LT3062824T - Telomerazė, koduojanti dnr vakciną - Google Patents

Telomerazė, koduojanti dnr vakciną

Info

Publication number
LT3062824T
LT3062824T LTEP14790592.1T LT14790592T LT3062824T LT 3062824 T LT3062824 T LT 3062824T LT 14790592 T LT14790592 T LT 14790592T LT 3062824 T LT3062824 T LT 3062824T
Authority
LT
Lithuania
Prior art keywords
encoding dna
dna vaccine
telomerase
telomerase encoding
vaccine
Prior art date
Application number
LTEP14790592.1T
Other languages
English (en)
Inventor
Pierre Langlade Demoyen
Simon Wain-Hobson
Thierry Huet
Christelle LIARD
Elodie PLIQUET
Original Assignee
Invectys
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Invectys filed Critical Invectys
Publication of LT3062824T publication Critical patent/LT3062824T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001157—Telomerase or TERT [telomerase reverse transcriptase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
LTEP14790592.1T 2013-10-28 2014-10-28 Telomerazė, koduojanti dnr vakciną LT3062824T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13190547 2013-10-28
PCT/EP2014/073164 WO2015063117A1 (en) 2013-10-28 2014-10-28 A telomerase encoding dna vaccine

Publications (1)

Publication Number Publication Date
LT3062824T true LT3062824T (lt) 2020-05-25

Family

ID=49515221

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP14790592.1T LT3062824T (lt) 2013-10-28 2014-10-28 Telomerazė, koduojanti dnr vakciną

Country Status (26)

Country Link
US (2) US10183065B2 (lt)
EP (2) EP3062824B1 (lt)
JP (1) JP6545162B2 (lt)
KR (1) KR102252756B1 (lt)
CN (1) CN106061509B (lt)
AU (1) AU2014343813B2 (lt)
BR (1) BR112016009002B1 (lt)
CA (1) CA2927702C (lt)
CY (1) CY1122839T1 (lt)
DK (1) DK3062824T3 (lt)
EA (1) EA034928B1 (lt)
ES (1) ES2771862T3 (lt)
HK (1) HK1225986A1 (lt)
HR (1) HRP20200211T1 (lt)
HU (1) HUE047898T2 (lt)
IL (1) IL245186B (lt)
LT (1) LT3062824T (lt)
MX (1) MX2016005389A (lt)
NZ (1) NZ719098A (lt)
PL (1) PL3062824T3 (lt)
PT (1) PT3062824T (lt)
RS (1) RS60232B1 (lt)
SG (1) SG11201603118TA (lt)
SI (1) SI3062824T1 (lt)
WO (1) WO2015063117A1 (lt)
ZA (1) ZA201603452B (lt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3359183T (pt) * 2015-10-06 2020-08-13 Invectys Construções de poliepítopo para utilização em imunoterapia
EP3622078A1 (en) 2017-05-09 2020-03-18 Invectys Recombinant measles vaccine expressing htert
CN114174514A (zh) * 2019-07-25 2022-03-11 诺华股份有限公司 可调节的表达系统
CA3167836A1 (en) * 2020-02-12 2021-08-19 Paul T. RANUM Compositions and methods for inducible alternative splicing regulation of gene expression
EP4171619A2 (en) * 2020-06-26 2023-05-03 National Breast Cancer Coalition Breast cancer vaccine
CN112063601B (zh) * 2020-09-22 2023-06-02 浙江愈方生物科技有限公司 一种灭活性端粒酶、具有其的腺病毒和人造mRNA及应用
EP4333887A1 (en) * 2021-05-05 2024-03-13 Inovio Pharmaceuticals, Inc. Vaccines against coronavirus and methods of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU642403B2 (en) 1989-02-17 1993-10-21 Coselco Mimotopes Pty Ltd Method for the use and synthesis of peptides
US5840839A (en) 1996-02-09 1998-11-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein
ATE245194T1 (de) 1996-10-01 2003-08-15 Geron Corp Katalytische untereinheit der menschlichen telomerase
AU2002363231A1 (en) 2001-10-29 2003-05-12 Baylor College Of Medicine Human telomerase reverse transcriptase as a class-ii restricted tumor-associated antigen
CA2490863A1 (en) 2002-06-27 2004-01-08 Geron Corporation Cancer vaccine containing cross-species epitopes of telomerase reverse transcriptase
EP1748067A1 (en) 2005-07-29 2007-01-31 Institut Pasteur Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes
ES2376010T3 (es) * 2006-10-12 2012-03-08 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. Prote�?na de fusión de transcriptasa inversa de la telomerasa, nucleótidos que la codifican y usos de la misma.
JP5630769B2 (ja) * 2008-04-11 2014-11-26 井戸川 雅史 アポトーシス誘導剤
WO2010037395A2 (en) 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
AU2014242915B2 (en) 2013-03-28 2018-08-09 Invectys A cancer vaccine for cats
CN106103489B (zh) * 2014-01-27 2020-10-02 分子模板公司 Mhc i类表位递送多肽

Also Published As

Publication number Publication date
PT3062824T (pt) 2020-02-21
ES2771862T3 (es) 2020-07-07
DK3062824T3 (da) 2020-02-17
BR112016009002A2 (pt) 2017-10-03
CA2927702C (en) 2022-06-07
SI3062824T1 (sl) 2020-04-30
US20190000946A1 (en) 2019-01-03
JP2017502649A (ja) 2017-01-26
EA201690884A1 (ru) 2016-11-30
EP3062824B1 (en) 2019-11-27
CY1122839T1 (el) 2021-10-29
HRP20200211T1 (hr) 2020-05-15
JP6545162B2 (ja) 2019-07-17
EP3666290A1 (en) 2020-06-17
KR102252756B1 (ko) 2021-05-17
EA034928B1 (ru) 2020-04-08
CA2927702A1 (en) 2015-05-07
SG11201603118TA (en) 2016-05-30
RS60232B1 (sr) 2020-06-30
CN106061509B (zh) 2022-04-08
HUE047898T2 (hu) 2020-05-28
AU2014343813A1 (en) 2016-05-19
HK1225986A1 (zh) 2017-09-22
ZA201603452B (en) 2020-08-26
CN106061509A (zh) 2016-10-26
BR112016009002B1 (pt) 2023-05-02
MX2016005389A (es) 2016-08-03
PL3062824T3 (pl) 2020-06-15
US10183065B2 (en) 2019-01-22
US20160263204A1 (en) 2016-09-15
IL245186B (en) 2021-02-28
AU2014343813B2 (en) 2020-02-27
WO2015063117A1 (en) 2015-05-07
EP3062824A1 (en) 2016-09-07
NZ719098A (en) 2022-08-26
IL245186A0 (en) 2016-06-30
KR20160111362A (ko) 2016-09-26

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