MX2010001754A - Derivados de azepina como inhibidores de gamma secretasa. - Google Patents
Derivados de azepina como inhibidores de gamma secretasa.Info
- Publication number
- MX2010001754A MX2010001754A MX2010001754A MX2010001754A MX2010001754A MX 2010001754 A MX2010001754 A MX 2010001754A MX 2010001754 A MX2010001754 A MX 2010001754A MX 2010001754 A MX2010001754 A MX 2010001754A MX 2010001754 A MX2010001754 A MX 2010001754A
- Authority
- MX
- Mexico
- Prior art keywords
- gamma
- secretase inhibitors
- azepine derivatives
- azepine
- derivatives
- Prior art date
Links
- 150000001538 azepines Chemical class 0.000 title 1
- 239000003540 gamma secretase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95572007P | 2007-08-14 | 2007-08-14 | |
| PCT/US2008/072049 WO2009023453A1 (en) | 2007-08-14 | 2008-08-04 | Azepine derivatives as gamma-secretase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010001754A true MX2010001754A (es) | 2010-05-14 |
Family
ID=39811736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010001754A MX2010001754A (es) | 2007-08-14 | 2008-08-04 | Derivados de azepina como inhibidores de gamma secretasa. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8188069B2 (OSRAM) |
| EP (1) | EP2178844A1 (OSRAM) |
| JP (1) | JP5385904B2 (OSRAM) |
| KR (1) | KR101136260B1 (OSRAM) |
| CN (1) | CN101778826B (OSRAM) |
| AU (1) | AU2008287124B2 (OSRAM) |
| BR (1) | BRPI0815135A2 (OSRAM) |
| CA (1) | CA2694209C (OSRAM) |
| EA (1) | EA017286B1 (OSRAM) |
| MX (1) | MX2010001754A (OSRAM) |
| WO (1) | WO2009023453A1 (OSRAM) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2669693C (en) | 2006-11-15 | 2018-06-12 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
| CA2743436C (en) | 2008-11-24 | 2017-10-31 | Massachusetts Eye & Ear Infirmary | Pathways to generate hair cells |
| TWI530489B (zh) | 2011-03-22 | 2016-04-21 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯二氮呯酮化合物 |
| WO2013036679A1 (en) * | 2011-09-07 | 2013-03-14 | Satori Pharmaceuticals, Inc. | Compounds useful for treating neurodegenerative disorders |
| CA2884309A1 (en) | 2012-09-07 | 2014-03-13 | Massachusetts Eye And Ear Infirmary | Methods and compositions for regenerating hair cells and/or supporting cells from differentiated cochlear cells or differentiated utricular cells by modulation of notch and cmyc activity |
| HK1211875A1 (en) | 2012-09-07 | 2016-06-03 | Massachusetts Eye & Ear Infirmary | Treating hearing loss |
| CN104822677A (zh) | 2012-09-21 | 2015-08-05 | 百时美施贵宝公司 | 氟烷基-1,4-苯并二氮杂*酮化合物 |
| CN104854094A (zh) | 2012-09-21 | 2015-08-19 | 百时美施贵宝公司 | 氟烷基二苯并二氮杂*酮化合物 |
| CN104797569A (zh) | 2012-09-21 | 2015-07-22 | 百时美施贵宝公司 | 取代的1,5-苯并二氮杂*酮化合物 |
| US9249157B2 (en) | 2012-09-21 | 2016-02-02 | Bristol-Myers Squibb Company | Tricyclic heterocycle compounds |
| WO2014047397A1 (en) | 2012-09-21 | 2014-03-27 | Bristol-Myers Squibb Company | Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds as notch|inhibitors |
| US9242940B2 (en) | 2012-09-21 | 2016-01-26 | Bristol-Myers Squibb Company | N-substituted bis(fluoroalkyl)-1,4-benzodiazepinone compounds |
| US9273075B2 (en) | 2012-09-21 | 2016-03-01 | Bristol-Myers Squibb Company | Prodrugs of 1,4-benzodiazepinone compounds |
