MX366152B - Modulacion por hutc de mediadores proinflamatorios de pulmon y enfermedades y trastornos pulmonares. - Google Patents

Modulacion por hutc de mediadores proinflamatorios de pulmon y enfermedades y trastornos pulmonares.

Info

Publication number
MX366152B
MX366152B MX2014014027A MX2014014027A MX366152B MX 366152 B MX366152 B MX 366152B MX 2014014027 A MX2014014027 A MX 2014014027A MX 2014014027 A MX2014014027 A MX 2014014027A MX 366152 B MX366152 B MX 366152B
Authority
MX
Mexico
Prior art keywords
umbilical cord
pro
cord tissue
inflammatory mediators
disorder
Prior art date
Application number
MX2014014027A
Other languages
English (en)
Other versions
MX2014014027A (es
Inventor
Anthony J Kihm
Original Assignee
Depuy Synthes Products Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Depuy Synthes Products Llc filed Critical Depuy Synthes Products Llc
Publication of MX2014014027A publication Critical patent/MX2014014027A/es
Publication of MX366152B publication Critical patent/MX366152B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a células derivadas de tejido de cordón umbilical para usarse en el tratamiento de enfermedad pulmonar obstructiva crónica (COPD) mediante la reducción de la producción de uno o más mediadores proinflamatorios implicados en la patología de COPD, en donde el uno o más mediadores proinflamatorios se seleccionan del grupo que consiste de TNFa, RANTES, IL-1ß y combinaciones de los mismos, y en donde las células son aisladas de tejido de cordón umbilical humano sustancialmente libre de sangre, son capaces de autorrenovarse y de expansión en cultivo, carecen de la producción de CD117 y CD45, y no expresan hTERT o telomerasa.
MX2014014027A 2012-05-14 2013-05-14 Modulacion por hutc de mediadores proinflamatorios de pulmon y enfermedades y trastornos pulmonares. MX366152B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/471,095 US20130302283A1 (en) 2012-05-14 2012-05-14 hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS
PCT/US2013/041002 WO2013173376A1 (en) 2012-05-14 2013-05-14 hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS

Publications (2)

Publication Number Publication Date
MX2014014027A MX2014014027A (es) 2015-02-10
MX366152B true MX366152B (es) 2019-06-28

Family

ID=48577869

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014014027A MX366152B (es) 2012-05-14 2013-05-14 Modulacion por hutc de mediadores proinflamatorios de pulmon y enfermedades y trastornos pulmonares.

Country Status (17)

Country Link
US (1) US20130302283A1 (es)
EP (1) EP2854825B1 (es)
JP (2) JP6647863B2 (es)
KR (2) KR20180136560A (es)
CN (1) CN104736160A (es)
AU (1) AU2013262946B2 (es)
BR (1) BR112014028409A2 (es)
CA (1) CA2872591C (es)
ES (1) ES2702349T3 (es)
IN (1) IN2014DN09084A (es)
MX (1) MX366152B (es)
PH (1) PH12014502508B1 (es)
PL (1) PL2854825T3 (es)
RU (1) RU2668389C2 (es)
SG (2) SG10201804052UA (es)
WO (1) WO2013173376A1 (es)
ZA (1) ZA201409184B (es)

