MX2011007684A - Agentes inductores de apoptosis para el tratamiento del cancer y enfermedades inmunes y autoinmunes. - Google Patents

Agentes inductores de apoptosis para el tratamiento del cancer y enfermedades inmunes y autoinmunes.

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Publication number
MX2011007684A
MX2011007684A MX2011007684A MX2011007684A MX2011007684A MX 2011007684 A MX2011007684 A MX 2011007684A MX 2011007684 A MX2011007684 A MX 2011007684A MX 2011007684 A MX2011007684 A MX 2011007684A MX 2011007684 A MX2011007684 A MX 2011007684A
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Mexico
Prior art keywords
apoptosis
immune
cancer
treatment
autoimmune diseases
Prior art date
Application number
MX2011007684A
Other languages
English (en)
Inventor
Gary T Wang
Laura Hexamer
Gerard M Sullivan
Aaron R Kunzer
Michael D Wendt
Steven W Elmore
Xilu Wang
Andrew J Souers
Cheol-Min Park
Original Assignee
Abbott Lab
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Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2011007684A publication Critical patent/MX2011007684A/es

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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen compuestos de Fórmula (1), en la cual A1, Z1, Z1A, Z2, Z2A', L1 y Z3 son como se define en las reivindicaciones, que inhiben la actividad de las proteínas antiapoptóticas BcI-2, composiciones que contiene los compuestos y su uso en el tratamiento de enfermedades durante la cual es expresada la proteína antiapoptótica Bcl-2.
MX2011007684A 2009-01-19 2010-01-15 Agentes inductores de apoptosis para el tratamiento del cancer y enfermedades inmunes y autoinmunes. MX2011007684A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14561109P 2009-01-19 2009-01-19
PCT/US2010/021245 WO2010083442A1 (en) 2009-01-19 2010-01-15 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Publications (1)

Publication Number Publication Date
MX2011007684A true MX2011007684A (es) 2011-08-08

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MX2011007684A MX2011007684A (es) 2009-01-19 2010-01-15 Agentes inductores de apoptosis para el tratamiento del cancer y enfermedades inmunes y autoinmunes.

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US (3) US8338466B2 (es)
EP (2) EP3095784A1 (es)
JP (1) JP5613177B2 (es)
KR (1) KR20110116161A (es)
CN (2) CN102282128B (es)
AU (1) AU2010204555B2 (es)
BR (1) BRPI1006115A8 (es)
CA (1) CA2747837A1 (es)
ES (1) ES2593427T3 (es)
IL (1) IL213622A (es)
MX (1) MX2011007684A (es)
NZ (1) NZ593594A (es)
RU (1) RU2538965C2 (es)
SG (1) SG172393A1 (es)
TW (1) TWI459943B (es)
WO (1) WO2010083442A1 (es)
ZA (1) ZA201104671B (es)

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RS56989B1 (sr) * 2008-11-07 2018-05-31 Amgen Res Munich Gmbh Lečenje pedijatrijske akutne limfoblastne leukemije
PT2342227E (pt) * 2008-11-07 2015-11-13 Amgen Res Munich Gmbh Tratamento da leucemia linfoblástica aguda
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
EP3095784A1 (en) 2009-01-19 2016-11-23 AbbVie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
MX2011007681A (es) * 2009-01-19 2011-08-08 Abbott Lab Agentes inducidores de apoptosis para el tratamiento del cancer y enfermedades inmunes y autoinmunes.
CN109897038B (zh) * 2009-05-26 2022-04-05 艾伯维爱尔兰无限公司 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
JP5959501B2 (ja) * 2010-03-25 2016-08-02 アッヴィ・インコーポレイテッド 癌ならびに免疫および自己免疫疾患の治療のためのアポトーシス誘導物質
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
CN103167867B (zh) 2010-10-29 2016-12-21 Abbvie 公司 含有细胞凋亡诱导药剂的固体分散体
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