IN2012DN00227A - - Google Patents
Info
- Publication number
- IN2012DN00227A IN2012DN00227A IN227DEN2012A IN2012DN00227A IN 2012DN00227 A IN2012DN00227 A IN 2012DN00227A IN 227DEN2012 A IN227DEN2012 A IN 227DEN2012A IN 2012DN00227 A IN2012DN00227 A IN 2012DN00227A
- Authority
- IN
- India
- Prior art keywords
- cefquinome
- particles
- acid
- addition salt
- sulfate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Disclosed is a process for the production of particles of a cefquinome acid addition salt, preferably cefquinome sulfate particles, by precipitation of cefquinome acid addition salt, preferably the sulfate, from a cefquinome betaine solution, wherein acid, preferably sulfuric acid, is added to the betaine solution. According to the invention the acid, preferably sulfuric acid, is added quickly in a single shot, in a molar excess of 40% to less than 100%. As a result, particles are formed that comprise agglomerates of microscale primary crystalline particles. This enables providing particles of cefquinome acid addition salt, preferably cefquinome sulfate, in particle sizes commensurate with micronized material, but with improved stability. Figure 1: Sedimentation (Turbiscan 4 hours). Formulation A
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09165895 | 2009-07-20 | ||
US22719509P | 2009-07-21 | 2009-07-21 | |
PCT/EP2010/060376 WO2011009827A1 (en) | 2009-07-20 | 2010-07-19 | Method of making cefquinome particles |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012DN00227A true IN2012DN00227A (en) | 2015-05-01 |
Family
ID=41217555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN227DEN2012 IN2012DN00227A (en) | 2009-07-20 | 2010-07-19 |
Country Status (15)
Country | Link |
---|---|
US (1) | US20120122832A1 (en) |
EP (1) | EP2456775B1 (en) |
JP (2) | JP5859436B2 (en) |
CN (1) | CN102471350B (en) |
AR (1) | AR077320A1 (en) |
AU (1) | AU2010275302B2 (en) |
BR (1) | BR112012001233B1 (en) |
CA (1) | CA2768088A1 (en) |
ES (1) | ES2432240T3 (en) |
IN (1) | IN2012DN00227A (en) |
MX (1) | MX2012000893A (en) |
PL (1) | PL2456775T3 (en) |
SG (1) | SG177728A1 (en) |
TW (1) | TWI400243B (en) |
WO (1) | WO2011009827A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR077320A1 (en) * | 2009-07-20 | 2011-08-17 | Intervet Int Bv | METHOD FOR THE PREPARATION OF CEFQUINOMA PARTICLES AND PHARMACEUTICAL FORMULATIONS THAT UNDERSTAND THEM. |
CN114869850B (en) * | 2022-06-20 | 2023-04-28 | 山东晟阳生物工程有限公司 | Cefquinome sulfate injection |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4910301A (en) * | 1985-08-05 | 1990-03-20 | Bristol-Myers Company | Cefepime cephalosporin salts |
US4791196A (en) * | 1986-09-26 | 1988-12-13 | Sankyo Company Limited | Crystalline cephem carboxylic acid addition salt |
DE3706020A1 (en) * | 1987-02-25 | 1988-09-08 | Hoechst Ag | CRYSTALLIZED CEPHEMIC ACID ADDITION SALTS AND METHOD FOR THE PRODUCTION THEREOF |
DE4440141A1 (en) * | 1994-11-10 | 1996-05-15 | Hoechst Ag | Novel crystalline cephem acid addition salts and process for their preparation |
UA72933C2 (en) | 1999-09-03 | 2005-05-16 | Янссен Фармацевтика Н.В. | Veterinary drug formulation for administering to specified animal through water distribution system |
WO2003063877A1 (en) * | 2002-02-01 | 2003-08-07 | Akzo Nobel N.V. | Cefquinome composition for intra-mammary administration in cattle |
MXPA05004219A (en) * | 2002-10-25 | 2005-06-08 | Akzo Nobel Nv | Prolonged release pharmaceutical composition. |
US6911441B2 (en) * | 2002-12-16 | 2005-06-28 | Akzo Nobel N.V. | Prolonged release pharmaceutical composition |
ITMI20042139A1 (en) | 2004-11-08 | 2005-02-08 | Acs Dobfar Spa | PROCEDURE FOR THE PRODUCTION OF CEFEPIME AND CEFAPOSPORINE ANALOGHE |
US20080318919A1 (en) * | 2005-10-29 | 2008-12-25 | Intervet International B.V. | Cefquinome Compositions and Methods of Their Use |
CN101050220A (en) * | 2007-05-21 | 2007-10-10 | 蒋春茂 | Method for preparing Cefquinome sulfate of antibiotics of animal |
CN101536985A (en) * | 2008-03-17 | 2009-09-23 | 天津瑞普生物技术集团有限公司 | Livestock cefquinome lung-targeted microspheres and preparation method thereof |
AR077320A1 (en) * | 2009-07-20 | 2011-08-17 | Intervet Int Bv | METHOD FOR THE PREPARATION OF CEFQUINOMA PARTICLES AND PHARMACEUTICAL FORMULATIONS THAT UNDERSTAND THEM. |
