MX2016005389A - Una vacuna de adn que codifica telomerasa. - Google Patents
Una vacuna de adn que codifica telomerasa.Info
- Publication number
- MX2016005389A MX2016005389A MX2016005389A MX2016005389A MX2016005389A MX 2016005389 A MX2016005389 A MX 2016005389A MX 2016005389 A MX2016005389 A MX 2016005389A MX 2016005389 A MX2016005389 A MX 2016005389A MX 2016005389 A MX2016005389 A MX 2016005389A
- Authority
- MX
- Mexico
- Prior art keywords
- telomerase
- encoding dna
- dna vaccine
- cells
- construct
- Prior art date
Links
- 108010017842 Telomerase Proteins 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title 1
- 101000655352 Homo sapiens Telomerase reverse transcriptase Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 206010058314 Dysplasia Diseases 0.000 abstract 1
- 102000007999 Nuclear Proteins Human genes 0.000 abstract 1
- 108010089610 Nuclear Proteins Proteins 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000004807 localization Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001157—Telomerase or TERT [telomerase reverse transcriptase]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La invención proporciona un constructo de ácido nucleico que comprende una secuencia que codifica una proteína telomerasa transcriptasa inversa humana (hTERT) que carece de la actividad catalítica de telomerasa y de una señal de localización nucleolar. El constructo es útil en desencadena una respuesta inmunitaria en un sujeto, contra las células que sobreexpresan telomerasa, de manera preferente células de displasia o células tumorales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13190547 | 2013-10-28 | ||
PCT/EP2014/073164 WO2015063117A1 (en) | 2013-10-28 | 2014-10-28 | A telomerase encoding dna vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016005389A true MX2016005389A (es) | 2016-08-03 |
Family
ID=49515221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016005389A MX2016005389A (es) | 2013-10-28 | 2014-10-28 | Una vacuna de adn que codifica telomerasa. |
Country Status (26)
Country | Link |
---|---|
US (2) | US10183065B2 (es) |
EP (2) | EP3062824B1 (es) |
JP (1) | JP6545162B2 (es) |
KR (1) | KR102252756B1 (es) |
CN (1) | CN106061509B (es) |
AU (1) | AU2014343813B2 (es) |
BR (1) | BR112016009002B1 (es) |
CA (1) | CA2927702C (es) |
CY (1) | CY1122839T1 (es) |
DK (1) | DK3062824T3 (es) |
EA (1) | EA034928B1 (es) |
ES (1) | ES2771862T3 (es) |
HK (1) | HK1225986A1 (es) |
HR (1) | HRP20200211T1 (es) |
HU (1) | HUE047898T2 (es) |
IL (1) | IL245186B (es) |
LT (1) | LT3062824T (es) |
MX (1) | MX2016005389A (es) |
NZ (1) | NZ719098A (es) |
PL (1) | PL3062824T3 (es) |
PT (1) | PT3062824T (es) |
RS (1) | RS60232B1 (es) |
SG (1) | SG11201603118TA (es) |
SI (1) | SI3062824T1 (es) |
WO (1) | WO2015063117A1 (es) |
ZA (1) | ZA201603452B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3359183T (pt) * | 2015-10-06 | 2020-08-13 | Invectys | Construções de poliepítopo para utilização em imunoterapia |
EP3622078A1 (en) | 2017-05-09 | 2020-03-18 | Invectys | Recombinant measles vaccine expressing htert |
CN114174514A (zh) * | 2019-07-25 | 2022-03-11 | 诺华股份有限公司 | 可调节的表达系统 |
CA3167836A1 (en) * | 2020-02-12 | 2021-08-19 | Paul T. RANUM | Compositions and methods for inducible alternative splicing regulation of gene expression |
EP4171619A2 (en) * | 2020-06-26 | 2023-05-03 | National Breast Cancer Coalition | Breast cancer vaccine |
CN112063601B (zh) * | 2020-09-22 | 2023-06-02 | 浙江愈方生物科技有限公司 | 一种灭活性端粒酶、具有其的腺病毒和人造mRNA及应用 |
