MX2014002967A - Antagonistas de los productos del agrupamiento de unigenes hs.459642 para la inhibicion de la proliferacion, del desarrollo o de la diferenciacion de las celulas madre incluyendo las celulas madre cancerosas. - Google Patents
Antagonistas de los productos del agrupamiento de unigenes hs.459642 para la inhibicion de la proliferacion, del desarrollo o de la diferenciacion de las celulas madre incluyendo las celulas madre cancerosas.Info
- Publication number
- MX2014002967A MX2014002967A MX2014002967A MX2014002967A MX2014002967A MX 2014002967 A MX2014002967 A MX 2014002967A MX 2014002967 A MX2014002967 A MX 2014002967A MX 2014002967 A MX2014002967 A MX 2014002967A MX 2014002967 A MX2014002967 A MX 2014002967A
- Authority
- MX
- Mexico
- Prior art keywords
- stem cells
- antagonists
- proliferation
- differentiation
- development
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
Abstract
La presente descripción proporciona los métodos y las composiciones para inhibir la proliferación, la diferenciación, o el desarrollo de las células madre y de las células madre cancerosas en un paciente en necesidad de los mismos. Los métodos implican administrar a un paciente la cantidad terapéuticamente eficaz de un antagonista de un producto del agrupamiento de unigenes Hs.459642, como un inhibidor de CACNA1H. Las composiciones incluyen un antagonista de un producto del agrupamiento de unigenes Hs.459642, como un inhibidor de CACNA1H. Esta descripción también proporciona los antagonistas específicos como los anticuerpos y los oligonucleótidos antisentido, y la terapia de combinación con uno o más agentes anticáncer adicionales. Tales métodos, antagonistas, y composiciones pueden ser útiles, por ejemplo, en el tratamiento del cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161533545P | 2011-09-12 | 2011-09-12 | |
PCT/US2012/054567 WO2013039859A1 (en) | 2011-09-12 | 2012-09-11 | Antagonists of products of the hs.459642 unigene cluster for the inhibition of proliferation, development or differentiation of stem cells including cancer stem cells |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2014002967A true MX2014002967A (es) | 2015-04-13 |
Family
ID=47830014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014002967A MX2014002967A (es) | 2011-09-12 | 2012-09-11 | Antagonistas de los productos del agrupamiento de unigenes hs.459642 para la inhibicion de la proliferacion, del desarrollo o de la diferenciacion de las celulas madre incluyendo las celulas madre cancerosas. |
Country Status (12)
Country | Link |
---|---|
US (2) | US20130064814A1 (es) |
EP (1) | EP2755674A4 (es) |
JP (1) | JP2014526475A (es) |
KR (1) | KR20140084034A (es) |
CN (1) | CN103957923B (es) |
AU (1) | AU2012309800B2 (es) |
CA (1) | CA2848311A1 (es) |
HK (1) | HK1200120A1 (es) |
IL (1) | IL231385A0 (es) |
MX (1) | MX2014002967A (es) |
SG (2) | SG11201400526TA (es) |
WO (1) | WO2013039859A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX360640B (es) | 2010-03-01 | 2018-11-09 | Tau Therapeutics Llc Star | Diagnosis e imagenologia de cancer. |
JP2017031059A (ja) | 2014-01-29 | 2017-02-09 | 学校法人慶應義塾 | がん幹細胞の増殖抑制剤および細胞内活性酸素蓄積誘導剤 |
JP6876502B2 (ja) * | 2016-04-25 | 2021-05-26 | クラシエホールディングス株式会社 | 未分化細胞除去剤 |
US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
WO2018058489A1 (zh) * | 2016-09-30 | 2018-04-05 | 武汉华大吉诺因生物科技有限公司 | Cacna1h衍生的肿瘤抗原多肽及其应用 |