-
2010
- 2010-07-16 AR ARP100102611A patent/AR077320A1/en not_active Application Discontinuation
- 2010-07-16 TW TW099123476A patent/TWI400243B/en not_active IP Right Cessation
- 2010-07-19 PL PL10734121T patent/PL2456775T3/en unknown
- 2010-07-19 WO PCT/EP2010/060376 patent/WO2011009827A1/en active Application Filing
- 2010-07-19 IN IN227DEN2012 patent/IN2012DN00227A/en unknown
- 2010-07-19 US US13/384,606 patent/US20120122832A1/en not_active Abandoned
- 2010-07-19 CN CN201080032586.XA patent/CN102471350B/en active Active
- 2010-07-19 MX MX2012000893A patent/MX2012000893A/en active IP Right Grant
- 2010-07-19 BR BR112012001233-9A patent/BR112012001233B1/en active IP Right Grant
- 2010-07-19 AU AU2010275302A patent/AU2010275302B2/en active Active
- 2010-07-19 JP JP2012521010A patent/JP5859436B2/en active Active
- 2010-07-19 ES ES10734121T patent/ES2432240T3/en active Active
- 2010-07-19 SG SG2012004644A patent/SG177728A1/en unknown
- 2010-07-19 CA CA2768088A patent/CA2768088A1/en not_active Abandoned
- 2010-07-19 EP EP10734121.6A patent/EP2456775B1/en active Active
-
2015
- 2015-10-09 JP JP2015200919A patent/JP6346144B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
BR112012001233B1 (en) | 2019-06-11 |
ES2432240T3 (en) | 2013-12-02 |
BR112012001233A2 (en) | 2016-03-08 |
TWI400243B (en) | 2013-07-01 |
CN102471350A (en) | 2012-05-23 |
US20120122832A1 (en) | 2012-05-17 |
CA2768088A1 (en) | 2011-01-27 |
PL2456775T3 (en) | 2014-01-31 |
EP2456775B1 (en) | 2013-08-21 |
JP2012533596A (en) | 2012-12-27 |
AU2010275302B2 (en) | 2014-10-09 |
MX2012000893A (en) | 2012-02-28 |
TW201116538A (en) | 2011-05-16 |
AU2010275302A1 (en) | 2012-02-02 |
JP2016047827A (en) | 2016-04-07 |
SG177728A1 (en) | 2012-02-28 |
JP6346144B2 (en) | 2018-06-20 |
CN102471350B (en) | 2015-05-06 |
WO2011009827A1 (en) | 2011-01-27 |
EP2456775A1 (en) | 2012-05-30 |
JP5859436B2 (en) | 2016-02-10 |
AR077320A1 (en) | 2011-08-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ742200A (en) | Treatment of osteoarthritis | |
JO3218B1 (en) | Production of high purity precipitated calcium carbonate | |
MX2013013024A (en) | Precipitated calcium carbonate from pulp mill waste having an improved brightness, method for the production and use thereof. | |
PE20141639A1 (en) | PROCESS FOR PREPARING CRYSTALLINE HIGH PURITY DIMETHYL SMOKE | |
MX2012010441A (en) | Improved microcapsules and production thereof. | |
WO2012013454A8 (en) | Process for reducing magnetic and/or oxidic impurities in lithium-metal-oxygen compounds | |
MY162811A (en) | Food containing milk ceramide, and process for production thereof | |
WO2016016766A3 (en) | A process for the preparation of isavuconazonium or its salt thereof | |
BR112013030973A8 (en) | process for the preparation of prostaglandin amides | |
MY185172A (en) | Gypsum-based building products and method for the manufacture thereof | |
MX2012013610A (en) | Complex obtained from hyaluronic acid or a salt thereof and chondroitin sulphate mixtures. | |
WO2015088625A3 (en) | Compounds and methods of promoting myelination | |
TN2015000372A1 (en) | A method for concentrating rare-earth metals in phosphogypsum | |
IN2012DN00227A (en) | ||
IL229664A (en) | Method for producing phosphoric acid of the dihydrate/hemihydrate type | |
IN2015DN00833A (en) | ||
UA103913C2 (en) | Micronutrient additive to feed mixtures for animals and birds in a bioavailable shape | |
RS53001B (en) | Delta crystalline form of the arginine salt of perindopril, a process for its preparation, and paharmaceutical compositions containing it | |
WO2011107843A3 (en) | Process for the preparation of atazanavir sulfate substantially free of diastereomers | |
AR068520A1 (en) | PROCESS FOR THE PRODUCTION OF MAGNESIUM SODIUM SULFATE AND HYDROXIDE | |
WO2009037901A1 (en) | Powder cosmetic and process for production of flaky calcium sulfate dihydrate to be used in the cosmetic | |
IN2015DN00662A (en) | ||
CA2797442A1 (en) | Process for the production of ferrous sulphate monohydrate | |
DK201470284A (en) | Method for producing high purity crystalline carbamide | |
WO2013030147A3 (en) | A process for preparing plastics with improved hydrolysis stability, the plastics prepared from the same and uses thereof |