MX2017007928A - Sistemas de modificación de genoma fúngico y métodos de uso. - Google Patents
Sistemas de modificación de genoma fúngico y métodos de uso.Info
- Publication number
- MX2017007928A MX2017007928A MX2017007928A MX2017007928A MX2017007928A MX 2017007928 A MX2017007928 A MX 2017007928A MX 2017007928 A MX2017007928 A MX 2017007928A MX 2017007928 A MX2017007928 A MX 2017007928A MX 2017007928 A MX2017007928 A MX 2017007928A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- genome modification
- modification systems
- fungal genome
- compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Se proporcionan composiciones y métodos para la modificación del genoma en un sitio diana en el genoma de una célula de hongo filamentoso. Los métodos y composiciones llevan a un polinucleótido guía/sistema de endonucleasa Cas para modificar o alterar el sitio diana. También se proporcionan aspectos en los que la célula de hongo filamentoso que se modifica tiene una ruta de extremos no homólogos defectuosa.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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CN2014093918 | 2014-12-16 | ||
CN2014093914 | 2014-12-16 | ||
CN2014093916 | 2014-12-16 | ||
PCT/US2015/065693 WO2016100272A1 (en) | 2014-12-16 | 2015-12-15 | Fungal genome modification systems and methods of use |
Publications (1)
Publication Number | Publication Date |
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MX2017007928A true MX2017007928A (es) | 2018-01-30 |
Family
ID=55083496
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017007928A MX2017007928A (es) | 2014-12-16 | 2015-12-15 | Sistemas de modificación de genoma fúngico y métodos de uso. |
MX2017007930A MX2017007930A (es) | 2014-12-16 | 2015-12-16 | Sistemas de modificación de genoma fúngico y métodos de uso. |
MX2017008036A MX2017008036A (es) | 2014-12-16 | 2015-12-16 | Sistemas de modificacion del genoma fungico y metodos de uso. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017007930A MX2017007930A (es) | 2014-12-16 | 2015-12-16 | Sistemas de modificación de genoma fúngico y métodos de uso. |
MX2017008036A MX2017008036A (es) | 2014-12-16 | 2015-12-16 | Sistemas de modificacion del genoma fungico y metodos de uso. |
Country Status (11)
Country | Link |
---|---|
US (3) | US11427829B2 (es) |
EP (3) | EP3234150A1 (es) |
JP (3) | JP6814142B2 (es) |
KR (3) | KR102350405B1 (es) |
CN (3) | CN107667171A (es) |
AU (3) | AU2015362784B2 (es) |
BR (3) | BR112017012837A2 (es) |
CA (3) | CA2971187C (es) |
DK (1) | DK3234152T3 (es) |
MX (3) | MX2017007928A (es) |
WO (3) | WO2016100272A1 (es) |
Families Citing this family (58)
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EP3613852A3 (en) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
US20150166985A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting von willebrand factor point mutations |
EP4079847A1 (en) | 2014-07-30 | 2022-10-26 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
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US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
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2015
- 2015-12-15 JP JP2017532765A patent/JP6814142B2/ja active Active
- 2015-12-15 MX MX2017007928A patent/MX2017007928A/es unknown
- 2015-12-15 WO PCT/US2015/065693 patent/WO2016100272A1/en active Application Filing
- 2015-12-15 BR BR112017012837A patent/BR112017012837A2/pt not_active Application Discontinuation
- 2015-12-15 AU AU2015362784A patent/AU2015362784B2/en active Active
- 2015-12-15 EP EP15823254.6A patent/EP3234150A1/en active Pending
- 2015-12-15 CN CN201580076187.6A patent/CN107667171A/zh active Pending
- 2015-12-15 KR KR1020177019683A patent/KR102350405B1/ko active IP Right Grant
- 2015-12-15 CA CA2971187A patent/CA2971187C/en active Active
- 2015-12-15 US US15/536,836 patent/US11427829B2/en active Active
- 2015-12-16 US US15/536,933 patent/US11401522B2/en active Active
- 2015-12-16 CA CA2971248A patent/CA2971248C/en active Active
- 2015-12-16 CN CN201580076181.9A patent/CN107278231A/zh active Pending
- 2015-12-16 EP EP15823268.6A patent/EP3234152B1/en active Active
- 2015-12-16 KR KR1020177019705A patent/KR102350402B1/ko active IP Right Grant
- 2015-12-16 BR BR112017012850A patent/BR112017012850A2/pt not_active Application Discontinuation
- 2015-12-16 DK DK15823268.6T patent/DK3234152T3/da active
- 2015-12-16 WO PCT/US2015/066195 patent/WO2016100571A1/en active Application Filing
- 2015-12-16 JP JP2017532637A patent/JP6814141B2/ja active Active
- 2015-12-16 EP EP15823267.8A patent/EP3234151A1/en active Pending
- 2015-12-16 KR KR1020177019686A patent/KR102350404B1/ko active IP Right Grant
- 2015-12-16 BR BR112017012851A patent/BR112017012851A2/pt not_active Application Discontinuation
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