EP4333887A1 (en) * | 2021-05-05 | 2024-03-13 | Inovio Pharmaceuticals, Inc. | Vaccines against coronavirus and methods of use |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU642403B2 (en) | 1989-02-17 | 1993-10-21 | Coselco Mimotopes Pty Ltd | Method for the use and synthesis of peptides |
US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
ATE245194T1 (de) | 1996-10-01 | 2003-08-15 | Geron Corp | Katalytische untereinheit der menschlichen telomerase |
AU2002363231A1 (en) | 2001-10-29 | 2003-05-12 | Baylor College Of Medicine | Human telomerase reverse transcriptase as a class-ii restricted tumor-associated antigen |
CA2490863A1 (en) | 2002-06-27 | 2004-01-08 | Geron Corporation | Cancer vaccine containing cross-species epitopes of telomerase reverse transcriptase |
EP1748067A1 (en) | 2005-07-29 | 2007-01-31 | Institut Pasteur | Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes |
ES2376010T3 (es) * | 2006-10-12 | 2012-03-08 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. | Prote�?na de fusión de transcriptasa inversa de la telomerasa, nucleótidos que la codifican y usos de la misma. |
JP5630769B2 (ja) * | 2008-04-11 | 2014-11-26 | 井戸川 雅史 | アポトーシス誘導剤 |
WO2010037395A2 (en) | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
AU2014242915B2 (en) | 2013-03-28 | 2018-08-09 | Invectys | A cancer vaccine for cats |
CN106103489B (zh) * | 2014-01-27 | 2020-10-02 | 分子模板公司 | Mhc i类表位递送多肽 |
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2014
- 2014-10-28 EP EP14790592.1A patent/EP3062824B1/en active Active
- 2014-10-28 DK DK14790592.1T patent/DK3062824T3/da active
- 2014-10-28 CA CA2927702A patent/CA2927702C/en active Active
- 2014-10-28 SI SI201431489T patent/SI3062824T1/sl unknown
- 2014-10-28 KR KR1020167014417A patent/KR102252756B1/ko active IP Right Grant
- 2014-10-28 NZ NZ719098A patent/NZ719098A/en unknown
- 2014-10-28 US US15/032,966 patent/US10183065B2/en active Active
- 2014-10-28 HU HUE14790592A patent/HUE047898T2/hu unknown
- 2014-10-28 ES ES14790592T patent/ES2771862T3/es active Active
- 2014-10-28 PT PT147905921T patent/PT3062824T/pt unknown
- 2014-10-28 AU AU2014343813A patent/AU2014343813B2/en active Active
- 2014-10-28 BR BR112016009002-0A patent/BR112016009002B1/pt active IP Right Grant
- 2014-10-28 PL PL14790592T patent/PL3062824T3/pl unknown
- 2014-10-28 RS RS20200144A patent/RS60232B1/sr unknown
- 2014-10-28 SG SG11201603118TA patent/SG11201603118TA/en unknown
- 2014-10-28 MX MX2016005389A patent/MX2016005389A/es active IP Right Grant
- 2014-10-28 EP EP19211063.3A patent/EP3666290A1/en not_active Withdrawn
- 2014-10-28 CN CN201480059350.3A patent/CN106061509B/zh active Active
- 2014-10-28 EA EA201690884A patent/EA034928B1/ru unknown
- 2014-10-28 WO PCT/EP2014/073164 patent/WO2015063117A1/en active Application Filing
- 2014-10-28 LT LTEP14790592.1T patent/LT3062824T/lt unknown
- 2014-10-28 JP JP2016526856A patent/JP6545162B2/ja active Active
-
2016
- 2016-04-18 IL IL245186A patent/IL245186B/en active IP Right Grant
- 2016-05-20 ZA ZA2016/03452A patent/ZA201603452B/en unknown
- 2016-12-20 HK HK16114445A patent/HK1225986A1/zh unknown
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2018
- 2018-08-24 US US16/111,475 patent/US20190000946A1/en active Pending
-
2020
- 2020-02-07 CY CY20201100119T patent/CY1122839T1/el unknown
- 2020-02-10 HR HRP20200211TT patent/HRP20200211T1/hr unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |