MX2011005369A - Inhibidores de glicogeno sintasa cinasa-3 beta que contienen derivados de 7-hidroxi-benzoimidazol-4-il-metanona. - Google Patents
Inhibidores de glicogeno sintasa cinasa-3 beta que contienen derivados de 7-hidroxi-benzoimidazol-4-il-metanona.Info
- Publication number
- MX2011005369A MX2011005369A MX2011005369A MX2011005369A MX2011005369A MX 2011005369 A MX2011005369 A MX 2011005369A MX 2011005369 A MX2011005369 A MX 2011005369A MX 2011005369 A MX2011005369 A MX 2011005369A MX 2011005369 A MX2011005369 A MX 2011005369A
- Authority
- MX
- Mexico
- Prior art keywords
- benzo
- imidazole
- hydroxy
- carboxamide
- thiophen
- Prior art date
Links
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 title claims abstract description 51
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 title claims abstract description 51
- 239000003112 inhibitor Substances 0.000 title claims abstract description 20
- GGRAFBSODPLTOT-UHFFFAOYSA-N 7-hydroxy-1h-benzimidazole-4-carbaldehyde Chemical class OC1=CC=C(C=O)C2=C1N=CN2 GGRAFBSODPLTOT-UHFFFAOYSA-N 0.000 title abstract 2
- -1 nitro, cyano, amino Chemical group 0.000 claims description 220
- 238000000034 method Methods 0.000 claims description 102
- 150000001875 compounds Chemical class 0.000 claims description 54
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 25
- 201000010099 disease Diseases 0.000 claims description 24
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 24
- 230000001419 dependent effect Effects 0.000 claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims description 17
- 208000024827 Alzheimer disease Diseases 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- 206010026749 Mania Diseases 0.000 claims description 15
- 208000019695 Migraine disease Diseases 0.000 claims description 15
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 15
- ZBNZAJFNDPPMDT-UHFFFAOYSA-N 1h-imidazole-5-carboxamide Chemical compound NC(=O)C1=CNC=N1 ZBNZAJFNDPPMDT-UHFFFAOYSA-N 0.000 claims description 14
- 206010027599 migraine Diseases 0.000 claims description 14
- WVKPYYLOFMTDHB-UHFFFAOYSA-N 2-norbornyl radical Chemical group C1CC2[CH]CC1C2 WVKPYYLOFMTDHB-UHFFFAOYSA-N 0.000 claims description 12
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 11
- 125000000623 heterocyclic group Chemical group 0.000 claims description 10
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 9
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 9
- 125000001424 substituent group Chemical group 0.000 claims description 9
- 150000001408 amides Chemical class 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 239000012453 solvate Substances 0.000 claims description 8
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims description 7
- 125000000304 alkynyl group Chemical group 0.000 claims description 7
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 claims description 7
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 6
- 125000003282 alkyl amino group Chemical group 0.000 claims description 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 5
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims description 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 3
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims description 3
- MSSDTZLYNMFTKN-UHFFFAOYSA-N 1-Piperazinecarboxaldehyde Chemical compound O=CN1CCNCC1 MSSDTZLYNMFTKN-UHFFFAOYSA-N 0.000 claims description 3
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical class 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 125000004043 oxo group Chemical group O=* 0.000 claims description 3
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims description 3
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 3
- PQOKBQCVPUXWDC-UHFFFAOYSA-N 2-(3-bicyclo[2.2.1]heptanyl)-7-hydroxy-n-(piperidin-3-ylmethyl)-1h-benzimidazole-4-carboxamide Chemical compound C1=2N=C(C3C4CCC(C4)C3)NC=2C(O)=CC=C1C(=O)NCC1CCCNC1 PQOKBQCVPUXWDC-UHFFFAOYSA-N 0.000 claims description 2
- FOPKNXVYPWDCPH-UHFFFAOYSA-N 2-cyclopropyl-7-hydroxy-n-(piperidin-4-ylmethyl)-1h-benzimidazole-4-carboxamide Chemical compound C1=2NC(C3CC3)=NC=2C(O)=CC=C1C(=O)NCC1CCNCC1 FOPKNXVYPWDCPH-UHFFFAOYSA-N 0.000 claims description 2
- HHWUJDYTPHLTIF-UHFFFAOYSA-N 7-hydroxy-2-phenyl-n-(piperidin-2-ylmethyl)-1h-benzimidazole-4-carboxamide Chemical compound C1=2NC(C=3C=CC=CC=3)=NC=2C(O)=CC=C1C(=O)NCC1CCCCN1 HHWUJDYTPHLTIF-UHFFFAOYSA-N 0.000 claims description 2
- UHYZCMYXHGAMGC-UHFFFAOYSA-N 7-hydroxy-n-(1-methylpiperidin-3-yl)-2-thiophen-2-yl-1h-benzimidazole-4-carboxamide Chemical compound C1N(C)CCCC1NC(=O)C1=CC=C(O)C2=C1N=C(C=1SC=CC=1)N2 UHYZCMYXHGAMGC-UHFFFAOYSA-N 0.000 claims description 2
- LRQSKLNGWMJWMJ-UHFFFAOYSA-N 7-hydroxy-n-(2-piperazin-1-ylethyl)-2-thiophen-2-yl-1h-benzimidazole-4-carboxamide Chemical compound C1=2N=C(C=3SC=CC=3)NC=2C(O)=CC=C1C(=O)NCCN1CCNCC1 LRQSKLNGWMJWMJ-UHFFFAOYSA-N 0.000 claims description 2
- DSUNIVRRAJRRDJ-UHFFFAOYSA-N 7-hydroxy-n-(4-hydroxycyclohexyl)-2-thiophen-2-yl-1h-benzimidazole-4-carboxamide Chemical compound C1CC(O)CCC1NC(=O)C1=CC=C(O)C2=C1N=C(C=1SC=CC=1)N2 DSUNIVRRAJRRDJ-UHFFFAOYSA-N 0.000 claims description 2
- VYRHSZRZVBIDCD-UHFFFAOYSA-N 7-hydroxy-n-(piperidin-2-ylmethyl)-2-thiophen-2-yl-1h-benzimidazole-4-carboxamide Chemical compound C1=2N=C(C=3SC=CC=3)NC=2C(O)=CC=C1C(=O)NCC1CCCCN1 VYRHSZRZVBIDCD-UHFFFAOYSA-N 0.000 claims description 2
- NJKUDKWJZPVSAI-UHFFFAOYSA-N 7-hydroxy-n-(pyrrolidin-3-ylmethyl)-2-thiophen-2-yl-1h-benzimidazole-4-carboxamide Chemical compound C1=2N=C(C=3SC=CC=3)NC=2C(O)=CC=C1C(=O)NCC1CCNC1 NJKUDKWJZPVSAI-UHFFFAOYSA-N 0.000 claims description 2
- FMCDOLBSRBSVDW-NSHDSACASA-N 7-hydroxy-n-[(3s)-piperidin-3-yl]-2-(thiophen-2-ylmethyl)-1h-benzimidazole-4-carboxamide Chemical compound C1=2N=C(CC=3SC=CC=3)NC=2C(O)=CC=C1C(=O)N[C@H]1CCCNC1 FMCDOLBSRBSVDW-NSHDSACASA-N 0.000 claims description 2
- LJPSIRPRIUNDAT-JTQLQIEISA-N 7-hydroxy-n-[(3s)-piperidin-3-yl]-2-thiophen-2-yl-1h-benzimidazole-4-carboxamide Chemical compound C1=2N=C(C=3SC=CC=3)NC=2C(O)=CC=C1C(=O)N[C@H]1CCCNC1 LJPSIRPRIUNDAT-JTQLQIEISA-N 0.000 claims description 2
- FQTGTVOVVRVTMG-GFCCVEGCSA-N 7-hydroxy-n-[[(3r)-piperidin-3-yl]methyl]-2-(thiophen-2-ylmethyl)-1h-benzimidazole-4-carboxamide Chemical compound C1=2N=C(CC=3SC=CC=3)NC=2C(O)=CC=C1C(=O)NC[C@@H]1CCCNC1 FQTGTVOVVRVTMG-GFCCVEGCSA-N 0.000 claims description 2
- FQTGTVOVVRVTMG-LBPRGKRZSA-N 7-hydroxy-n-[[(3s)-piperidin-3-yl]methyl]-2-(thiophen-2-ylmethyl)-1h-benzimidazole-4-carboxamide Chemical compound C1=2N=C(CC=3SC=CC=3)NC=2C(O)=CC=C1C(=O)NC[C@H]1CCCNC1 FQTGTVOVVRVTMG-LBPRGKRZSA-N 0.000 claims description 2
- ITBAAQYBVUPCCT-UHFFFAOYSA-N 7-hydroxy-n-piperidin-4-yl-2-thiophen-2-yl-1h-benzimidazole-4-carboxamide Chemical compound C1=2N=C(C=3SC=CC=3)NC=2C(O)=CC=C1C(=O)NC1CCNCC1 ITBAAQYBVUPCCT-UHFFFAOYSA-N 0.000 claims description 2
- WTHXQDHNQUSBSY-UHFFFAOYSA-N 7-hydroxy-n-pyrrolidin-3-yl-2-thiophen-2-yl-1h-benzimidazole-4-carboxamide Chemical compound C1=2N=C(C=3SC=CC=3)NC=2C(O)=CC=C1C(=O)NC1CCNC1 WTHXQDHNQUSBSY-UHFFFAOYSA-N 0.000 claims description 2
- WZXNSEUSWNYXAB-KJYZHBAISA-N N[C@H]1CC[C@H](CC1)CN1C(=NC2=C1C(=CC=C2C(=O)N)O)C2C1CCC(C2)C1 Chemical compound N[C@H]1CC[C@H](CC1)CN1C(=NC2=C1C(=CC=C2C(=O)N)O)C2C1CCC(C2)C1 WZXNSEUSWNYXAB-KJYZHBAISA-N 0.000 claims description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
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- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
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- AMFHAOZWFGPCHS-UHFFFAOYSA-N 4-[(7-hydroxy-2-thiophen-2-yl-1h-benzimidazole-4-carbonyl)amino]cyclohexane-1-carboxylic acid Chemical compound C1CC(C(=O)O)CCC1NC(=O)C1=CC=C(O)C2=C1N=C(C=1SC=CC=1)N2 AMFHAOZWFGPCHS-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11654308P | 2008-11-20 | 2008-11-20 | |
| PCT/JP2009/004975 WO2010058512A1 (en) | 2008-11-20 | 2009-09-29 | Glycogen synthase kinase-3 beta inhibitors containing 7-hydroxy-benzoimidazole-4-yl-methanone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011005369A true MX2011005369A (es) | 2011-06-20 |
Family
ID=42197956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011005369A MX2011005369A (es) | 2008-11-20 | 2009-09-29 | Inhibidores de glicogeno sintasa cinasa-3 beta que contienen derivados de 7-hidroxi-benzoimidazol-4-il-metanona. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20110301146A1 (OSRAM) |
| EP (1) | EP2358365A4 (OSRAM) |
| JP (1) | JP2012509249A (OSRAM) |
| KR (1) | KR20110086750A (OSRAM) |
| CN (1) | CN102292083A (OSRAM) |
| AU (1) | AU2009318719A1 (OSRAM) |
| BR (1) | BRPI0920959A2 (OSRAM) |
| CA (1) | CA2744012A1 (OSRAM) |
| CO (1) | CO6361935A2 (OSRAM) |
| IL (1) | IL212704A0 (OSRAM) |
| MX (1) | MX2011005369A (OSRAM) |
| RU (1) | RU2011124960A (OSRAM) |
| SG (1) | SG171761A1 (OSRAM) |
| WO (1) | WO2010058512A1 (OSRAM) |
| ZA (1) | ZA201104487B (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2011107227A (ru) * | 2008-07-30 | 2012-09-10 | Онкотерапи Сайенс, Инк. (Jp) | Бензоимидазольные производные и ингибиторы гликоген-синтаза-киназы-3 бета, содержащие такие производные |
| CN101619058A (zh) * | 2009-01-08 | 2010-01-06 | 上海交通大学 | 一种苯并咪唑-4-酰胺型衍生物 |
| CA3134613A1 (en) | 2019-04-02 | 2020-10-08 | Aligos Therapeutics, Inc. | Compounds targeting prmt5 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006515013A (ja) * | 2003-01-23 | 2006-05-18 | クリスタルジェノミクス、インコーポレイテッド | グリコーゲン合成酵素キナーゼ３β活性抑制剤、組成物及びその製造方法 |
| TWI372050B (en) * | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| AU2009310310A1 (en) * | 2008-10-30 | 2010-05-06 | Oncotherapy Science, Inc. | 7-Hydroxy-benzoimidazole-4-yl-methanone Derivatives and PBK inhibitors containing the same |
-
2009
- 2009-09-29 EP EP09827294A patent/EP2358365A4/en not_active Withdrawn
- 2009-09-29 CN CN2009801549899A patent/CN102292083A/zh not_active Withdrawn
- 2009-09-29 MX MX2011005369A patent/MX2011005369A/es unknown
- 2009-09-29 RU RU2011124960/04A patent/RU2011124960A/ru unknown
- 2009-09-29 AU AU2009318719A patent/AU2009318719A1/en not_active Withdrawn
- 2009-09-29 CA CA2744012A patent/CA2744012A1/en not_active Abandoned
- 2009-09-29 BR BRPI0920959A patent/BRPI0920959A2/pt not_active IP Right Cessation
- 2009-09-29 WO PCT/JP2009/004975 patent/WO2010058512A1/en not_active Ceased
- 2009-09-29 KR KR1020117014051A patent/KR20110086750A/ko not_active Withdrawn
- 2009-09-29 US US13/129,361 patent/US20110301146A1/en not_active Abandoned
- 2009-09-29 SG SG2011036282A patent/SG171761A1/en unknown
- 2009-09-29 JP JP2011522179A patent/JP2012509249A/ja not_active Withdrawn
-
2011
- 2011-05-05 IL IL212704A patent/IL212704A0/en unknown
- 2011-05-19 CO CO11061830A patent/CO6361935A2/es not_active Application Discontinuation
- 2011-06-17 ZA ZA2011/04487A patent/ZA201104487B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2011124960A (ru) | 2012-12-27 |
| AU2009318719A1 (en) | 2011-06-30 |
| CO6361935A2 (es) | 2012-01-20 |
| KR20110086750A (ko) | 2011-07-29 |
| ZA201104487B (en) | 2012-03-28 |
| SG171761A1 (en) | 2011-07-28 |
| US20110301146A1 (en) | 2011-12-08 |
| EP2358365A1 (en) | 2011-08-24 |
| WO2010058512A1 (en) | 2010-05-27 |
| CN102292083A (zh) | 2011-12-21 |
| CA2744012A1 (en) | 2010-05-27 |
| BRPI0920959A2 (pt) | 2017-07-11 |
| JP2012509249A (ja) | 2012-04-19 |
| IL212704A0 (en) | 2011-07-31 |
| EP2358365A4 (en) | 2012-05-30 |
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