CA2762186A1 - Substituted pyrazole inhibitors of c-met protein kinase - Google Patents
Substituted pyrazole inhibitors of c-met protein kinase Download PDFInfo
- Publication number
- CA2762186A1 CA2762186A1 CA2762186A CA2762186A CA2762186A1 CA 2762186 A1 CA2762186 A1 CA 2762186A1 CA 2762186 A CA2762186 A CA 2762186A CA 2762186 A CA2762186 A CA 2762186A CA 2762186 A1 CA2762186 A1 CA 2762186A1
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- Prior art keywords
- compound
- hydrogen
- methyl
- compound according
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000002700 urine Anatomy 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical class CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 229960000653 valrubicin Drugs 0.000 description 1
- ZOCKGBMQLCSHFP-KQRAQHLDSA-N valrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)C(=O)COC(=O)CCCC)[C@H]1C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O1 ZOCKGBMQLCSHFP-KQRAQHLDSA-N 0.000 description 1
- 229950000578 vatalanib Drugs 0.000 description 1
- YCOYDOIWSSHVCK-UHFFFAOYSA-N vatalanib Chemical compound C1=CC(Cl)=CC=C1NC(C1=CC=CC=C11)=NN=C1CC1=CC=NC=C1 YCOYDOIWSSHVCK-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- HHJUWIANJFBDHT-KOTLKJBCSA-N vindesine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(N)=O)N4C)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 HHJUWIANJFBDHT-KOTLKJBCSA-N 0.000 description 1
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- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
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- ZPFVQKPWGDRLHL-ZLYBXYBFSA-N zosuquidar trihydrochloride Chemical compound Cl.Cl.Cl.C([C@H](COC=1C2=CC=CN=C2C=CC=1)O)N(CC1)CCN1C1C2=CC=CC=C2[C@H]2C(F)(F)[C@H]2C2=CC=CC=C12 ZPFVQKPWGDRLHL-ZLYBXYBFSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18178409P | 2009-05-28 | 2009-05-28 | |
| US61/181,784 | 2009-05-28 | ||
| PCT/US2010/036309 WO2010138663A1 (en) | 2009-05-28 | 2010-05-27 | Substituted pyrazole inhibitors of c-met protein kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2762186A1 true CA2762186A1 (en) | 2010-12-02 |
Family
ID=42370912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2762186A Abandoned CA2762186A1 (en) | 2009-05-28 | 2010-05-27 | Substituted pyrazole inhibitors of c-met protein kinase |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8269012B2 (enExample) |
| EP (1) | EP2435444A1 (enExample) |
| JP (1) | JP2012528185A (enExample) |
| CN (1) | CN102448968A (enExample) |
| AU (1) | AU2010254053A1 (enExample) |
| CA (1) | CA2762186A1 (enExample) |
| MX (1) | MX2011012522A (enExample) |
| WO (1) | WO2010138663A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2435443B1 (en) * | 2009-05-28 | 2013-07-31 | Vertex Pharmaceuticals Incorporated | Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase |
| ES2712717T3 (es) * | 2012-07-27 | 2019-05-14 | Sato Pharma | Compuesto de difluorometileno |
| CN103073491A (zh) * | 2013-01-25 | 2013-05-01 | 桑迪亚医药技术（上海）有限责任公司 | 一种2-（5,7-二氟-6-喹啉基）乙酸/丙酸（酯）的合成方法 |
| CN106924260B (zh) * | 2015-12-31 | 2018-05-25 | 北京浦润奥生物科技有限责任公司 | 化合物在制备用于治疗脑胶质瘤的药物中的用途 |
| GR1009565B (el) * | 2016-07-14 | 2019-08-06 | Galenica Α.Ε. | Νεα παραγωγα 1,2,4-τριαζολο-[3,4-b]-1,3,4-θειαδιαζολιων |
| CN109897054B (zh) * | 2017-12-08 | 2021-12-10 | 中国药科大学 | 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003000660A1 (fr) * | 2001-06-22 | 2003-01-03 | Kirin Beer Kabushiki Kaisha | Derive de quinoleine et derive de quinoleine permettant d'inhiber l'auto-phosphorylation du recepteur des proliferateurs des hepatocytes, ainsi que des compositions medicinales contenant ce derive |
| EP1713484A2 (en) * | 2004-01-23 | 2006-10-25 | Amgen Inc. | Compounds and methods of use |
| ATE492544T1 (de) * | 2004-08-26 | 2011-01-15 | Pfizer | Pyrazol-substituierte aminoheteroarylverbindungen als proteinkinasehemmer |
| NZ568666A (en) * | 2005-11-30 | 2011-09-30 | Vertex Pharma | [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazole derivative as inhibitors of c-Met |
| CA2688823A1 (en) * | 2007-05-21 | 2008-11-27 | Sgx Pharmaceuticals, Inc. | Heterocyclic kinase modulators |
| AU2009316756B2 (en) * | 2008-11-19 | 2016-02-25 | Vertex Pharmaceuticals Incorporated | A triazolothiadiazole inhibitor of c-Met protein kinase |
| EP2435443B1 (en) * | 2009-05-28 | 2013-07-31 | Vertex Pharmaceuticals Incorporated | Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase |
-
2010
- 2010-05-27 EP EP10730618A patent/EP2435444A1/en not_active Withdrawn
- 2010-05-27 JP JP2012513239A patent/JP2012528185A/ja active Pending
- 2010-05-27 WO PCT/US2010/036309 patent/WO2010138663A1/en not_active Ceased
- 2010-05-27 CN CN2010800231025A patent/CN102448968A/zh active Pending
- 2010-05-27 US US12/788,608 patent/US8269012B2/en not_active Expired - Fee Related
- 2010-05-27 CA CA2762186A patent/CA2762186A1/en not_active Abandoned
- 2010-05-27 MX MX2011012522A patent/MX2011012522A/es not_active Application Discontinuation
- 2010-05-27 AU AU2010254053A patent/AU2010254053A1/en not_active Abandoned
- 2010-05-27 US US12/788,715 patent/US8269013B2/en active Active
-
2012
- 2012-09-17 US US13/621,396 patent/US20130018072A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2435444A1 (en) | 2012-04-04 |
| US20130018072A1 (en) | 2013-01-17 |
| JP2012528185A (ja) | 2012-11-12 |
| US8269013B2 (en) | 2012-09-18 |
| US20110124684A1 (en) | 2011-05-26 |
| CN102448968A (zh) | 2012-05-09 |
| MX2011012522A (es) | 2012-02-08 |
| US8269012B2 (en) | 2012-09-18 |
| AU2010254053A1 (en) | 2011-12-01 |
| WO2010138663A1 (en) | 2010-12-02 |
| US20100305155A1 (en) | 2010-12-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8217056B2 (en) | Triazolothiadiazole inhibitor of c-Met protein kinase | |
| US8269013B2 (en) | Substituted pyrazole inhibitors of c-Met protein kinase | |
| US8263776B2 (en) | Inhibitors of c-Met protein kinase | |
| EP2435443B1 (en) | Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase | |
| US8263777B2 (en) | Aminopyrazole triazolothiadiazole inhibitor of c-Met protein kinase | |
| HK1169401A (en) | Substituted pyrazole inhibitors of c-met protein kinase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20140527 |