MX2015011144A - Compuestos de quinolina y naftiridina, substituidos, como inhibidores de monoanina-oxidasas (mao). - Google Patents
Compuestos de quinolina y naftiridina, substituidos, como inhibidores de monoanina-oxidasas (mao).Info
- Publication number
- MX2015011144A MX2015011144A MX2015011144A MX2015011144A MX2015011144A MX 2015011144 A MX2015011144 A MX 2015011144A MX 2015011144 A MX2015011144 A MX 2015011144A MX 2015011144 A MX2015011144 A MX 2015011144A MX 2015011144 A MX2015011144 A MX 2015011144A
- Authority
- MX
- Mexico
- Prior art keywords
- treating
- enhancing
- disorders
- mao
- cognitive
- Prior art date
Links
- 229940082992 antihypertensives mao inhibitors Drugs 0.000 title 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 title 1
- 150000005054 naphthyridines Chemical class 0.000 title 1
- 150000003248 quinolines Chemical class 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 abstract 3
- 102000010909 Monoamine Oxidase Human genes 0.000 abstract 2
- 108010062431 Monoamine oxidase Proteins 0.000 abstract 2
- 150000005829 chemical entities Chemical class 0.000 abstract 2
- 230000001149 cognitive effect Effects 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007996 neuronal plasticity Effects 0.000 abstract 1
- 230000004112 neuroprotection Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
- 238000013456 study Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención proporciona una entidad química de la Fórmula (I), en donde R1, R2, R3, Y y n tienen cualquiera de los valores descritos en la presente y composiciones que comprenden estas entidades químicas; métodos para elaborarlos; y su uso en una amplia variedad de métodos, incluyendo estudios metabólicos y de reacción cinética, técnicas de detección y formación de imágenes, y tratamientos radioactivos; y terapias incluyendo la inhibición selectiva de MAO y MAO-B, mejora de plasticidad neuronal, tratamiento de trastornos neurológicos, provisión de neuroprotección, tratamiento de deterioro cognitivo o motriz asociado con un trastorno del CNS, mejora de la eficiencia del entrenamiento cognitivo y motriz, provisión de neurorecuperación y neuro-rehabilitación, mejora de la eficiencia de protocolos de entrenamiento humano-animal, y tratamiento de trastornos periféricos (incluyendo obesidad, diabetes, y trastornos cardiometábolicos) y sus co-morbilidades asociadas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361785872P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/020881 WO2014158916A1 (en) | 2013-03-14 | 2014-03-05 | Substituted naphthyridine and quinoline compounds as mao inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015011144A true MX2015011144A (es) | 2016-02-09 |
Family
ID=51530146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015011144A MX2015011144A (es) | 2013-03-14 | 2014-03-05 | Compuestos de quinolina y naftiridina, substituidos, como inhibidores de monoanina-oxidasas (mao). |
Country Status (16)
Country | Link |
---|---|
US (4) | US9102674B2 (es) |
EP (1) | EP2970125B1 (es) |
JP (1) | JP6346658B2 (es) |
KR (1) | KR20150127172A (es) |
CN (1) | CN105143190B (es) |
AU (1) | AU2014241759B2 (es) |
BR (1) | BR112015022202A2 (es) |
CA (1) | CA2895287A1 (es) |
HK (1) | HK1220185A1 (es) |
IL (1) | IL240805B (es) |
MX (1) | MX2015011144A (es) |
NZ (1) | NZ711598A (es) |
RU (1) | RU2661156C2 (es) |
SG (1) | SG11201504704TA (es) |
TW (1) | TWI657078B (es) |
WO (1) | WO2014158916A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6346658B2 (ja) | 2013-03-14 | 2018-06-20 | ダート・ニューロサイエンス・(ケイマン)・リミテッド | Mao阻害剤としての置換ナフチリジン及びキノリン化合物 |
BR112017005376A2 (pt) * | 2014-09-17 | 2018-08-14 | Dart Neuroscience Cayman Ltd | inibidores de mao-b e reabilitação. |
CN104496998B (zh) * | 2014-12-15 | 2017-07-11 | 陕西嘉禾生物科技股份有限公司 | 一种1′‑苄基‑2′‑酮‑5′,7′,8′‑三氢‑螺‑[1,3‑二氧五环‑2]‑喹啉的制备方法 |
WO2016125187A1 (en) | 2015-02-03 | 2016-08-11 | Council Of Scientific & Industrial Research | Novel quinoline derivatives and preparation thereof |
