MX2013008545A - Derivados de homo- y hetero-poliaminoacidos de fulereno c60, metodo para producir los mismos, y composiciones farmaceuticas con base en dichos derivados. - Google Patents

Derivados de homo- y hetero-poliaminoacidos de fulereno c60, metodo para producir los mismos, y composiciones farmaceuticas con base en dichos derivados.

Info

Publication number
MX2013008545A
MX2013008545A MX2013008545A MX2013008545A MX2013008545A MX 2013008545 A MX2013008545 A MX 2013008545A MX 2013008545 A MX2013008545 A MX 2013008545A MX 2013008545 A MX2013008545 A MX 2013008545A MX 2013008545 A MX2013008545 A MX 2013008545A
Authority
MX
Mexico
Prior art keywords
fullerene
polyamino
hetero
derivatives
homo
Prior art date
Application number
MX2013008545A
Other languages
English (en)
Other versions
MX354436B (es
Inventor
Davidovich Rasnetsov Lev
Yudelevich Shvartsman Iakov
Nikolaevna Suvorona Olga
Original Assignee
Davidovich Rasnetsov Lev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Davidovich Rasnetsov Lev filed Critical Davidovich Rasnetsov Lev
Publication of MX2013008545A publication Critical patent/MX2013008545A/es
Publication of MX354436B publication Critical patent/MX354436B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2604/00—Fullerenes, e.g. C60 buckminsterfullerene or C70

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

La invención se refiere a la industria farmacéutica y a la medicina, específicamente a nuevos derivados de homo- y hetero-poliaminoácidos de fulereno C60 de fórmula general: C60(H)x{NH(CH2)nCOO-}x{NH3+(L) COOH}x en donde n = 2-5, x = 3, L = -(CH2)m, en donde m = 1-5, o - CO(CH2)kCH(NH2)-, en donde k = 1-2, caracterizados en que los compuestos comprenden grupos de aminoácidos unidos covalentemente y formas iónicas polares de aminoácidos, y también a un método para producir dichos derivados, y a la producción de composiciones farmacéuticas con base en los mismos. El método para producir derivados de homo- y hetero-poliaminoácios de fulereno se basa en la reacción de un enlace nucleófilo de aminoácidos a fulereno, formando derivados de aminoácidos de fulereno unidos covalentemente, con la introducción posterior de formas iónicas polares de los aminoácidos. Una composición farmacéutica comprende, como sustancia activa, derivados de homo- y hetero-poliaminoácidos de fulereno de fórmula C60(H)x{NH(CH2)nCOO-}x{NH3+(L) COOH}x en donde n = 2-5, X = 3, L = -(CH2)m, en donde m = 1-5, o -CO(CH2)kCH(NH2)-, en donde k = 1-2.
MX2013008545A 2011-02-01 2012-02-06 Derivados de homo- y hetero-poliaminoácidos de fulereno c60, método para producir los mismos, y composiciones farmacéuticas con base en dichos derivados. MX354436B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2011103574/04A RU2458914C1 (ru) 2011-02-01 2011-02-01 Гомо- и гетеро-полиаминокислотные производные фуллерена c60, способ их получения и фармацевтические композиции на их основе
PCT/RU2012/000062 WO2012105872A1 (ru) 2011-02-01 2012-02-06 Гомо- и гетеро-полиаминокислотные производные фуллерена с60, способ их получения и фармацевтические композиции на их основе

Publications (2)

Publication Number Publication Date
MX2013008545A true MX2013008545A (es) 2016-09-08
MX354436B MX354436B (es) 2018-03-06

Family

ID=46602956

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013008545A MX354436B (es) 2011-02-01 2012-02-06 Derivados de homo- y hetero-poliaminoácidos de fulereno c60, método para producir los mismos, y composiciones farmacéuticas con base en dichos derivados.

Country Status (14)

Country Link
US (1) US9221746B2 (es)
EP (1) EP2674415B1 (es)
AP (1) AP4014A (es)
AU (1) AU2012212707B2 (es)
BR (1) BR112013012910A2 (es)
EA (1) EA020801B1 (es)
ES (1) ES2582872T3 (es)
HK (1) HK1190386A1 (es)
IL (1) IL226736A (es)
MX (1) MX354436B (es)
RU (1) RU2458914C1 (es)
UA (1) UA110345C2 (es)
WO (1) WO2012105872A1 (es)
ZA (1) ZA201303447B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103450486B (zh) * 2013-05-14 2016-09-14 成立 双亲有机聚富勒烯树状分子交联的聚阳离子聚合物凝胶物质及其制备方法
CN104478886A (zh) * 2014-12-30 2015-04-01 郑州大学 一种富勒烯双加成氨基酸及其合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811460A (en) 1994-01-24 1998-09-22 The Regents Of The University Of California Water soluble fullerenes with antiviral activity
RU2162819C2 (ru) 1999-01-05 2001-02-10 Тверской государственный технический университет Способ получения водорастворимых производных фуллеренов
US20030027870A1 (en) * 2001-05-15 2003-02-06 Wilson Stephen R. Fullerene derivatives that modulate nitric oxide synthase and clamodulin activity
RU2196602C1 (ru) * 2002-01-22 2003-01-20 Закрытое акционерное общество "ДЕСКО" Средство для ингибирования вич и цмв-инфекций и способ их ингибирования
RU2213048C1 (ru) * 2002-07-08 2003-09-27 Закрытое акционерное общество "ДЕСКО" Способ получения водорастворимых солей аминокислотных производных фуллерена
RU2213049C1 (ru) * 2002-07-08 2003-09-27 Закрытое акционерное общество "ДЕСКО" Способ получения водорастворимых аминокислотных производных фуллерена
RU2236852C1 (ru) * 2003-06-23 2004-09-27 Закрытое акционерное общество "ДЕСКО" Средство для ингибирования репродукции оболоченных вирусов, способ его получения, фармацевтическая композиция и способ ингибирования вирусных инфекций
WO2005070827A2 (en) 2004-01-14 2005-08-04 William Marsh Rice University Fullerene based amino acids
RU2316320C1 (ru) * 2006-06-19 2008-02-10 Лев Давидович Раснецов Противовирусное средство
CA2687557A1 (en) 2007-06-19 2008-12-31 Institute Of Problems Of Chemical Physics Ras (Ipcp Ras) Polyfunctional fullerene c60 amino acid derivatives
CN101335691B (zh) 2007-06-28 2012-09-12 华为技术有限公司 一种数据传输方法、交织器和通信装置

Also Published As

Publication number Publication date
EA020801B1 (ru) 2015-01-30
AU2012212707A1 (en) 2013-03-07
IL226736A (en) 2016-05-31
AP2013007072A0 (en) 2013-08-31
EA201201448A1 (ru) 2013-03-29
US9221746B2 (en) 2015-12-29
AP4014A (en) 2017-01-25
ES2582872T3 (es) 2016-09-15
MX354436B (es) 2018-03-06
EP2674415B1 (en) 2016-04-20
UA110345C2 (en) 2015-12-25
US20130165691A1 (en) 2013-06-27
BR112013012910A2 (pt) 2020-03-31
EP2674415A1 (en) 2013-12-18
HK1190386A1 (zh) 2014-07-04
WO2012105872A1 (ru) 2012-08-09
AU2012212707B2 (en) 2014-03-20
RU2458914C1 (ru) 2012-08-20
ZA201303447B (en) 2014-01-29
EP2674415A4 (en) 2014-09-10

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