MX2013007295A - Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2. - Google Patents
Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2.Info
- Publication number
- MX2013007295A MX2013007295A MX2013007295A MX2013007295A MX2013007295A MX 2013007295 A MX2013007295 A MX 2013007295A MX 2013007295 A MX2013007295 A MX 2013007295A MX 2013007295 A MX2013007295 A MX 2013007295A MX 2013007295 A MX2013007295 A MX 2013007295A
- Authority
- MX
- Mexico
- Prior art keywords
- quinoxalines
- aza
- receptor modulators
- crth2 receptor
- compounds
- Prior art date
Links
- 150000003252 quinoxalines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000009389 Prostaglandin D receptors Human genes 0.000 abstract 1
- 108050000258 Prostaglandin D receptors Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- Chemical & Material Sciences (AREA)
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- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426886P | 2010-12-23 | 2010-12-23 | |
| PCT/US2011/065716 WO2012087861A1 (en) | 2010-12-23 | 2011-12-19 | Quinoxalines and aza-quinoxalines as crth2 receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013007295A true MX2013007295A (es) | 2013-08-26 |
Family
ID=46314391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013007295A MX2013007295A (es) | 2010-12-23 | 2011-12-19 | Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9469615B2 (enExample) |
| EP (1) | EP2661428B1 (enExample) |
| JP (1) | JP5952829B2 (enExample) |
| KR (1) | KR20130133219A (enExample) |
| CN (1) | CN103702985B (enExample) |
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| US9290453B2 (en) | 2010-12-23 | 2016-03-22 | Merck Sharp & Dohme Corp. | Quinolines and aza-quinolines as CRTH2 receptor modulators |
| AU2012223232B2 (en) * | 2011-03-02 | 2017-05-25 | Bioenergenix | Heterocyclic compounds for the inhibition of PASK |
| PH12013502619A1 (en) | 2011-06-17 | 2014-02-17 | Merck Sharp & Dohme | Cycloalkyl-fused tetrahydroquinolines as crth2 receptor modulators |
| JP6097765B2 (ja) | 2011-12-21 | 2017-03-15 | アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd | ヘテロシクリル誘導体及びプロスタグランジンd2受容体調節剤としてのそれらの使用 |
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| US9169270B2 (en) | 2012-07-05 | 2015-10-27 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators |
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| US20160159808A1 (en) | 2013-07-24 | 2016-06-09 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US10160756B2 (en) | 2014-03-31 | 2018-12-25 | The Trustees Of The University Of Pennsylvania | Antiviral compounds and methods using same |
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| MX2022007534A (es) * | 2019-12-17 | 2022-09-23 | Merck Sharp & Dohme Llc | Inhibidores de prmt5. |
| WO2021126729A1 (en) * | 2019-12-17 | 2021-06-24 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| CN110981820B (zh) * | 2019-12-25 | 2023-05-19 | 上海彩迩文生化科技有限公司 | 一种酸性条件下合成喹喔啉-2-酮的方法 |
| EP4568668A2 (en) * | 2022-08-11 | 2025-06-18 | MapLight Therapeutics, Inc. | Gpr6 inverse agonists |
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| WO2007138112A2 (en) | 2006-06-01 | 2007-12-06 | Devgen N.V. | Compounds that interact with ion channels, in particular with ion channels from the kv family |
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| RU2011130793A (ru) * | 2008-12-25 | 2013-01-27 | Тайсо Фармасьютикал, Ко., Лтд. | Изохинолиновое производное |
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| JP5696856B2 (ja) | 2009-09-03 | 2015-04-08 | バイオエナジェニックス | Paskの阻害用複素環式化合物 |
| EP2627178B1 (en) | 2010-10-11 | 2018-05-02 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as crth2 antagonists |
| US9290453B2 (en) | 2010-12-23 | 2016-03-22 | Merck Sharp & Dohme Corp. | Quinolines and aza-quinolines as CRTH2 receptor modulators |
| PH12013502619A1 (en) | 2011-06-17 | 2014-02-17 | Merck Sharp & Dohme | Cycloalkyl-fused tetrahydroquinolines as crth2 receptor modulators |
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- 2011-12-19 RU RU2013134334/04A patent/RU2589709C2/ru not_active IP Right Cessation
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- 2011-12-19 BR BR112013015397A patent/BR112013015397A2/pt not_active Application Discontinuation
- 2011-12-19 ES ES11851281.3T patent/ES2635030T3/es active Active
- 2011-12-19 WO PCT/US2011/065716 patent/WO2012087861A1/en not_active Ceased
- 2011-12-19 CA CA2818597A patent/CA2818597A1/en not_active Abandoned
- 2011-12-19 EP EP11851281.3A patent/EP2661428B1/en active Active
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- 2011-12-19 MX MX2013007295A patent/MX2013007295A/es not_active Application Discontinuation
- 2011-12-21 TW TW100147844A patent/TW201307302A/zh unknown
- 2011-12-22 AR ARP110104895A patent/AR084573A1/es unknown
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|---|---|
| AU2011349524A1 (en) | 2013-05-30 |
| TW201307302A (zh) | 2013-02-16 |
| KR20130133219A (ko) | 2013-12-06 |
| BR112013015397A2 (pt) | 2016-09-20 |
| CA2818597A1 (en) | 2012-06-28 |
| EP2661428B1 (en) | 2017-06-07 |
| EP2661428A1 (en) | 2013-11-13 |
| AR084573A1 (es) | 2013-05-29 |
| RU2589709C2 (ru) | 2016-07-10 |
| RU2013134334A (ru) | 2015-01-27 |
| US20130303517A1 (en) | 2013-11-14 |
| CN103702985B (zh) | 2016-02-17 |
| WO2012087861A1 (en) | 2012-06-28 |
| ES2635030T3 (es) | 2017-10-02 |
| EP2661428A4 (en) | 2014-12-17 |
| AU2011349524B2 (en) | 2016-06-02 |
| JP2014500323A (ja) | 2014-01-09 |
| CN103702985A (zh) | 2014-04-02 |
| JP5952829B2 (ja) | 2016-07-13 |
| US9469615B2 (en) | 2016-10-18 |
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