MX2012013740A - Metodos para tratar trastornos resistentes al metotrexato con 10-propargil-10-deaza-aminopterina. - Google Patents
Metodos para tratar trastornos resistentes al metotrexato con 10-propargil-10-deaza-aminopterina.Info
- Publication number
- MX2012013740A MX2012013740A MX2012013740A MX2012013740A MX2012013740A MX 2012013740 A MX2012013740 A MX 2012013740A MX 2012013740 A MX2012013740 A MX 2012013740A MX 2012013740 A MX2012013740 A MX 2012013740A MX 2012013740 A MX2012013740 A MX 2012013740A
- Authority
- MX
- Mexico
- Prior art keywords
- deazaaminopterin
- propargyl
- methods
- methotrexate
- treating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona con un método para tratar un trastorno resistente de metotrexato en un individuo, en donde el método comprende la administración al individuo una cantidad efectiva de 10-propargil-10-deazaaminopterin o sus sales farmacéuticamente aceptables.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35087110P | 2010-06-02 | 2010-06-02 | |
PCT/US2011/038953 WO2011153368A1 (en) | 2010-06-02 | 2011-06-02 | Methods for treating methotrexate-resistant disorders with 10-propargyl-10-deazaaminopterin |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012013740A true MX2012013740A (es) | 2013-07-29 |
MX339793B MX339793B (es) | 2016-06-10 |
Family
ID=45067077
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013740A MX339793B (es) | 2010-06-02 | 2011-06-02 | Metodos para tratar trastornos resistentes al metotrexato con 10-propargil-10-deaza-aminopterina. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20130143891A1 (es) |
EP (1) | EP2575466B1 (es) |
JP (1) | JP5897558B2 (es) |
KR (1) | KR20130115993A (es) |
CN (1) | CN102984940B (es) |
AU (1) | AU2011261384B2 (es) |
BR (1) | BR112012030764A2 (es) |
CA (1) | CA2800900A1 (es) |
DK (1) | DK2575466T3 (es) |
ES (1) | ES2541689T3 (es) |
HK (1) | HK1179823A1 (es) |
IL (1) | IL223078A (es) |
MX (1) | MX339793B (es) |
RU (1) | RU2586299C2 (es) |
WO (1) | WO2011153368A1 (es) |
ZA (1) | ZA201209673B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9901578B2 (en) | 2007-08-17 | 2018-02-27 | Allos Therapeutics, Inc. | Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer |
ES2596953T3 (es) | 2010-02-02 | 2017-01-13 | Allos Therapeutics, Inc. | Diastereómeros de 10-propargil-10-desazaaminopterina para uso en el tratamiento del cáncer de pulmón |
US20130178441A1 (en) * | 2010-08-10 | 2013-07-11 | Allos Therapeutics, Inc. | Methods for Extending Progression-Free Survival using 10-Propargyl-10-Deazaaminopterin |
WO2013177713A1 (en) * | 2012-05-31 | 2013-12-05 | Alphora Research Inc. | Process for preparation of an antifolate agent |
WO2014020553A1 (en) * | 2012-08-03 | 2014-02-06 | Fresenius Kabi Oncology Ltd. | Salts of pralatrexate |
CN104628727B (zh) * | 2013-11-07 | 2018-08-21 | 正大天晴药业集团股份有限公司 | 一种普拉曲沙的晶型及其制备方法 |
CN104628728A (zh) * | 2013-11-08 | 2015-05-20 | 深圳海王药业有限公司 | 一种普拉曲沙的制备方法 |
CN103588775B (zh) * | 2013-11-12 | 2016-08-17 | 连云港恒运医药科技有限公司 | 普拉曲沙降解杂质及其制备方法 |
CN105272983B (zh) * | 2014-06-12 | 2021-01-15 | 连云港润众制药有限公司 | 一种高纯度普拉曲沙固体及其制备方法 |
