MX2017011879A - Inhibidores de pcsk9 para el tratamiento de trastornos del metabolismo de lipoproteínas". - Google Patents
Inhibidores de pcsk9 para el tratamiento de trastornos del metabolismo de lipoproteínas".Info
- Publication number
- MX2017011879A MX2017011879A MX2017011879A MX2017011879A MX2017011879A MX 2017011879 A MX2017011879 A MX 2017011879A MX 2017011879 A MX2017011879 A MX 2017011879A MX 2017011879 A MX2017011879 A MX 2017011879A MX 2017011879 A MX2017011879 A MX 2017011879A
- Authority
- MX
- Mexico
- Prior art keywords
- pcsk9
- inhibitors
- treatment
- metabolism disorders
- lipoprotein metabolism
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La presente divulgación hace referencia a inhibidores de proteína convertasa subtilisina/kexina tipo 9 (PCSK9) para el tratamiento de trastornos del metabolismo de lipoproteínas.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201570158 | 2015-03-20 | ||
DKPA201570623 | 2015-10-02 | ||
DKPA201570839 | 2015-12-21 | ||
PCT/DK2016/050082 WO2016150444A1 (en) | 2015-03-20 | 2016-03-18 | Inhibitors of pcsk9 for treatment of lipoprotein metabolism disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017011879A true MX2017011879A (es) | 2018-04-10 |
Family
ID=55696811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017011879A MX2017011879A (es) | 2015-03-20 | 2016-03-18 | Inhibidores de pcsk9 para el tratamiento de trastornos del metabolismo de lipoproteínas". |
Country Status (10)
Country | Link |
---|---|
US (3) | US10688119B2 (es) |
EP (2) | EP3271405A1 (es) |
JP (2) | JP6869894B2 (es) |
KR (1) | KR20170123345A (es) |
CN (1) | CN107531798B (es) |
AU (2) | AU2016235662B2 (es) |
BR (1) | BR112017020091A2 (es) |
CA (1) | CA2979756A1 (es) |
MX (1) | MX2017011879A (es) |
WO (1) | WO2016150444A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112017020091A2 (pt) | 2015-03-20 | 2018-11-06 | Aarhus Universitet | inibidores de pcsk9 para tratamento de distúrbios do metabolismo de lipoproteínas |
EP3515455B1 (en) | 2016-09-20 | 2021-04-14 | Aarhus Universitet | Compounds for treatment of lipoprotein metabolism disorders |
CN108753821A (zh) * | 2018-06-13 | 2018-11-06 | 黄河科技学院 | 一种基于细胞的pcsk9抑制剂筛选方法 |
WO2020010186A1 (en) * | 2018-07-06 | 2020-01-09 | Derek Klarin | Pcsk9 variants |
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DE3422407A1 (de) * | 1984-06-16 | 1986-03-06 | B. Braun Melsungen Ag, 3508 Melsungen | Verwendung von heparinderivaten zur selektiven extrakorporalen praezipitation von low-density-lipoproteinen aus vollserum oder plasma |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
AU2753292A (en) | 1991-10-04 | 1993-05-03 | Procter & Gamble Company, The | Cholesterol lowering compounds and process for making them |
EP0617706B1 (en) | 1991-11-25 | 2001-10-17 | Enzon, Inc. | Multivalent antigen-binding proteins |
GB9221657D0 (en) | 1992-10-15 | 1992-11-25 | Scotgen Ltd | Recombinant bispecific antibodies |
EP0628078B1 (en) | 1992-12-11 | 1999-12-08 | The Dow Chemical Company | Multivalent single chain antibodies |
US6255296B1 (en) * | 1994-01-11 | 2001-07-03 | Endomatrix, Inc. | Composition and method for treating a patient susceptible to or suffering from a cardiovascular disorder or disease |
US6258798B1 (en) * | 1999-09-07 | 2001-07-10 | Pharmacia Ab | Method for treatment of unstable coronary artery disease by an early revascularisation together with administration of a low molecular weight heparin |
ES2295228T3 (es) | 2000-11-30 | 2008-04-16 | Medarex, Inc. | Roedores transcromosomicos transgenicos para la preparacion de anticuerpos humanos. |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
UA80399C2 (en) * | 2001-11-13 | 2007-09-25 | Glaxo Group Ltd | Use of specific dose of fondaparinux sodium for the treatment of acs |
JP4554910B2 (ja) * | 2002-11-01 | 2010-09-29 | 生化学工業株式会社 | 血糖低下剤 |
EP1603543A4 (en) * | 2003-02-28 | 2009-03-04 | Florey Howard Inst | THERAPEUTIC COMPOSITIONS |
JP2010505432A (ja) * | 2006-10-09 | 2010-02-25 | サンタリス ファーマ アー/エス | Pcsk9を調節するためのrnaアンタゴニスト化合物 |
WO2008118883A1 (en) * | 2007-03-24 | 2008-10-02 | Isis Pharmaceuticals, Inc. | Administering antisense oligonucleotides complementary to human apolipoprotein b |
JOP20080381B1 (ar) * | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
WO2009049370A1 (en) | 2007-10-16 | 2009-04-23 | Progen Pharmaceuticals Limited | Novel sulfated oligosaccharide derivatives |
JP2011501952A (ja) * | 2007-10-26 | 2011-01-20 | シェーリング コーポレイション | 脂質障害およびコレステロール障害を治療するための抗pcsk9および方法 |
ES2340902B1 (es) * | 2008-07-01 | 2011-05-03 | Laboratorios Farmaceuticos Rovi, S.A. | Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas. |
TWI445716B (zh) | 2008-09-12 | 2014-07-21 | Rinat Neuroscience Corp | Pcsk9拮抗劑類 |
CN101757019B (zh) * | 2008-11-10 | 2011-06-08 | 鲁南制药集团股份有限公司 | 用于减肥或治疗代谢综合征的药物组合物 |
JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
WO2011051961A1 (en) * | 2009-10-01 | 2011-05-05 | Cadila Healthcare Limited | Compounds for the treatment of dyslipidemia and related diseases |
WO2011053048A2 (ko) | 2009-10-29 | 2011-05-05 | 연세대학교 산학협력단 | 신규 혈관누출 차단제 |
AR079336A1 (es) * | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
CA2820953A1 (en) * | 2010-12-22 | 2012-06-28 | Genentech, Inc. | Anti-pcsk9 antibodies and methods of use |
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CN103476797A (zh) * | 2011-01-28 | 2013-12-25 | 赛诺菲 | 包含针对pcsk9的人抗体的药物组合物 |
WO2012109530A1 (en) | 2011-02-11 | 2012-08-16 | Irm Llc | Pcsk9 antagonists |
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EP2794661B1 (en) | 2011-12-20 | 2019-03-06 | Adaerata, Limited Partnership | Single domain antibodies as inhibitors of pcsk9 |
WO2013148284A1 (en) | 2012-03-29 | 2013-10-03 | Genentech, Inc. | Antibodies that bind to a pcsk9 cleavage site and methods of use |
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WO2014107739A1 (en) * | 2013-01-07 | 2014-07-10 | Eleven Biotherapeutics, Inc. | Antibodies against pcsk9 |
CA2905237A1 (en) * | 2013-03-15 | 2014-09-18 | Adaerata, Limited Partnership | Small molecule modulators of pcsk9 and methods of use thereof |
US20160039945A1 (en) | 2013-03-15 | 2016-02-11 | Amgen Inc. | Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9 |
US9480703B2 (en) * | 2013-10-29 | 2016-11-01 | Shaker A. Mousa | Method and composition of glycosaminoglycans in sickle cell and vascular disorders |
BR112017020091A2 (pt) | 2015-03-20 | 2018-11-06 | Aarhus Universitet | inibidores de pcsk9 para tratamento de distúrbios do metabolismo de lipoproteínas |
EP3515455B1 (en) * | 2016-09-20 | 2021-04-14 | Aarhus Universitet | Compounds for treatment of lipoprotein metabolism disorders |
-
2016
- 2016-03-18 BR BR112017020091-0A patent/BR112017020091A2/pt active Search and Examination
- 2016-03-18 WO PCT/DK2016/050082 patent/WO2016150444A1/en active Application Filing
- 2016-03-18 MX MX2017011879A patent/MX2017011879A/es unknown
- 2016-03-18 CA CA2979756A patent/CA2979756A1/en active Pending
- 2016-03-18 US US15/558,491 patent/US10688119B2/en active Active
- 2016-03-18 EP EP16714751.1A patent/EP3271405A1/en not_active Withdrawn
- 2016-03-18 AU AU2016235662A patent/AU2016235662B2/en not_active Ceased
- 2016-03-18 CN CN201680026131.4A patent/CN107531798B/zh not_active Expired - Fee Related
- 2016-03-18 KR KR1020177030055A patent/KR20170123345A/ko not_active Application Discontinuation
- 2016-03-18 JP JP2017549203A patent/JP6869894B2/ja active Active
- 2016-03-18 EP EP21175700.0A patent/EP3973958A3/en not_active Withdrawn
-
2020
- 2020-05-04 US US16/865,661 patent/US20200330504A1/en not_active Abandoned
- 2020-10-15 AU AU2020256388A patent/AU2020256388A1/en not_active Abandoned
-
2021
- 2021-04-14 JP JP2021068527A patent/JP2021119148A/ja active Pending
- 2021-11-22 US US17/532,414 patent/US20220072032A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2016235662B2 (en) | 2020-07-30 |
US20180193376A1 (en) | 2018-07-12 |
JP2021119148A (ja) | 2021-08-12 |
JP6869894B2 (ja) | 2021-05-12 |
EP3973958A2 (en) | 2022-03-30 |
AU2020256388A1 (en) | 2020-11-12 |
AU2016235662A1 (en) | 2017-10-12 |
BR112017020091A2 (pt) | 2018-11-06 |
CN107531798B (zh) | 2022-02-18 |
US20220072032A1 (en) | 2022-03-10 |
CA2979756A1 (en) | 2016-09-29 |
US20200330504A1 (en) | 2020-10-22 |
KR20170123345A (ko) | 2017-11-07 |
EP3973958A3 (en) | 2022-06-22 |
CN107531798A (zh) | 2018-01-02 |
WO2016150444A1 (en) | 2016-09-29 |
JP2018511596A (ja) | 2018-04-26 |
EP3271405A1 (en) | 2018-01-24 |
US10688119B2 (en) | 2020-06-23 |
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