MX2012008961A - Fluorometanos multiples sustituidos como isosteros selectivos y bioactivos. - Google Patents
Fluorometanos multiples sustituidos como isosteros selectivos y bioactivos.Info
- Publication number
- MX2012008961A MX2012008961A MX2012008961A MX2012008961A MX2012008961A MX 2012008961 A MX2012008961 A MX 2012008961A MX 2012008961 A MX2012008961 A MX 2012008961A MX 2012008961 A MX2012008961 A MX 2012008961A MX 2012008961 A MX2012008961 A MX 2012008961A
- Authority
- MX
- Mexico
- Prior art keywords
- fluoromethanes
- isosteres
- bioactive
- selective
- multiple substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/27—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/54—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
- C07H5/10—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium to sulfur
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Se divulgan fluorometanos sustituidos; composiciones farmacéuticas que comprenden una cantidad terapéuticamente efectiva de los mismos; procesos para preparar dichos fluorometanos; y métodos para el uso de los mismos en el alivio de infección y parasitismo. También se divulgan métodos para la identificación de fluorometanos sustituidos para modular la actividad de receptores y enzimas que enlazan y/o modifican ligandos y sustratos que contienen fosfato.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30104210P | 2010-02-03 | 2010-02-03 | |
PCT/US2011/023657 WO2011097421A1 (en) | 2010-02-03 | 2011-02-03 | Multiple substituted fluoromethanes as selective and bioactive isosteres |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012008961A true MX2012008961A (es) | 2013-04-29 |
Family
ID=44355784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012008961A MX2012008961A (es) | 2010-02-03 | 2011-02-03 | Fluorometanos multiples sustituidos como isosteros selectivos y bioactivos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US9199914B2 (es) |
EP (1) | EP2531465A4 (es) |
JP (1) | JP2013518897A (es) |
KR (1) | KR20130028058A (es) |
CN (1) | CN102811989A (es) |
AU (1) | AU2011212925A1 (es) |
CA (1) | CA2826623A1 (es) |
IL (1) | IL221298A0 (es) |
MX (1) | MX2012008961A (es) |
WO (1) | WO2011097421A1 (es) |
ZA (1) | ZA201205917B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9199914B2 (en) | 2010-02-03 | 2015-12-01 | Meh Associates, Inc. | Multiple substituted fluoromethanes as selective and bioactive isosteres |
DK2386682T3 (da) * | 2010-04-27 | 2014-06-23 | Omya Int Ag | Fremgangsmåde til fremstilling af strukturerede materialer under anvendelse af nano-fibrillære cellulosegeler |
PL2386683T3 (pl) * | 2010-04-27 | 2014-08-29 | Omya Int Ag | Sposób wytwarzania materiałów kompozytowych na bazie żelu |
CN102702257B (zh) * | 2012-05-15 | 2014-08-13 | 武汉理工大学 | 一种用于高温质子交换膜中的含氮多膦酸烷氧基硅烷的制备方法 |
CN116057048A (zh) | 2020-07-07 | 2023-05-02 | 罗维拉威尔吉利大学 | 用于有机化合物的多氟烷基硫醇化的试剂及其生产方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1567221A1 (de) * | 1965-06-01 | 1970-04-16 | Berlin Chemie Veb | Systemische Fungizide |
GB8613703D0 (en) * | 1986-06-05 | 1986-07-09 | Ici America Inc | Difluoro peptide compounds |
US5008202A (en) * | 1988-11-29 | 1991-04-16 | Sequoia Turner Corporation | Blood diluent for red blood cell analysis |
DE4008179A1 (de) * | 1990-03-12 | 1991-09-19 | Schering Ag | Fluorbenzolsulfonamide |
JPH0948792A (ja) * | 1994-12-28 | 1997-02-18 | Sumitomo Pharmaceut Co Ltd | ルイスx誘導体 |
IT1277737B1 (it) | 1995-12-28 | 1997-11-12 | Zambon Spa | Derivati tiolici ad attivita' inibitrice delle metallopeptidasi |
US5917074A (en) | 1997-10-07 | 1999-06-29 | University Of Massachusetts | Preparation and applications of fluorinated propargyl phosphonate reagents |
