MX2018008862A - Metodo para preparar una composicion farmaceutica que comprende un derivado de quinolina o una sal del mismo. - Google Patents
Metodo para preparar una composicion farmaceutica que comprende un derivado de quinolina o una sal del mismo.Info
- Publication number
- MX2018008862A MX2018008862A MX2018008862A MX2018008862A MX2018008862A MX 2018008862 A MX2018008862 A MX 2018008862A MX 2018008862 A MX2018008862 A MX 2018008862A MX 2018008862 A MX2018008862 A MX 2018008862A MX 2018008862 A MX2018008862 A MX 2018008862A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical composition
- salt
- quinoline derivative
- preparing
- preparing pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
La presente invención proporciona un método para preparar una composición farmacéutica que comprende un derivado de quinolina o una de sus sales. De manera específica, la invención proporciona un método para preparar una composición farmacéutica que comprende una (R,E)-N-(4-(3-cloro-4-(piridin-2-ilmetoxi)fenilamino )-3-ciano-7-etoxiquinolin-6-il)-3-(1-metilpirrolidin-2-il)-propen amida o una de sus sales farmacéuticamente aceptables. El método comprende utilizar un agente humectante que comprenda al menos un solvente orgánico para una granulación por vía húmeda en un proceso de preparación de la composición farmacéutica. La composición farmacéutica preparada utilizando el método tiene una distribución uniforme de tamaños de grano durante el proceso de preparación y una propiedad de disolución rápida y uniforme.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610057228 | 2016-01-27 | ||
PCT/CN2017/072156 WO2017129088A1 (zh) | 2016-01-27 | 2017-01-23 | 一种含有喹啉衍生物或其盐的药物组合物的制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018008862A true MX2018008862A (es) | 2018-09-07 |
Family
ID=59397365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018008862A MX2018008862A (es) | 2016-01-27 | 2017-01-23 | Metodo para preparar una composicion farmaceutica que comprende un derivado de quinolina o una sal del mismo. |
Country Status (23)
Country | Link |
---|---|
US (1) | US10722469B2 (es) |
EP (1) | EP3378479B1 (es) |
JP (1) | JP6937308B2 (es) |
KR (1) | KR20180103090A (es) |
CN (2) | CN107405345A (es) |
AU (1) | AU2017211737B2 (es) |
BR (1) | BR112018014544A2 (es) |
CA (1) | CA3008701A1 (es) |
CY (1) | CY1123149T1 (es) |
DK (1) | DK3378479T3 (es) |
ES (1) | ES2811031T3 (es) |
HK (1) | HK1243357A1 (es) |
HR (1) | HRP20201155T1 (es) |
HU (1) | HUE050255T2 (es) |
LT (1) | LT3378479T (es) |
MX (1) | MX2018008862A (es) |
PL (1) | PL3378479T3 (es) |
PT (1) | PT3378479T (es) |
RS (1) | RS60747B1 (es) |
RU (1) | RU2735807C2 (es) |
SI (1) | SI3378479T1 (es) |
TW (1) | TWI720115B (es) |
WO (1) | WO2017129088A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI700086B (zh) * | 2017-10-24 | 2020-08-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | 一種含有喹啉衍生物的藥物組合物 |
KR102511672B1 (ko) * | 2018-03-23 | 2023-03-17 | 우시 상량 바이오테크놀로지 씨오., 엘티디. | 의약 조성물, 그 제조방법 및 사용 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2283651C2 (ru) * | 2001-12-21 | 2006-09-20 | Пфайзер Продактс Инк. | Способы мокрой грануляции азитромицина |
US20060039968A1 (en) * | 2002-10-08 | 2006-02-23 | Ramalingam Manikandan | Gabapentin tablets and method for their preparation |
EP1417958A1 (en) * | 2002-11-08 | 2004-05-12 | Pari GmbH | Wet granulation process |
CN101824029A (zh) * | 2009-03-05 | 2010-09-08 | 厦门艾德生物医药科技有限公司 | 酪氨酸激酶不可逆抑制剂、其药物组合物及其用途 |
CN102020639A (zh) * | 2009-09-14 | 2011-04-20 | 上海恒瑞医药有限公司 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
CN102675287A (zh) | 2011-03-11 | 2012-09-19 | 江苏恒瑞医药股份有限公司 | (e)-n-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2r)-1-甲基吡咯烷-2-基]丙-2-烯酰胺的可药用的盐、其制备方法及其在医药上的应用 |
US20130150386A1 (en) * | 2011-12-09 | 2013-06-13 | Syndax Pharmaceuticals, Inc. | Methods for the treatment of lung cancer |
CN103987700B (zh) * | 2012-03-09 | 2016-08-31 | 江苏豪森药业集团有限公司 | 4-喹唑啉胺类衍生物及其用途 |
CN103539783A (zh) * | 2012-07-12 | 2014-01-29 | 江苏恒瑞医药股份有限公司 | 一种酪氨酸激酶抑制剂的二马来酸盐的i型结晶及制备方法 |
US9676746B2 (en) * | 2015-01-30 | 2017-06-13 | Biomed Valley Discoveries, Inc. | Crystalline forms of C21H22Cl2N4O2 |
-
2017
- 2017-01-23 AU AU2017211737A patent/AU2017211737B2/en not_active Ceased
- 2017-01-23 CA CA3008701A patent/CA3008701A1/en active Pending
- 2017-01-23 JP JP2018534780A patent/JP6937308B2/ja active Active
- 2017-01-23 RS RS20200902A patent/RS60747B1/sr unknown
- 2017-01-23 WO PCT/CN2017/072156 patent/WO2017129088A1/zh active Application Filing
- 2017-01-23 LT LTEP17743703.5T patent/LT3378479T/lt unknown
- 2017-01-23 RU RU2018128416A patent/RU2735807C2/ru active
- 2017-01-23 MX MX2018008862A patent/MX2018008862A/es unknown
- 2017-01-23 HU HUE17743703A patent/HUE050255T2/hu unknown
- 2017-01-23 KR KR1020187022626A patent/KR20180103090A/ko not_active Application Discontinuation
- 2017-01-23 TW TW106102384A patent/TWI720115B/zh active
- 2017-01-23 BR BR112018014544-0A patent/BR112018014544A2/pt not_active IP Right Cessation
- 2017-01-23 PL PL17743703T patent/PL3378479T3/pl unknown
- 2017-01-23 PT PT177437035T patent/PT3378479T/pt unknown
- 2017-01-23 CN CN201780000924.3A patent/CN107405345A/zh active Pending
- 2017-01-23 DK DK17743703.5T patent/DK3378479T3/da active
- 2017-01-23 EP EP17743703.5A patent/EP3378479B1/en active Active
- 2017-01-23 CN CN201811023692.6A patent/CN108938586B/zh active Active
- 2017-01-23 ES ES17743703T patent/ES2811031T3/es active Active
- 2017-01-23 SI SI201730345T patent/SI3378479T1/sl unknown
- 2017-01-23 US US16/071,572 patent/US10722469B2/en active Active
-
2018
- 2018-03-02 HK HK18103053.8A patent/HK1243357A1/zh unknown
-
2020
- 2020-07-23 HR HRP20201155TT patent/HRP20201155T1/hr unknown
- 2020-07-27 CY CY20201100686T patent/CY1123149T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
RU2018128416A3 (es) | 2020-04-21 |
HUE050255T2 (hu) | 2020-11-30 |
DK3378479T3 (da) | 2020-08-03 |
JP2019503373A (ja) | 2019-02-07 |
CN108938586A (zh) | 2018-12-07 |
TW201726138A (zh) | 2017-08-01 |
PL3378479T3 (pl) | 2020-11-02 |
EP3378479A1 (en) | 2018-09-26 |
EP3378479A4 (en) | 2018-12-19 |
US10722469B2 (en) | 2020-07-28 |
US20190054025A1 (en) | 2019-02-21 |
CY1123149T1 (el) | 2021-10-29 |
PT3378479T (pt) | 2020-07-20 |
AU2017211737B2 (en) | 2022-04-28 |
CN108938586B (zh) | 2021-05-14 |
JP6937308B2 (ja) | 2021-09-22 |
ES2811031T3 (es) | 2021-03-10 |
RS60747B1 (sr) | 2020-10-30 |
CA3008701A1 (en) | 2017-08-03 |
CN107405345A (zh) | 2017-11-28 |
HRP20201155T1 (hr) | 2020-10-30 |
LT3378479T (lt) | 2020-09-10 |
TWI720115B (zh) | 2021-03-01 |
SI3378479T1 (sl) | 2020-10-30 |
RU2735807C2 (ru) | 2020-11-09 |
EP3378479B1 (en) | 2020-06-17 |
HK1243357A1 (zh) | 2018-07-13 |
WO2017129088A1 (zh) | 2017-08-03 |
RU2018128416A (ru) | 2020-02-27 |
AU2017211737A1 (en) | 2018-08-02 |
BR112018014544A2 (pt) | 2018-12-11 |
KR20180103090A (ko) | 2018-09-18 |
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