MX2015005271A - Polinucleotidos, polipeptidos y metodos de suso novedoso de aciltransferasa. - Google Patents

Polinucleotidos, polipeptidos y metodos de suso novedoso de aciltransferasa.

Info

Publication number
MX2015005271A
MX2015005271A MX2015005271A MX2015005271A MX2015005271A MX 2015005271 A MX2015005271 A MX 2015005271A MX 2015005271 A MX2015005271 A MX 2015005271A MX 2015005271 A MX2015005271 A MX 2015005271A MX 2015005271 A MX2015005271 A MX 2015005271A
Authority
MX
Mexico
Prior art keywords
dgat1
chimeric
proteins
methods
protein
Prior art date
Application number
MX2015005271A
Other languages
English (en)
Other versions
MX354445B (es
Inventor
Richard William Scott
Marissa Roldan
Amy Christina Curran
David Charles Taylor
Elizabeth-France Marillia
Nicholas John Roberts
Somrutai Winichayakul
Original Assignee
Agres Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agres Ltd filed Critical Agres Ltd
Publication of MX2015005271A publication Critical patent/MX2015005271A/es
Publication of MX354445B publication Critical patent/MX354445B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10L—FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G, C10K; LIQUEFIED PETROLEUM GAS; ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE OR UNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL; FIRELIGHTERS
    • C10L1/00—Liquid carbonaceous fuels
    • C10L1/02—Liquid carbonaceous fuels essentially based on components consisting of carbon, hydrogen, and oxygen only
    • C10L1/026—Liquid carbonaceous fuels essentially based on components consisting of carbon, hydrogen, and oxygen only for compression ignition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10L—FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G, C10K; LIQUEFIED PETROLEUM GAS; ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE OR UNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL; FIRELIGHTERS
    • C10L2200/00—Components of fuel compositions
    • C10L2200/04—Organic compounds
    • C10L2200/0461—Fractions defined by their origin
    • C10L2200/0469—Renewables or materials of biological origin
    • C10L2200/0476—Biodiesel, i.e. defined lower alkyl esters of fatty acids first generation biodiesel
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10L—FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G, C10K; LIQUEFIED PETROLEUM GAS; ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE OR UNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL; FIRELIGHTERS
    • C10L2270/00—Specifically adapted fuels
    • C10L2270/02—Specifically adapted fuels for internal combustion engines
    • C10L2270/026—Specifically adapted fuels for internal combustion engines for diesel engines, e.g. automobiles, stationary, marine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/0102—Diacylglycerol O-acyltransferase (2.3.1.20)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • General Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La invención proporciona proteínas DGAT1 quiméricas que comprenden: a) en sus extremos N-terminales una porción N-terminal de una primera proteína DGAT1, y b) en sus extremos C-terminales, una porción C-terminal de una segunda proteína DGAT1. Las proteínas DGAT quiméricas muestran actividad mejorada en relación a por lo menos una de la primera proteína DGAT1 y la segunda proteína DGAT1. Las proteínas DGAT quiméricas de la invención se pueden expresar en células para incrementar la acumulación de lípido celular y/o modificar el perfil de lípido celular. La invención también proporciona polinucleátidos que codifican para las proteínas DGAT1 quiméricas, células y composiciones que comprenden los polinucleótidos o proteínas DGAT1 quiméricas, y métodos de uso de las proteínas DGAT1 quiméricas para producir aceite.
MX2015005271A 2012-10-30 2013-10-22 Polinucleotidos, polipeptidos y metodos de uso novedoso de aciltransferasa. MX354445B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261720119P 2012-10-30 2012-10-30
PCT/IB2013/059526 WO2014068439A2 (en) 2012-10-30 2013-10-22 Improved acyltransferase polynucleotides, polypeptides, and methods of use

Publications (2)

Publication Number Publication Date
MX2015005271A true MX2015005271A (es) 2015-10-29
MX354445B MX354445B (es) 2018-03-06

Family

ID=50628190

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015005271A MX354445B (es) 2012-10-30 2013-10-22 Polinucleotidos, polipeptidos y metodos de uso novedoso de aciltransferasa.

Country Status (13)

Country Link
US (1) US9896694B2 (es)
EP (1) EP2914726B1 (es)
CN (1) CN104903451B (es)
AR (1) AR093290A1 (es)
AU (1) AU2013340445B2 (es)
BR (1) BR112015009467B1 (es)
CA (1) CA2889985C (es)
ES (1) ES2715327T3 (es)
IN (1) IN2015DN03964A (es)
MX (1) MX354445B (es)
NZ (1) NZ706834A (es)
PL (1) PL2914726T3 (es)
WO (1) WO2014068439A2 (es)

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AU2013340443B2 (en) 2012-10-30 2019-06-06 Agresearch Limited Enhanced acyltransferase polynucleotides, polypeptides, and methods of use
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CN110462043A (zh) 2016-09-02 2019-11-15 联邦科学技术研究组织 具有修饰的性状的植物
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Also Published As

Publication number Publication date
AU2013340445B2 (en) 2019-08-22
US9896694B2 (en) 2018-02-20
IN2015DN03964A (es) 2015-10-02
PL2914726T3 (pl) 2019-06-28
AR093290A1 (es) 2015-05-27
NZ706834A (en) 2019-04-26
EP2914726B1 (en) 2018-12-05
CN104903451B (zh) 2020-12-01
CN104903451A (zh) 2015-09-09
CA2889985A1 (en) 2014-05-08
EP2914726A4 (en) 2016-05-18
BR112015009467B1 (pt) 2022-07-19
ES2715327T3 (es) 2019-06-03
WO2014068439A2 (en) 2014-05-08
MX354445B (es) 2018-03-06
US20150284736A1 (en) 2015-10-08
AU2013340445A1 (en) 2015-05-07
WO2014068439A3 (en) 2014-07-17
CA2889985C (en) 2022-09-06
EP2914726A2 (en) 2015-09-09
BR112015009467A2 (pt) 2017-11-14

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