MX2016001200A - Derivado de bifenilo novedoso y metodo para preparar el mismo. - Google Patents
Derivado de bifenilo novedoso y metodo para preparar el mismo.Info
- Publication number
- MX2016001200A MX2016001200A MX2016001200A MX2016001200A MX2016001200A MX 2016001200 A MX2016001200 A MX 2016001200A MX 2016001200 A MX2016001200 A MX 2016001200A MX 2016001200 A MX2016001200 A MX 2016001200A MX 2016001200 A MX2016001200 A MX 2016001200A
- Authority
- MX
- Mexico
- Prior art keywords
- biphenyl derivative
- disease
- novel biphenyl
- isomer
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Abstract
La presente invención proporciona derivados de bifenilo novedosos, isómeros de los mismos, o sales farmacéuticamente aceptables de los mismos, métodos para preparar los mismos, y una composición farmacéutica que contiene los mismos. Los derivados de bifenilo novedosos, isómeros de los mismos, o sales farmacéuticamente aceptables de los mismos, como se describe en la presente invención, actúan como antagonistas del receptor muscarínico M3, y de esta manera son útiles para la prevención o tratamiento de una enfermedad seleccionada del grupo que consiste de enfermedad pulmonar obstructiva crónica, asma, síndrome de intestino irritable, incontinencia urinaria, rinitis, colitis espasmódica, cistitis crónica, enfermedad de Alzheimer, demencia senil, glaucoma, esquizofrenia, enfermedad de reflujo gastroesofágico, arritmia cardiaca, y síndromes de hipersalivación.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020130090175A KR101538846B1 (ko) | 2013-07-30 | 2013-07-30 | 신규한 바이페닐 유도체 및 그의 제조방법 |
| PCT/KR2014/006483 WO2015016511A1 (ko) | 2013-07-30 | 2014-07-17 | 신규한 바이페닐 유도체 및 그의 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016001200A true MX2016001200A (es) | 2016-08-17 |
| MX366639B MX366639B (es) | 2019-07-17 |
Family
ID=52431993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016001200A MX366639B (es) | 2013-07-30 | 2014-07-17 | Derivado de bifenilo novedoso y metodo para preparar el mismo. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9828339B2 (es) |
| EP (1) | EP3029026B1 (es) |
| JP (1) | JP6109425B2 (es) |
| KR (1) | KR101538846B1 (es) |
| CN (1) | CN105555761B (es) |
| AU (1) | AU2014297144B2 (es) |
| CA (1) | CA2919624C (es) |
| ES (1) | ES2710389T3 (es) |
| HK (1) | HK1218755A1 (es) |
| IL (1) | IL243830B (es) |
| MX (1) | MX366639B (es) |
| MY (1) | MY175411A (es) |
| PH (1) | PH12016500197A1 (es) |
| PT (1) | PT3029026T (es) |
| RU (1) | RU2644234C2 (es) |
| SG (1) | SG11201600624RA (es) |
| TR (1) | TR201901449T4 (es) |
| UA (1) | UA116480C2 (es) |
| WO (1) | WO2015016511A1 (es) |
| ZA (1) | ZA201601227B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2019002301A (es) * | 2016-08-26 | 2019-12-11 | Dong A St Co Ltd | Nueva sal de (r)-(1-metilpirrolidin-3-il) metil (3'-chloro-4'-fluoro- [1,1'-bifenil]-2-il) carbamato y una forma cristalina del misma. |
| KR102239776B1 (ko) | 2016-08-26 | 2021-04-13 | 동아에스티 주식회사 | (r)-(1-메틸피롤리딘-3-일)메틸(3'-클로로-4'-플루오로-[1,1'-비페닐]-2-일)카바메이트의 신규염 및 이의 결정형 |
| KR102611847B1 (ko) * | 2023-03-27 | 2023-12-12 | 주식회사 이플라스크 | 무스카린 수용체 길항 활성을 갖는 신규한 피롤리디늄 화합물 및 이의 용도 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1140447A (zh) * | 1994-02-10 | 1997-01-15 | 山之内制药株式会社 | 新的氨基甲酸酯衍生物及其药物组合物 |
| AU685225B2 (en) * | 1994-02-10 | 1998-01-15 | Yamanouchi Pharmaceutical Co., Ltd. | Novel carbamate derivative and medicinal composition containing the same |
| US5613402A (en) * | 1995-06-06 | 1997-03-25 | Itt Automotive, Inc. | Adjustable set bearing |
