MX2010011329A - Analogos de insulina especificos de isoforma. - Google Patents

Analogos de insulina especificos de isoforma.

Info

Publication number
MX2010011329A
MX2010011329A MX2010011329A MX2010011329A MX2010011329A MX 2010011329 A MX2010011329 A MX 2010011329A MX 2010011329 A MX2010011329 A MX 2010011329A MX 2010011329 A MX2010011329 A MX 2010011329A MX 2010011329 A MX2010011329 A MX 2010011329A
Authority
MX
Mexico
Prior art keywords
insulin
analogue
isoform
binding
chain
Prior art date
Application number
MX2010011329A
Other languages
English (en)
Inventor
Weiss Michael
Whittaker Jonathan
Original Assignee
Univ Case Western Reserve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Case Western Reserve filed Critical Univ Case Western Reserve
Publication of MX2010011329A publication Critical patent/MX2010011329A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Un método para tratar un mamífero al administrar una cantidad fisiológicamente efectiva de un análogo de insulina o una sal fisiológicamente aceptable del mismo, donde el análogo de insulina exhibe más de dos veces mayor afinidad de enlace a la isoforma de receptor A (IR-A) de insulina que a la isoforma de receptor B (IR-B) de insulina. El análogo de insulina puede ser un análogo de insulina de cadena sencilla o una sal fisiológicamente aceptable del mismo, que contiene una secuencia de cadena A de insulina o un análogo de la misma y una secuencia de cadena B de insulina o un análogo de la misma conectada por un polipéptido de 4-13 aminoácidos. Un análogo de insulina de cadena sencilla puede exhibir mayor enlace de receptor de insulina in vitro a IR-A pero menor enlace a IR-B que la insulina normal mientras que exhibe menor que o igual enlace a IGFR que la insulina normal.
MX2010011329A 2008-04-22 2009-04-22 Analogos de insulina especificos de isoforma. MX2010011329A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4698508P 2008-04-22 2008-04-22
PCT/US2009/041439 WO2009132129A2 (en) 2008-04-22 2009-04-22 Isoform-specific insulin analogues

Publications (1)

Publication Number Publication Date
MX2010011329A true MX2010011329A (es) 2011-03-15

Family

ID=41217411

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010011329A MX2010011329A (es) 2008-04-22 2009-04-22 Analogos de insulina especificos de isoforma.

Country Status (12)

Country Link
US (1) US20110195896A1 (es)
EP (1) EP2296692A4 (es)
JP (1) JP2011521621A (es)
KR (1) KR20110021758A (es)
CN (1) CN102065885A (es)
AU (1) AU2009240636A1 (es)
BR (1) BRPI0911571A2 (es)
CA (1) CA2722168A1 (es)
MX (1) MX2010011329A (es)
NZ (1) NZ588857A (es)
RU (1) RU2010147076A (es)
WO (1) WO2009132129A2 (es)

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JP6829928B2 (ja) * 2014-10-06 2021-02-17 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎ Ｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 二相性単鎖インスリン類似体
JP6898231B6 (ja) 2014-10-29 2021-07-28 ジーランド ファーマ アクティーゼルスカブ Ｇｉｐアゴニスト化合物及び方法
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US10501546B2 (en) 2015-09-04 2019-12-10 The California Institute For Biomedical Research Insulin immunoglobulin fusion proteins
MX2018006103A (es) * 2015-12-23 2018-09-21 Univ Case Western Reserve Encapsulacion de analogos de insulina ultra-estables dentro de materiales fundidos de polimero.
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Also Published As

Publication number Publication date
JP2011521621A (ja) 2011-07-28
WO2009132129A3 (en) 2010-01-21
RU2010147076A (ru) 2012-05-27
WO2009132129A2 (en) 2009-10-29
AU2009240636A1 (en) 2009-10-29
US20110195896A1 (en) 2011-08-11
EP2296692A2 (en) 2011-03-23
EP2296692A4 (en) 2012-06-06
CN102065885A (zh) 2011-05-18
NZ588857A (en) 2012-07-27
BRPI0911571A2 (pt) 2018-04-03
KR20110021758A (ko) 2011-03-04
CA2722168A1 (en) 2009-10-29

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