MX2012000893A - Metodo para formar particulas de cefquinoma. - Google Patents
Metodo para formar particulas de cefquinoma.Info
- Publication number
- MX2012000893A MX2012000893A MX2012000893A MX2012000893A MX2012000893A MX 2012000893 A MX2012000893 A MX 2012000893A MX 2012000893 A MX2012000893 A MX 2012000893A MX 2012000893 A MX2012000893 A MX 2012000893A MX 2012000893 A MX2012000893 A MX 2012000893A
- Authority
- MX
- Mexico
- Prior art keywords
- cefquinome
- particles
- acid
- addition salt
- sulfate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Se describe un procedimiento para la producción de partículas de una sal de adición ácida de cefquinoma, preferiblemente partículas de sulfato de cefquinoma, por precipitación de la sal de adición ácida de cefquinoma, preferiblemente el sulfato, de una solución de betaína de cefquinoma, en donde ácido, preferiblemente ácido sulfúrico, es añadido a la solución de betaína; de acuerdo con la invención el ácido, preferiblemente ácido sulfúrico, es agregado rápidamente en una sola aplicación, en un exceso molar de 40% a menos de 100%; como resultado, se forman partículas que comprenden aglomerados de partículas cristalinas primarias de microescala; esto permite proporcionar partículas de sal de adición ácida de cefquinoma, preferiblemente sulfato de cefquinoma, en tamaños de partículas conmensurados con material micronizado, pero con estabilidad mejorada.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09165895 | 2009-07-20 | ||
| US22719509P | 2009-07-21 | 2009-07-21 | |
| PCT/EP2010/060376 WO2011009827A1 (en) | 2009-07-20 | 2010-07-19 | Method of making cefquinome particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012000893A true MX2012000893A (es) | 2012-02-28 |
Family
ID=41217555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012000893A MX2012000893A (es) | 2009-07-20 | 2010-07-19 | Metodo para formar particulas de cefquinoma. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20120122832A1 (es) |
| EP (1) | EP2456775B1 (es) |
| JP (2) | JP5859436B2 (es) |
| CN (1) | CN102471350B (es) |
| AR (1) | AR077320A1 (es) |
| AU (1) | AU2010275302B2 (es) |
| BR (1) | BR112012001233B1 (es) |
| CA (1) | CA2768088A1 (es) |
| ES (1) | ES2432240T3 (es) |
| IN (1) | IN2012DN00227A (es) |
| MX (1) | MX2012000893A (es) |
| PL (1) | PL2456775T3 (es) |
| SG (1) | SG177728A1 (es) |
| TW (1) | TWI400243B (es) |
| WO (1) | WO2011009827A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI400243B (zh) * | 2009-07-20 | 2013-07-01 | Intervet Int Bv | 製造西喹諾（ｃｅｆｑｕｉｎｏｍｅ）粒子的方法 |
| CN114869850B (zh) * | 2022-06-20 | 2023-04-28 | 山东晟阳生物工程有限公司 | 硫酸头孢喹肟注射液 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4910301A (en) * | 1985-08-05 | 1990-03-20 | Bristol-Myers Company | Cefepime cephalosporin salts |
| US4791196A (en) * | 1986-09-26 | 1988-12-13 | Sankyo Company Limited | Crystalline cephem carboxylic acid addition salt |
| DE3706020A1 (de) | 1987-02-25 | 1988-09-08 | Hoechst Ag | Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung |
| DE4440141A1 (de) * | 1994-11-10 | 1996-05-15 | Hoechst Ag | Neue kristalline Cephem-Säureadditionssalze und Verfahren zu ihrer Herstellung |
| BR0013754A (pt) | 1999-09-03 | 2002-05-21 | Janssen Pharmaceutica Nv | Formulação veterinaria para administração de uma droga insolúvel em água a um animal alvo através de um sistema de distribuição de água |
| WO2003063877A1 (en) * | 2002-02-01 | 2003-08-07 | Akzo Nobel N.V. | Cefquinome composition for intra-mammary administration in cattle |
| JP4584715B2 (ja) * | 2002-10-25 | 2010-11-24 | インターベツト・インターナシヨナル・ベー・ベー | 持続放出性医薬組成物 |
| US6911441B2 (en) * | 2002-12-16 | 2005-06-28 | Akzo Nobel N.V. | Prolonged release pharmaceutical composition |
| ITMI20042139A1 (it) | 2004-11-08 | 2005-02-08 | Acs Dobfar Spa | Procedimento per la produzione di cefepime e cefaposporine analoghe |
| PT1945223E (pt) * | 2005-10-29 | 2010-10-14 | Intervet Int Bv | Composições de cefquinoma e métodos para a sua utilização |
| CN101050220A (zh) * | 2007-05-21 | 2007-10-10 | 蒋春茂 | 一种动物抗生素硫酸头孢喹肟的制备方法 |
| CN101536985A (zh) * | 2008-03-17 | 2009-09-23 | 天津瑞普生物技术集团有限公司 | 一种畜禽使用的头孢喹肟肺靶向微球及其制备方法 |
| TWI400243B (zh) * | 2009-07-20 | 2013-07-01 | Intervet Int Bv | 製造西喹諾（ｃｅｆｑｕｉｎｏｍｅ）粒子的方法 |
-
2010
- 2010-07-16 TW TW099123476A patent/TWI400243B/zh not_active IP Right Cessation
- 2010-07-16 AR ARP100102611A patent/AR077320A1/es not_active Application Discontinuation
- 2010-07-19 AU AU2010275302A patent/AU2010275302B2/en active Active
- 2010-07-19 SG SG2012004644A patent/SG177728A1/en unknown
- 2010-07-19 JP JP2012521010A patent/JP5859436B2/ja active Active
- 2010-07-19 US US13/384,606 patent/US20120122832A1/en not_active Abandoned
- 2010-07-19 PL PL10734121T patent/PL2456775T3/pl unknown
- 2010-07-19 BR BR112012001233-9A patent/BR112012001233B1/pt active IP Right Grant
- 2010-07-19 WO PCT/EP2010/060376 patent/WO2011009827A1/en active Application Filing
- 2010-07-19 ES ES10734121T patent/ES2432240T3/es active Active
- 2010-07-19 IN IN227DEN2012 patent/IN2012DN00227A/en unknown
- 2010-07-19 CA CA2768088A patent/CA2768088A1/en not_active Abandoned
- 2010-07-19 MX MX2012000893A patent/MX2012000893A/es active IP Right Grant
- 2010-07-19 EP EP10734121.6A patent/EP2456775B1/en active Active
- 2010-07-19 CN CN201080032586.XA patent/CN102471350B/zh active Active
-
2015
- 2015-10-09 JP JP2015200919A patent/JP6346144B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IN2012DN00227A (es) | 2015-05-01 |
| PL2456775T3 (pl) | 2014-01-31 |
| AU2010275302A1 (en) | 2012-02-02 |
| EP2456775A1 (en) | 2012-05-30 |
| JP2016047827A (ja) | 2016-04-07 |
| SG177728A1 (en) | 2012-02-28 |
| US20120122832A1 (en) | 2012-05-17 |
| TWI400243B (zh) | 2013-07-01 |
| EP2456775B1 (en) | 2013-08-21 |
| AR077320A1 (es) | 2011-08-17 |
| TW201116538A (en) | 2011-05-16 |
| CN102471350A (zh) | 2012-05-23 |
| CA2768088A1 (en) | 2011-01-27 |
| ES2432240T3 (es) | 2013-12-02 |
| JP5859436B2 (ja) | 2016-02-10 |
| CN102471350B (zh) | 2015-05-06 |
| BR112012001233B1 (pt) | 2019-06-11 |
| AU2010275302B2 (en) | 2014-10-09 |
| JP6346144B2 (ja) | 2018-06-20 |
| WO2011009827A1 (en) | 2011-01-27 |
| BR112012001233A2 (pt) | 2016-03-08 |
| JP2012533596A (ja) | 2012-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |