MX2018003562A - Derivados de hidroxialquil tiadiazol. - Google Patents
Derivados de hidroxialquil tiadiazol.Info
- Publication number
- MX2018003562A MX2018003562A MX2018003562A MX2018003562A MX2018003562A MX 2018003562 A MX2018003562 A MX 2018003562A MX 2018003562 A MX2018003562 A MX 2018003562A MX 2018003562 A MX2018003562 A MX 2018003562A MX 2018003562 A MX2018003562 A MX 2018003562A
- Authority
- MX
- Mexico
- Prior art keywords
- safety profile
- excellent solubility
- possess excellent
- human
- subunit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a la necesidad de un nuevo antibiótico que tiene un mecanismo de acción novedoso, el cual presenta fuerte actividad antibacteriana no solamente contra la bacteria sensible, sino también contra la bacteria resistente del mismo, y al mismo tiempo posee excelente perfil de solubilidad y seguridad susceptible para usarse humano. Como un resultado de la investigación extensiva, los presentes inventores han encontrado que un compuesto representado por la fórmula general (I), (ver Fórmula) un estereoisómero, o una sal del mismo farmacéuticamente aceptable inhibe la subunidad GyrB de girasa de ADN y/o subunidad ParE de topoisomerasa IV, posee excelente perfil de seguridad y solubilidad para usarse en humano para el tratamiento de enfermedades infecciosas bacterianas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3119DE2015 | 2015-09-30 | ||
PCT/IB2016/055795 WO2017056012A1 (en) | 2015-09-30 | 2016-09-28 | Hydroxyalkyl thiadiazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018003562A true MX2018003562A (es) | 2018-06-19 |
Family
ID=57218949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018003562A MX2018003562A (es) | 2015-09-30 | 2016-09-28 | Derivados de hidroxialquil tiadiazol. |
Country Status (19)
Country | Link |
---|---|
US (1) | US10399968B2 (es) |
EP (1) | EP3356361B1 (es) |
JP (1) | JP6824256B2 (es) |
KR (1) | KR20180054650A (es) |
CN (1) | CN108137574B (es) |
AU (1) | AU2016330271B2 (es) |
BR (1) | BR112018006276A2 (es) |
CA (1) | CA2999982C (es) |
CO (1) | CO2018003548A2 (es) |
ES (1) | ES2817749T3 (es) |
HK (1) | HK1252275A1 (es) |
IL (1) | IL258411B (es) |
MX (1) | MX2018003562A (es) |
MY (1) | MY184406A (es) |
PH (1) | PH12018500697A1 (es) |
RU (1) | RU2737892C1 (es) |
TW (1) | TW201731844A (es) |
WO (1) | WO2017056012A1 (es) |
ZA (1) | ZA201801718B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017056012A1 (en) * | 2015-09-30 | 2017-04-06 | Daiichi Sankyo Company, Limited | Hydroxyalkyl thiadiazole derivatives |
CA3056571C (en) | 2017-03-14 | 2021-11-23 | Daiichi Sankyo Company, Limited | N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives |
EP3847172A1 (en) | 2018-09-03 | 2021-07-14 | Univerza v Ljubljani | New class of dna gyrase and/or topoisomerase iv inhibitors with activity against gram-positive and gram-negative bacteria |
EP4263503A1 (en) | 2020-12-17 | 2023-10-25 | Univerza V Ljubljani | New n-phenylpyrrolamide inhibitors of dna gyrase and topoisomerase iv with antibacterial activity |
CN115466246B (zh) | 2021-06-11 | 2024-02-06 | 中国医学科学院药物研究所 | 吡咯酰哌啶胺类化合物及其用途 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200526626A (en) | 2003-09-13 | 2005-08-16 | Astrazeneca Ab | Chemical compounds |
UA94901C2 (ru) | 2005-02-18 | 2011-06-25 | Астразенека Аб | Антибактериальные производные пиперидина |
WO2006087544A2 (en) | 2005-02-18 | 2006-08-24 | Astrazeneca Ab | Pyrrole derivatives as dna gyrase and topoisomerase inhibitors |
WO2006087548A2 (en) | 2005-02-18 | 2006-08-24 | Astrazeneca Ab | Pyrrole derivatives as dna gyrase and topoisomerase inhibitors |
WO2006092608A1 (en) | 2005-03-04 | 2006-09-08 | Astrazeneca Ab | Tricyclic derivatives of azetidine and pyrrole with antibacterial activity |
CN101171247A (zh) | 2005-03-04 | 2008-04-30 | 阿斯利康(瑞典)有限公司 | 作为dna促旋酶和拓扑异构酶抑制剂的吡咯衍生物 |
JP2009520785A (ja) | 2005-12-23 | 2009-05-28 | アストラゼネカ アクチボラグ | 抗菌性のピロロピリジン、ピロロピリミジン、及びピロロアゼピン |
WO2008020229A2 (en) | 2006-08-17 | 2008-02-21 | Astrazeneca Ab | Antibacterial pyrrolecarboxamides |
TW200819437A (en) | 2006-08-17 | 2008-05-01 | Astrazeneca Ab | Chemical compounds |
WO2008020227A2 (en) | 2006-08-17 | 2008-02-21 | Astrazeneca Ab | Antibacterial pyrrolecarboxamides |
TW200906412A (en) | 2007-06-12 | 2009-02-16 | Astrazeneca Ab | Piperidine compounds and uses thereof |
TWI498115B (zh) | 2007-12-27 | 2015-09-01 | Daiichi Sankyo Co Ltd | 咪唑羰基化合物 |
EP2326640A1 (en) | 2008-07-30 | 2011-06-01 | Ranbaxy Laboratories Limited | Pyrrole carboxylic acid derivatives as antibacterial agents |
TW201026694A (en) | 2008-12-12 | 2010-07-16 | Astrazeneca Ab | Compound 468 |
TW201026695A (en) | 2008-12-12 | 2010-07-16 | Astrazeneca Ab | Piperidine compounds and uses thereof-596 |
JP2011026305A (ja) * | 2009-06-24 | 2011-02-10 | Daiichi Sankyo Co Ltd | イミダゾールカルボニル化合物を含有する医薬組成物 |
WO2014057415A2 (en) | 2012-10-10 | 2014-04-17 | Vitas Pharma Research Pvt Ltd | Inhibitors of dna gyrase for the treatment of bacterial infections |
WO2017056012A1 (en) * | 2015-09-30 | 2017-04-06 | Daiichi Sankyo Company, Limited | Hydroxyalkyl thiadiazole derivatives |
-
2016
- 2016-09-28 WO PCT/IB2016/055795 patent/WO2017056012A1/en active Application Filing
- 2016-09-28 US US15/764,264 patent/US10399968B2/en active Active
- 2016-09-28 EP EP16788802.3A patent/EP3356361B1/en active Active
- 2016-09-28 KR KR1020187009045A patent/KR20180054650A/ko not_active Application Discontinuation
- 2016-09-28 MX MX2018003562A patent/MX2018003562A/es active IP Right Grant
- 2016-09-28 MY MYPI2018000462A patent/MY184406A/en unknown
- 2016-09-28 CN CN201680056244.9A patent/CN108137574B/zh active Active
- 2016-09-28 AU AU2016330271A patent/AU2016330271B2/en not_active Ceased
- 2016-09-28 ES ES16788802T patent/ES2817749T3/es active Active
- 2016-09-28 RU RU2018115999A patent/RU2737892C1/ru active
- 2016-09-28 CA CA2999982A patent/CA2999982C/en active Active
- 2016-09-28 JP JP2018515598A patent/JP6824256B2/ja active Active
- 2016-09-28 BR BR112018006276-6A patent/BR112018006276A2/pt not_active Application Discontinuation
- 2016-09-29 TW TW105131310A patent/TW201731844A/zh unknown
-
2018
- 2018-03-13 ZA ZA2018/01718A patent/ZA201801718B/en unknown
- 2018-03-27 IL IL258411A patent/IL258411B/en unknown
- 2018-03-27 PH PH12018500697A patent/PH12018500697A1/en unknown
- 2018-04-03 CO CONC2018/0003548A patent/CO2018003548A2/es unknown
- 2018-09-11 HK HK18111652.6A patent/HK1252275A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
TW201731844A (zh) | 2017-09-16 |
JP2018529696A (ja) | 2018-10-11 |
IL258411B (en) | 2021-08-31 |
CN108137574A (zh) | 2018-06-08 |
AU2016330271A1 (en) | 2018-04-12 |
CA2999982C (en) | 2020-07-28 |
CN108137574B (zh) | 2021-12-28 |
CA2999982A1 (en) | 2017-04-06 |
IL258411A (en) | 2018-05-31 |
RU2737892C1 (ru) | 2020-12-04 |
US20180327399A1 (en) | 2018-11-15 |
ZA201801718B (en) | 2019-01-30 |
ES2817749T3 (es) | 2021-04-08 |
MY184406A (en) | 2021-04-01 |
AU2016330271B2 (en) | 2020-04-30 |
WO2017056012A1 (en) | 2017-04-06 |
BR112018006276A2 (pt) | 2018-10-16 |
HK1252275A1 (zh) | 2019-05-24 |
EP3356361B1 (en) | 2020-07-08 |
JP6824256B2 (ja) | 2021-02-03 |
KR20180054650A (ko) | 2018-05-24 |
PH12018500697A1 (en) | 2018-10-01 |
US10399968B2 (en) | 2019-09-03 |
CO2018003548A2 (es) | 2018-07-19 |
EP3356361A1 (en) | 2018-08-08 |
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Legal Events
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FG | Grant or registration |