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WO2009085216A2 (en) 2007-12-20 2009-07-09 Squicor Compositions and methods for detecting or elimninating senescent cells to diagnose or treat disease
CN102387807A (zh) 2008-12-19 2012-03-21 先进科技及再生医学有限责任公司 肺部疾病和病症的治疗
WO2012177927A1 (en) 2011-06-21 2012-12-27 Mayo Foundation For Medical Education And Research Transgenic animals capable of being induced to delete senescent cells
MX2014007093A (es) 2011-12-13 2014-10-13 Buck Inst For Res On Aging Metodos para mejorar terapias medicas.
US20150064137A1 (en) 2012-04-17 2015-03-05 Kythera Biopharmaceuticals, Inc. Use of engineered viruses to specifically kill senescent cells
US9901081B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse for determining the role of senescent cells in cancer
US9901080B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells
WO2014089124A1 (en) 2012-12-03 2014-06-12 Cenexys, Inc. Immunogenic compositions for inducing an immune response for elimination of senescent cells
IL286427B2 (en) 2014-01-28 2024-08-01 Mayo Found Medical Education & Res Inhibitors bcl-2 anti-apoptotic protein family members for treatment of non cancer pulmonary disease or an opthalmic disease
US10328058B2 (en) 2014-01-28 2019-06-25 Mayo Foundation For Medical Education And Research Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
US20190269675A1 (en) 2014-01-28 2019-09-05 Buck Institute for Research and Aging Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents
US20170216286A1 (en) 2014-01-28 2017-08-03 Mayo Foundation For Medical Education And Research Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid
WO2017096615A1 (zh) * 2015-12-11 2017-06-15 郭镭 一种从脐带华通氏胶组织中分离提取hUC-MSC的方法
WO2017096607A1 (zh) * 2015-12-11 2017-06-15 郭镭 一种从脐带外层羊膜组织中分离提取hUC-MSC的方法
CN105420184A (zh) * 2015-12-11 2016-03-23 郭镭 一种从脐带外层羊膜组织中分离培养脐带间充质干细胞的方法
WO2017096618A1 (zh) * 2015-12-11 2017-06-15 郭镭 一种从脐带外层羊膜组织中分离培养脐带间充质干细胞的方法
CN105462919A (zh) * 2015-12-11 2016-04-06 郭镭 一种从脐带华通氏胶组织中分离提取hUC-MSC的方法
EP3388512B1 (en) * 2015-12-11 2023-08-23 Lei Guo Method for separating and culturing mesenchymal stem cells from wharton's jelly tissue of umbilical cord
CN105420185A (zh) * 2015-12-11 2016-03-23 郭镭 一种从脐带外层羊膜组织中分离提取hUC-MSC的方法
WO2019083995A1 (en) * 2017-10-23 2019-05-02 Cell Medicine, Inc. MESENCHYMAL STEM CELL THERAPY OF LEIGH SYNDROME
US12473336B2 (en) 2018-02-21 2025-11-18 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses thereof
CN113015535A (zh) * 2018-10-05 2021-06-22 得克萨斯大学体系董事会 扩增间充质基质细胞的方法
AU2020240049A1 (en) 2019-03-19 2021-11-04 Figene, Llc Treatment of chronic obstructive pulmonary disease and lung degeneration using activated fibroblasts and exosome derivatives thereof
US20230091910A1 (en) * 2019-04-02 2023-03-23 Centagen, Inc. Engineered System of Stem Cell Rejuvenation to Treat Aging and Disease
CN110923308A (zh) * 2019-12-12 2020-03-27 河南师范大学 特发性肺纤维化疾病诊断标志物及其制备诊断或预后工具中的应用
WO2021183774A1 (en) * 2020-03-12 2021-09-16 Angion Biomedica Corp. Treating acute respiratory distress
CN112511569B (zh) * 2021-02-07 2021-05-11 杭州筋斗腾云科技有限公司 网络资源访问请求的处理方法、系统及计算机设备

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Also Published As

Publication number Publication date
US20130302283A1 (en) 2013-11-14
JP2018118984A (ja) 2018-08-02
CA2872591C (en) 2021-11-30
CA2872591A1 (en) 2013-11-21
SG10201804052UA (en) 2018-07-30
RU2014150508A (ru) 2016-07-10
PL2854825T3 (pl) 2019-04-30
RU2668389C2 (ru) 2018-09-28
CN104736160A (zh) 2015-06-24
IN2014DN09084A (es) 2015-05-22
EP2854825B1 (en) 2018-10-31
BR112014028409A2 (pt) 2018-07-24
PH12014502508A1 (en) 2014-12-22
JP6779931B2 (ja) 2020-11-04
SG11201407376SA (en) 2015-03-30
WO2013173376A1 (en) 2013-11-21
AU2013262946B2 (en) 2018-02-01
HK1208381A1 (en) 2016-03-04
KR20180136560A (ko) 2018-12-24
EP2854825A1 (en) 2015-04-08
ZA201409184B (en) 2017-06-28
MX2014014027A (es) 2015-02-10
JP2015518830A (ja) 2015-07-06
AU2013262946A1 (en) 2015-01-22
KR20150009586A (ko) 2015-01-26
ES2702349T3 (es) 2019-02-28
JP6647863B2 (ja) 2020-02-14
PH12014502508B1 (en) 2014-12-22

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