MX2014004724A - Composicion para uso en el aumento de sensibilidad a la insulina y/o la reduccion de resistencia a la insulina. - Google Patents
Composicion para uso en el aumento de sensibilidad a la insulina y/o la reduccion de resistencia a la insulina.Info
- Publication number
- MX2014004724A MX2014004724A MX2014004724A MX2014004724A MX2014004724A MX 2014004724 A MX2014004724 A MX 2014004724A MX 2014004724 A MX2014004724 A MX 2014004724A MX 2014004724 A MX2014004724 A MX 2014004724A MX 2014004724 A MX2014004724 A MX 2014004724A
- Authority
- MX
- Mexico
- Prior art keywords
- composition
- insulin resistance
- reducing
- lnnt
- lacto
- Prior art date
Links
- 206010022489 Insulin Resistance Diseases 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title abstract 4
- AXQLFFDZXPOFPO-UHFFFAOYSA-N UNPD216 Natural products O1C(CO)C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(NC(=O)C)C1OC(C1O)C(O)C(CO)OC1OC1C(O)C(O)C(O)OC1CO AXQLFFDZXPOFPO-UHFFFAOYSA-N 0.000 abstract 3
- AXQLFFDZXPOFPO-UNTPKZLMSA-N beta-D-Galp-(1->3)-beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-beta-D-Glcp Chemical compound O([C@@H]1O[C@H](CO)[C@H](O)[C@@H]([C@H]1O)O[C@H]1[C@@H]([C@H]([C@H](O)[C@@H](CO)O1)O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)NC(=O)C)[C@H]1[C@H](O)[C@@H](O)[C@H](O)O[C@@H]1CO AXQLFFDZXPOFPO-UNTPKZLMSA-N 0.000 abstract 3
- IEQCXFNWPAHHQR-UHFFFAOYSA-N lacto-N-neotetraose Natural products OCC1OC(OC2C(C(OC3C(OC(O)C(O)C3O)CO)OC(CO)C2O)O)C(NC(=O)C)C(O)C1OC1OC(CO)C(O)C(O)C1O IEQCXFNWPAHHQR-UHFFFAOYSA-N 0.000 abstract 3
- USIPEGYTBGEPJN-UHFFFAOYSA-N lacto-N-tetraose Natural products O1C(CO)C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(NC(=O)C)C1OC1C(O)C(CO)OC(OC(C(O)CO)C(O)C(O)C=O)C1O USIPEGYTBGEPJN-UHFFFAOYSA-N 0.000 abstract 3
- 229940062780 lacto-n-neotetraose Drugs 0.000 abstract 3
- RBMYDHMFFAVMMM-PLQWBNBWSA-N neolactotetraose Chemical compound O([C@H]1[C@H](O)[C@H]([C@@H](O[C@@H]1CO)O[C@@H]1[C@H]([C@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[C@H](CO)[C@@H]1O)O)NC(=O)C)[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O RBMYDHMFFAVMMM-PLQWBNBWSA-N 0.000 abstract 3
- 229920001542 oligosaccharide Polymers 0.000 abstract 3
- 150000002482 oligosaccharides Chemical class 0.000 abstract 3
- 229940062827 2'-fucosyllactose Drugs 0.000 abstract 1
- HWHQUWQCBPAQQH-UHFFFAOYSA-N 2-O-alpha-L-Fucosyl-lactose Natural products OC1C(O)C(O)C(C)OC1OC1C(O)C(O)C(CO)OC1OC(C(O)CO)C(O)C(O)C=O HWHQUWQCBPAQQH-UHFFFAOYSA-N 0.000 abstract 1
- HWHQUWQCBPAQQH-BWRPKUOHSA-N 2-fucosyllactose Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O HWHQUWQCBPAQQH-BWRPKUOHSA-N 0.000 abstract 1
- SNFSYLYCDAVZGP-UHFFFAOYSA-N UNPD26986 Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(OC(O)C(O)C2O)CO)OC(CO)C(O)C1O SNFSYLYCDAVZGP-UHFFFAOYSA-N 0.000 abstract 1
- 208000030941 fetal growth restriction Diseases 0.000 abstract 1
- 208000004104 gestational diabetes Diseases 0.000 abstract 1
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000006041 probiotic Substances 0.000 abstract 1
- 230000000529 probiotic effect Effects 0.000 abstract 1
- 235000018291 probiotics Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Microbiology (AREA)
- Pediatric Medicine (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
[a invención describe una composición que comprende al menos un ácido graso de cadena larga poliinsaturado, al menos un probiótico y una mezcla de oligosacáridos, donde dicha mezcla contiene al menos un de lacto-N-neotetraosa (LNnT) y lacto-N-tetraosa (LNT), al menos un oligosacárido N-acetilado diferente de LNnT y LNT, al menos un oligosacárido sialilado y al menos un oligosacárido neutro, para ser usado en el aumento de la sensibilidad a la insulina y/o para reducir la resistencia a la insulina. Además esta composición opcionalmente comprende 2'-fucosil lactosa (FL). Esta composición está particularmente adaptada para el uso en lactantes que han nacido prematuros y/o que experimentaron RCIU, en mujeres embarazadas que padecen de diabetes gestacional y en niños, adolescentes, y adultos que sufren de Resistencia a la insulina y/o diabetes tipo II.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11185603 | 2011-10-18 | ||
| PCT/EP2012/070356 WO2013057061A1 (en) | 2011-10-18 | 2012-10-15 | Composition for use in increasing insulin sensitivity and/or reducing insulin resistance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014004724A true MX2014004724A (es) | 2015-02-05 |
| MX350436B MX350436B (es) | 2017-09-06 |
Family
ID=47046594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014004724A MX350436B (es) | 2011-10-18 | 2012-10-15 | Composicion para uso en el aumento de sensibilidad a la insulina y/o la reduccion de resistencia a la insulina. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9636367B2 (es) |
| EP (1) | EP2768314B1 (es) |
| CN (1) | CN103889240B (es) |
| AU (1) | AU2012325072B2 (es) |
| BR (1) | BR112014008657A2 (es) |
| CL (1) | CL2014000832A1 (es) |
| ES (1) | ES2560023T3 (es) |
| MX (1) | MX350436B (es) |
| PL (1) | PL2768314T3 (es) |
| PT (1) | PT2768314E (es) |
| RU (1) | RU2604503C2 (es) |
| WO (1) | WO2013057061A1 (es) |
| ZA (1) | ZA201403593B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105899089A (zh) * | 2013-12-19 | 2016-08-24 | 雀巢产品技术援助有限公司 | 用于减少婴儿代谢应激、降低肠道通透性和接近母乳喂养婴儿的生长速度的营养组合物 |
| US10835544B2 (en) | 2014-12-08 | 2020-11-17 | Glycom A/S | Synthetic composition for regulating satiety |
| US10881674B2 (en) * | 2014-12-08 | 2021-01-05 | Glycom A/S | Synthetic composition for treating metabolic disorders |
| US10987368B2 (en) | 2014-12-08 | 2021-04-27 | Glycom A/S | Synthetic composition for preventing or treating CVD |
| CN115350200A (zh) * | 2014-12-08 | 2022-11-18 | 格礼卡姆股份公司 | 用于治疗代谢障碍的合成组合物 |
| US10751354B2 (en) | 2015-09-14 | 2020-08-25 | Glycom A/S | Synthetic composition for microbiota modulation |
| WO2017103850A1 (en) | 2015-12-15 | 2017-06-22 | Glycom A/S | Mixture of hmos |
| CN108777996A (zh) * | 2016-04-11 | 2018-11-09 | 雀巢产品技术援助有限公司 | 提供代谢有益效果的婴儿营养 |
| WO2017215721A1 (en) * | 2016-06-15 | 2017-12-21 | Glycom A/S | Synthetic compositions comprising human milk oligosaccharides for use γν the prevention and treatment of disorders |
| MX2019002607A (es) | 2016-09-07 | 2019-09-18 | Univ Temple | Composiciones y metodos para el tratamiento de resistencia a la insulina. |
| TWI658791B (zh) * | 2017-09-25 | 2019-05-11 | 愛之味股份有限公司 | 具有調節血脂、改善腸道菌叢及提升免疫力功能的富含寡醣乳製品及其製法 |
| CA3088630A1 (en) | 2017-12-15 | 2019-06-20 | Solarea Bio, Inc. | Microbial compositions and methods for treating type 2 diabetes, obesity, and metabolic syndrome |
| WO2019123316A1 (en) * | 2017-12-22 | 2019-06-27 | Glycom A/S | Composition comprising hmos for preventing or reducing nociception |
| WO2019180965A1 (ja) * | 2018-03-23 | 2019-09-26 | 森永乳業株式会社 | 学童期以降の高血糖に起因する疾患の予防のための乳幼児用組成物 |
| GB2573539A (en) * | 2018-05-09 | 2019-11-13 | Mjn Us Holdings Llc | Wellbeing supplement for postpartum maternal nutrition |
| WO2020051379A1 (en) | 2018-09-05 | 2020-03-12 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases |
| US11980647B2 (en) | 2018-09-05 | 2024-05-14 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause |
| CN113163832A (zh) * | 2018-11-30 | 2021-07-23 | 雀巢产品有限公司 | 用于增强胰腺成熟和胰岛素生物合成的婴儿营养组合物 |
| CN111165825A (zh) * | 2019-07-17 | 2020-05-19 | 江苏西宏生物医药有限公司 | 一种术前经肠营养组合物 |
| WO2023092150A1 (en) | 2021-11-22 | 2023-05-25 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422346A (en) * | 1988-01-06 | 1995-06-06 | California Natural Products | Instant dried dahlia inulin juice and its method of production and usage |
