MX2010003323A - Composiciones de poliplex de quitosana-acido nucleico de alta concentracion. - Google Patents

Composiciones de poliplex de quitosana-acido nucleico de alta concentracion.

Info

Publication number
MX2010003323A
MX2010003323A MX2010003323A MX2010003323A MX2010003323A MX 2010003323 A MX2010003323 A MX 2010003323A MX 2010003323 A MX2010003323 A MX 2010003323A MX 2010003323 A MX2010003323 A MX 2010003323A MX 2010003323 A MX2010003323 A MX 2010003323A
Authority
MX
Mexico
Prior art keywords
nucleic acid
chitosan
high concentration
compositions
methods
Prior art date
Application number
MX2010003323A
Other languages
English (en)
Inventor
Eric C Hsu
Carlos Fleet
Anthony Cheung
Jun Gao
Original Assignee
Engene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Engene Inc filed Critical Engene Inc
Publication of MX2010003323A publication Critical patent/MX2010003323A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La invención provee composiciones y dispersiones de poliplejo de quitosana-ácido nucleico altamente concentradas y métodos para producir las composiciones y dispersiones. Los métodos de mezcla de los poliplejos de quitosana-ácido nucleico incluyen una mezcla en línea de solución de quitosana y solución de ácido nucleico seguida por concentración adicional de la dispersión de poliplejos de quitosana-ácido nucleico, opcionalmente con un inhibidor de agregación. Además, se proveen métodos para alterar el diámetro de los poliplejos de quitosana-ácido nucleico.
MX2010003323A 2007-09-28 2008-09-26 Composiciones de poliplex de quitosana-acido nucleico de alta concentracion. MX2010003323A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97631607P 2007-09-28 2007-09-28
PCT/CA2008/001714 WO2009039657A1 (en) 2007-09-28 2008-09-26 High concentration chitosan-nucleic acid polyplex compositions

Publications (1)

Publication Number Publication Date
MX2010003323A true MX2010003323A (es) 2010-07-28

Family

ID=40510712

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003323A MX2010003323A (es) 2007-09-28 2008-09-26 Composiciones de poliplex de quitosana-acido nucleico de alta concentracion.

Country Status (20)

Country Link
US (3) US8722646B2 (es)
EP (1) EP2195035B1 (es)
JP (2) JP5650533B2 (es)
KR (2) KR101761289B1 (es)
CN (1) CN101873867B (es)
AU (1) AU2008302979B2 (es)
BR (1) BRPI0817725A2 (es)
CA (1) CA2700842C (es)
DK (1) DK2195035T3 (es)
ES (1) ES2660846T3 (es)
IL (1) IL204677A (es)
MX (1) MX2010003323A (es)
NO (1) NO2195035T3 (es)
PL (1) PL2195035T3 (es)
PT (1) PT2195035T (es)
RU (1) RU2010116775A (es)
SG (1) SG187403A1 (es)
SI (1) SI2195035T1 (es)
WO (1) WO2009039657A1 (es)
ZA (1) ZA201002169B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009039657A1 (en) 2007-09-28 2009-04-02 Engene, Inc. High concentration chitosan-nucleic acid polyplex compositions
US20100261780A1 (en) * 2009-03-31 2010-10-14 Engene, Inc. Highly Acidic Chitosan-Nucleic Acid Polyplex Compositions
JP5824527B2 (ja) * 2010-12-07 2015-11-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 供給物混合装置およびその使用
AU2013234795B2 (en) * 2012-03-21 2016-12-22 Engene, Inc. Dually derivatized chitosan nanoparticles and methods of making and using the same for gene transfer in vivo
ITTO20121107A1 (it) * 2012-12-19 2014-06-20 Idea Medical Devices S R L Composizione a base di polidesossiribonucleotidi e relativi usi
DK3049473T3 (da) 2013-09-25 2022-01-03 Engene Inc Dobbeltderivatiserede chitosannanopartikler og fremgangsmåder til fremstilling og anvendelse heraf til genoverførsel in vivo
WO2015125147A1 (en) 2014-02-20 2015-08-27 B. G. Negev Technologies And Applications Ltd Anionic polyplexes for use in the delivery of nucleic acids
US10653768B2 (en) 2015-04-13 2020-05-19 Curevac Real Estate Gmbh Method for producing RNA compositions
KR101710639B1 (ko) * 2016-06-07 2017-03-08 주식회사 파마리서치프로덕트 핵산, 키토산 및 히알루론산을 포함하는 조직 증강용 충전 조성물 및 이의 제조방법
CN109310800B (zh) * 2016-07-29 2022-01-07 医药研究有限公司 包含核酸和壳聚糖的肩袖撕裂修复用组合物
RU2697527C1 (ru) * 2018-06-06 2019-08-15 Федеральное государственное учреждение "Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук" (ФГУ ФИЦ Биотехнологии РАН) Иммуноадъювантная композиция для вакцин против инфекционных агентов вирусной и бактериальной природы
EP3693024A1 (en) * 2019-02-05 2020-08-12 Altona Diagnostics GmbH Control for nucleic acid preparation and/or detection methods

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184037B1 (en) * 1996-05-17 2001-02-06 Genemedicine, Inc. Chitosan related compositions and methods for delivery of nucleic acids and oligonucleotides into a cell
ES2175433T3 (es) * 1996-07-10 2002-11-16 West Pharm Serv Drug Res Ltd Composiciones indicadas para la administracion de genes en celulas epiteliales.
AU2868099A (en) * 1998-02-13 1999-08-30 Selective Genetics, Inc. Concurrent flow mixing methods and apparatuses for the preparation of gene therapy vectors and compositions prepared thereby
EP1104309B8 (en) 1998-08-14 2006-07-05 Valentis Inc. Co-lyophilized complex comprising a nucleic acid vector and a formulating agent
US6251599B1 (en) * 1998-11-06 2001-06-26 Selective Genetics, Inc. Stabilized nucleic acid compositions and methods of preparation and use thereof
DE10141971A1 (de) 2001-08-28 2003-03-27 Siemens Ag Adaptive Kanalschätzung in einem OFDM-basierten Mobilfunksystem durch Variation der Anzahl der Pilotsymbole
EP1306127B2 (en) * 2001-10-26 2011-09-07 OctoPlus PolyActive Sciences B.V. Method for the preparation of purified microparticles
NO317653B1 (no) * 2002-05-03 2004-11-29 Stiftelsen Biopolymer Formulering som omfatter komplekser av kitosanoligomerer og nukleinsyre, fremgangsmate for a fremstille formuleringen samt anvendelser derav.
NO317654B1 (no) * 2002-05-03 2004-11-29 Stiftelsen Biopolymer Formulering som inneholder en nukleinsyre og et kitosan, fremgangsmate for fremstilling av formuleringen, samt anvendelser derav.
KR100613734B1 (ko) * 2004-09-07 2006-08-22 굿젠 주식회사 키토산을 이용한 ｄｎａ 보관방법 및 분석방법 및 이를이용한 ｄｎａ 제품
WO2009039657A1 (en) * 2007-09-28 2009-04-02 Engene, Inc. High concentration chitosan-nucleic acid polyplex compositions

Also Published As

Publication number Publication date
US20180215839A1 (en) 2018-08-02
IL204677A0 (en) 2010-11-30
JP2010540468A (ja) 2010-12-24
EP2195035A1 (en) 2010-06-16
DK2195035T3 (en) 2018-03-12
IL204677A (en) 2016-12-29
KR20150115964A (ko) 2015-10-14
RU2010116775A (ru) 2011-11-10
SI2195035T1 (en) 2018-05-31
US9850323B2 (en) 2017-12-26
ZA201002169B (en) 2011-05-25
CN101873867A (zh) 2010-10-27
EP2195035A4 (en) 2012-02-22
JP5650533B2 (ja) 2015-01-07
CN101873867B (zh) 2015-09-23
ES2660846T3 (es) 2018-03-26
US8722646B2 (en) 2014-05-13
AU2008302979A1 (en) 2009-04-02
BRPI0817725A2 (pt) 2017-05-16
CA2700842A1 (en) 2009-04-02
EP2195035B1 (en) 2017-12-06
PT2195035T (pt) 2018-03-07
KR20100077155A (ko) 2010-07-07
JP2014208696A (ja) 2014-11-06
AU2008302979B2 (en) 2014-09-04
NO2195035T3 (es) 2018-05-05
PL2195035T3 (pl) 2018-07-31
CA2700842C (en) 2016-10-11
WO2009039657A1 (en) 2009-04-02
US20110039917A1 (en) 2011-02-17
SG187403A1 (en) 2013-02-28
KR101761289B1 (ko) 2017-08-04
US20140350091A1 (en) 2014-11-27
US10647785B2 (en) 2020-05-12

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