CA2762186A1 - Substituted pyrazole inhibitors of c-met protein kinase - Google Patents
Substituted pyrazole inhibitors of c-met protein kinase Download PDFInfo
- Publication number
- CA2762186A1 CA2762186A1 CA2762186A CA2762186A CA2762186A1 CA 2762186 A1 CA2762186 A1 CA 2762186A1 CA 2762186 A CA2762186 A CA 2762186A CA 2762186 A CA2762186 A CA 2762186A CA 2762186 A1 CA2762186 A1 CA 2762186A1
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- Prior art keywords
- compound
- hydrogen
- methyl
- compound according
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18178409P | 2009-05-28 | 2009-05-28 | |
| US61/181,784 | 2009-05-28 | ||
| PCT/US2010/036309 WO2010138663A1 (en) | 2009-05-28 | 2010-05-27 | Substituted pyrazole inhibitors of c-met protein kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2762186A1 true CA2762186A1 (en) | 2010-12-02 |
Family
ID=42370912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2762186A Abandoned CA2762186A1 (en) | 2009-05-28 | 2010-05-27 | Substituted pyrazole inhibitors of c-met protein kinase |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8269013B2 (enExample) |
| EP (1) | EP2435444A1 (enExample) |
| JP (1) | JP2012528185A (enExample) |
| CN (1) | CN102448968A (enExample) |
| AU (1) | AU2010254053A1 (enExample) |
| CA (1) | CA2762186A1 (enExample) |
| MX (1) | MX2011012522A (enExample) |
| WO (1) | WO2010138663A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA106082C2 (uk) * | 2009-05-28 | 2014-07-25 | Вертекс Фармасьютікалз Інкорпорейтед | АМІНОПІРАЗОЛ ТРИАЗОЛОТІАДІАЗОЛЬНІ ІНГІБІТОРИ ПРОТЕЇНКІНАЗИ c-МЕТ |
| WO2014017643A1 (ja) * | 2012-07-27 | 2014-01-30 | 佐藤製薬株式会社 | ジフルオロメチレン化合物 |
| CN103073491A (zh) * | 2013-01-25 | 2013-05-01 | 桑迪亚医药技术（上海）有限责任公司 | 一种2-（5,7-二氟-6-喹啉基）乙酸/丙酸（酯）的合成方法 |
| CN108853108A (zh) * | 2015-12-31 | 2018-11-23 | 北京浦润奥生物科技有限责任公司 | 化合物在制备用于治疗脑胶质瘤的药物中的用途 |
| GR1009565B (el) * | 2016-07-14 | 2019-08-06 | Galenica Α.Ε. | Νεα παραγωγα 1,2,4-τριαζολο-[3,4-b]-1,3,4-θειαδιαζολιων |
| CN109897054B (zh) * | 2017-12-08 | 2021-12-10 | 中国药科大学 | 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2454538A1 (en) * | 2001-06-22 | 2003-01-03 | Kirin Beer Kabushiki Kaisha | Quinoline derivatives and quinazoline derivatives capable of inhibiting autophosphorylation of hepatocyte growth factor receptors, and pharmaceutical composition comprising the same |
| WO2005070891A2 (en) * | 2004-01-23 | 2005-08-04 | Amgen Inc | Compounds and methods of use |
| CA2577937C (en) * | 2004-08-26 | 2010-12-21 | Pfizer Inc. | Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors |
| US7728017B2 (en) | 2005-11-30 | 2010-06-01 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-Met and uses thereof |
| US20090156594A1 (en) * | 2007-05-21 | 2009-06-18 | Sgx Pharmaceuticals, Inc. | Heterocyclic kinase modulators |
| MX2011005250A (es) * | 2008-11-19 | 2011-07-29 | Vertex Pharma | Inhibidores de triazolotiadiazol de cinasa de proteina c-met. |
| UA106082C2 (uk) * | 2009-05-28 | 2014-07-25 | Вертекс Фармасьютікалз Інкорпорейтед | АМІНОПІРАЗОЛ ТРИАЗОЛОТІАДІАЗОЛЬНІ ІНГІБІТОРИ ПРОТЕЇНКІНАЗИ c-МЕТ |
-
2010
- 2010-05-27 US US12/788,715 patent/US8269013B2/en active Active
- 2010-05-27 MX MX2011012522A patent/MX2011012522A/es not_active Application Discontinuation
- 2010-05-27 JP JP2012513239A patent/JP2012528185A/ja active Pending
- 2010-05-27 CA CA2762186A patent/CA2762186A1/en not_active Abandoned
- 2010-05-27 WO PCT/US2010/036309 patent/WO2010138663A1/en not_active Ceased
- 2010-05-27 US US12/788,608 patent/US8269012B2/en not_active Expired - Fee Related
- 2010-05-27 CN CN2010800231025A patent/CN102448968A/zh active Pending
- 2010-05-27 EP EP10730618A patent/EP2435444A1/en not_active Withdrawn
- 2010-05-27 AU AU2010254053A patent/AU2010254053A1/en not_active Abandoned
-
2012
- 2012-09-17 US US13/621,396 patent/US20130018072A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2435444A1 (en) | 2012-04-04 |
| US8269013B2 (en) | 2012-09-18 |
| WO2010138663A1 (en) | 2010-12-02 |
| US20110124684A1 (en) | 2011-05-26 |
| MX2011012522A (es) | 2012-02-08 |
| US8269012B2 (en) | 2012-09-18 |
| CN102448968A (zh) | 2012-05-09 |
| AU2010254053A1 (en) | 2011-12-01 |
| US20100305155A1 (en) | 2010-12-02 |
| JP2012528185A (ja) | 2012-11-12 |
| US20130018072A1 (en) | 2013-01-17 |
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| Publication | Publication Date | Title |
|---|---|---|
| US8217056B2 (en) | Triazolothiadiazole inhibitor of c-Met protein kinase | |
| US8269013B2 (en) | Substituted pyrazole inhibitors of c-Met protein kinase | |
| US8263776B2 (en) | Inhibitors of c-Met protein kinase | |
| EP2435443B1 (en) | Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase | |
| US8263777B2 (en) | Aminopyrazole triazolothiadiazole inhibitor of c-Met protein kinase | |
| HK1169401A (en) | Substituted pyrazole inhibitors of c-met protein kinase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20140527 |