MX2017001229A - Receptores de antigenos quimericos especificos de egfrviii para inmunoterapia de cancer. - Google Patents
Receptores de antigenos quimericos especificos de egfrviii para inmunoterapia de cancer.Info
- Publication number
- MX2017001229A MX2017001229A MX2017001229A MX2017001229A MX2017001229A MX 2017001229 A MX2017001229 A MX 2017001229A MX 2017001229 A MX2017001229 A MX 2017001229A MX 2017001229 A MX2017001229 A MX 2017001229A MX 2017001229 A MX2017001229 A MX 2017001229A
- Authority
- MX
- Mexico
- Prior art keywords
- chimeric antigen
- antigen receptors
- cancer immunotherapy
- egfrviii
- specific chimeric
- Prior art date
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title abstract 4
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 title abstract 3
- 238000002619 cancer immunotherapy Methods 0.000 title 1
- 210000002865 immune cell Anatomy 0.000 abstract 2
- 208000007860 Anus Neoplasms Diseases 0.000 abstract 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 208000005017 glioblastoma Diseases 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 230000009257 reactivity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464403—Receptors for growth factors
- A61K39/464404—Epidermal growth factor receptors [EGFR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/47—Brain; Nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a receptores de antígeno quimérico (CAR) que son proteínas quiméricas recombinantes capaces de redirigir especificidad de célula inmune y reactividad hacia antígenos de membrana seleccionados, y más en particular en donde unión a ligando extracelular es un scFV derivado de un anticuerpo monoclonal de EGFRvlll, confiriendo inmunidad específica contra células EGFRvIII positivas. Las células inmunes manipuladas de TCR KO dotadas con dichos CARs son particularmente adecuadas para tratar cáncer pulmonar, cánceres anales y glioblastoma multiforme.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201470466 | 2014-07-29 | ||
PCT/EP2015/067439 WO2016016341A1 (en) | 2014-07-29 | 2015-07-29 | EGFRvIII SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017001229A true MX2017001229A (es) | 2017-05-01 |
Family
ID=51300485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017001229A MX2017001229A (es) | 2014-07-29 | 2015-07-29 | Receptores de antigenos quimericos especificos de egfrviii para inmunoterapia de cancer. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20170275366A1 (es) |
EP (1) | EP3174556A1 (es) |
JP (1) | JP2017522884A (es) |
KR (2) | KR20180125632A (es) |
CN (1) | CN107074973A (es) |
AU (1) | AU2015295346A1 (es) |
BR (1) | BR112017001818A2 (es) |
CA (1) | CA2956307A1 (es) |
IL (1) | IL250339A0 (es) |
MX (1) | MX2017001229A (es) |
RU (1) | RU2017102769A (es) |
WO (1) | WO2016016341A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3405490T3 (da) | 2016-01-21 | 2022-01-10 | Pfizer | Mono- og bispecifikke antistoffer mod epidermal vækstfaktorreceptor variant iii og cd3 og anvendelser deraf |
SG11201805872SA (en) * | 2016-01-21 | 2018-08-30 | Pfizer | Chimeric antigen receptors targeting epidermal growth factor receptor variant iii |
AU2017296237A1 (en) * | 2016-07-15 | 2019-01-03 | Poseida Therapeutics, Inc. | Chimeric antigen receptors (CARS) specific for MUC1 and methods for their use |
JP2019536437A (ja) | 2016-10-03 | 2019-12-19 | ジュノー セラピューティクス インコーポレイテッド | Hpv特異的結合分子 |
CA3039014A1 (en) | 2016-10-04 | 2018-04-12 | Precision Biosciences, Inc. | Co-stimulatory domains for use in genetically-modified cells |
CN110520530A (zh) * | 2016-10-18 | 2019-11-29 | 明尼苏达大学董事会 | 肿瘤浸润性淋巴细胞和治疗方法 |
CN108276493B (zh) * | 2016-12-30 | 2023-11-14 | 南京传奇生物科技有限公司 | 一种嵌合抗原受体及其应用 |
JP2020516276A (ja) * | 2017-04-14 | 2020-06-11 | ザ ジェネラル ホスピタル コーポレイション | 腫瘍微小環境を標的にするキメラ抗原受容体t細胞 |
KR102302714B1 (ko) * | 2017-04-26 | 2021-09-17 | 주식회사 파이안바이오테크놀로지 | 신호전달 막단백질의 경막 부위를 이용한 목적단백질의 인간세포 막 표면 발현 방법 |
CN111954679A (zh) | 2017-10-03 | 2020-11-17 | 朱诺治疗学股份有限公司 | Hpv特异性结合分子 |
CN109694854B (zh) * | 2017-10-20 | 2023-11-21 | 亘喜生物科技(上海)有限公司 | 通用型嵌合抗原受体t细胞制备技术 |
CN109750035B (zh) * | 2017-11-02 | 2020-06-05 | 上海邦耀生物科技有限公司 | 靶向并引导Cas9蛋白高效切割TCR及B2M基因座的sgRNA |
WO2019114751A1 (zh) * | 2017-12-12 | 2019-06-20 | 科济生物医药(上海)有限公司 | 免疫效应细胞和辐射联用治疗肿瘤 |
JP2021520211A (ja) | 2018-04-05 | 2021-08-19 | ジュノー セラピューティクス インコーポレイテッド | 組換え受容体を発現するt細胞、関連ポリヌクレオチド、および方法 |
JP2021520202A (ja) | 2018-04-05 | 2021-08-19 | ジュノー セラピューティクス インコーポレイテッド | 組換え受容体を発現する細胞の作製方法および関連組成物 |
PE20201345A1 (es) | 2018-04-05 | 2020-11-25 | Juno Therapeutics Inc | Receptores de celulas t, y celulas disenadas que expresan los mismos |
CN112292400A (zh) * | 2018-04-13 | 2021-01-29 | 桑格摩生物治疗法国公司 | 对白介素-23受体特异的嵌合抗原受体 |
MX2020012028A (es) * | 2018-05-11 | 2021-03-29 | Crispr Therapeutics Ag | Metodos y composiciones para tratar el cancer. |
US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
CN114957475B (zh) * | 2018-09-26 | 2023-06-20 | 福州拓新天成生物科技有限公司 | 抗b7-h3的单克隆抗体及其在细胞治疗中的应用 |
WO2020068366A1 (en) | 2018-09-26 | 2020-04-02 | W. L. Gore & Associates, Inc. | Cell encapsulation devices with controlled cell bed thickness |
EP3870600A1 (en) | 2018-10-24 | 2021-09-01 | Obsidian Therapeutics, Inc. | Er tunable protein regulation |
CN109485731A (zh) * | 2018-11-02 | 2019-03-19 | 广东克瑞斯普生物科技有限公司 | 一种靶向EGFRvIII的嵌合抗原受体 |
US20220175897A1 (en) * | 2018-12-20 | 2022-06-09 | Oslo Universitetssykehus Hf | Chimeric Antigen Receptors (CARS) and Their Use in Medicine |
SG10202105790QA (en) * | 2018-12-21 | 2021-07-29 | Hoffmann La Roche | Antibodies binding to cd3 |
EP3769816A1 (en) * | 2019-07-25 | 2021-01-27 | Ospedale Pediatrico Bambino Gesù | Car-cd123 vector and uses thereof |
WO2021046451A1 (en) | 2019-09-06 | 2021-03-11 | Obsidian Therapeutics, Inc. | Compositions and methods for dhfr tunable protein regulation |
WO2021260186A1 (en) | 2020-06-26 | 2021-12-30 | Juno Therapeutics Gmbh | Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods |
EP4263600A1 (en) | 2020-12-18 | 2023-10-25 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
IL303270A (en) | 2020-12-21 | 2023-07-01 | Allogene Therapeutics Inc | The CD45–GATE vehicle activates a protease |
KR20230142470A (ko) | 2021-01-29 | 2023-10-11 | 알로젠 테라퓨틱스 인코포레이티드 | 동종이계 세포 산물의 T 세포 인식을 완화하기 위한TAP2, NLRC5, β2m, TRAC, RFX5, RFXAP, 및 RFXANK 중 하나 이상의 녹다운 또는 녹아웃 |
WO2022171195A1 (zh) * | 2021-02-11 | 2022-08-18 | 兰州大学第二医院 | 抗cd87抗体与抗pd1抗体联合治疗胃癌 |
US20240108654A1 (en) | 2021-03-03 | 2024-04-04 | Juno Therapeutics, Inc. | Combination of a t cell therapy and a dgk inhibitor |
WO2023286840A1 (ja) * | 2021-07-16 | 2023-01-19 | ノイルイミューン・バイオテック株式会社 | 抗EGFRviii抗体、ポリペプチド、前記ポリペプチドを発現する細胞、前記細胞を含む医薬組成物、前記細胞の製造方法、及び、前記ポリペプチドをコードする塩基配列を含むポリヌクレオチド又はベクター |
WO2023081900A1 (en) | 2021-11-08 | 2023-05-11 | Juno Therapeutics, Inc. | Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods |
WO2024010119A1 (ko) * | 2022-07-07 | 2024-01-11 | 주식회사 유틸렉스 | 돌연변이 egfr 및 epha2를 동시 타겟하는 키메라 항원 수용체 |
WO2024026445A1 (en) | 2022-07-29 | 2024-02-01 | Allogene Therapeutics Inc. | Engineered cells with reduced gene expression to mitigate immune cell recognition |
US20240085403A1 (en) * | 2022-08-16 | 2024-03-14 | Allogene Therapeutics, Inc. | Method for inhibiting adventitious viral infection |
WO2024054944A1 (en) | 2022-09-08 | 2024-03-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing |
WO2024100604A1 (en) | 2022-11-09 | 2024-05-16 | Juno Therapeutics Gmbh | Methods for manufacturing engineered immune cells |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69334095T2 (de) * | 1992-07-17 | 2007-04-12 | Dana-Farber Cancer Institute, Boston | Verfahren zur intrazellulären Bindung von zielgerichteten Molekülen |
US20080045437A1 (en) * | 2006-03-10 | 2008-02-21 | Barbara Pfeifer | Soap bar with hidden indicia |
US20100105136A1 (en) * | 2006-10-09 | 2010-04-29 | The General Hospital Corporation | Chimeric t-cell receptors and t-cells targeting egfrviii on tumors |
US20120079000A1 (en) * | 2010-09-27 | 2012-03-29 | Motorola-Mobility, Inc. | Selectively receiving media content |
MX347078B (es) * | 2010-12-09 | 2017-04-10 | Univ Pennsylvania | Uso de celulas t modificadas por receptor de antigeno quimerico para tratar cancer. |
US9402865B2 (en) * | 2011-01-18 | 2016-08-02 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating cancer |
IL285335B2 (en) * | 2011-04-08 | 2023-12-01 | Us Health | Chimeric antigen receptors against epidermal growth factor receptor variant III and their use in cancer treatment |
MX367730B (es) * | 2012-09-04 | 2019-09-04 | Cellectis | Receptor de antigeno quimerico multi-cadena y usos del mismo. |
ES2718903T3 (es) * | 2012-10-24 | 2019-07-05 | Us Health | Receptores de antígenos quiméricos M971 |
CN105358576B (zh) * | 2013-02-20 | 2020-05-05 | 诺华股份有限公司 | 使用人源化抗EGFRvIII嵌合抗原受体治疗癌症 |
US10287354B2 (en) * | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
-
2015
- 2015-07-29 US US15/526,649 patent/US20170275366A1/en not_active Abandoned
- 2015-07-29 EP EP15744213.8A patent/EP3174556A1/en not_active Withdrawn
- 2015-07-29 KR KR1020187033242A patent/KR20180125632A/ko active Application Filing
- 2015-07-29 CN CN201580050653.3A patent/CN107074973A/zh active Pending
- 2015-07-29 RU RU2017102769A patent/RU2017102769A/ru not_active Application Discontinuation
- 2015-07-29 BR BR112017001818A patent/BR112017001818A2/pt not_active Application Discontinuation
- 2015-07-29 WO PCT/EP2015/067439 patent/WO2016016341A1/en active Application Filing
- 2015-07-29 AU AU2015295346A patent/AU2015295346A1/en not_active Abandoned
- 2015-07-29 KR KR1020177005490A patent/KR20170036087A/ko not_active Application Discontinuation
- 2015-07-29 JP JP2017504153A patent/JP2017522884A/ja active Pending
- 2015-07-29 MX MX2017001229A patent/MX2017001229A/es unknown
- 2015-07-29 CA CA2956307A patent/CA2956307A1/en not_active Abandoned
-
2017
- 2017-01-29 IL IL250339A patent/IL250339A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL250339A0 (en) | 2017-03-30 |
RU2017102769A (ru) | 2018-08-28 |
KR20170036087A (ko) | 2017-03-31 |
RU2017102769A3 (es) | 2018-08-28 |
AU2015295346A1 (en) | 2017-02-16 |
BR112017001818A2 (pt) | 2017-11-21 |
CN107074973A (zh) | 2017-08-18 |
JP2017522884A (ja) | 2017-08-17 |
WO2016016341A1 (en) | 2016-02-04 |
EP3174556A1 (en) | 2017-06-07 |
KR20180125632A (ko) | 2018-11-23 |
US20170275366A1 (en) | 2017-09-28 |
CA2956307A1 (en) | 2016-02-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2017001229A (es) | Receptores de antigenos quimericos especificos de egfrviii para inmunoterapia de cancer. | |
MX2019012244A (es) | Receptores de antigeno quimerico especifico de cd123 para inmunoterapia de cancer. | |
MX2016012855A (es) | Receptores de antigeno quimerico especifico de cd33 para inmunoterapia de cancer. | |
MX367787B (es) | Receptores de antígenos quimericos ror1 (ntrkr1) específicos para inmunoterapia del cáncer. | |
MX2017009181A (es) | Receptores de antigenos quimericos de cadena sencilla especificos de anti-cll1 para inmunoterapia de cancer. | |
PH12018501042A1 (en) | Antibodies and antibody fragments for site-specific conjugation | |
MX2022011659A (es) | Proteinas de union a antigeno que se unen a pd-l1. | |
PH12015502479A1 (en) | Cd19 specific chimeric antigen receptor and uses thereof | |
MX2019001184A (es) | Anticuerpos anti-idiotípicos y métodos relacionados. | |
PH12016502491A1 (en) | Bispecific heterodimeric diabodies and uses thereof | |
MX2020011788A (es) | Acoplador trifuncional de antigeno de celulas t y metodos y usos del mismo. | |
MX2020003046A (es) | Anticuerpos anti-hla-a2 y metodos para utilizar los mismos. | |
MX2015008740A (es) | Variantes de regiones fc de igg1 de humano y usos de las mismas. | |
MX2017006966A (es) | Anticuerpos heterodimericos que se unen a cd3 y a antigenos tumorales. | |
MY175869A (en) | Compositions and methods for immunotherapy | |
MY190711A (en) | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor | |
MX2016003744A (es) | Anticuerpos tem8 y su uso. | |
MY164647A (en) | Cea antibodies | |
NZ629553A (en) | Anti-big-endothelin-1 (big-et-1) antibodies and uses thereof | |
EP3722313A4 (en) | ANTIBODY OR ITS BINDING FRAGMENT TO THE ANTIGEN TO SPECIFICALLY RECOGNIZE A B-CELL MALIGNITY, CHEMERIC ANTIGEN RECEPTOR INCLUDING IT, AND ITS USE | |
MX2020003047A (es) | Nuevos anticuerpos anti-hla-a2 y usos de los mismos. | |
MX2020003193A (es) | Anticuerpos recombinantes mono- o biespecificos multivalentes para fines analiticos. | |
WO2014016702A3 (en) | Humanized forms of monoclonal antibodies to human gnrh receptor | |
EP3730519A4 (en) | ANTIBODY OR ANTIGENT BINDING FRAGMENT THEREOF FOR THE SPECIFIC DETECTION OF B-CELL MALIGNOMAS, CHIMERA ANTIGEN RECEPTOR THEREOF AND USE THEREOF | |
NZ725519A (en) | Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and a monoclonal antibody against tim-3 |