EA201171347A1 - Комбинированная вакцина против кори и малярии - Google Patents

Комбинированная вакцина против кори и малярии

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EA201171347A1
EA201171347A1 EA201171347A EA201171347A EA201171347A1 EA 201171347 A1 EA201171347 A1 EA 201171347A1 EA 201171347 A EA201171347 A EA 201171347A EA 201171347 A EA201171347 A EA 201171347A EA 201171347 A1 EA201171347 A1 EA 201171347A1
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Eurasian Patent Office
Prior art keywords
malaria
falciparum
protein
vaccine
msp1
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EA201171347A
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English (en)
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EA026916B1 (ru
Inventor
Райнхард Глюк
Агата Фаццио
Вивиана Джаннино
Мартин Биллетер
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Кадила Хелзкэр Лимитед
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Application filed by Кадила Хелзкэр Лимитед filed Critical Кадила Хелзкэр Лимитед
Publication of EA201171347A1 publication Critical patent/EA201171347A1/ru
Publication of EA026916B1 publication Critical patent/EA026916B1/ru

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Abstract

Изобретение относится к комбинированной вакцине против кори и малярии, содержащей различные ослабленные рекомбинантные векторы кори-малярии, включающие гетерологичную нуклеиновую кислоту, кодирующую несколько антигенов Plasmodium falciparum. Предпочтительно оно относится к вирусным векторам, которые включают нуклеиновые кислоты, кодирующие циркумспорозоитный (CS) белок Р.falciparum, белок 1 поверхности мерозоита (MSP1) P.falciparum и его производные (р-42; р-83-30-38) в их гликозилированной и секретируемой формах и антиген 1 апикальной мембраны (АМА1) Р.falciparum в его заякоренной или секретируемой форме. Вирусный вектор берет начало от ослабленного вируса кори, базирующегося на штамме, который используется в качестве вакцины и эффективен для доставки интересующего гена и который эффективно связывается с релевантными иммунными клетками и инфицирует их. В предпочтительном варианте осуществления белки CS, MSP1 и АМА1 генерируются вирусом, в результате чего они вызывают сильный иммунный ответ у млекопитающих, предпочтительно человека; экспрессия белков повышена благодаря оптимизации кодонами человека. Более того, изобретение относится к применению рекомбинантной вакцины для профилактического лечения малярии.
EA201171347A 2009-05-05 2010-05-03 Комбинированная вакцина против кори и малярии EA026916B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1181MU2009 2009-05-05
PCT/IN2010/000287 WO2010128524A2 (en) 2009-05-05 2010-05-03 Combined measles-malaria vaccine

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EA201171347A1 true EA201171347A1 (ru) 2012-05-30
EA026916B1 EA026916B1 (ru) 2017-05-31

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US (2) US9119815B2 (ru)
EP (2) EP2818175B1 (ru)
JP (2) JP2012526102A (ru)
KR (3) KR20120014918A (ru)
CN (2) CN102458427B (ru)
AU (1) AU2010245645A1 (ru)
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Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2427139T3 (es) 2002-06-20 2013-10-29 Institut Pasteur Virus recombinantes del sarampión que expresan epítopos de antígenos de virus de ARN y uso de los virus recombinantes para la preparación de composiciones de vacuna
ES2330309T3 (es) * 2002-06-20 2009-12-09 Institut Pasteur Adnc infeccioso de una cepa de vacuna aprobada de virus del sarampion. uso para composiciones inmunogenicas.
CA2432738A1 (en) 2003-02-26 2004-08-26 Philippe Despres New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications
CN103965335A (zh) * 2013-01-29 2014-08-06 苏州偲聚生物材料有限公司 多肽、包含该多肽的检测器件和检测试剂盒
EP2873728A1 (en) * 2013-11-18 2015-05-20 Institut Pasteur A subunit vaccine platform based on multimeric ribonucleoproteins comprising nucleoproteins of a non-segmented negative-strand RNA virus as carriers of heterologous polypeptides
EP3796932A1 (en) * 2018-05-23 2021-03-31 Institut Pasteur Recombinant measles virus expressing proteins of a plasmodium parasite and their applications

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86100979A (zh) 1985-02-07 1986-12-17 史密丝克莱恩贝克曼公司 疟疾疫苗的制备方法
US5112749A (en) 1987-10-02 1992-05-12 Praxis Biologics, Inc. Vaccines for the malaria circumsporozoite protein
US5756101A (en) 1991-07-01 1998-05-26 Pasteur Merieux Serums Et Vaccins Malaria recombinant poxvirus
US5766597A (en) 1991-03-07 1998-06-16 Virogenetics Corporation Malaria recombinant poxviruses
JPH06505397A (ja) 1991-03-20 1994-06-23 ヴァイロジェネティクス　コーポレイション マラリア組換体ポックスウイルス
FR2697022B1 (fr) * 1992-10-19 1994-12-16 Pasteur Institut Antigènes de Plasmodium falciparum capables d'induire des anticorps protecteurs à large spectre - Application à la vaccination.
DK0780475T4 (da) 1995-08-09 2006-10-23 Schweiz Serum & Impfinst Fremgangsmåde til fremstilling af infektiöse negativ-streng RNA-virus
US6146642A (en) * 1998-09-14 2000-11-14 Mount Sinai School Of Medicine, Of The City University Of New York Recombinant new castle disease virus RNA expression systems and vaccines
US6942866B2 (en) * 2000-08-16 2005-09-13 Apovia, Inc. Malaria immunogen and vaccine
DE10249390A1 (de) 2002-10-23 2004-05-13 Ruprecht-Karls-Universität Heidelberg Rekombinante MVA-Stämme als potentielle Impfstoffe gegen P.falciparum-Malaria
DK200201741A (da) * 2002-11-12 2003-09-16 Statens Seruminstitut Vaccine comprising chimeric malaria proteins derived from Plasmodium falciparum
US20050208078A1 (en) * 2003-11-20 2005-09-22 Hoffman Stephen L Methods for the prevention of malaria
EP1573012B1 (en) 2002-12-17 2011-11-30 Crucell Holland B.V. Recombinant viral-based malaria vaccines
US8486420B2 (en) * 2005-02-15 2013-07-16 The University Of North Carolina At Chapel Hill Live virus vaccines
WO2009021931A1 (en) 2007-08-13 2009-02-19 Glaxosmithkline Biologicals S.A. Vaccines
AU2009336562B2 (en) * 2008-05-26 2012-12-20 Cadila Healthcare Limited Combined measles-human papilloma vaccine
JP2010099041A (ja) * 2008-10-27 2010-05-06 Arigen Pharmaceuticals Inc 麻疹及びマラリア感染症に対する２価ワクチンとして有用な組換え体麻疹ウイルス

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NZ596223A (en) 2014-04-30
CA2760787C (en) 2017-06-06
MY175250A (en) 2020-06-17
EP2818175B1 (en) 2018-11-21
US9308250B2 (en) 2016-04-12
EP2427201A2 (en) 2012-03-14
EP2818175A1 (en) 2014-12-31
CN102458427A (zh) 2012-05-16
WO2010128524A8 (en) 2011-11-24
KR101616572B1 (ko) 2016-05-11
KR20120014918A (ko) 2012-02-20
CA2760787A1 (en) 2010-11-11
JP2012526102A (ja) 2012-10-25
HK1221635A1 (zh) 2017-06-09
EA026916B1 (ru) 2017-05-31
KR20140070659A (ko) 2014-06-10
SG10201402048UA (en) 2014-08-28
UA104180C2 (ru) 2014-01-10
WO2010128524A3 (en) 2011-03-24
IL216102A (en) 2016-05-31
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BRPI1007584A2 (pt) 2016-12-06
AU2010245645A1 (en) 2011-12-08
US20120121538A1 (en) 2012-05-17
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US20150071876A1 (en) 2015-03-12
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