MX2019013634A - Composiciones y metodos para tratar cancer con mutaciones de braf atipicas. - Google Patents

Composiciones y metodos para tratar cancer con mutaciones de braf atipicas.

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Publication number
MX2019013634A
MX2019013634A MX2019013634A MX2019013634A MX2019013634A MX 2019013634 A MX2019013634 A MX 2019013634A MX 2019013634 A MX2019013634 A MX 2019013634A MX 2019013634 A MX2019013634 A MX 2019013634A MX 2019013634 A MX2019013634 A MX 2019013634A
Authority
MX
Mexico
Prior art keywords
methods
compositions
treating cancer
atypical
braf mutations
Prior art date
Application number
MX2019013634A
Other languages
English (en)
Inventor
Saha Saurabh
Decrescenzo Gary
WELSCH Dean
Original Assignee
Biomed Valley Discoveries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomed Valley Discoveries Inc filed Critical Biomed Valley Discoveries Inc
Publication of MX2019013634A publication Critical patent/MX2019013634A/es

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Abstract

La presente invención se refiere a, entre otros, métodos, composiciones farmacéuticas, y kits para tratar o aliviar los efectos de un cáncer en un sujeto, el cual alberga una mutación de BRAF atípica (es decir, una mutación de BRAF no V600E/K), que comprende un inhibidor de ERK. También se proporcionan métodos para identificar un sujeto que tiene un cáncer mutante de BRAF atípico quién podría beneficiarse de la terapia que comprende un inhibidor de ERK.
MX2019013634A 2017-05-16 2018-05-15 Composiciones y metodos para tratar cancer con mutaciones de braf atipicas. MX2019013634A (es)

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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190225689A1 (en) 2018-01-22 2019-07-25 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-pd-1 antibodies
CN109771436A (zh) * 2019-03-06 2019-05-21 康赋葆(深圳)生物医药科技有限公司 四氢姜黄素与卡培他滨联合治疗大肠癌的应用
CN113811303A (zh) * 2019-05-16 2021-12-17 伊莱利利公司 用于治疗brafv600e结直肠癌的erk1/2抑制剂与braf抑制剂和egfr抑制剂的三药组合
GB201913123D0 (en) * 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
GB201913121D0 (en) * 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
GB201913124D0 (en) * 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
CN110538316B (zh) * 2019-10-17 2021-10-15 滨州医学院 5-fu和胰高血糖素联合用于制备治疗结直肠癌的药物的用途和药物组合物
US20230226030A1 (en) * 2020-02-18 2023-07-20 Novartis Ag Therapeutic combinations comprising a raf inhibitor for use in treating braf mutant nsclc
WO2022179568A1 (en) * 2021-02-25 2022-09-01 Westlake Therapeutics (Hangzhou) Co., Limited Neoantigenic peptide and its use for treating braf gene mutation related diseases
KR20230156731A (ko) * 2021-03-09 2023-11-14 제넨테크, 인크. 뇌암 치료에 이용하기 위한 벨바라페닙
WO2023049798A1 (en) * 2021-09-22 2023-03-30 Henry Ford Health System Hdac3 inhibitors for the treatment of langerhans cell histiocytosis and langerhans cell sarcoma
CN116570599B (zh) * 2023-07-04 2023-10-20 四川大学华西医院 Vs6766联合ly3009120的应用及药物组合物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2639416C (en) * 2007-09-11 2019-12-31 F. Hoffmann-La Roche Ag Diagnostic test for susceptibility to b-raf kinase inhibitors
CN108245518B (zh) * 2012-08-09 2021-08-31 细胞基因公司 利用3-(4-((4-(吗啉代甲基)苯甲基)氧基)-1-氧代异二氢吲哚-2-基)哌啶-2,6- 二酮治疗癌症的方法
JP6320382B2 (ja) * 2012-08-13 2018-05-09 ザ ロックフェラー ユニヴァーシティ メラノーマの処置および診断
AU2014233805B2 (en) * 2013-03-21 2018-10-18 Array Biopharma Inc. Combination therapy comprising a B-Raf inhibitor and a second inhibitor
CA2908508C (en) * 2013-03-29 2023-09-19 Biomed Valley Discoveries, Inc. C. novyi for the treatment of solid tumors in humans
US11007174B2 (en) * 2013-07-12 2021-05-18 Piramal Enterprises Limited Pharmaceutical combination for the treatment of melanoma
EP3984537B1 (en) * 2013-12-20 2024-03-20 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of type 2 mek and erk inhibitors
MX2016008201A (es) * 2013-12-20 2017-04-27 Biomed Valley Discoveries Inc Tratamiento del cancer usando combinaciones de inhibidores de erk y raf.
WO2015095835A1 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Methods of modulating radioiodine uptake for the treatment of radioiodine-refractory cancers
AU2014368925A1 (en) * 2013-12-20 2016-07-21 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of MEK type I and ERK inhibitors
AU2014368916B2 (en) * 2013-12-20 2020-04-30 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of PI3K/Akt pathway and ERK inhibitors
WO2015095840A1 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of cdk and erk inhibitors
WO2015095842A2 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers
JP7036594B2 (ja) * 2014-07-14 2022-03-15 ウニベルジテート チューリッヒ プロレクトラット エムエンベー Ｂｒａｆ陽性癌を患っている患者を、ｂｒａｆ阻害剤に対する非レスポンダーであると及びｍａｐｋ／ｅｒｋ阻害剤に対するレスポンダーであると同定する手段及び方法
WO2016025650A1 (en) * 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Combinations of an erk inhibitor and a cdk4/6 inhibitor and related methods
DK3307727T3 (da) * 2015-06-15 2024-01-08 Asana Biosciences Llc Heterocykliske inhibitorer af erk1 og erk2 og deres anvendelse i behandlingen af kræft
US20190071668A1 (en) * 2015-07-08 2019-03-07 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment, prevention, and treatment of cancer using slncr isoforms

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