MX2012003315A - Dispositivo y metodo mejorados para el suministro de un medicamento. - Google Patents
Dispositivo y metodo mejorados para el suministro de un medicamento.Info
- Publication number
- MX2012003315A MX2012003315A MX2012003315A MX2012003315A MX2012003315A MX 2012003315 A MX2012003315 A MX 2012003315A MX 2012003315 A MX2012003315 A MX 2012003315A MX 2012003315 A MX2012003315 A MX 2012003315A MX 2012003315 A MX2012003315 A MX 2012003315A
- Authority
- MX
- Mexico
- Prior art keywords
- nicotine
- base
- supply
- source
- acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 178
- 239000003814 drug Substances 0.000 title description 50
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 605
- 229960002715 nicotine Drugs 0.000 claims abstract description 596
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 595
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- 150000001875 compounds Chemical class 0.000 claims description 162
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- RFEJUZJILGIRHQ-OMDKHLBYSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 RFEJUZJILGIRHQ-OMDKHLBYSA-N 0.000 claims description 46
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US24308709P | 2009-09-16 | 2009-09-16 | |
| US24286309P | 2009-09-16 | 2009-09-16 | |
| PCT/US2010/047271 WO2011034723A1 (en) | 2009-09-16 | 2010-08-31 | Improved device and method for delivery of a medicament |
Publications (1)
| Publication Number | Publication Date |
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| MX2012003315A true MX2012003315A (es) | 2012-06-08 |
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| MX2012003315A MX2012003315A (es) | 2009-09-16 | 2010-08-31 | Dispositivo y metodo mejorados para el suministro de un medicamento. |
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| US10244793B2 (en) | 2005-07-19 | 2019-04-02 | Juul Labs, Inc. | Devices for vaporization of a substance |
| US8991402B2 (en) | 2007-12-18 | 2015-03-31 | Pax Labs, Inc. | Aerosol devices and methods for inhaling a substance and uses thereof |
| US10136672B2 (en) | 2010-05-15 | 2018-11-27 | Rai Strategic Holdings, Inc. | Solderless directly written heating elements |
| US8757147B2 (en) | 2010-05-15 | 2014-06-24 | Minusa Holdings Llc | Personal vaporizing inhaler with internal light source |
| US9861772B2 (en) | 2010-05-15 | 2018-01-09 | Rai Strategic Holdings, Inc. | Personal vaporizing inhaler cartridge |
| US9095175B2 (en) | 2010-05-15 | 2015-08-04 | R. J. Reynolds Tobacco Company | Data logging personal vaporizing inhaler |
| US9259035B2 (en) | 2010-05-15 | 2016-02-16 | R. J. Reynolds Tobacco Company | Solderless personal vaporizing inhaler |
| US11344683B2 (en) | 2010-05-15 | 2022-05-31 | Rai Strategic Holdings, Inc. | Vaporizer related systems, methods, and apparatus |
| US9999250B2 (en) | 2010-05-15 | 2018-06-19 | Rai Strategic Holdings, Inc. | Vaporizer related systems, methods, and apparatus |
| US9743691B2 (en) | 2010-05-15 | 2017-08-29 | Rai Strategic Holdings, Inc. | Vaporizer configuration, control, and reporting |
| US10159278B2 (en) | 2010-05-15 | 2018-12-25 | Rai Strategic Holdings, Inc. | Assembly directed airflow |
| US11247003B2 (en) | 2010-08-23 | 2022-02-15 | Darren Rubin | Systems and methods of aerosol delivery with airflow regulation |
| WO2012106739A1 (de) | 2011-02-11 | 2012-08-16 | Helmut Buchberger | Inhalatorkomponente |
| AT510837B1 (de) | 2011-07-27 | 2012-07-15 | Helmut Dr Buchberger | Inhalatorkomponente |
| US8528569B1 (en) | 2011-06-28 | 2013-09-10 | Kyle D. Newton | Electronic cigarette with liquid reservoir |
| KR20170118233A (ko) * | 2011-12-08 | 2017-10-24 | 필립모리스 프로덕츠 에스.에이. | 공기류를 조정하는 에어로졸 발생 장치 |
| GB2504076A (en) | 2012-07-16 | 2014-01-22 | Nicoventures Holdings Ltd | Electronic smoking device |
| GB2504075A (en) | 2012-07-16 | 2014-01-22 | Nicoventures Holdings Ltd | Electronic smoking device |
| US10517530B2 (en) | 2012-08-28 | 2019-12-31 | Juul Labs, Inc. | Methods and devices for delivering and monitoring of tobacco, nicotine, or other substances |
| US10111461B2 (en) * | 2012-09-10 | 2018-10-30 | Healthier Choices Management Corp | Electronic vaping material container |
| US10034988B2 (en) | 2012-11-28 | 2018-07-31 | Fontem Holdings I B.V. | Methods and devices for compound delivery |
| TW201427719A (zh) | 2012-12-18 | 2014-07-16 | Philip Morris Products Sa | 氣溶膠產生系統用之經封裝的揮發性液體源 |
| US9993023B2 (en) | 2013-02-22 | 2018-06-12 | Altria Client Services Llc | Electronic smoking article |
| CA2902502A1 (en) | 2013-02-22 | 2014-08-28 | Altria Client Services Llc. | Electronic smoking article |
| WO2014130692A1 (en) * | 2013-02-22 | 2014-08-28 | Altria Client Services Inc. | Electronic smoking article |
| BR112015019663B1 (pt) | 2013-03-15 | 2021-05-18 | Philip Morris Products S.A. | sistema gerador de aerossol e método para controlar a formação de um aerossol de partículas de sal de nicotina |
| US10653180B2 (en) | 2013-06-14 | 2020-05-19 | Juul Labs, Inc. | Multiple heating elements with separate vaporizable materials in an electric vaporization device |
| NZ709773A (en) | 2013-03-15 | 2018-06-29 | Philip Morris Products Sa | Aerosol-generating system having a piercing element |
| US10279934B2 (en) * | 2013-03-15 | 2019-05-07 | Juul Labs, Inc. | Fillable vaporizer cartridge and method of filling |
| AU2013382373B2 (en) | 2013-03-15 | 2017-11-02 | Philip Morris Products S.A. | Aerosol-generating device comprising multiple solid-liquid phase-change materials |
| CN103190708A (zh) * | 2013-04-16 | 2013-07-10 | 湖北中烟工业有限责任公司 | 化学加热式无烟卷烟 |
| WO2014182736A1 (en) | 2013-05-06 | 2014-11-13 | Ploom, Inc. | Nicotine salt formulations for aerosol devices and methods thereof |
| NZ712478A (en) | 2013-05-21 | 2018-08-31 | Philip Morris Products Sa | Aerosol-generating system comprising a delivery enhancing compound source and a medicament source |
| JP6832701B2 (ja) | 2013-05-21 | 2021-02-24 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 電熱エアロゾル送達システム |
| UA117370C2 (uk) | 2013-07-03 | 2018-07-25 | Філіп Морріс Продактс С.А. | Система, що генерує аерозоль, багаторазового застосування |
| CA3006188C (en) | 2013-07-11 | 2019-12-31 | Alexza Pharmaceuticals, Inc. | Nicotine salt with meta-salicylic acid |
| MY179801A (en) | 2013-07-19 | 2020-11-16 | Altria Client Services Llc | Liquid aerosol formulation of an electronic smoking article |
| SG11201601950VA (en) | 2013-09-19 | 2016-04-28 | Philip Morris Products Sa | Aerosol-generating system for generating nicotine salt particles |
| WO2015042412A1 (en) | 2013-09-20 | 2015-03-26 | E-Nicotine Technology. Inc. | Devices and methods for modifying delivery devices |
| US10039321B2 (en) | 2013-11-12 | 2018-08-07 | Vmr Products Llc | Vaporizer |
| MX2016007283A (es) | 2013-12-05 | 2017-01-06 | Pax Labs Inc | Formulacion liquida de nicotina para dispositivos en aerosol y metodos de los mismos. |
| EP3079511B1 (en) | 2013-12-11 | 2019-01-30 | JT International SA | Heating system and method of heating for an inhaler device |
| PL3082484T3 (pl) * | 2013-12-19 | 2020-05-18 | Philip Morris Products S.A. | Układ wytwarzania aerozolu |
| US10058129B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
| US10076139B2 (en) | 2013-12-23 | 2018-09-18 | Juul Labs, Inc. | Vaporizer apparatus |
| US10159282B2 (en) | 2013-12-23 | 2018-12-25 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
| USD825102S1 (en) | 2016-07-28 | 2018-08-07 | Juul Labs, Inc. | Vaporizer device with cartridge |
| CA3132332C (en) | 2013-12-23 | 2023-10-17 | Juul Labs, Inc. | Vaporization device systems and methods |
| US9549573B2 (en) | 2013-12-23 | 2017-01-24 | Pax Labs, Inc. | Vaporization device systems and methods |
| US20160366947A1 (en) | 2013-12-23 | 2016-12-22 | James Monsees | Vaporizer apparatus |
| USD842536S1 (en) | 2016-07-28 | 2019-03-05 | Juul Labs, Inc. | Vaporizer cartridge |
| MX2016008739A (es) * | 2014-01-02 | 2016-10-13 | Philip Morris Products Sa | Sistema generador de aerosol que comprende una capsula polimerica cilindrica. |
| US11065402B2 (en) | 2014-02-04 | 2021-07-20 | Gseh Holistic, Inc. | Aromatherapy vaporization device |
| US10238764B2 (en) | 2014-08-19 | 2019-03-26 | Vapium Inc. | Aromatherapy vaporization device |
| US10709173B2 (en) | 2014-02-06 | 2020-07-14 | Juul Labs, Inc. | Vaporizer apparatus |
| US12279646B2 (en) | 2014-02-06 | 2025-04-22 | Juul Labs, Inc. | Cartridge of vaporization device systems having unequal transverse cartridge dimensions |
| TWI761216B (zh) | 2014-02-06 | 2022-04-11 | 美商尤爾實驗室有限公司 | 產生可吸入氣膠之裝置及用於該裝置之可分離匣 |
| GB201403356D0 (en) * | 2014-02-26 | 2014-04-09 | Nicoventures Holdings Ltd | A process for preparing a nicotine-containing formulation |
| US20150257447A1 (en) * | 2014-03-11 | 2015-09-17 | Voodoo Science Llc | Electronic Cigarette Assembly |
| WO2015139186A1 (zh) * | 2014-03-17 | 2015-09-24 | 昂纳自动化技术（深圳）有限公司 | 电子烟注油针 |
| GB2524735B (en) | 2014-03-31 | 2017-10-25 | Nicoventures Holdings Ltd | Re-charging pack for an e-cigarette |
| GB2524736B (en) | 2014-03-31 | 2021-02-24 | Nicoventures Holdings Ltd | Re-charging pack for an e-cigarette |
| CA2948851A1 (en) | 2014-05-16 | 2015-11-19 | Pax Labs, Inc. | Systems and methods for aerosolizing a smokeable material |
| CN106255429A (zh) | 2014-05-21 | 2016-12-21 | 菲利普莫里斯生产公司 | 具有内部感受器的气溶胶生成制品 |
| GB2528710B (en) * | 2014-07-24 | 2018-12-26 | Nicoventures Holdings Ltd | E-cigarette re-charging system |
| PL3171720T3 (pl) | 2014-07-24 | 2019-04-30 | Nicoventures Holdings Ltd | Opakowanie do ładowania dla e-papierosa |
| GB201418817D0 (en) | 2014-10-22 | 2014-12-03 | British American Tobacco Co | Apparatus and method for generating an inhalable medium, and a cartridge for use therewith |
| GB2535427A (en) | 2014-11-07 | 2016-08-24 | Nicoventures Holdings Ltd | Solution |
| GB2532062A (en) * | 2014-11-07 | 2016-05-11 | Nicoventures Holdings Ltd | Container |
| MA40890A (fr) * | 2014-11-07 | 2017-09-12 | S A S C Ag | Dispositif chauffant de cigarette électronique |
| HUE045363T2 (hu) | 2014-11-17 | 2019-12-30 | Mcneil Ab | Elektromos nikotin-kibocsátó rendszer |
| KR20170083621A (ko) | 2014-11-17 | 2017-07-18 | 맥닐 에이비 | 전자식 니코틴 전달 시스템에 사용하기 위한 일회용 카트리지 |
| KR102682702B1 (ko) | 2014-12-05 | 2024-07-09 | 쥴 랩스, 인크. | 교정된 투여량 제어 |
| GB2533135B (en) | 2014-12-11 | 2020-11-11 | Nicoventures Holdings Ltd | Aerosol provision systems |
| GB201503411D0 (en) | 2015-02-27 | 2015-04-15 | British American Tobacco Co | Apparatus and method for generating an inhalable medium, and a cartridge for use therewith |
| CN112716051B (zh) | 2015-03-27 | 2024-04-19 | 菲利普莫里斯生产公司 | 包括破裂部分的气溶胶生成系统 |
| CN107427077B (zh) | 2015-03-27 | 2021-02-02 | 菲利普莫里斯生产公司 | 可重复密封的气溶胶生成制品 |
| RU2695834C2 (ru) | 2015-03-27 | 2019-07-29 | Филип Моррис Продактс С.А. | Система, генерирующая аэрозоль, содержащая упругий элемент |
| JP6701218B2 (ja) | 2015-03-27 | 2020-05-27 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | バイメタルストリップを備えるエアロゾル発生システム |
| WO2016156212A1 (en) * | 2015-03-27 | 2016-10-06 | Philip Morris Products S.A. | Aerosol-generating system comprising integrated piercing element |
| GB201505597D0 (en) | 2015-03-31 | 2015-05-13 | British American Tobacco Co | Article for use with apparatus for heating smokable material |
| GB201505593D0 (en) | 2015-03-31 | 2015-05-13 | British American Tobacco Co | Article for use with apparatus for heating smokable material |
| GB201505595D0 (en) | 2015-03-31 | 2015-05-13 | British American Tobacco Co | Cartridge for use with apparatus for heating smokeable material |
| KR102642688B1 (ko) * | 2015-06-29 | 2024-03-05 | 필립모리스 프로덕츠 에스.에이. | 에어로졸 발생 시스템용 카트리지 |
| AU2016297677B2 (en) * | 2015-07-20 | 2020-10-08 | Medical Developments International Limited | Inhaler device for inhalable liquids |
| US10034494B2 (en) | 2015-09-15 | 2018-07-31 | Rai Strategic Holdings, Inc. | Reservoir for aerosol delivery devices |
| HK1256568A1 (zh) * | 2015-09-16 | 2019-09-27 | A‧蒂尔曼 | 一种处理由电子香烟提供汽化液体流的方法和配制装置及用於口服含附加组分的汽化液体的电子香烟 |
| US10327472B2 (en) * | 2015-09-25 | 2019-06-25 | Altria Client Services Llc | Pre-vaporization formulation for controlling acidity in an e-vaping device |
| GB2542838B (en) | 2015-10-01 | 2022-01-12 | Nicoventures Trading Ltd | Aerosol provision system |
| GB201517471D0 (en) | 2015-10-02 | 2015-11-18 | British American Tobacco Co | Apparatus for generating an inhalable medium |
| SG11201806801VA (en) | 2016-02-11 | 2018-09-27 | Juul Labs Inc | Securely attaching cartridges for vaporizer devices |
| WO2017139595A1 (en) | 2016-02-11 | 2017-08-17 | Pax Labs, Inc. | Fillable vaporizer cartridge and method of filling |
| UA126061C2 (uk) | 2016-02-25 | 2022-08-10 | Джуул Лебз, Інк. | Системи та способи керування випарним пристроєм |
| US10455863B2 (en) | 2016-03-03 | 2019-10-29 | Altria Client Services Llc | Cartridge for electronic vaping device |
| US10433580B2 (en) | 2016-03-03 | 2019-10-08 | Altria Client Services Llc | Methods to add menthol, botanic materials, and/or non-botanic materials to a cartridge, and/or an electronic vaping device including the cartridge |
| US10368580B2 (en) | 2016-03-08 | 2019-08-06 | Altria Client Services Llc | Combined cartridge for electronic vaping device |
| US10405582B2 (en) | 2016-03-10 | 2019-09-10 | Pax Labs, Inc. | Vaporization device with lip sensing |
| US10357060B2 (en) | 2016-03-11 | 2019-07-23 | Altria Client Services Llc | E-vaping device cartridge holder |
| US10368581B2 (en) | 2016-03-11 | 2019-08-06 | Altria Client Services Llc | Multiple dispersion generator e-vaping device |
| KR101654901B1 (ko) * | 2016-03-21 | 2016-09-06 | 오충환 | 전자담배 어셈블리 |
| WO2017185051A1 (en) | 2016-04-22 | 2017-10-26 | Pax Labs, Inc. | Aerosol devices having compartmentalized materials |
| MY192211A (en) | 2016-04-27 | 2022-08-08 | Nicoventures Trading Ltd | Electronic aerosol provision system and vaporizer therefor |
| WO2017186811A1 (en) | 2016-04-28 | 2017-11-02 | Philip Morris Products S.A. | Cartridge comprising a coupling element for use in an aerosol-generating system |
| USD849996S1 (en) | 2016-06-16 | 2019-05-28 | Pax Labs, Inc. | Vaporizer cartridge |
| USD836541S1 (en) | 2016-06-23 | 2018-12-25 | Pax Labs, Inc. | Charging device |
| USD851830S1 (en) | 2016-06-23 | 2019-06-18 | Pax Labs, Inc. | Combined vaporizer tamp and pick tool |
| USD848057S1 (en) | 2016-06-23 | 2019-05-07 | Pax Labs, Inc. | Lid for a vaporizer |
| US10292426B2 (en) * | 2016-06-24 | 2019-05-21 | Altria Client Services, Llc | E-vaping device cartridge with superabsorbent polymer |
| US10463077B2 (en) * | 2016-06-24 | 2019-11-05 | Altria Client Services Llc | Cartridge for e-vaping device with open-microchannels |
| EP3272236B1 (en) | 2016-07-22 | 2021-06-16 | Fontem Holdings 1 B.V. | Electronic smoking device |
| US11660403B2 (en) | 2016-09-22 | 2023-05-30 | Juul Labs, Inc. | Leak-resistant vaporizer device |
| GB201618481D0 (en) | 2016-11-02 | 2016-12-14 | British American Tobacco Investments Ltd | Aerosol provision article |
| WO2018102696A1 (en) | 2016-12-02 | 2018-06-07 | Vmr Products Llc | Vaporizer |
| US11413407B2 (en) | 2017-03-23 | 2022-08-16 | Stamford Devices Ltd. | Aerosol delivery device |
| US10118847B2 (en) * | 2017-04-11 | 2018-11-06 | Alexander B. Howe | Structures for the reduction of water impurities and methods for the deployment thereof |
| USD887632S1 (en) | 2017-09-14 | 2020-06-16 | Pax Labs, Inc. | Vaporizer cartridge |
| KR102016846B1 (ko) * | 2018-02-26 | 2019-08-30 | 주식회사 케이티앤지 | 흡연 물품용 카트리지 및 이를 포함하는 에어로졸 흡입기 |
| KR102021229B1 (ko) * | 2018-03-06 | 2019-09-11 | 주식회사 케이티앤지 | 에어로졸 흡입기 |
| US12102118B2 (en) | 2018-03-09 | 2024-10-01 | Rai Strategic Holdings, Inc. | Electronically heated heat-not-burn smoking article |
| KR20200140812A (ko) | 2018-04-06 | 2020-12-16 | 필립모리스 프로덕츠 에스.에이. | 니코틴 겔 |
| KR102368183B1 (ko) * | 2018-04-25 | 2022-02-25 | 주식회사 케이티앤지 | 에어로졸 흡입기 |
| US10888125B2 (en) | 2018-06-27 | 2021-01-12 | Juul Labs, Inc. | Vaporizer device with subassemblies |
| EP3813911A1 (en) * | 2018-06-27 | 2021-05-05 | Juul Labs, Inc. | Vaporizer device |
| US10897925B2 (en) | 2018-07-27 | 2021-01-26 | Joseph Pandolfino | Articles and formulations for smoking products and vaporizers |
| US20200035118A1 (en) | 2018-07-27 | 2020-01-30 | Joseph Pandolfino | Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes |
| GB201812373D0 (en) | 2018-07-30 | 2018-09-12 | Nicoventures Trading Ltd | Generation of an inhalable medium |
| US11413409B2 (en) | 2018-09-12 | 2022-08-16 | Juul Labs, Inc. | Vaporizer including positive temperature coefficient of resistivity (PTCR) heating element |
| WO2020097567A1 (en) | 2018-11-08 | 2020-05-14 | Juul Labs, Inc. | Vaporizer device with more than one heating element |
| US11553734B2 (en) | 2018-11-08 | 2023-01-17 | Juul Labs, Inc. | Cartridges for vaporizer devices |
| GB201818711D0 (en) | 2018-11-16 | 2019-01-02 | Nicoventures Trading Ltd | Method |
| WO2020141113A1 (en) | 2019-01-04 | 2020-07-09 | Nicoventures Trading Limited | Aerosol generation |
| EP3905909B1 (en) | 2019-01-04 | 2024-03-13 | Nicoventures Trading Limited | Aerosol generation |
| JP2022516311A (ja) | 2019-01-04 | 2022-02-25 | ニコベンチャーズ トレーディング リミテッド | エアロゾルの発生 |
| US11064727B2 (en) | 2019-02-06 | 2021-07-20 | Altria Client Services Llc | Sensor apparatuses and systems |
| GB201903228D0 (en) * | 2019-03-11 | 2019-04-24 | Nicoventures Trading Ltd | Aerosol generation device heater element manufacture |
| GB201903250D0 (en) * | 2019-03-11 | 2019-04-24 | Nicoventures Trading Ltd | Aerosol provision device |
| US11330838B2 (en) * | 2019-07-19 | 2022-05-17 | R. J. Reynolds Tobacco Company | Holder for aerosol delivery device with detachable cartridge |
| LU101510B1 (en) * | 2019-12-02 | 2021-06-04 | Herrera Arturo Solis | (S)-3-[1-Methylpyrrolidin-2-yl]pyridine, analogues thereof, precursors thereof, or its derivatives, for the use as a pharmaceutical in form of an aerosol and dispensing device |
| CN213045192U (zh) * | 2019-12-13 | 2021-04-27 | 安德烈斯·唐·塞巴斯蒂安 | 加热不燃烧烟制品 |
| US12240813B2 (en) | 2020-05-19 | 2025-03-04 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
| WO2022070190A1 (en) * | 2020-09-30 | 2022-04-07 | Omega Life Science Ltd. | Electronic cigarettes and cartridges |
| KR102647379B1 (ko) | 2020-10-19 | 2024-03-13 | 주식회사 케이티앤지 | 유기 산을 포함하는 에어로졸 생성 물품 |
| KR20230167895A (ko) * | 2022-06-03 | 2023-12-12 | 주식회사 케이티앤지 | 니코틴 전이가 방지된 흡연물품 및 이를 포함하는 에어로졸 생성 시스템 |
| CN115868662B (zh) * | 2022-12-24 | 2025-02-14 | 东莞市吉纯生物技术有限公司 | 一种新型尼古丁盐及其制备方法、雾化液 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US830626A (en) | 1905-02-23 | 1906-09-11 | James E Van Ness | Vaporizer. |
| BE333223A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1925-03-03 | |||
| US3258015A (en) * | 1964-02-04 | 1966-06-28 | Battelle Memorial Institute | Smoking device |
| US3356094A (en) | 1965-09-22 | 1967-12-05 | Battelle Memorial Institute | Smoking devices |
| IL73912A0 (en) | 1984-01-09 | 1985-03-31 | Advanced Tobacco Prod | Nicotine preparation |
| US4965074A (en) * | 1985-03-05 | 1990-10-23 | Ciba-Geigy Corporation | Method of treating memory impairment |
| US4715387A (en) | 1985-08-23 | 1987-12-29 | The Regents Of The Univ. Of California | Aerosol for use in the reduction of tobacco smoking |
| US5033483A (en) | 1985-10-28 | 1991-07-23 | R. J. Reynolds Tobacco Company | Smoking article with tobacco jacket |
| IL84516A0 (en) | 1986-12-12 | 1988-04-29 | Reynolds Tobacco Co R | Smoking articles comprising impact modifying agents |
| US4765348A (en) | 1986-12-12 | 1988-08-23 | Brown & Williamson Tobacco Corporation | Non-combustible simulated cigarette device |
| US4830028A (en) | 1987-02-10 | 1989-05-16 | R. J. Reynolds Tobacco Company | Salts provided from nicotine and organic acid as cigarette additives |
| US4830643A (en) | 1988-07-13 | 1989-05-16 | W. L. Gore & Associates, Inc. | Expanded polytetrafluoroethylene tubular container |
| GB8819291D0 (en) | 1988-08-12 | 1988-09-14 | British American Tobacco Co | Improvements relating to smoking articles |
| CA1313805C (en) | 1988-10-19 | 1993-02-23 | Hermann Schwartz | Article for simulation of smoking |
| US4924886A (en) | 1988-11-21 | 1990-05-15 | Brown & Williamson Tobacco Corporation | Smoking article |
| JP2925565B2 (ja) | 1989-01-19 | 1999-07-28 | 日本たばこ産業株式会社 | 無煙たばこ |
| US4955397A (en) | 1989-07-10 | 1990-09-11 | Brown & Williamson Tobacco Corporation | Cigarette |
| US5105834A (en) | 1989-12-18 | 1992-04-21 | R.J. Reynolds Tobacco Company | Cigarette and cigarette filter element therefor |
| CA2069687A1 (en) | 1991-06-28 | 1992-12-29 | Chandra Kumar Banerjee | Tobacco smoking article with electrochemical heat source |
| US5327915A (en) | 1992-11-13 | 1994-07-12 | Brown & Williamson Tobacco Corp. | Smoking article |
| US6102036A (en) | 1994-04-12 | 2000-08-15 | Smoke-Stop | Breath activated inhaler |
| KR200148015Y1 (ko) | 1996-07-29 | 1999-06-15 | 이해규 | 파레트를 이용한 차량 이송장치 |
| US20020017295A1 (en) | 2000-07-07 | 2002-02-14 | Weers Jeffry G. | Phospholipid-based powders for inhalation |
| US6284262B1 (en) * | 1999-01-26 | 2001-09-04 | Virgil A. Place | Compact dosage unit for buccal administration of a pharmacologically active agent |
| GB9909357D0 (en) | 1999-04-24 | 1999-06-16 | Glaxo Group Ltd | Medicament carrier |
| SE0104388D0 (sv) | 2001-12-27 | 2001-12-27 | Pharmacia Ab | New formulation and use and manufacture thereof |
| US6772756B2 (en) | 2002-02-09 | 2004-08-10 | Advanced Inhalation Revolutions Inc. | Method and system for vaporization of a substance |
| CA2481287C (en) | 2002-04-12 | 2011-08-02 | Philip Morris Products S.A. | Partially reduced nanoparticle additives to lower the amount of carbon monoxide and/or nitric oxide in the mainstream smoke of a cigarette |
| WO2003094900A1 (en) | 2002-05-13 | 2003-11-20 | Alexza Molecular Delivery Corporation | Delivery of drug amines through an inhalation route |
| US7767698B2 (en) | 2002-06-03 | 2010-08-03 | Mcneil Ab | Formulation and use thereof |
| SE0201669D0 (sv) * | 2002-06-03 | 2002-06-03 | Pharmacia Ab | New formulation and use thereof |
| RU2304913C2 (ru) | 2003-04-14 | 2007-08-27 | Джапан Тобакко Инк. | Усовершенствованная сигарета с уменьшенным распространением пламени |
| CN100381083C (zh) * | 2003-04-29 | 2008-04-16 | 韩力 | 一种非可燃性电子喷雾香烟 |
| PL1663168T3 (pl) | 2003-09-08 | 2009-07-31 | Mcneil Ab | Preparaty nikotyny i ich zastosowanie |
| DE10356925B4 (de) | 2003-12-05 | 2006-05-11 | Lts Lohmann Therapie-Systeme Ag | Inhalator für basische pharmazeutische Wirkstoffe sowie Verfahren für dessen Herstellung |
| US20050267120A1 (en) | 2004-04-14 | 2005-12-01 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
| WO2006004646A1 (en) | 2004-06-28 | 2006-01-12 | Nektar Therapeutics | Aerosol formulation comprising nicotine salt |
| AU2004322756B2 (en) * | 2004-08-12 | 2011-04-14 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| US8322350B2 (en) | 2004-12-30 | 2012-12-04 | Philip Morris Usa Inc. | Aerosol generator |
| US20070102013A1 (en) | 2005-09-30 | 2007-05-10 | Philip Morris Usa Inc. | Electrical smoking system |
| EP2134395B1 (en) * | 2007-03-30 | 2020-03-18 | Philip Morris Products S.A. | Device for delivery of a medicament |
| NZ594585A (en) * | 2009-03-17 | 2014-01-31 | Philip Morris Prod | Tobacco-based nicotine aerosol generation system |
-
2010
- 2010-08-31 JP JP2012529786A patent/JP5702389B2/ja active Active
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| IN2012DN02325A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-08-21 |
| NZ599060A (en) | 2014-10-31 |
| JP5702389B2 (ja) | 2015-04-15 |
| MY163517A (en) | 2017-09-15 |
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