WO2010127420A9 - Sequências geneticamente modificadas de antígenos de plasmodium vivax - Google Patents

Sequências geneticamente modificadas de antígenos de plasmodium vivax Download PDF

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Publication number
WO2010127420A9
WO2010127420A9 PCT/BR2009/000130 BR2009000130W WO2010127420A9 WO 2010127420 A9 WO2010127420 A9 WO 2010127420A9 BR 2009000130 W BR2009000130 W BR 2009000130W WO 2010127420 A9 WO2010127420 A9 WO 2010127420A9
Authority
WO
WIPO (PCT)
Prior art keywords
genetically modified
plasmodium vivax
antigens
dbp
sequences encoding
Prior art date
Application number
PCT/BR2009/000130
Other languages
English (en)
French (fr)
Other versions
WO2010127420A1 (pt
Inventor
Oscar Bruna Romero
Ricardo Tostes Gazzinelli
Marisa Cristina Da Fonseca
Cristiana Ferreira Alves De Brito
Flávio DA FONSECA GUIMARÃES
Cristina Lima Carrara
Leoneide Erica Maduro Bouillet
Maurício MARTINS RODRIGUES
Irene Soares
Bruna De Andrade Pereira
Original Assignee
Universidade Federal De Minas Gerais - Ufmg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade Federal De Minas Gerais - Ufmg filed Critical Universidade Federal De Minas Gerais - Ufmg
Priority to PCT/BR2009/000130 priority Critical patent/WO2010127420A1/pt
Priority to BRPI0924581A priority patent/BRPI0924581A2/pt
Priority to CN2009801603910A priority patent/CN102575256A/zh
Publication of WO2010127420A1 publication Critical patent/WO2010127420A1/pt
Publication of WO2010127420A9 publication Critical patent/WO2010127420A9/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A presente invenção diz respeito à construção de seqϋências genéticas modificadas que compreendem seqϋências para antígenos (DBP-PA, DBP-AM, DBP-MT, AMA-1, CS e MSP-1) de Plasmodium vivax, as respectivas proteínas recombinantes codificadas pelas referidas seqϋências e vírus geneticamente modificados que expressam antígenos recombinantes. Além disso, a presente invenção se refere a um método de vacinação dose-reforço (prime-boost) que utiliza vetores adenovirais ou poxvirais, proteínas purificadas para imunização de mamíferos e composições vacinais ύteis para serem utilizadas como vacina contra malária.
PCT/BR2009/000130 2009-05-05 2009-05-05 Sequências geneticamente modificadas de antígenos de plasmodium vivax WO2010127420A1 (pt)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/BR2009/000130 WO2010127420A1 (pt) 2009-05-05 2009-05-05 Sequências geneticamente modificadas de antígenos de plasmodium vivax
BRPI0924581A BRPI0924581A2 (pt) 2009-05-05 2009-05-05 seqüências geneticamente modificadas de antígenos de plasmodium vivax, composições vacinais contendo proteínas recombinantes e vírus recombinantes que expressam esses antígenos e método de vacinação dose-reforço contra malária
CN2009801603910A CN102575256A (zh) 2009-05-05 2009-05-05 编码间日疟原虫抗原的经遗传修饰的序列

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/BR2009/000130 WO2010127420A1 (pt) 2009-05-05 2009-05-05 Sequências geneticamente modificadas de antígenos de plasmodium vivax

Publications (2)

Publication Number Publication Date
WO2010127420A1 WO2010127420A1 (pt) 2010-11-11
WO2010127420A9 true WO2010127420A9 (pt) 2010-12-29

Family

ID=43049863

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2009/000130 WO2010127420A1 (pt) 2009-05-05 2009-05-05 Sequências geneticamente modificadas de antígenos de plasmodium vivax

Country Status (3)

Country Link
CN (1) CN102575256A (pt)
BR (1) BRPI0924581A2 (pt)
WO (1) WO2010127420A1 (pt)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055181A2 (en) * 2000-01-31 2001-08-02 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, Centers For Disease Control And Prevention Recombinant multivalent malarial vaccines against plasmodium vivax
GB0706912D0 (en) * 2007-04-10 2007-05-16 Isis Innovation Novel viral vaccines

Also Published As

Publication number Publication date
BRPI0924581A2 (pt) 2016-07-19
WO2010127420A1 (pt) 2010-11-11
CN102575256A (zh) 2012-07-11

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