| WO1991016449A1 (en) | 1990-04-16 | 1991-10-31 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
| US5545553A (en) | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
| US6946451B2 (en) * | 2002-02-04 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Insulin secretion promoter |
| US6942857B2 (en) * | 2002-08-09 | 2005-09-13 | Bioneer Corporation | Microorganisms for preventing and/or treating obesity or diabetes mellitus |
| GB0302929D0 (en) * | 2003-02-10 | 2003-03-12 | Inst Of Child Health | Nutrient composition |
| US20050175759A1 (en) * | 2004-02-09 | 2005-08-11 | Atul Singhal | Newborn infant formulas and feeding methods |
| SE529185C2 (sv) * | 2005-10-07 | 2007-05-22 | Arla Foods Amba | Användning av probiotiska bakterier för tillverkning av livsmedel eller läkemedel för förhindrande av övervikt |
| PL1962823T3 (pl) * | 2005-12-23 | 2015-08-31 | Nutricia Nv | Kompozycja zawierająca wielonienasycone kwasy tłuszczowe, białka i mangan i/lub molibden do poprawy składu błony komórkowej |
| BRPI0707620A2 (pt) * | 2006-02-10 | 2011-05-10 | Nestec Sa | mistura de oligossacarÍdeo |
| MY149913A (en) * | 2006-03-07 | 2013-10-31 | Nestec Sa | Synbiotic mixture |
| WO2008054193A1 (en) * | 2006-11-02 | 2008-05-08 | N.V. Nutricia | Nutritional products that comprise saccharide oligomers |
| EP2011506A1 (en) * | 2007-07-05 | 2009-01-07 | Nestec S.A. | Supplementation of maternal diet |
| PL2217246T3 (pl) * | 2007-11-08 | 2015-06-30 | Nestec Sa | Zastosowanie oligosacharydów zawierających n-acetylolaktozaminę do dojrzewania odpowiedzi odpornościowych u noworodków |
| EP2072052A1 (en) * | 2007-12-17 | 2009-06-24 | Nestec S.A. | Prevention of opportunistic infections in immune-compromised subjects |
| EP2143341A1 (en) * | 2008-07-08 | 2010-01-13 | Nestec S.A. | Nutritional Composition Containing Oligosaccharide Mixture |
| RU2559646C2 (ru) * | 2009-04-01 | 2015-08-10 | Нестек С.А. | Снижение риска ожирения |
| EP2258216A1 (en) * | 2009-06-02 | 2010-12-08 | Nestec S.A. | Nutritional Composition for Supporting Brain Development and Function of Toddlers |
-
2012
- 2012-10-15 ES ES12775227.7T patent/ES2560023T3/es active Active
- 2012-10-15 AU AU2012325072A patent/AU2012325072B2/en active Active
- 2012-10-15 MX MX2014004724A patent/MX350436B/es active IP Right Grant
- 2012-10-15 PL PL12775227T patent/PL2768314T3/pl unknown
- 2012-10-15 WO PCT/EP2012/070356 patent/WO2013057061A1/en active Application Filing
- 2012-10-15 US US14/352,596 patent/US9636367B2/en active Active
- 2012-10-15 EP EP12775227.7A patent/EP2768314B1/en active Active
- 2012-10-15 CN CN201280051320.9A patent/CN103889240B/zh active Active
- 2012-10-15 BR BR112014008657A patent/BR112014008657A2/pt active Search and Examination
- 2012-10-15 PT PT127752277T patent/PT2768314E/pt unknown
- 2012-10-15 RU RU2014119903/13A patent/RU2604503C2/ru active
-
2014
- 2014-04-04 CL CL2014000832A patent/CL2014000832A1/es unknown
- 2014-05-16 ZA ZA2014/03593A patent/ZA201403593B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX350436B (es) | 2017-09-06 |
| CL2014000832A1 (es) | 2014-08-22 |
| BR112014008657A2 (pt) | 2017-04-25 |
| CN103889240A (zh) | 2014-06-25 |
| US20140286909A1 (en) | 2014-09-25 |
| US9636367B2 (en) | 2017-05-02 |
| AU2012325072A2 (en) | 2014-05-29 |
| CN103889240B (zh) | 2016-09-14 |
| AU2012325072B2 (en) | 2015-12-03 |
| EP2768314B1 (en) | 2015-11-25 |
| PT2768314E (pt) | 2016-02-17 |
| WO2013057061A1 (en) | 2013-04-25 |
| RU2604503C2 (ru) | 2016-12-10 |
| PL2768314T3 (pl) | 2016-05-31 |
| RU2014119903A (ru) | 2015-11-27 |
| ES2560023T3 (es) | 2016-02-17 |
| ZA201403593B (en) | 2016-09-28 |
| AU2012325072A1 (en) | 2014-03-13 |
| EP2768314A1 (en) | 2014-08-27 |
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