ビット バイオ リミテッド 肝細胞作製方法
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WO2022054856A1 (ja) * 2020-09-10 2022-03-17 Jsr株式会社 オリゴデンドロサイト様細胞の製造方法
CN112430624B (zh) * 2020-11-25 2023-08-18 汕头大学 一种斑马鱼肌肉特异诱导型表达载体及应用
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
WO2022118972A1 (ja) * 2020-12-04 2022-06-09 国立大学法人神戸大学 高発現高制御性遺伝子スイッチ
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