WO2016179432A2 (en) | 2015-05-05 | 2016-11-10 | Dart Neuroscience, Llc | Systems and methods for cognitive testing |
CN108602826A (zh) * | 2016-02-04 | 2018-09-28 | 默克专利有限公司 | 作为半导体的[1,5]二氮杂萘化合物和聚合物 |
US11370775B2 (en) * | 2016-09-14 | 2022-06-28 | Yufeng Jane Tseng | Substituted benzimidazole derivatives as D-amino acid oxidase (DAAO) inhibitors |
WO2018064465A1 (en) * | 2016-09-29 | 2018-04-05 | The Regents Of The University Of California | Compounds for increasing neural plasticity |
CN107216331B (zh) * | 2017-07-07 | 2019-06-18 | 华南理工大学 | 一种四氢萘啶并四氢喹唑啉衍生物及其合成方法和应用 |
KR102005019B1 (ko) * | 2018-04-04 | 2019-07-31 | 한국과학기술연구원 | 뇌졸중의 예방 및 치료용 조성물 |
CN108658977A (zh) * | 2018-04-12 | 2018-10-16 | 苏州康润医药有限公司 | 一种7-溴-1,5-萘啶-3-甲酸的合成方法 |
MX2021010198A (es) | 2019-02-27 | 2021-09-21 | Univ California | Indoles n-sustituidos y otros heterociclos para el tratamiento de trastornos cerebrales. |
KR20210134689A (ko) | 2019-02-27 | 2021-11-10 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 뇌 장애를 치료하기 위한 아제피노-인돌 및 다른 헤테로사이클 |
CN112939952A (zh) * | 2021-02-02 | 2021-06-11 | 深圳市第二人民医院(深圳市转化医学研究院) | 一种3-羟基查尔酮衍生物及其用途 |
CN112898276A (zh) * | 2021-02-02 | 2021-06-04 | 深圳市第二人民医院(深圳市转化医学研究院) | 一种查尔酮衍生物及其用途 |
CN114437068A (zh) * | 2022-02-21 | 2022-05-06 | 深圳市儿童医院 | 一种萘啶衍生物及其作为单胺氧化酶抑制剂的用途 |
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GB1138540A (en) * | 1966-09-19 | 1969-01-01 | Ici Ltd | Quinoline derivatives |
SU550385A1 (ru) * | 1975-09-22 | 1977-03-15 | Институт Биологической И Медицинской Химии Амн Ссср | 8-( -Метил - -пропинил-2)-аминометилхинолин как ингибитор моноаминоксидазы и способ его получени |
US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
JPH04295470A (ja) | 1991-03-22 | 1992-10-20 | Wakamoto Pharmaceut Co Ltd | モノアミンオキシダーゼ−b酵素阻害活性を有する1,2,4−オキサジアゾール誘導体及びその製造法 |
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ATE399545T1 (de) | 1996-11-08 | 2008-07-15 | Nippon Chemiphar Co | Mittel zur verringerung der eigeweidefette |
EP0994095A1 (en) | 1996-12-24 | 2000-04-19 | Nippon Chemiphar Co., Ltd. | Propionic acid derivatives |
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- 2014-03-05 MX MX2015011144A patent/MX2015011144A/es unknown
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- 2014-03-05 RU RU2015137619A patent/RU2661156C2/ru not_active IP Right Cessation
- 2014-03-05 BR BR112015022202A patent/BR112015022202A2/pt active Search and Examination
- 2014-03-05 AU AU2014241759A patent/AU2014241759B2/en not_active Ceased
- 2014-03-05 CA CA2895287A patent/CA2895287A1/en not_active Abandoned
- 2014-03-05 SG SG11201504704TA patent/SG11201504704TA/en unknown
- 2014-03-05 CN CN201480023943.4A patent/CN105143190B/zh not_active Expired - Fee Related
- 2014-03-05 WO PCT/US2014/020881 patent/WO2014158916A1/en active Application Filing
- 2014-03-05 NZ NZ711598A patent/NZ711598A/en not_active IP Right Cessation
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EP2970125A4 (en) | 2016-07-27 |
CN105143190B (zh) | 2017-08-18 |
WO2014158916A1 (en) | 2014-10-02 |
HK1220185A1 (zh) | 2017-04-28 |
IL240805A0 (en) | 2015-10-29 |
US20160074377A1 (en) | 2016-03-17 |
NZ711598A (en) | 2016-09-30 |
TW201506012A (zh) | 2015-02-16 |
SG11201504704TA (en) | 2015-07-30 |
US20140275548A1 (en) | 2014-09-18 |
BR112015022202A2 (pt) | 2017-07-18 |
AU2014241759A1 (en) | 2015-09-17 |
AU2014241759B2 (en) | 2017-10-19 |
US9675605B2 (en) | 2017-06-13 |
CA2895287A1 (en) | 2014-10-02 |
US9150572B2 (en) | 2015-10-06 |
US20170312263A1 (en) | 2017-11-02 |
RU2015137619A (ru) | 2017-04-20 |
JP6346658B2 (ja) | 2018-06-20 |
JP2016512256A (ja) | 2016-04-25 |
CN105143190A (zh) | 2015-12-09 |
US9956213B2 (en) | 2018-05-01 |
EP2970125B1 (en) | 2018-07-18 |
TWI657078B (zh) | 2019-04-21 |
RU2661156C2 (ru) | 2018-07-12 |
US20140315944A1 (en) | 2014-10-23 |
IL240805B (en) | 2018-07-31 |
US9102674B2 (en) | 2015-08-11 |
KR20150127172A (ko) | 2015-11-16 |
EP2970125A1 (en) | 2016-01-20 |
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