MX2011012522A - Inhibidores de pirazol sustituido de proteina cinasa c-met. - Google Patents

Inhibidores de pirazol sustituido de proteina cinasa c-met.

Info

Publication number
MX2011012522A
MX2011012522A MX2011012522A MX2011012522A MX2011012522A MX 2011012522 A MX2011012522 A MX 2011012522A MX 2011012522 A MX2011012522 A MX 2011012522A MX 2011012522 A MX2011012522 A MX 2011012522A MX 2011012522 A MX2011012522 A MX 2011012522A
Authority
MX
Mexico
Prior art keywords
protein kinase
met protein
substituted pyrazole
pyrazole inhibitors
inhibitors
Prior art date
Application number
MX2011012522A
Other languages
English (en)
Spanish (es)
Inventor
Qing Tang
David Lauffer
Pan Li
Nathan Waal
Steven Ronkin
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2011012522A publication Critical patent/MX2011012522A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MX2011012522A 2009-05-28 2010-05-27 Inhibidores de pirazol sustituido de proteina cinasa c-met. MX2011012522A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18178409P 2009-05-28 2009-05-28
PCT/US2010/036309 WO2010138663A1 (en) 2009-05-28 2010-05-27 Substituted pyrazole inhibitors of c-met protein kinase

Publications (1)

Publication Number Publication Date
MX2011012522A true MX2011012522A (es) 2012-02-08

Family

ID=42370912

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011012522A MX2011012522A (es) 2009-05-28 2010-05-27 Inhibidores de pirazol sustituido de proteina cinasa c-met.

Country Status (8)

Country Link
US (3) US8269012B2 (enExample)
EP (1) EP2435444A1 (enExample)
JP (1) JP2012528185A (enExample)
CN (1) CN102448968A (enExample)
AU (1) AU2010254053A1 (enExample)
CA (1) CA2762186A1 (enExample)
MX (1) MX2011012522A (enExample)
WO (1) WO2010138663A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2435443B1 (en) * 2009-05-28 2013-07-31 Vertex Pharmaceuticals Incorporated Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase
ES2712717T3 (es) * 2012-07-27 2019-05-14 Sato Pharma Compuesto de difluorometileno
CN103073491A (zh) * 2013-01-25 2013-05-01 桑迪亚医药技术（上海）有限责任公司 一种2-（5,7-二氟-6-喹啉基）乙酸/丙酸（酯）的合成方法
CN106924260B (zh) * 2015-12-31 2018-05-25 北京浦润奥生物科技有限责任公司 化合物在制备用于治疗脑胶质瘤的药物中的用途
GR1009565B (el) * 2016-07-14 2019-08-06 Galenica Α.Ε. Νεα παραγωγα 1,2,4-τριαζολο-[3,4-b]-1,3,4-θειαδιαζολιων
CN109897054B (zh) * 2017-12-08 2021-12-10 中国药科大学 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000660A1 (fr) * 2001-06-22 2003-01-03 Kirin Beer Kabushiki Kaisha Derive de quinoleine et derive de quinoleine permettant d'inhiber l'auto-phosphorylation du recepteur des proliferateurs des hepatocytes, ainsi que des compositions medicinales contenant ce derive
EP1713484A2 (en) * 2004-01-23 2006-10-25 Amgen Inc. Compounds and methods of use
ATE492544T1 (de) * 2004-08-26 2011-01-15 Pfizer Pyrazol-substituierte aminoheteroarylverbindungen als proteinkinasehemmer
NZ568666A (en) * 2005-11-30 2011-09-30 Vertex Pharma [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazole derivative as inhibitors of c-Met
CA2688823A1 (en) * 2007-05-21 2008-11-27 Sgx Pharmaceuticals, Inc. Heterocyclic kinase modulators
AU2009316756B2 (en) * 2008-11-19 2016-02-25 Vertex Pharmaceuticals Incorporated A triazolothiadiazole inhibitor of c-Met protein kinase
EP2435443B1 (en) * 2009-05-28 2013-07-31 Vertex Pharmaceuticals Incorporated Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase

Also Published As

Publication number Publication date
EP2435444A1 (en) 2012-04-04
US20130018072A1 (en) 2013-01-17
JP2012528185A (ja) 2012-11-12
US8269013B2 (en) 2012-09-18
US20110124684A1 (en) 2011-05-26
CA2762186A1 (en) 2010-12-02
CN102448968A (zh) 2012-05-09
US8269012B2 (en) 2012-09-18
AU2010254053A1 (en) 2011-12-01
WO2010138663A1 (en) 2010-12-02
US20100305155A1 (en) 2010-12-02

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Legal Events

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