MX2014014027A - Modulacion por hutc de mediadores proinflamatorios de pulmon y enfermedades y trastornos pulmonares. - Google Patents
Modulacion por hutc de mediadores proinflamatorios de pulmon y enfermedades y trastornos pulmonares.Info
- Publication number
- MX2014014027A MX2014014027A MX2014014027A MX2014014027A MX2014014027A MX 2014014027 A MX2014014027 A MX 2014014027A MX 2014014027 A MX2014014027 A MX 2014014027A MX 2014014027 A MX2014014027 A MX 2014014027A MX 2014014027 A MX2014014027 A MX 2014014027A
- Authority
- MX
- Mexico
- Prior art keywords
- umbilical cord
- pro
- cord tissue
- inflammatory mediators
- disorder
- Prior art date
Links
- 208000019693 Lung disease Diseases 0.000 title abstract 10
- 230000000770 proinflammatory effect Effects 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 210000004072 lung Anatomy 0.000 title 1
- 210000003954 umbilical cord Anatomy 0.000 abstract 5
- 208000027418 Wounds and injury Diseases 0.000 abstract 4
- 230000006378 damage Effects 0.000 abstract 4
- 208000014674 injury Diseases 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 230000007170 pathology Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 abstract 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 abstract 1
- 108010017842 Telomerase Proteins 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Esta invención abarca métodos, composiciones farmacéuticas, y kits, que usan células derivadas de tejido de cordón umbilical, para modular (por ejemplo, reducir) la producción de mediadores proinflamatorios implicados en la patología de una enfermedad, trastorno, y/o lesión pulmonar en un paciente que tiene la enfermedad, trastorno, y/o lesión pulmonar; la invención abarca además métodos, composiciones farmacéuticas, y kits, que usan células derivadas de tejido de cordón umbilical, para inhibir la producción de mediadores proinflamatorios implicados en la patología de una enfermedad, trastorno, y/o lesión pulmonar en un paciente que tiene la enfermedad, trastorno, y/o lesión pulmonar con el uso de células derivadas de tejido de cordón umbilical; en una modalidad, las células derivadas de tejido de cordón umbilical se aíslan del tejido de cordón umbilical humano sustancialmente libre de sangre, tienen la capacidad de autorrenovación y de expansión en cultivo, carecen de la producción de CD117 o CD45, y no expresan hTERT o telomerasa.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/471,095 US20130302283A1 (en) | 2012-05-14 | 2012-05-14 | hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS |
| PCT/US2013/041002 WO2013173376A1 (en) | 2012-05-14 | 2013-05-14 | hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014014027A true MX2014014027A (es) | 2015-02-10 |
| MX366152B MX366152B (es) | 2019-06-28 |
Family
ID=48577869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014014027A MX366152B (es) | 2012-05-14 | 2013-05-14 | Modulacion por hutc de mediadores proinflamatorios de pulmon y enfermedades y trastornos pulmonares. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20130302283A1 (es) |
| EP (1) | EP2854825B1 (es) |
| JP (2) | JP6647863B2 (es) |
| KR (2) | KR20150009586A (es) |
| CN (1) | CN104736160A (es) |
| AU (1) | AU2013262946B2 (es) |
| BR (1) | BR112014028409A2 (es) |
| CA (1) | CA2872591C (es) |
| ES (1) | ES2702349T3 (es) |
| HK (1) | HK1208381A1 (es) |
| IN (1) | IN2014DN09084A (es) |
| MX (1) | MX366152B (es) |
| PH (1) | PH12014502508B1 (es) |
| PL (1) | PL2854825T3 (es) |
| RU (1) | RU2668389C2 (es) |
| SG (2) | SG11201407376SA (es) |
| WO (1) | WO2013173376A1 (es) |
| ZA (1) | ZA201409184B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120156134A1 (en) | 2007-12-20 | 2012-06-21 | Shayne Squires | Compositions and methods for detecting or eliminating senescent cells to diagnose or treat disease |
| AU2009327384B2 (en) | 2008-12-19 | 2014-07-10 | DePuy Synthes Products, LLC | Treatment of lung and pulmonary diseases and disorders |
| WO2012177927A1 (en) | 2011-06-21 | 2012-12-27 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
| BR112014014529A2 (pt) | 2011-12-13 | 2019-09-24 | Buck Inst For Res On Aging | métodos para melhorar terapias médicas |
| US20150064137A1 (en) | 2012-04-17 | 2015-03-05 | Kythera Biopharmaceuticals, Inc. | Use of engineered viruses to specifically kill senescent cells |
| US9901080B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells |
| US9901081B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse for determining the role of senescent cells in cancer |
| US10279018B2 (en) | 2012-12-03 | 2019-05-07 | Unity Biotechnology, Inc. | Immunogenic compositions for inducing an immune response for elimination of senescent cells |
| RU2716256C2 (ru) | 2014-01-28 | 2020-03-11 | Бак Инститьют Фо Ресеч Он Эйджинг | Способы и композиции для уничтожения стареющих клеток и для лечения заболеваний и расстройств, ассоциированных со старением |
| US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
| US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
| WO2017096615A1 (zh) * | 2015-12-11 | 2017-06-15 | 郭镭 | 一种从脐带华通氏胶组织中分离提取hUC-MSC的方法 |
| CN105420185A (zh) * | 2015-12-11 | 2016-03-23 | 郭镭 | 一种从脐带外层羊膜组织中分离提取hUC-MSC的方法 |
| WO2017096607A1 (zh) * | 2015-12-11 | 2017-06-15 | 郭镭 | 一种从脐带外层羊膜组织中分离提取hUC-MSC的方法 |
| CN105462919A (zh) * | 2015-12-11 | 2016-04-06 | 郭镭 | 一种从脐带华通氏胶组织中分离提取hUC-MSC的方法 |
| US11254915B2 (en) | 2015-12-11 | 2022-02-22 | Lei Guo | Method for separating and culturing mesenchymal stem cells from Wharton's jelly tissue of umbilical cord |
| WO2017096618A1 (zh) * | 2015-12-11 | 2017-06-15 | 郭镭 | 一种从脐带外层羊膜组织中分离培养脐带间充质干细胞的方法 |
| CN105420184A (zh) * | 2015-12-11 | 2016-03-23 | 郭镭 | 一种从脐带外层羊膜组织中分离培养脐带间充质干细胞的方法 |
| US20210038650A1 (en) * | 2017-10-23 | 2021-02-11 | Cell Medicine, Inc. | Mesenchymal stem cell therapy of leigh syndrome |
| JP7549355B2 (ja) * | 2018-10-05 | 2024-09-11 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 間葉系間質細胞を拡大するための方法 |
| US11975030B2 (en) | 2019-03-19 | 2024-05-07 | Figene, Llc | Treatment of chronic obstructive pulmonary disease and lung degeneration using activated fibroblasts and exosome derivatives thereof |
| WO2020206187A1 (en) * | 2019-04-02 | 2020-10-08 | Centagen, Inc | Engineered system of stem cell rejuvenation to treat aging and disease |
| CN110923308A (zh) * | 2019-12-12 | 2020-03-27 | 河南师范大学 | 特发性肺纤维化疾病诊断标志物及其制备诊断或预后工具中的应用 |
| WO2021183774A1 (en) * | 2020-03-12 | 2021-09-16 | Angion Biomedica Corp. | Treating acute respiratory distress |
| CN112511569B (zh) * | 2021-02-07 | 2021-05-11 | 杭州筋斗腾云科技有限公司 | 网络资源访问请求的处理方法、系统及计算机设备 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5955343A (en) | 1992-12-28 | 1999-09-21 | Massachusetts Institute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
| US5670483A (en) | 1992-12-28 | 1997-09-23 | Massachusetts Insititute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
| US6610540B1 (en) | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
| EP1171006B1 (en) | 1999-04-16 | 2006-03-29 | Wm. MARSH RICE UNIVERSITY | Functionalized poly(propylene fumarate) and poly(propylene fumarate-co-ethylene glycol) |
| US6355699B1 (en) | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
| US6555374B1 (en) | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
| US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
| US7449180B2 (en) | 2001-02-06 | 2008-11-11 | John Kisiday | Macroscopic scaffold containing amphiphilic peptides encapsulating cells |