CN107488178B (zh) * | 2016-06-10 | 2020-05-12 | 山东新时代药业有限公司 | 一种高纯度普拉曲沙中间体的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5354751A (en) * | 1992-03-03 | 1994-10-11 | Sri International | Heteroaroyl 10-deazaamino-pterine compounds and use for rheumatoid arthritis |
WO1993022312A1 (en) * | 1992-04-29 | 1993-11-11 | Sri International | Deazaaminopterins for treatment of inflammation |
ES2313737T3 (es) * | 1996-07-17 | 2009-03-01 | Sloan-Kettering Institute For Cancer Research | Composiciones purificadas de 10-propargil-10-deazaaminopterina y sus metodos de uso en el tratamiento de tumores. |
US6323205B1 (en) * | 1996-07-17 | 2001-11-27 | Sloan-Kettering Institute For Cancer Research | Combinations of 10-propargyl-10-deazaaminopterin and taxols and methods of using same in the treatment of tumors |
PL1750716T3 (pl) * | 2004-05-30 | 2009-01-30 | Sloan Kettering Inst Cancer Res | Terapia chłoniaka z komórek t z zastosowaniem 10-propargilo-10-deaza-aminopteryny |
-
2011
- 2011-06-02 WO PCT/US2011/038953 patent/WO2011153368A1/en active Application Filing
- 2011-06-02 CN CN201180026765.7A patent/CN102984940B/zh not_active Expired - Fee Related
- 2011-06-02 BR BR112012030764A patent/BR112012030764A2/pt not_active IP Right Cessation
- 2011-06-02 DK DK11790419.3T patent/DK2575466T3/en active
- 2011-06-02 MX MX2012013740A patent/MX339793B/es active IP Right Grant
- 2011-06-02 ES ES11790419.3T patent/ES2541689T3/es active Active
- 2011-06-02 JP JP2013513352A patent/JP5897558B2/ja not_active Expired - Fee Related
- 2011-06-02 RU RU2012148767/15A patent/RU2586299C2/ru not_active IP Right Cessation
- 2011-06-02 KR KR1020127032329A patent/KR20130115993A/ko not_active Application Discontinuation
- 2011-06-02 CA CA2800900A patent/CA2800900A1/en not_active Abandoned
- 2011-06-02 EP EP11790419.3A patent/EP2575466B1/en not_active Not-in-force
- 2011-06-02 AU AU2011261384A patent/AU2011261384B2/en not_active Ceased
- 2011-06-02 US US13/702,650 patent/US20130143891A1/en not_active Abandoned
-
2012
- 2012-11-15 IL IL223078A patent/IL223078A/en not_active IP Right Cessation
- 2012-12-20 ZA ZA2012/09673A patent/ZA201209673B/en unknown
-
2013
- 2013-06-17 HK HK13107058.9A patent/HK1179823A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP5897558B2 (ja) | 2016-03-30 |
WO2011153368A1 (en) | 2011-12-08 |
CN102984940A (zh) | 2013-03-20 |
BR112012030764A2 (pt) | 2015-09-29 |
US20130143891A1 (en) | 2013-06-06 |
EP2575466B1 (en) | 2015-04-08 |
AU2011261384B2 (en) | 2015-01-22 |
EP2575466A4 (en) | 2013-07-17 |
DK2575466T3 (en) | 2015-07-20 |
JP2013527245A (ja) | 2013-06-27 |
KR20130115993A (ko) | 2013-10-22 |
EP2575466A1 (en) | 2013-04-10 |
ZA201209673B (en) | 2014-03-26 |
CA2800900A1 (en) | 2011-12-08 |
IL223078A (en) | 2016-07-31 |
RU2586299C2 (ru) | 2016-06-10 |
MX339793B (es) | 2016-06-10 |
HK1179823A1 (en) | 2013-10-11 |
ES2541689T3 (es) | 2015-07-23 |
CN102984940B (zh) | 2016-01-13 |
AU2011261384A1 (en) | 2012-12-06 |
RU2012148767A (ru) | 2014-07-20 |
IL223078A0 (en) | 2013-02-03 |
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