MX2013003238A - Regimen de vacunacion de sensibilizacion y refuerzo heterologo contra malaria. - Google Patents
Regimen de vacunacion de sensibilizacion y refuerzo heterologo contra malaria.Info
- Publication number
- MX2013003238A MX2013003238A MX2013003238A MX2013003238A MX2013003238A MX 2013003238 A MX2013003238 A MX 2013003238A MX 2013003238 A MX2013003238 A MX 2013003238A MX 2013003238 A MX2013003238 A MX 2013003238A MX 2013003238 A MX2013003238 A MX 2013003238A
- Authority
- MX
- Mexico
- Prior art keywords
- recombinant adenovirus
- malaria
- boosting composition
- subject
- adenovirus vector
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10361—Methods of inactivation or attenuation
- C12N2710/10362—Methods of inactivation or attenuation by genetic engineering
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10371—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La invención provee métodos para inducir una respuesta inmunológica en un sujeto contra un antígeno de un parásito causante de malaria, preferiblemente P. falciparum, el método comprende: (i) administrar a un sujeto una composición de sensibilización que comprende antígeno proteináceo con adyuvante que comprende proteína de circumsporozoito (CS) o una parte inmunogénica. de la misma de un parásito causante de malaria; (ii) administrar al sujeto una primera composición de refuerzo que comprende un vector de adenovirus recombinante que comprende ácido nucleico que codifica proteína de CS o una parte inmunogénica de la misma de un parásito causante de malaria; y (iii) administrar al sujeto una segunda composición de refuerzo que comprende un vector de adenovirus recombinante que comprende ácido nucleico que codifica proteína de CS o una parte inmunogénica de la misma de un parásito causante de malaria, en donde ya sea la primera composición de refuerzo comprende vector de adenovirus recombinante de serotipo 35 (Ad35) y la segunda composición de refuerzo comprende un adenovirus recombinante de Ad26, o en donde la primera composición de refuerzo comprende un vector de adenovirus recombinante de Ad26 y la segunda composición de refuerzo comprende un adenovirus recombinante de Ad35.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40415610P | 2010-09-27 | 2010-09-27 | |
| EP10180251 | 2010-09-27 | ||
| PCT/EP2011/065434 WO2012041669A1 (en) | 2010-09-27 | 2011-09-07 | Heterologous prime boost vaccination regimen against malaria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013003238A true MX2013003238A (es) | 2013-05-30 |
| MX354752B MX354752B (es) | 2018-03-20 |
Family
ID=43416881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013003238A MX354752B (es) | 2010-09-27 | 2011-09-07 | Regimen de vacunacion de sensibilizacion y refuerzo heterologo contra malaria. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9168292B2 (es) |
| AU (1) | AU2011310838B2 (es) |
| BR (1) | BR112013004582A2 (es) |
| CA (1) | CA2809463C (es) |
| MX (1) | MX354752B (es) |
| WO (1) | WO2012041669A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014CN04742A (es) | 2011-11-28 | 2015-09-18 | Crucell Holland Bv | |
| EP3486256A3 (en) | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention B.V. | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| ZA201608812B (en) | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| CN109803676A (zh) * | 2016-04-12 | 2019-05-24 | 牛津大学创新有限公司 | 初免靶向 |
| CA3133971A1 (en) * | 2019-03-20 | 2020-09-24 | Turnstone Biologics Inc. | Sequential heterologous boost oncolytic viral mmunotherapy |
| EP4021470A4 (en) * | 2019-08-27 | 2023-09-20 | Turnstone Biologics Corp. | METHODS FOR INDUCING AN IMMUNE RESPONSE AGAINST NEOANTIGENS |
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-
2011
- 2011-09-07 BR BR112013004582A patent/BR112013004582A2/pt not_active Application Discontinuation
- 2011-09-07 US US13/823,581 patent/US9168292B2/en not_active Expired - Fee Related
- 2011-09-07 AU AU2011310838A patent/AU2011310838B2/en not_active Ceased
- 2011-09-07 CA CA2809463A patent/CA2809463C/en not_active Expired - Fee Related
- 2011-09-07 MX MX2013003238A patent/MX354752B/es active IP Right Grant
- 2011-09-07 WO PCT/EP2011/065434 patent/WO2012041669A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013004582A2 (pt) | 2016-09-06 |
| WO2012041669A1 (en) | 2012-04-05 |
| CA2809463C (en) | 2021-05-25 |
| AU2011310838B2 (en) | 2015-11-05 |
| CA2809463A1 (en) | 2012-04-05 |
| MX354752B (es) | 2018-03-20 |
| AU2011310838A1 (en) | 2013-03-28 |
| US9168292B2 (en) | 2015-10-27 |
| US20130216580A1 (en) | 2013-08-22 |
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