MX2012007322A - Compuestos carboxamida y su uso como inhibidores de calpaina iv. - Google Patents

Info

Publication number

MX2012007322A

MX2012007322A MX2012007322A MX2012007322A MX2012007322A MX 2012007322 A MX2012007322 A MX 2012007322A MX 2012007322 A MX2012007322 A MX 2012007322A MX 2012007322 A MX2012007322 A MX 2012007322A MX 2012007322 A MX2012007322 A MX 2012007322A

Authority

MX

Mexico

Prior art keywords

phenyl

alkyl

pyrazol

dioxo

aryl

Prior art date

2009-12-22

Links

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• -1 Carboxamide compounds Chemical class 0.000 title claims abstract description 756
• 108010079785 calpain inhibitors Proteins 0.000 title description 23
• 150000001875 compounds Chemical class 0.000 claims abstract description 253
• 108010032088 Calpain Proteins 0.000 claims abstract description 75
• 102000007590 Calpain Human genes 0.000 claims abstract description 75
• 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 70
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• 229910052736 halogen Inorganic materials 0.000 claims abstract description 38
• 150000003839 salts Chemical class 0.000 claims abstract description 26
• 230000000694 effects Effects 0.000 claims abstract description 20
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 20
• 150000004677 hydrates Chemical class 0.000 claims abstract description 18
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 5
• JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 claims abstract description 5
• 108010081348 HRT1 protein Hairy Proteins 0.000 claims abstract description 5
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• VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 claims abstract description 5
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims abstract description 4
• 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims abstract description 3
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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 51
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• 229910052739 hydrogen Inorganic materials 0.000 claims description 28
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 27
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• 239000011570 nicotinamide Substances 0.000 claims description 27
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• 125000000217 alkyl group Chemical group 0.000 claims description 24
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 22
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• DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 8
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