WO2019103578A1 (ko) * | 2017-11-27 | 2019-05-31 | (주)프로스테믹스 | 올리고뉴클레오티드 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
CA3127871A1 (en) | 2019-03-01 | 2020-09-10 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
TR199801581T2 (xx) | 1996-02-14 | 1998-10-21 | Isis Pharmaceuticals, Inc. | �ekerle de�i�tirilmi� bo�luklu oligon�kleotid'ler. |
US6251886B1 (en) * | 1998-12-07 | 2001-06-26 | Schering Corporation | Methods of using temozolomide in the treatment of cancers |
ZA200305980B (en) * | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
DE60322509D1 (de) | 2002-01-17 | 2008-09-11 | Univ British Columbia | Bispezifische antisense oligonukleotide die igfbp-2 und igfbp-5 inhibieren und deren verwendung |
AU2005211764B2 (en) * | 2004-02-11 | 2011-07-21 | University Of Virginia Patent Foundation | Inhibiting CAV3 isoforms and the delta25B splice varients for the diagnosis and treatment of cancer |
US7662240B2 (en) * | 2004-06-22 | 2010-02-16 | The Timken Company | Seal for worm gear speed reducer |
KR100743255B1 (ko) | 2006-05-04 | 2007-07-27 | 한국과학기술연구원 | T-형 칼슘 채널에 활성을 지닌 신규1,3-다이옥소아이소인돌 유도체 |
SG10201503407WA (en) * | 2006-12-19 | 2015-06-29 | Genentech Inc | Vegf-specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors |
WO2009036059A2 (en) * | 2007-09-10 | 2009-03-19 | Boston Biomedical, Inc. | Novel stat3 pathway inhibitors and cancer stem cell inhibitors |
MY155603A (en) * | 2008-07-08 | 2015-11-13 | Oncomed Pharm Inc | Notch-binding agents and antagonists and methods of use thereof |
MX344725B (es) * | 2009-06-05 | 2017-01-05 | Tau Therapeutics Llc * | Metodo entrelazado para tratar cancer o una condicion precancerosa. |
-
2012
- 2012-09-11 CN CN201280055308.5A patent/CN103957923B/zh not_active Expired - Fee Related
- 2012-09-11 KR KR1020147009726A patent/KR20140084034A/ko not_active Application Discontinuation
- 2012-09-11 JP JP2014529965A patent/JP2014526475A/ja active Pending
- 2012-09-11 SG SG11201400526TA patent/SG11201400526TA/en unknown
- 2012-09-11 WO PCT/US2012/054567 patent/WO2013039859A1/en active Application Filing
- 2012-09-11 AU AU2012309800A patent/AU2012309800B2/en not_active Ceased
- 2012-09-11 SG SG10201601917XA patent/SG10201601917XA/en unknown
- 2012-09-11 CA CA2848311A patent/CA2848311A1/en not_active Abandoned
- 2012-09-11 EP EP12832679.0A patent/EP2755674A4/en not_active Withdrawn
- 2012-09-11 US US13/609,942 patent/US20130064814A1/en not_active Abandoned
- 2012-09-11 MX MX2014002967A patent/MX2014002967A/es unknown
-
2014
- 2014-03-06 IL IL231385A patent/IL231385A0/en unknown
-
2015
- 2015-01-21 HK HK15100687.1A patent/HK1200120A1/xx unknown
-
2019
- 2019-11-15 US US16/685,279 patent/US20200197516A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2012309800A1 (en) | 2014-05-01 |
WO2013039859A1 (en) | 2013-03-21 |
SG10201601917XA (en) | 2016-04-28 |
KR20140084034A (ko) | 2014-07-04 |
EP2755674A1 (en) | 2014-07-23 |
SG11201400526TA (en) | 2014-04-28 |
CN103957923B (zh) | 2018-05-25 |
CA2848311A1 (en) | 2013-03-21 |
US20200197516A1 (en) | 2020-06-25 |
CN103957923A (zh) | 2014-07-30 |
JP2014526475A (ja) | 2014-10-06 |
HK1200120A1 (en) | 2015-07-31 |
US20130064814A1 (en) | 2013-03-14 |
EP2755674A4 (en) | 2015-04-08 |
IL231385A0 (en) | 2014-04-30 |
AU2012309800B2 (en) | 2017-10-05 |
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