MX2019000844A - Proteinas de union de tipo anticuerpo biespecificas que se unen especificamente a cd3 y cd123. - Google Patents
Proteinas de union de tipo anticuerpo biespecificas que se unen especificamente a cd3 y cd123.Info
- Publication number
- MX2019000844A MX2019000844A MX2019000844A MX2019000844A MX2019000844A MX 2019000844 A MX2019000844 A MX 2019000844A MX 2019000844 A MX2019000844 A MX 2019000844A MX 2019000844 A MX2019000844 A MX 2019000844A MX 2019000844 A MX2019000844 A MX 2019000844A
- Authority
- MX
- Mexico
- Prior art keywords
- binding
- antibody
- binding protein
- bispecific antibody
- proteins specifically
- Prior art date
Links
- 108091008324 binding proteins Proteins 0.000 title abstract 5
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 102000023732 binding proteins Human genes 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16305923 | 2016-07-18 | ||
| PCT/EP2017/068020 WO2018015340A1 (en) | 2016-07-18 | 2017-07-17 | Bispecific antibody-like binding proteins specifically binding to cd3 and cd123 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019000844A true MX2019000844A (es) | 2019-07-04 |
Family
ID=56507555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019000844A MX2019000844A (es) | 2016-07-18 | 2017-07-17 | Proteinas de union de tipo anticuerpo biespecificas que se unen especificamente a cd3 y cd123. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20190241657A1 (enExample) |
| EP (1) | EP3484924A1 (enExample) |
| JP (2) | JP7071329B2 (enExample) |
| KR (1) | KR20190028771A (enExample) |
| CN (1) | CN109715665A (enExample) |
| AR (1) | AR109264A1 (enExample) |
| AU (1) | AU2017299125A1 (enExample) |
| BR (1) | BR112019000770A2 (enExample) |
| CA (1) | CA3030943A1 (enExample) |
| CL (1) | CL2019000119A1 (enExample) |
| CO (1) | CO2019001367A2 (enExample) |
| CR (1) | CR20190072A (enExample) |
| DO (1) | DOP2019000011A (enExample) |
| EA (1) | EA201990321A1 (enExample) |
| EC (1) | ECSP19011185A (enExample) |
| IL (1) | IL264248A (enExample) |
| MA (1) | MA45680A (enExample) |
| MX (1) | MX2019000844A (enExample) |
| PE (1) | PE20190514A1 (enExample) |
| PH (1) | PH12019500122A1 (enExample) |
| SG (1) | SG11201900400QA (enExample) |
| TN (1) | TN2019000015A1 (enExample) |
| TW (1) | TWI790206B (enExample) |
| WO (1) | WO2018015340A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY202412A (en) | 2015-01-23 | 2024-04-27 | Sanofi Sa | Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123 |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| EA039859B1 (ru) | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| MY195542A (en) | 2016-02-03 | 2023-01-31 | Amgen Res Munich Gmbh | Psma and CD3 Bispecific T Cell Engaging Antibody Constructs |
| TWI790206B (zh) * | 2016-07-18 | 2023-01-21 | 法商賽諾菲公司 | 特異性結合至ｃｄ３和ｃｄ１２３的雙特異性抗體樣結合蛋白 |
| KR20210110567A (ko) * | 2018-10-30 | 2021-09-08 | 마크로제닉스, 인크. | 혈액암의 치료를 위한 이중특이적 CD123 x CD3 디아바디 |
| CN113874400B (zh) | 2019-03-11 | 2025-02-07 | 詹森生物科技公司 | 抗Vβ17/抗CD123双特异性抗体 |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| CN111349163B (zh) * | 2020-02-05 | 2024-07-16 | 北京智仁美博生物科技有限公司 | 针对cd123的单克隆抗体 |
| TWI874613B (zh) * | 2020-03-17 | 2025-03-01 | 美商西雅圖免疫公司 | 微型導引和導航控制(miniGNC)類抗體蛋白及其製造和使用方法 |
| KR20230062833A (ko) | 2020-08-10 | 2023-05-09 | 얀센 바이오테크 인코포레이티드 | 생물공학적 바이러스 특이적 림프구 생산을 위한 재료 및 방법 |
| WO2022056197A1 (en) | 2020-09-11 | 2022-03-17 | Janssen Biotech, Inc. | Immune targeting molecules and uses thereof |
| TW202227495A (zh) | 2020-09-11 | 2022-07-16 | 美商健生生物科技公司 | 用於調節β鏈介導之免疫的方法及組成物 |
| EP4271709A1 (en) * | 2020-12-31 | 2023-11-08 | Sanofi | Multifunctional natural killer (nk) cell engagers binding to nkp46 and cd123 |
| HUE071594T2 (hu) | 2021-01-28 | 2025-09-28 | Regeneron Pharma | Készítmények és módszerek a citokinfelszabadulási szindróma kezelésére |
| JP2024508709A (ja) * | 2021-02-17 | 2024-02-28 | アイジーエム バイオサイエンシズ インコーポレイテッド | 抗ｃｄ１２３結合分子及びその使用法 |
| CN113368232B (zh) * | 2021-06-02 | 2022-08-26 | 上海交通大学 | 多特异性抗原结合蛋白及其应用 |
| AU2022323756A1 (en) * | 2021-08-06 | 2023-12-14 | Cimeio Therapeutics Ag | Discernible cell surface protein variants for use in cell therapy |
| KR20250004700A (ko) | 2022-04-11 | 2025-01-08 | 리제너론 파마슈티칼스 인코포레이티드 | 보편적 종양 세포 사멸을 위한 조성물 및 방법 |
| AU2024223918A1 (en) | 2023-02-17 | 2025-09-11 | Regeneron Pharmaceuticals, Inc. | Induced nk cells responsive to cd3/taa bispecific antibodies |
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| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4361549A (en) | 1979-04-26 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
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| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
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| KR101837053B1 (ko) * | 2008-10-01 | 2018-03-12 | 암젠 리서치 (뮌헨) 게엠베하 | 종간 특이적 ＰＳＣＡｘＣＤ３, ＣＤ19ｘＣＤ3, ｃ-ＭＥＴｘＣＤ3, 엔도시알린ｘＣＤ3, ＥｐＣＡＭｘＣＤ3, ＩＧＦ-1ＲｘＣＤ3 또는 ＦＡＰαｘＣＤ3 이중특이적 단일쇄 항체 |
| TWI743461B (zh) * | 2011-03-28 | 2021-10-21 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
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| MY202412A (en) * | 2015-01-23 | 2024-04-27 | Sanofi Sa | Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123 |
| TWI790206B (zh) * | 2016-07-18 | 2023-01-21 | 法商賽諾菲公司 | 特異性結合至ｃｄ３和ｃｄ１２３的雙特異性抗體樣結合蛋白 |
-
2017
- 2017-07-14 TW TW106123588A patent/TWI790206B/zh not_active IP Right Cessation
- 2017-07-17 JP JP2019502257A patent/JP7071329B2/ja active Active
- 2017-07-17 AR ARP170101993A patent/AR109264A1/es unknown
- 2017-07-17 WO PCT/EP2017/068020 patent/WO2018015340A1/en not_active Ceased
- 2017-07-17 CR CR20190072A patent/CR20190072A/es unknown
- 2017-07-17 TN TNP/2019/000015A patent/TN2019000015A1/en unknown
- 2017-07-17 MX MX2019000844A patent/MX2019000844A/es unknown
- 2017-07-17 AU AU2017299125A patent/AU2017299125A1/en not_active Abandoned
- 2017-07-17 MA MA045680A patent/MA45680A/fr unknown
- 2017-07-17 BR BR112019000770A patent/BR112019000770A2/pt not_active IP Right Cessation
- 2017-07-17 EA EA201990321A patent/EA201990321A1/ru unknown
- 2017-07-17 PE PE2019000065A patent/PE20190514A1/es not_active Application Discontinuation
- 2017-07-17 EP EP17749380.6A patent/EP3484924A1/en not_active Withdrawn
- 2017-07-17 SG SG11201900400QA patent/SG11201900400QA/en unknown
- 2017-07-17 US US16/318,599 patent/US20190241657A1/en not_active Abandoned
- 2017-07-17 KR KR1020197004345A patent/KR20190028771A/ko not_active Withdrawn
- 2017-07-17 CN CN201780056945.7A patent/CN109715665A/zh active Pending
- 2017-07-17 CA CA3030943A patent/CA3030943A1/en active Pending
-
2019
- 2019-01-15 IL IL264248A patent/IL264248A/en unknown
- 2019-01-16 PH PH12019500122A patent/PH12019500122A1/en unknown
- 2019-01-16 DO DO2019000011A patent/DOP2019000011A/es unknown
- 2019-01-16 CL CL2019000119A patent/CL2019000119A1/es unknown
- 2019-02-15 CO CONC2019/0001367A patent/CO2019001367A2/es unknown
- 2019-02-15 EC ECSENADI201911185A patent/ECSP19011185A/es unknown
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2022
- 2022-05-02 JP JP2022075664A patent/JP2022105138A/ja active Pending
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|---|---|
| SG11201900400QA (en) | 2019-02-27 |
| TN2019000015A1 (en) | 2020-07-15 |
| DOP2019000011A (es) | 2019-05-15 |
| CO2019001367A2 (es) | 2019-02-19 |
| AR109264A1 (es) | 2018-11-14 |
| AU2017299125A1 (en) | 2019-03-07 |
| KR20190028771A (ko) | 2019-03-19 |
| US20190241657A1 (en) | 2019-08-08 |
| WO2018015340A1 (en) | 2018-01-25 |
| CA3030943A1 (en) | 2018-01-25 |
| CL2019000119A1 (es) | 2019-06-14 |
| EP3484924A1 (en) | 2019-05-22 |
| TWI790206B (zh) | 2023-01-21 |
| MA45680A (fr) | 2019-05-22 |
| PH12019500122A1 (en) | 2019-04-15 |
| TW201811830A (zh) | 2018-04-01 |
| EA201990321A1 (ru) | 2019-06-28 |
| CN109715665A (zh) | 2019-05-03 |
| JP2019531701A (ja) | 2019-11-07 |
| JP7071329B2 (ja) | 2022-05-18 |
| JP2022105138A (ja) | 2022-07-12 |
| BR112019000770A2 (pt) | 2019-07-02 |
| ECSP19011185A (es) | 2019-02-28 |
| IL264248A (en) | 2019-02-28 |
| PE20190514A1 (es) | 2019-04-10 |
| CR20190072A (es) | 2019-06-25 |
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