GB9723566D0 (en) * | 1997-11-08 | 1998-01-07 | Glaxo Group Ltd | Chemical compounds |
ATE309207T1 (de) | 1999-08-27 | 2005-11-15 | Sugen Inc | Phosphat-mimetika sowie behandlungsmethoden unter verwendung von phosphatase-inhibitoren |
JP2003533546A (ja) * | 2000-05-22 | 2003-11-11 | スミスクライン・ビーチャム・コーポレイション | Mura活性をモジュレーションする方法 |
US20040033896A1 (en) | 2000-06-02 | 2004-02-19 | Gerard Koether | Substituted pyrimidine and pyridine herbicides |
CZ305971B6 (cs) * | 2000-12-28 | 2016-06-01 | Kissei Pharmaceutical Co., Ltd. | Deriváty glukopyranosyloxypyrazolu a jejich použití v léčivech |
AU2002305073A1 (en) * | 2001-03-22 | 2002-10-08 | Research Foundation Of The City University Of New York | Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids |
US7420002B2 (en) * | 2001-06-11 | 2008-09-02 | Xenoport | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues |
SE0202430D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
US7670631B2 (en) * | 2003-03-12 | 2010-03-02 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Method for the prevention of malaria infection of humans by hepatocyte growth factor antagonists |
JP4484027B2 (ja) * | 2003-12-08 | 2010-06-16 | 三菱瓦斯化学株式会社 | 光学活性2―アルキル−d−システインアミド又はその塩、及びこれらの化合物の製造方法。 |
KR20140033237A (ko) * | 2005-10-07 | 2014-03-17 | 엑셀리시스, 인코포레이티드 | 포스파티딜이노시톨 3-키나아제 억제제 및 이의 사용 방법 |
JP5099692B2 (ja) | 2005-12-27 | 2012-12-19 | 国立大学法人群馬大学 | 新規トリハロメチオニン誘導体及びそれを含む医薬 |
AU2007253819B2 (en) * | 2006-05-23 | 2011-02-17 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
US8242174B2 (en) | 2007-02-01 | 2012-08-14 | Panthera Biopharma Llc | Hydroxamic acid derivatives of aniline useful as therapeutic agents for treating anthrax poisoning |
CA2686994A1 (en) | 2007-05-11 | 2008-11-20 | Mpex Pharmaceuticals, Inc. | Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof |
WO2009081958A1 (ja) * | 2007-12-26 | 2009-07-02 | Shionogi & Co., Ltd. | グリコペプチド抗生物質配糖化誘導体 |
DE102008015032A1 (de) * | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
JP2011006359A (ja) * | 2009-06-26 | 2011-01-13 | Nagoya Institute Of Technology | トリフルオロメチルメチオニン及びその誘導体の簡便合成方法。 |
US9199914B2 (en) | 2010-02-03 | 2015-12-01 | Meh Associates, Inc. | Multiple substituted fluoromethanes as selective and bioactive isosteres |
-
2011
- 2011-02-03 US US13/576,911 patent/US9199914B2/en not_active Expired - Fee Related
- 2011-02-03 CA CA2826623A patent/CA2826623A1/en not_active Abandoned
- 2011-02-03 AU AU2011212925A patent/AU2011212925A1/en not_active Abandoned
- 2011-02-03 EP EP11740381.6A patent/EP2531465A4/en not_active Withdrawn
- 2011-02-03 JP JP2012552093A patent/JP2013518897A/ja active Pending
- 2011-02-03 WO PCT/US2011/023657 patent/WO2011097421A1/en active Application Filing
- 2011-02-03 MX MX2012008961A patent/MX2012008961A/es unknown
- 2011-02-03 CN CN2011800133510A patent/CN102811989A/zh active Pending
- 2011-02-03 KR KR1020127022971A patent/KR20130028058A/ko not_active Application Discontinuation
-
2012
- 2012-08-05 IL IL221298A patent/IL221298A0/en unknown
- 2012-08-06 ZA ZA2012/05917A patent/ZA201205917B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2011097421A1 (en) | 2011-08-11 |
CN102811989A (zh) | 2012-12-05 |
CA2826623A1 (en) | 2011-08-11 |
WO2011097421A8 (en) | 2011-10-27 |
EP2531465A4 (en) | 2015-12-30 |
AU2011212925A1 (en) | 2012-09-06 |
EP2531465A1 (en) | 2012-12-12 |
JP2013518897A (ja) | 2013-05-23 |
US9199914B2 (en) | 2015-12-01 |
KR20130028058A (ko) | 2013-03-18 |
IL221298A0 (en) | 2012-10-31 |
US20120302519A1 (en) | 2012-11-29 |
ZA201205917B (en) | 2013-10-30 |
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