MX2012002827A - Agonistas inversos y antagonistas de histamina h3 y metodos para usar los mismos. - Google Patents

Agonistas inversos y antagonistas de histamina h3 y metodos para usar los mismos.

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Publication number
MX2012002827A
MX2012002827A MX2012002827A MX2012002827A MX2012002827A MX 2012002827 A MX2012002827 A MX 2012002827A MX 2012002827 A MX2012002827 A MX 2012002827A MX 2012002827 A MX2012002827 A MX 2012002827A MX 2012002827 A MX2012002827 A MX 2012002827A
Authority
MX
Mexico
Prior art keywords
methods
histamine
compounds
antagonists
inverse agonists
Prior art date
Application number
MX2012002827A
Other languages
English (en)
Inventor
Qun Kevin Fang
Milan Chytil
Sharon R Engel
Original Assignee
Sunovion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunovion Pharmaceuticals Inc filed Critical Sunovion Pharmaceuticals Inc
Publication of MX2012002827A publication Critical patent/MX2012002827A/es

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Aquí se proporciona compuestos de imidazolilo fusionados, métodos de síntesis, y métodos para usar los mismos. Los compuestos proporcionados aquí son útiles para el tratamiento, la prevención y/o el manejo de varis trastornos, incluyendo, por ejemplo, trastornos neurodegenerativos y trastornos metabólicos. Los compuestos proporcionados aquí inhiben la actividad de los receptores H3 de la histamina, y modulan la liberación de varios neurotransmisores, tales como, por ejemplo, histamina, acetilcolina, norepinefrina, y dopamina (por ejemplo, en las sinapsis). También se proporcionan aquí las composiciones farmacéuticas que contienen los compuestos y sus métodos de uso.
MX2012002827A 2009-09-11 2010-09-09 Agonistas inversos y antagonistas de histamina h3 y metodos para usar los mismos. MX2012002827A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24184009P 2009-09-11 2009-09-11
PCT/US2010/048199 WO2011031816A2 (en) 2009-09-11 2010-09-09 Histamine h3 inverse agonists and antagonists and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2012002827A true MX2012002827A (es) 2012-04-10

Family

ID=43259785

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Application Number Title Priority Date Filing Date
MX2012002827A MX2012002827A (es) 2009-09-11 2010-09-09 Agonistas inversos y antagonistas de histamina h3 y metodos para usar los mismos.
MX2012002898A MX2012002898A (es) 2009-09-11 2010-09-09 Agonistas y antagonistas inversos de histamina h3 y metodos de uso para los mismos.

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MX2012002898A MX2012002898A (es) 2009-09-11 2010-09-09 Agonistas y antagonistas inversos de histamina h3 y metodos de uso para los mismos.

Country Status (8)

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US (2) US20120172350A1 (es)
EP (2) EP2475664A2 (es)
JP (2) JP2013504580A (es)
CN (2) CN102686586A (es)
AU (2) AU2010292285A1 (es)
CA (2) CA2772525A1 (es)
MX (2) MX2012002827A (es)
WO (2) WO2011031818A2 (es)

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CN102596955A (zh) 2012-07-18
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US20110065694A1 (en) 2011-03-17
WO2011031818A3 (en) 2012-05-10
CA2772525A1 (en) 2011-03-17
MX2012002898A (es) 2012-04-02
WO2011031816A2 (en) 2011-03-17
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