| TWI614238B (zh) | 2012-09-21 | 2018-02-11 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥 |
| CN105308030A (zh) | 2012-09-21 | 2016-02-03 | 百时美施贵宝公司 | 烷基、氟烷基-1,4-苯并二氮杂*酮化合物 |
| JP2016515625A (ja) | 2013-04-04 | 2016-05-30 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 増殖性疾患を治療するための併用療法 |
| WO2015073524A1 (en) * | 2013-11-12 | 2015-05-21 | Drexel University | Novel methods of treating or preventing alzheimer's disease |
| US20170314027A1 (en) | 2014-08-06 | 2017-11-02 | Massachusetts Eye And Ear Infirmary | Increasing atoh1 life to drive sensorineural hair cell differentiantion |
| WO2016069906A1 (en) | 2014-10-29 | 2016-05-06 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
| US11185536B2 (en) | 2015-12-04 | 2021-11-30 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
| KR20180117628A (ko) | 2016-01-29 | 2018-10-29 | 매사추세츠 아이 앤드 이어 인퍼머리 | 내이 지지 세포의 확장 및 분화 및 그의 사용 방법 |
| WO2017180385A1 (en) | 2016-04-12 | 2017-10-19 | Eli Lilly And Company | Combination therapy with notch and pi3k/mtor inhibitors for use in treating cancer |
| WO2017180389A1 (en) | 2016-04-12 | 2017-10-19 | Eli Lilly And Company | Combination therapy with notch and cdk4/6 inhibitors for the treatment of cancer |
| KR102362222B1 (ko) | 2016-05-16 | 2022-02-11 | 더 제너럴 하스피탈 코포레이션 | 폐 상피 공학에서 인간 기도 줄기 세포 |
| JP7194022B2 (ja) | 2016-05-20 | 2022-12-21 | イーライ リリー アンド カンパニー | Ｎｏｔｃｈ阻害剤とＰＤ－１またはＰＤ－Ｌ１阻害剤との併用療法 |
| EP3525796A1 (en) | 2016-10-12 | 2019-08-21 | Eli Lilly and Company | Targeted treatment of mature t-cell lymphoma |
| AU2017376109A1 (en) | 2016-12-16 | 2019-07-11 | Pipeline Therapeutics, Inc. | Methods of treating cochlear synaptopathy |
| BR112019017120A8 (pt) | 2017-02-17 | 2023-05-02 | Hutchinson Fred Cancer Res | Terapias de combinação para tratamento de cânceres e distúrbios autoimunes relacionados a bcma |
| EP3615055A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| EP3615068A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| MA50564A (fr) | 2017-11-06 | 2020-09-16 | Hutchinson Fred Cancer Res | Association d'une thérapie cellulaire et d'un inhibiteur de gamma secrétase |
| WO2019148067A1 (en) | 2018-01-26 | 2019-08-01 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss |
| US11492409B2 (en) | 2018-06-01 | 2022-11-08 | Novartis Ag | Binding molecules against BCMA and uses thereof |
| WO2020261093A1 (en) | 2019-06-24 | 2020-12-30 | Novartis Ag | Dosing regimen and combination therapies for multispecific antibodies targeting b-cell maturation antigen |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69739236D1 (de) * | 1996-12-23 | 2009-03-12 | Lilly Co Eli | Cycloalkyl-, lactam-, lacton- und verwandte verbindungen als hemmer der beta-amyloidpeptidfreisetzung |
| US7468365B2 (en) * | 2000-11-17 | 2008-12-23 | Eli Lilly And Company | Lactam compound |
| UA74849C2 (en) | 2000-11-17 | 2006-02-15 | Lilly Co Eli | Lactam |
| TW200502221A (en) | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| US7342007B2 (en) | 2003-03-14 | 2008-03-11 | Astrazeneca Ab | Lactams and uses thereof |
-
2008
- 2008-08-04 US US12/669,048 patent/US8188069B2/en not_active Expired - Fee Related
- 2008-08-04 CN CN2008801030083A patent/CN101778826B/zh not_active Expired - Fee Related
- 2008-08-04 MX MX2010001754A patent/MX2010001754A/es active IP Right Grant
- 2008-08-04 BR BRPI0815135-0A2A patent/BRPI0815135A2/pt not_active IP Right Cessation
- 2008-08-04 JP JP2010521080A patent/JP5385904B2/ja not_active Expired - Fee Related
- 2008-08-04 EA EA201070278A patent/EA017286B1/ru not_active IP Right Cessation
- 2008-08-04 EP EP08827545A patent/EP2178844A1/en not_active Withdrawn
- 2008-08-04 CA CA2694209A patent/CA2694209C/en not_active Expired - Fee Related
- 2008-08-04 AU AU2008287124A patent/AU2008287124B2/en not_active Ceased
- 2008-08-04 WO PCT/US2008/072049 patent/WO2009023453A1/en not_active Ceased
- 2008-08-04 KR KR1020107002906A patent/KR101136260B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2178844A1 (en) | 2010-04-28 |
| JP5385904B2 (ja) | 2014-01-08 |
| AU2008287124B2 (en) | 2013-06-06 |
| US8188069B2 (en) | 2012-05-29 |
| CA2694209C (en) | 2013-09-17 |
| JP2010536766A (ja) | 2010-12-02 |
| EA017286B1 (ru) | 2012-11-30 |
| CN101778826B (zh) | 2012-10-31 |
| CN101778826A (zh) | 2010-07-14 |
| EA201070278A1 (ru) | 2010-06-30 |
| US20100197660A1 (en) | 2010-08-05 |
| WO2009023453A1 (en) | 2009-02-19 |
| KR101136260B1 (ko) | 2012-04-19 |
| BRPI0815135A2 (pt) | 2015-02-03 |
| CA2694209A1 (en) | 2009-02-19 |
| AU2008287124A1 (en) | 2009-02-19 |
| KR20100032924A (ko) | 2010-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2010001754A (es) | Derivados de azepina como inhibidores de gamma secretasa. | |
| MX2009000884A (es) | Derivados de piridizinona. | |
| MY153915A (en) | Organic compounds | |
| MX2011005934A (es) | Compuestos organicos. | |
| GEP20156242B (en) | 2-arylimidazole derivatives as pde10a enzyme inhibitors | |
| AU2010246749A8 (en) | Thiophene derivatives | |
| MY147994A (en) | Azabiphenylaminobenzoic acid derivatives as dhodh inhibitors | |
| AU2009236256A8 (en) | Small molecule inhibitors of the pleckstrin homology domain and methods for using same | |
| MA33803B1 (fr) | Inhibiteur de bromodomaine de benzodiazépine | |
| MY151986A (en) | Adamantyl diamide derivatives and uses of same | |
| SI2134691T1 (sl) | Derivati kvinolina kot PARP in TANK inhibitorji | |
| MX2012006805A (es) | Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa. | |
| MX2012004780A (es) | Inhibidores de akt. | |
| EA201071224A1 (ru) | Ингибиторы limk2, композиции, содержащие их, и способы их применения | |
| TW200745084A (en) | Novel compounds | |
| TW200738653A (en) | Anthranilamide/2-amino-heteroarene carboxamide derivatives | |
| MY149512A (en) | Pyrazolylaminopyridine derivatives useful as kinase inhibitors | |
| MX2010009022A (es) | Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso. | |
| UA99787C2 (en) | Lactams as beta secretase inhibitors | |
| TN2011000207A1 (en) | Akt and p70 s6 kinase inhibitors | |
| TW200738627A (en) | Trialkylsilyl-indoles | |
| SG158091A1 (en) | Imidazoazepinone compounds | |
| MX2010004604A (es) | Derivados de pirazol como inhibidores de 5-lo. | |
| PT1877367E (pt) | Derivados do acetileno | |
| MX2012007253A (es) | Derivados triciclicos y sus usos y composiciones farmaceuticas. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |