MX2009007865A - Combinaciones de benzotiazolona agonista de receptores adrenergicos beta 2. - Google Patents

Combinaciones de benzotiazolona agonista de receptores adrenergicos beta 2.

Info

Publication number
MX2009007865A
MX2009007865A MX2009007865A MX2009007865A MX2009007865A MX 2009007865 A MX2009007865 A MX 2009007865A MX 2009007865 A MX2009007865 A MX 2009007865A MX 2009007865 A MX2009007865 A MX 2009007865A MX 2009007865 A MX2009007865 A MX 2009007865A
Authority
MX
Mexico
Prior art keywords
antagonist
inhibitor
bromide
azoniabicyclo
hydroxy
Prior art date
Application number
MX2009007865A
Other languages
English (en)
Inventor
Stephen Connolly
Elaine Bridget Cadogan
David John Nicholls
Katherine Elisabeth Wiley
Alan Young
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2009007865A publication Critical patent/MX2009007865A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/428Thiazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención estipula un producto farmacéutico que comprende un primer principio activo que es N-[2-(dietilamino)etil]-N-(2-{[2-(4 -hidroxi-2-oxo-2,3-dihidro-l,3-benzotiazol-7-il)etil]amino}etil)3 [2-(1-naftil)etoxi]propanamida o una de sus sales y un segundo principio activo seleccionado entre: un agonista no esteroide del receptor de glucocorticoides (receptor GR); un antioxidante; un antagonista de CCR1; un antagonista de receptores de quimiocinas (no CCR1); un corticosteroide; un antagonista de CRTh2; un antagonista de DP1; un inductor de histona deacetilasa; un inhibidor de IKK2; un inhibidor de COX; un inhibidor de lipoxigenasa; un antagonista de receptores de leucotrienos; un inhibidor de MPO; un antagonista muscarínico que es bromuro de aclidinio, glicopirrolato, bromuro de oxitropio, pirenzepina, telenzepina, bromuro de tiotropio, bromuro de 3(R)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azon iabiciclo[2.2.2]octano, bromuro de 3(R)-1-fenetil-3-(9H-xanteno-9- carboniloxi)-1-azoniabiciclo[2.2.2]octano o bromuro de (3R)-3-[(2S)-2-ciclopentil-2-hidroxi-2-tien-2-ilacetoxi]-1-(2-fen oxietil)-1-azoniabiciclo[2.2.2]octano; un inhibidor de p38; un inhibidor de PDE; un agonista de PPAR; un inhibidor de proteasas; una estatina; un antagonista de trornboxanos; un vasodilatador; o un bloqueador de ENaC (bloqueador de canales epiteliales de sodio); y su uso en el tratamiento de una enfermedad respiratoria.
MX2009007865A 2007-02-08 2008-02-06 Combinaciones de benzotiazolona agonista de receptores adrenergicos beta 2. MX2009007865A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0702456.5A GB0702456D0 (en) 2007-02-08 2007-02-08 New combination
PCT/GB2008/000386 WO2008096111A1 (en) 2007-02-08 2008-02-06 Combinations of beta- 2 -adrenoceptor agonistic benzothiazolone

Publications (1)

Publication Number Publication Date
MX2009007865A true MX2009007865A (es) 2009-07-31

Family

ID=37898976

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009007865A MX2009007865A (es) 2007-02-08 2008-02-06 Combinaciones de benzotiazolona agonista de receptores adrenergicos beta 2.

Country Status (29)

Country Link
US (2) US20100029732A1 (es)
EP (2) EP2117542B1 (es)
JP (1) JP2010518056A (es)
KR (1) KR20090114391A (es)
CN (1) CN101652137A (es)
AR (1) AR065277A1 (es)
AT (1) ATE520401T1 (es)
AU (1) AU2008212713A1 (es)
BR (1) BRPI0806964A2 (es)
CA (1) CA2675465A1 (es)
CL (1) CL2008000379A1 (es)
CO (1) CO6210723A2 (es)
CY (1) CY1111932T1 (es)
DK (1) DK2117542T3 (es)
EC (1) ECSP099567A (es)
ES (1) ES2368967T3 (es)
GB (1) GB0702456D0 (es)
HR (1) HRP20110695T1 (es)
IL (1) IL199840A0 (es)
MX (1) MX2009007865A (es)
PE (1) PE20081759A1 (es)
PL (1) PL2117542T3 (es)
PT (1) PT2117542E (es)
RS (1) RS51956B (es)
RU (1) RU2009133255A (es)
SI (1) SI2117542T1 (es)
TW (1) TW200843750A (es)
UY (1) UY30906A1 (es)
WO (1) WO2008096111A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200738658A (en) 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
TW200738659A (en) * 2005-08-29 2007-10-16 Astrazeneca Ab Novel compounds
TW200745067A (en) 2006-03-14 2007-12-16 Astrazeneca Ab Novel compounds
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
TW200833670A (en) 2006-12-20 2008-08-16 Astrazeneca Ab Novel compounds 569
GB0702458D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab Salts 668
BRPI0822693A2 (pt) 2008-05-13 2015-07-07 Astrazeneca Ab Derivados de quinuclidina como antagonistas do receptor muscarínico m3
BRPI0912657A2 (pt) * 2008-05-13 2016-01-26 Astrazeneca Ab produto farmacêutico compreendendo um antagonista de receptor muscarínico e um agonista beta2-adrenorreceptor
EP2303873A4 (en) 2008-06-18 2012-01-04 Astrazeneca Ab BENZOXAZINE DERIVATIVES AS A BETA2 ADRENORE RECEPTOR AGONIST FOR THE TREATMENT OF RESPIRATORY DISEASES
CN102131505A (zh) * 2008-06-20 2011-07-20 阿斯利康(瑞典)有限公司 用于调节β2-肾上腺素受体活性的包含4-羟基-2-氧代-2,3-二氢-1,3-苯并噻唑-7-基化合物的药物组合物
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
US9827212B2 (en) 2009-03-18 2017-11-28 The Trustees Of The University Of Pennsylvania Compositions and methods for treating asthma and other lung diseases
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
HUE044653T2 (hu) 2009-07-22 2019-11-28 PureTech Health LLC Készítmények olyan rendellenességek kezelésére, amelyek muszkarin-receptor aktiválással enyhíthetõk
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
WO2016038116A1 (en) 2014-09-09 2016-03-17 Vectura Limited Formulation comprising glycopyrrolate, method and apparatus
EA032221B1 (ru) * 2015-05-04 2019-04-30 Астразенека Аб Производные пиразола, пригодные в качестве ингибиторов белка, активирующего 5-липоксигеназу (flap)
CA3180743A1 (en) 2018-09-28 2020-04-02 Karuna Therapeutics, Inc. Composition comprising xanomeline and trospium for treating disorders ameliorated by muscarinic receptor activation

Family Cites Families (17)

* Cited by examiner, † Cited by third party
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SE378109B (es) 1972-05-19 1975-08-18 Bofors Ab
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
CO5300399A1 (es) 2000-02-25 2003-07-31 Astrazeneca Ab Heterocicliocs que contienen nitrogeno, proceso para su preparacion y composiciones farmaceuticas que los contienen
AR028948A1 (es) 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
SE0100902D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0104251D0 (sv) 2001-12-14 2001-12-14 Astrazeneca Ab Novel compounds
SE0301569D0 (sv) 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SA04250253B1 (ar) 2003-08-21 2009-11-10 استرازينيكا ايه بي احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
SE0302486D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
GB0324790D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Amide derivatives
GB0402797D0 (en) * 2004-02-09 2004-03-10 Novartis Ag Organic compounds
SE0401762D0 (sv) 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
CA2583428A1 (en) 2004-09-03 2006-03-09 Plexxikon, Inc. Bicyclic heteroaryl pde4b inhibitors
AU2005300150A1 (en) 2004-10-29 2006-05-04 Astrazeneca Ab Novel sulphonamide derivatives as glucocorticoid receptor modulators for the treatment of inflammatory diseases
US20090012051A1 (en) 2005-03-15 2009-01-08 Kyowa Hakko Kogyo Co., Ltd. External preparation
TW200738658A (en) * 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
TW200821316A (en) 2006-07-19 2008-05-16 Astrazeneca Ab Novel compounds 243

Also Published As

Publication number Publication date
US20080242649A1 (en) 2008-10-02
BRPI0806964A2 (pt) 2014-04-08
CO6210723A2 (es) 2010-10-20
JP2010518056A (ja) 2010-05-27
RS51956B (en) 2012-02-29
ATE520401T1 (de) 2011-09-15
AU2008212713A1 (en) 2008-08-14
ECSP099567A (es) 2009-09-29
KR20090114391A (ko) 2009-11-03
AR065277A1 (es) 2009-05-27
PL2117542T3 (pl) 2011-12-30
EP2117542B1 (en) 2011-08-17
CL2008000379A1 (es) 2008-10-24
RU2009133255A (ru) 2011-03-20
EP2364704A1 (en) 2011-09-14
PT2117542E (pt) 2011-10-06
UY30906A1 (es) 2008-09-30
CA2675465A1 (en) 2008-08-14
HRP20110695T1 (hr) 2011-11-30
DK2117542T3 (da) 2011-10-31
WO2008096111A1 (en) 2008-08-14
GB0702456D0 (en) 2007-03-21
IL199840A0 (en) 2010-04-15
CY1111932T1 (el) 2015-11-04
PE20081759A1 (es) 2009-01-31
US20100029732A1 (en) 2010-02-04
TW200843750A (en) 2008-11-16
CN101652137A (zh) 2010-02-17
ES2368967T3 (es) 2011-11-24
SI2117542T1 (sl) 2011-11-30
EP2117542A1 (en) 2009-11-18

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