| JP5057629B2 (ja) | 2001-02-06 | 2012-10-24 | マサチューセッツ インスティテュート オブ テクノロジー | ペプチド足場での組織細胞のカプセル化およびその使用 |
| US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| US9969977B2 (en) | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| PL1641913T3 (pl) | 2003-06-27 | 2016-06-30 | Depuy Synthes Products Inc | Komórki poporodowe pochodzące z tkanek pępowinowych i sposoby ich wytwarzania i zastosowania |
| NZ592839A (en) * | 2008-11-21 | 2012-10-26 | Anthrogenesis Corp | Treatment of diseases, disorders or conditions of the lung using placental cells |
| AU2009327384B2 (en) * | 2008-12-19 | 2014-07-10 | DePuy Synthes Products, LLC | Treatment of lung and pulmonary diseases and disorders |
| BRPI1013409A2 (pt) * | 2009-03-26 | 2018-01-16 | Advanced Tech And Regenerative Medicine Llc | células de tecido de cordão umbilical humano como terapia para doença de alzheimer |
| EP2624847B1 (en) * | 2010-10-05 | 2017-09-13 | AAL Scientifics, Inc. | Human lung stem cells and uses thereof |
-
2012
- 2012-05-14 US US13/471,095 patent/US20130302283A1/en not_active Abandoned
-
2013
- 2013-05-14 KR KR20147034858A patent/KR20150009586A/ko active Search and Examination
- 2013-05-14 ES ES13727699T patent/ES2702349T3/es active Active
- 2013-05-14 CA CA2872591A patent/CA2872591C/en not_active Expired - Fee Related
- 2013-05-14 KR KR1020187035600A patent/KR20180136560A/ko not_active IP Right Cessation
- 2013-05-14 SG SG11201407376SA patent/SG11201407376SA/en unknown
- 2013-05-14 WO PCT/US2013/041002 patent/WO2013173376A1/en active Application Filing
- 2013-05-14 BR BR112014028409A patent/BR112014028409A2/pt active Search and Examination
- 2013-05-14 MX MX2014014027A patent/MX366152B/es active IP Right Grant
- 2013-05-14 JP JP2015512766A patent/JP6647863B2/ja not_active Expired - Fee Related
- 2013-05-14 CN CN201380037639.0A patent/CN104736160A/zh active Pending
- 2013-05-14 RU RU2014150508A patent/RU2668389C2/ru active
- 2013-05-14 PL PL13727699T patent/PL2854825T3/pl unknown
- 2013-05-14 SG SG10201804052UA patent/SG10201804052UA/en unknown
- 2013-05-14 AU AU2013262946A patent/AU2013262946B2/en not_active Ceased
- 2013-05-14 EP EP13727699.4A patent/EP2854825B1/en not_active Not-in-force
-
2014
- 2014-10-30 IN IN9084DEN2014 patent/IN2014DN09084A/en unknown
- 2014-11-10 PH PH12014502508A patent/PH12014502508B1/en unknown
- 2014-12-12 ZA ZA2014/09184A patent/ZA201409184B/en unknown
-
2015
- 2015-09-21 HK HK15109248.4A patent/HK1208381A1/xx not_active IP Right Cessation
-
2018
- 2018-03-14 JP JP2018046570A patent/JP6779931B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HK1208381A1 (en) | 2016-03-04 |
| AU2013262946A1 (en) | 2015-01-22 |
| WO2013173376A1 (en) | 2013-11-21 |
| SG10201804052UA (en) | 2018-07-30 |
| SG11201407376SA (en) | 2015-03-30 |
| KR20180136560A (ko) | 2018-12-24 |
| MX366152B (es) | 2019-06-28 |
| JP2015518830A (ja) | 2015-07-06 |
| EP2854825A1 (en) | 2015-04-08 |
| BR112014028409A2 (pt) | 2018-07-24 |
| PH12014502508A1 (en) | 2014-12-22 |
| CN104736160A (zh) | 2015-06-24 |
| ES2702349T3 (es) | 2019-02-28 |
| JP6647863B2 (ja) | 2020-02-14 |
| RU2668389C2 (ru) | 2018-09-28 |
| EP2854825B1 (en) | 2018-10-31 |
| RU2014150508A (ru) | 2016-07-10 |
| PH12014502508B1 (en) | 2014-12-22 |
| ZA201409184B (en) | 2017-06-28 |
| IN2014DN09084A (es) | 2015-05-22 |
| CA2872591C (en) | 2021-11-30 |
| AU2013262946B2 (en) | 2018-02-01 |
| PL2854825T3 (pl) | 2019-04-30 |
| JP6779931B2 (ja) | 2020-11-04 |
| JP2018118984A (ja) | 2018-08-02 |
| CA2872591A1 (en) | 2013-11-21 |
| KR20150009586A (ko) | 2015-01-26 |
| US20130302283A1 (en) | 2013-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |