MX2016013999A - Conjugado farmaco-anticuerpo y su uso para el tratamiento contra el cancer. - Google Patents
Conjugado farmaco-anticuerpo y su uso para el tratamiento contra el cancer.Info
- Publication number
- MX2016013999A MX2016013999A MX2016013999A MX2016013999A MX2016013999A MX 2016013999 A MX2016013999 A MX 2016013999A MX 2016013999 A MX2016013999 A MX 2016013999A MX 2016013999 A MX2016013999 A MX 2016013999A MX 2016013999 A MX2016013999 A MX 2016013999A
- Authority
- MX
- Mexico
- Prior art keywords
- antibody
- drug
- conjugate
- treatment
- cancer
- Prior art date
Links
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 4
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- OFDNQWIFNXBECV-VFSYNPLYSA-N dolastatin 10 Chemical class CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-VFSYNPLYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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Abstract
La presente invención se relaciona con un conjugado fármaco-anticuerpo. Considerando un aspecto, la invención se relaciona con un conjugado fármaco-anticuerpo que comprende un anticuerpo capaz unirse a un Objetivo, el anticuerpo se conjuga con al menos un fármaco seleccionado a partir de derivados de dolastatina 10 y auristatinas. La invención también comprende un método de tratamiento y el uso de dicho conjugado fármaco-anticuerpo para el tratamiento contra el cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14305621 | 2014-04-25 | ||
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