| MXPA02005596A (es) | 1999-12-07 | 2004-09-10 | Theravance Inc | Derivados de carbamato con actividad antagonista para el rerceptor muscarinico. |
| TW200534855A (en) * | 2004-01-13 | 2005-11-01 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| US20080262075A1 (en) | 2004-08-19 | 2008-10-23 | Ranbaxy Laboratories Limited | Pyrrolidine Derivatives as Muscarinic Receptor Antagonists |
| US20090012116A1 (en) * | 2005-07-11 | 2009-01-08 | Naresh Kumar | Muscarinic Receptor Antagonists |
| MX2008002805A (es) | 2005-09-21 | 2008-04-07 | Pfizer Ltd | Derivados de carboxamida como antagonistas del receptor muscarinico. |
| KR20090107567A (ko) * | 2007-02-09 | 2009-10-13 | 아스텔라스세이야쿠 가부시키가이샤 | 아자 가교환 화합물 |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| KR101341693B1 (ko) | 2011-03-16 | 2013-12-16 | 동아에스티 주식회사 | 생약추출물을 함유하는 퇴행성 신경질환의 치료 및 예방을 위한 조성물 |
| KR101341692B1 (ko) | 2011-03-16 | 2013-12-20 | 동아에스티 주식회사 | 복합생약추출물을 함유하는 당뇨병성 말초 신경병증의 치료 및 예방을 위한 조성물 |
| KR101457789B1 (ko) | 2013-02-13 | 2014-11-03 | 동아제약 주식회사 | 상처 치료용 필름형성 약제학적 조성물 및 그의 제조방법 |
-
2013
- 2013-07-30 KR KR1020130090175A patent/KR101538846B1/ko active IP Right Grant
-
2014
- 2014-07-17 CN CN201480050982.3A patent/CN105555761B/zh active Active
- 2014-07-17 UA UAA201601871A patent/UA116480C2/uk unknown
- 2014-07-17 MX MX2016001200A patent/MX366639B/es active IP Right Grant
- 2014-07-17 EP EP14831249.9A patent/EP3029026B1/en active Active
- 2014-07-17 PT PT14831249T patent/PT3029026T/pt unknown
- 2014-07-17 TR TR2019/01449T patent/TR201901449T4/tr unknown
- 2014-07-17 MY MYPI2016700263A patent/MY175411A/en unknown
- 2014-07-17 JP JP2016531513A patent/JP6109425B2/ja active Active
- 2014-07-17 US US14/909,096 patent/US9828339B2/en active Active
- 2014-07-17 ES ES14831249T patent/ES2710389T3/es active Active
- 2014-07-17 WO PCT/KR2014/006483 patent/WO2015016511A1/ko active Application Filing
- 2014-07-17 RU RU2016106977A patent/RU2644234C2/ru active
- 2014-07-17 CA CA2919624A patent/CA2919624C/en active Active
- 2014-07-17 SG SG11201600624RA patent/SG11201600624RA/en unknown
- 2014-07-17 AU AU2014297144A patent/AU2014297144B2/en active Active
-
2016
- 2016-01-28 PH PH12016500197A patent/PH12016500197A1/en unknown
- 2016-01-28 IL IL243830A patent/IL243830B/en active IP Right Grant
- 2016-02-23 ZA ZA2016/01227A patent/ZA201601227B/en unknown
- 2016-06-13 HK HK16106779.6A patent/HK1218755A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR101538846B1 (ko) | 2015-07-22 |
| TR201901449T4 (tr) | 2019-02-21 |
| EP3029026A1 (en) | 2016-06-08 |
| CN105555761B (zh) | 2018-12-11 |
| HK1218755A1 (zh) | 2017-03-10 |
| US20160176816A1 (en) | 2016-06-23 |
| IL243830B (en) | 2019-07-31 |
| KR20150014673A (ko) | 2015-02-09 |
| SG11201600624RA (en) | 2016-03-30 |
| PT3029026T (pt) | 2019-02-06 |
| AU2014297144B2 (en) | 2017-06-08 |
| JP2016525571A (ja) | 2016-08-25 |
| CN105555761A (zh) | 2016-05-04 |
| PH12016500197B1 (en) | 2016-05-02 |
| IL243830A0 (en) | 2016-04-21 |
| BR112016001746A2 (pt) | 2017-08-01 |
| ZA201601227B (en) | 2017-11-29 |
| MY175411A (en) | 2020-06-24 |
| RU2644234C2 (ru) | 2018-02-09 |
| WO2015016511A1 (ko) | 2015-02-05 |
| CA2919624A1 (en) | 2015-02-05 |
| EP3029026B1 (en) | 2018-12-05 |
| UA116480C2 (uk) | 2018-03-26 |
| BR112016001746A8 (pt) | 2020-01-21 |
| EP3029026A4 (en) | 2017-01-11 |
| RU2016106977A (ru) | 2017-09-01 |
| MX366639B (es) | 2019-07-17 |
| ES2710389T3 (es) | 2019-04-24 |
| CA2919624C (en) | 2018-07-24 |
| JP6109425B2 (ja) | 2017-04-05 |
| PH12016500197A1 (en) | 2016-05-02 |
| AU2014297144A1 (en) | 2016-03-03 |
| US9828339B2 (en) | 2017-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |