MX2017010240A - Polimeros de tiol-eno degradables y metodos para hacer los mismos. - Google Patents

Polimeros de tiol-eno degradables y metodos para hacer los mismos.

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Publication number
MX2017010240A
MX2017010240A MX2017010240A MX2017010240A MX2017010240A MX 2017010240 A MX2017010240 A MX 2017010240A MX 2017010240 A MX2017010240 A MX 2017010240A MX 2017010240 A MX2017010240 A MX 2017010240A MX 2017010240 A MX2017010240 A MX 2017010240A
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MX
Mexico
Prior art keywords
thiol
ene
radical
methods
thiol groups
Prior art date
Application number
MX2017010240A
Other languages
English (en)
Inventor
V Kazantsev Alexei
D Mariner Peter
Stanton Martin
Original Assignee
Mosaic Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mosaic Biosciences Inc filed Critical Mosaic Biosciences Inc
Publication of MX2017010240A publication Critical patent/MX2017010240A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
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  • Chemical & Material Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
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  • Transplantation (AREA)
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Abstract

Se proporcionan métodos para ligar polipéptidos (incluyendo péptidos y proteínas) a otras porciones por el uso de químicas de tioleno imitadas por radical, por ejemplo, modificar un polipéptido al introducir grupos tiol reactivos y hacer reaccionar los grupos tiol con reactivos que contienen olefina o reactivos que contienen alquino bajo condiciones que soportan reacciones de radical tiol-eno o tiol-ino. Los grupos tiol reactivos tienen una actividad mayor para reacciones de radical tiol-eno que un grupo tiol cisteína, incluyendo grupos tiol que se separan del respaldo péptido por al menos dos átomos de carbono, por ejemplo, el grupo tiol de un residuo de homocisteína. También se proporcionan composiciones y biomateriales que contienen los polipéptidos ligados, por ejemplo, conjugados péptido y proteína, y polímeros de hidrogel biocompatibles basados en tiol-eno, y sus usos en el campo médico.
MX2017010240A 2015-02-09 2016-02-09 Polimeros de tiol-eno degradables y metodos para hacer los mismos. MX2017010240A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562114034P 2015-02-09 2015-02-09
PCT/US2016/017189 WO2016130573A2 (en) 2015-02-09 2016-02-09 Degradable thiol-ene polymers and methods of making thereof

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MX2017010240A true MX2017010240A (es) 2017-12-04

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US (2) US10912837B2 (es)
EP (1) EP3256167B1 (es)
JP (1) JP2018507908A (es)
KR (1) KR20170116109A (es)
CN (1) CN107530440A (es)
AU (1) AU2016219475A1 (es)
BR (1) BR112017017029A2 (es)
CA (1) CA2976231A1 (es)
HK (2) HK1248528A1 (es)
MX (1) MX2017010240A (es)
RU (1) RU2017131285A (es)
WO (1) WO2016130573A2 (es)

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US7288608B2 (en) 2001-10-10 2007-10-30 Regents Of The University Of Colorado Degradable thiol-ene polymers
WO2012103445A2 (en) 2011-01-28 2012-08-02 The Regents Of The University Of Colorado, A Body Corporate Convalently cross linked hydrogels and methods of making and using same
US9988433B2 (en) 2013-03-14 2018-06-05 Mosaic Biosciences, Inc. Covalent modification of biological macromolecules
EP2822533B1 (en) 2012-02-02 2021-01-20 Mosaic Biosciences, Inc. Biomaterials for delivery of blood extracts and methods of using same
WO2016130573A2 (en) * 2015-02-09 2016-08-18 Mosaic Biosciences, Inc. Degradable thiol-ene polymers and methods of making thereof
US20210002469A1 (en) * 2018-03-19 2021-01-07 The Regents Of The University Of Colorado, A Body Corporate Tough, healable composites displaying stress relaxation at the resin-filler interface
GB2575793A (en) * 2018-07-20 2020-01-29 Montanuniv Leoben Resin composition suitable for printing and printing methods
EP3680273B1 (en) * 2019-01-08 2022-03-09 Université de Montpellier Branched-block copolymer photo-crosslinker functionalized with photoreactive groups and its use for shaping degradable photo-crosslinked elastomers suitable for medical and tissue-engineering applications
WO2020232270A1 (en) * 2019-05-14 2020-11-19 Mosaic Biosciences, Inc. Degradable polymeric tissue scaffold
CN112126081B (zh) * 2019-06-24 2023-01-31 中国科学院苏州纳米技术与纳米仿生研究所 基于逆Diels-Alder反应的可快速固化水凝胶、其制备方法及应用
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