MX2016013048A - Combinación de inhibidor de egfr e inhibidor de mek para el uso en el tratamiento de cáncer mutado por nras. - Google Patents
Combinación de inhibidor de egfr e inhibidor de mek para el uso en el tratamiento de cáncer mutado por nras.Info
- Publication number
- MX2016013048A MX2016013048A MX2016013048A MX2016013048A MX2016013048A MX 2016013048 A MX2016013048 A MX 2016013048A MX 2016013048 A MX2016013048 A MX 2016013048A MX 2016013048 A MX2016013048 A MX 2016013048A MX 2016013048 A MX2016013048 A MX 2016013048A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- inhibitor
- combination
- nras
- mutated cancer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La invención se refiere a los métodos para identificar resistencia a la terapia para cáncer, mediante la identificación de una mutación E63K NRAS, una mutación G12V NRAS o una ganancia del número de copias del gen NRAS. Un aspecto adicional de la invención se refiere a métodos de tratamiento que pueden superar tales mecanismos de resistencia, que implican el uso de un inhibidor de EGFR en combinación con un inhibidor de MEK para el tratamiento de cánceres que implican una mutación NRAS seleccionada de E63K, G12V, G12R, G12A, G12D, G12S y G12C, y/o cáncer que implica una ganancia del número de copias del gen NRAS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461975088P | 2014-04-04 | 2014-04-04 | |
US201462013573P | 2014-06-18 | 2014-06-18 | |
PCT/GB2015/051042 WO2015150826A1 (en) | 2014-04-04 | 2015-04-02 | Combination of egfr inhibitor and mek inhibitor for use in the treatment of nras mutated cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016013048A true MX2016013048A (es) | 2017-04-27 |
MX369111B MX369111B (es) | 2019-10-29 |
Family
ID=52824498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016013048A MX369111B (es) | 2014-04-04 | 2015-04-02 | Combinación de inhibidor de egfr e inhibidor de mek para el uso en el tratamiento de cáncer mutado por nras. |
Country Status (15)
Country | Link |
---|---|
US (2) | US20200237758A1 (es) |
EP (1) | EP3125885B1 (es) |
JP (1) | JP6549147B2 (es) |
KR (1) | KR102406334B1 (es) |
CN (1) | CN106456774A (es) |
AU (1) | AU2015242407B2 (es) |
CA (1) | CA2943402C (es) |
DK (1) | DK3125885T3 (es) |
ES (1) | ES2890556T3 (es) |
HU (1) | HUE055747T2 (es) |
MA (1) | MA39841A (es) |
MX (1) | MX369111B (es) |
PL (1) | PL3125885T3 (es) |
RU (1) | RU2683276C2 (es) |
WO (1) | WO2015150826A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2018013413A (es) | 2016-05-26 | 2019-06-06 | Zeno Royalties & Milestones Llc | Compuestos inhibidores de egfr. |
WO2018218633A1 (en) * | 2017-06-02 | 2018-12-06 | Beijing Percans Oncology Co. Ltd. | Combination therapies for treating cancers |
WO2019195959A1 (en) | 2018-04-08 | 2019-10-17 | Cothera Biosciences, Inc. | Combination therapy for cancers with braf mutation |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050176740A1 (en) * | 2002-04-08 | 2005-08-11 | Spector Neil L. | Cancer treatment method comprising administering an erb-family inhibitor and a raf and/or ras inhibitor |
MX2011005002A (es) * | 2008-11-11 | 2011-05-25 | Lilly Co Eli | Inhibidor de p70 s6 quinasa y terapia de combinacion de inhibidor del receptor de egfr. |
PL3686194T3 (pl) * | 2011-07-27 | 2022-01-17 | Astrazeneca Ab | Związki 2-(2,4,5-podstawione-anilino)pirymidynowe |
DK2797957T3 (da) * | 2011-11-23 | 2019-09-23 | Medimmune Llc | Bindingsmolekyler specifikke for her3 og anvendelser deraf |
US20150071918A1 (en) * | 2012-05-09 | 2015-03-12 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Peptides for the treatment of cancer |
WO2014028909A1 (en) * | 2012-08-16 | 2014-02-20 | Ohio State Innovation Foundation | Stat3 inhibitors and their anticancer use |
US20140066465A1 (en) * | 2012-09-04 | 2014-03-06 | The Cleveland Clinic Foundation | CANCER TREATMENT USING TYROSINE KINASE AND NF-kB INHIBITORS |
-
2015
- 2015-04-02 ES ES15715805T patent/ES2890556T3/es active Active
- 2015-04-02 PL PL15715805T patent/PL3125885T3/pl unknown
- 2015-04-02 JP JP2016560813A patent/JP6549147B2/ja active Active
- 2015-04-02 US US15/301,448 patent/US20200237758A1/en not_active Abandoned
- 2015-04-02 EP EP15715805.6A patent/EP3125885B1/en active Active
- 2015-04-02 MX MX2016013048A patent/MX369111B/es active IP Right Grant
- 2015-04-02 KR KR1020167030569A patent/KR102406334B1/ko active IP Right Grant
- 2015-04-02 DK DK15715805.6T patent/DK3125885T3/da active
- 2015-04-02 CA CA2943402A patent/CA2943402C/en active Active
- 2015-04-02 AU AU2015242407A patent/AU2015242407B2/en active Active
- 2015-04-02 CN CN201580022665.5A patent/CN106456774A/zh active Pending
- 2015-04-02 WO PCT/GB2015/051042 patent/WO2015150826A1/en active Application Filing
- 2015-04-02 HU HUE15715805A patent/HUE055747T2/hu unknown
- 2015-04-02 RU RU2016140626A patent/RU2683276C2/ru active
- 2015-04-02 MA MA039841A patent/MA39841A/fr unknown
-
2020
- 2020-12-16 US US17/123,777 patent/US20210177844A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20210177844A1 (en) | 2021-06-17 |
JP6549147B2 (ja) | 2019-07-24 |
DK3125885T3 (da) | 2021-09-27 |
HUE055747T2 (hu) | 2021-12-28 |
US20200237758A1 (en) | 2020-07-30 |
ES2890556T3 (es) | 2022-01-20 |
MA39841A (fr) | 2017-02-08 |
AU2015242407B2 (en) | 2017-11-09 |
CN106456774A (zh) | 2017-02-22 |
RU2016140626A (ru) | 2018-05-07 |
MX369111B (es) | 2019-10-29 |
JP2017511341A (ja) | 2017-04-20 |
RU2016140626A3 (es) | 2018-10-23 |
KR20160135362A (ko) | 2016-11-25 |
WO2015150826A1 (en) | 2015-10-08 |
KR102406334B1 (ko) | 2022-06-07 |
PL3125885T3 (pl) | 2021-12-06 |
RU2683276C2 (ru) | 2019-03-27 |
EP3125885B1 (en) | 2021-06-30 |
CA2943402C (en) | 2022-12-13 |
EP3125885A1 (en) | 2017-02-08 |
CA2943402A1 (en) | 2015-10-08 |
AU2015242407A1 (en) | 2016-10-13 |
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