MX2010000474A - Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral. - Google Patents

Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral.

Info

Publication number
MX2010000474A
MX2010000474A MX2010000474A MX2010000474A MX2010000474A MX 2010000474 A MX2010000474 A MX 2010000474A MX 2010000474 A MX2010000474 A MX 2010000474A MX 2010000474 A MX2010000474 A MX 2010000474A MX 2010000474 A MX2010000474 A MX 2010000474A
Authority
MX
Mexico
Prior art keywords
akt
compound
subject invention
cell
pkb
Prior art date
Application number
MX2010000474A
Other languages
English (en)
Spanish (es)
Inventor
Said M Sebti
Jin Q Cheng
Mei Sun
Original Assignee
Univ South Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ South Florida filed Critical Univ South Florida
Publication of MX2010000474A publication Critical patent/MX2010000474A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
MX2010000474A 2007-07-12 2008-07-14 Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral. MX2010000474A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94936507P 2007-07-12 2007-07-12
PCT/US2008/069974 WO2009009793A2 (en) 2007-07-12 2008-07-14 Inhibitors of akt/pkb with anti-tumor activity

Publications (1)

Publication Number Publication Date
MX2010000474A true MX2010000474A (es) 2010-06-23

Family

ID=40229514

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010000474A MX2010000474A (es) 2007-07-12 2008-07-14 Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral.

Country Status (10)

Country Link
US (2) US8183249B2 (https=)
EP (1) EP2173352B1 (https=)
JP (1) JP5568471B2 (https=)
KR (1) KR101618037B1 (https=)
CN (1) CN101743007B (https=)
AU (1) AU2008274956B2 (https=)
BR (1) BRPI0815563A2 (https=)
CA (1) CA2695330C (https=)
MX (1) MX2010000474A (https=)
WO (1) WO2009009793A2 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2576765C (en) * 2004-09-03 2013-05-28 Applied Research Systems Ars Holding N.V. Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors
EP2173352B1 (en) * 2007-07-12 2016-09-07 University of South Florida Inhibitors of akt/pkb with anti-tumor activity
EP2300011A4 (en) 2008-05-27 2012-06-20 Dmi Life Sciences Inc THERAPEUTIC PROCESSES AND COMPOUNDS
CA2810844C (en) 2010-09-07 2017-03-21 Dmi Acquisition Corp. Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions
WO2012158197A2 (en) * 2010-11-11 2012-11-22 Lyndor Biosciences L.L.C. Compounds useful as akt/pkb modulators and uses thereof
KR102021157B1 (ko) 2011-04-01 2019-09-11 제넨테크, 인크. Ａｋｔ 억제제 화합물 및 아비라테론의 조합물, 및 사용 방법
EP3617330B1 (en) * 2011-04-01 2023-12-27 Genentech, Inc. Biomarkers for predicting sensitivity to cancer treatments
CN102225067B (zh) * 2011-04-29 2012-10-03 济南环肽医药科技有限公司 一种治疗胃癌的药物组合物
SG10201608087WA (en) 2011-10-10 2016-11-29 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
EP3721884A1 (en) 2011-10-10 2020-10-14 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease with da-dkp (= aspartyl-alanyl diketopiperazine)
CN103841974A (zh) 2011-10-28 2014-06-04 安皮奥制药股份有限公司 鼻炎的治疗
GB201207722D0 (en) * 2012-05-02 2012-06-13 Bergenbio As Method
KR101461626B1 (ko) * 2012-08-02 2014-11-28 서울대학교산학협력단 Ａｋｔ１ 억제제 및 소수성 항암제를 포함하는 항암용 약학적 조성물
WO2014074883A1 (en) * 2012-11-08 2014-05-15 Lyndor Biosciences L.L.C. Novel synthesis of ld101
CA2906864A1 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
CN105764501A (zh) 2013-07-26 2016-07-13 现代化制药公司 改善比生群治疗效益的组合物
US9986375B2 (en) * 2014-02-12 2018-05-29 Google Llc Energy-efficient location determination
CA2958080A1 (en) 2014-08-18 2016-02-25 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
FR3033499A1 (fr) * 2015-03-11 2016-09-16 Centre Leon-Berard Composition pour le traitement des tumeurs neuroendocrines pancreatiques
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
CN114099681B (zh) * 2020-12-04 2023-03-10 周清华 Akt/stat3作为免疫检查点抑制剂的靶点的用途
EP4486390A1 (en) * 2022-03-02 2025-01-08 Terremoto Biosciences, Inc Covalent modifiers of akt1 and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) * 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) * 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US5167649A (en) 1988-08-22 1992-12-01 Zook Gerald P Drug delivery system for the removal of dermal lesions
US4938949A (en) * 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
JP4407008B2 (ja) * 2000-05-11 2010-02-03 パナソニック株式会社 カラー画像形成装置
UA72612C2 (en) * 2000-07-06 2005-03-15 Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
AU2003232071A1 (en) * 2002-05-06 2003-11-17 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis c virus infection
AU2005228410A1 (en) * 2004-03-29 2005-10-13 University Of South Florida Effective treatment of tumors and cancer with triciribine and related compounds
WO2008094321A2 (en) * 2006-10-04 2008-08-07 Universtiy Of South Florida Akt sensitization of cancer cells
EP2173352B1 (en) * 2007-07-12 2016-09-07 University of South Florida Inhibitors of akt/pkb with anti-tumor activity

Also Published As

Publication number Publication date
AU2008274956A1 (en) 2009-01-15
JP2010533206A (ja) 2010-10-21
US9359347B2 (en) 2016-06-07
AU2008274956B2 (en) 2014-08-21
KR101618037B1 (ko) 2016-05-04
WO2009009793A2 (en) 2009-01-15
US20090028855A1 (en) 2009-01-29
BRPI0815563A2 (pt) 2015-02-18
CA2695330A1 (en) 2009-01-15
EP2173352A4 (en) 2011-07-27
US8183249B2 (en) 2012-05-22
EP2173352A2 (en) 2010-04-14
EP2173352B1 (en) 2016-09-07
JP5568471B2 (ja) 2014-08-06
CN101743007B (zh) 2015-04-08
KR20100066438A (ko) 2010-06-17
US20130034598A1 (en) 2013-02-07
CN101743007A (zh) 2010-06-16
CA2695330C (en) 2017-06-13
WO2009009793A3 (en) 2009-03-26

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