MX2009004697A - Metodos de control de calidad para las emulsiones aceite en agua que contienen escualeno. - Google Patents
Metodos de control de calidad para las emulsiones aceite en agua que contienen escualeno.Info
- Publication number
- MX2009004697A MX2009004697A MX2009004697A MX2009004697A MX2009004697A MX 2009004697 A MX2009004697 A MX 2009004697A MX 2009004697 A MX2009004697 A MX 2009004697A MX 2009004697 A MX2009004697 A MX 2009004697A MX 2009004697 A MX2009004697 A MX 2009004697A
- Authority
- MX
- Mexico
- Prior art keywords
- oil
- water emulsions
- quality control
- control methods
- squalene
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/21—Hydrocarbon
- Y10T436/214—Acyclic [e.g., methane, octane, isoparaffin, etc.]
- Y10T436/216—Unsaturated [e.g., ethylene, diene, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Colloid Chemistry (AREA)
- Edible Oils And Fats (AREA)
- General Factory Administration (AREA)
- Steering-Linkage Mechanisms And Four-Wheel Steering (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Las mediciones del contenido de escualeno de las emulsiones aceite en agua pueden ser utilizadas como una manera para verificar los problemas durante la producción. En particular, se ha encontrado que una caída en el contenido de escualeno puede indicar que ocurrieron problemas de filtración. La prueba del contenido de escualeno en los lotes finales es más fácil de investigar que las características del filtro, y así pues un ensayo de escualeno simplifica el control de calidad en las emulsiones aceite en agua.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0622282.2A GB0622282D0 (en) | 2006-11-08 | 2006-11-08 | Quality control methods |
PCT/IB2007/004229 WO2008056263A2 (en) | 2006-11-08 | 2007-11-06 | Quality control methods for oil-in-water emulsions containing squalene |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009004697A true MX2009004697A (es) | 2009-05-21 |
Family
ID=37594567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009004697A MX2009004697A (es) | 2006-11-08 | 2007-11-06 | Metodos de control de calidad para las emulsiones aceite en agua que contienen escualeno. |
Country Status (26)
Country | Link |
---|---|
US (2) | US8562943B2 (es) |
EP (2) | EP2029170B1 (es) |
JP (1) | JP2010509202A (es) |
KR (1) | KR20090083448A (es) |
CN (1) | CN101534856A (es) |
AT (1) | ATE446770T1 (es) |
AU (1) | AU2007319006B2 (es) |
BR (1) | BRPI0718858A2 (es) |
CA (1) | CA2668854C (es) |
CY (1) | CY1110248T1 (es) |
DE (1) | DE602007003021D1 (es) |
DK (1) | DK2029170T3 (es) |
EA (1) | EA200900665A1 (es) |
ES (1) | ES2335160T3 (es) |
GB (1) | GB0622282D0 (es) |
HK (1) | HK1126148A1 (es) |
HR (1) | HRP20100046T1 (es) |
IL (1) | IL198084A0 (es) |
MX (1) | MX2009004697A (es) |
NO (1) | NO20092137L (es) |
PL (1) | PL2029170T3 (es) |
PT (1) | PT2029170E (es) |
RS (1) | RS51214B (es) |
SI (1) | SI2029170T1 (es) |
WO (1) | WO2008056263A2 (es) |
ZA (1) | ZA200902870B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0622282D0 (en) * | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
EP2291194B1 (en) * | 2008-06-25 | 2017-02-22 | Braasch Biotech LLC | Compositions and methods for enhanced somatostatin immunogenicity |
CA2735404C (en) * | 2008-08-28 | 2013-04-16 | Novartis Ag | Production of squalene from hyper-producing yeasts |
WO2010103022A2 (en) * | 2009-03-12 | 2010-09-16 | Sanofi Pasteur | Oil-in-water adjuvanted influenza vaccine |
DE102009056883B4 (de) | 2009-12-03 | 2012-08-16 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
DE102009056884B4 (de) | 2009-12-03 | 2021-03-18 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
CA2780425C (en) | 2009-12-03 | 2014-02-04 | Novartis Ag | Hydrophilic filtration during manufacture of vaccine adjuvants |
DE102009056871A1 (de) | 2009-12-03 | 2011-06-22 | Novartis AG, 4056 | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
MX2012006216A (es) | 2009-12-03 | 2012-07-12 | Novartis Ag | Circulacion de componentes durante la homogenizacion de emulsiones. |
DK2380558T4 (da) | 2009-12-03 | 2020-01-27 | Novartis Ag | Arrangement af interaktions- og modtrykskamre til mikrofluidisering |
UA110103C2 (uk) | 2010-01-27 | 2015-11-25 | Ґлаксосмітклайн Байолоджікалз С.А. | Модифікований туберкульозний антиген |
JP5946188B2 (ja) * | 2010-05-12 | 2016-07-05 | ノバルティス アーゲー | スクアレンを調製するための改良された方法 |
GB201009676D0 (en) | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
GB201009671D0 (en) * | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
GB201009673D0 (en) * | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
US20130210823A1 (en) | 2010-06-25 | 2013-08-15 | Syngenta Participations Ag | Methods for controlling mites |
JP6345603B2 (ja) | 2012-03-08 | 2018-06-20 | ノバルティス アーゲー | 追加免疫ワクチンのアジュバント化された処方物 |
CN104602705A (zh) | 2012-09-06 | 2015-05-06 | 诺华股份有限公司 | 血清组b脑膜炎球菌和d/t/p的联合疫苗 |
SG11201502599TA (en) | 2012-10-12 | 2015-05-28 | Glaxosmithkline Biolog Sa | Non-cross-linked acellular pertussis antigens for use in combination vaccines |
CN105007935A (zh) | 2012-12-18 | 2015-10-28 | 葛兰素史密丝克莱恩生物有限公司 | 用于保护免于白喉和/或破伤风的缀合物 |
EP3226904B1 (en) | 2014-12-02 | 2019-03-06 | Novartis AG | Manufacture of surfactant-containing compositions |
CN104531349A (zh) * | 2015-01-23 | 2015-04-22 | 上海交通大学 | 一种降低油脂加工中3-氯-1,2-丙二醇酯的方法 |
JP6992057B2 (ja) | 2016-06-10 | 2022-01-13 | クラリティ コスメティックス インコーポレイテッド | 非面皰形成性の毛髪および頭皮ケア製剤ならびにその使用方法 |
KR101717281B1 (ko) * | 2016-08-19 | 2017-03-16 | 제주대학교 산학협력단 | 스쿠티카증에 대한 어류 복합 백신 조성물 |
CN107462729B (zh) * | 2017-08-10 | 2018-11-23 | 迈克生物股份有限公司 | 一种载脂蛋白a1检测试剂盒及检测方法 |
CN107462730B (zh) * | 2017-08-10 | 2018-10-12 | 迈克生物股份有限公司 | 一种补体c4检测试剂盒及检测方法 |
JP2023532944A (ja) | 2020-06-30 | 2023-08-01 | セキラス ユーケー リミテッド | 水中油型エマルジョンアジュバントの低温濾過 |
CN112213438A (zh) * | 2020-10-12 | 2021-01-12 | 青岛易邦生物工程有限公司 | 一种灭活疫苗佐剂白油检验方法 |
CN113842455B (zh) * | 2021-08-27 | 2022-05-13 | 北京康乐卫士生物技术股份有限公司 | 一种新型冠状病毒疫苗的佐剂及其应用和新型冠状病毒二价重组疫苗 |
WO2024126194A1 (en) * | 2022-12-12 | 2024-06-20 | Evonik Operations Gmbh | Process for obtaining plant-based squalene |
CN118059227A (zh) * | 2024-04-22 | 2024-05-24 | 江苏瑞科生物技术股份有限公司 | 一种水包油乳剂在制备狂犬病免疫套装中的应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
US5718904A (en) * | 1995-06-02 | 1998-02-17 | American Home Products Corporation | Adjuvants for viral vaccines |
AU8298298A (en) * | 1997-07-08 | 1999-02-08 | Chiron Corporation | Use of submicron oil-in-water emulsions with dna vaccines |
CN1399539A (zh) | 1999-09-24 | 2003-02-26 | 史密丝克莱恩比彻姆生物有限公司 | 含有聚氧乙烯烷基醚或聚氧乙烯烷基酯以及至少一种非离子表面活性剂的佐剂 |
GB9923176D0 (en) * | 1999-09-30 | 1999-12-01 | Smithkline Beecham Biolog | Novel composition |
PL362964A1 (en) * | 2000-10-02 | 2004-11-02 | Glaxosmithkline Biologicals S.A. | Vaccine |
US6861410B1 (en) * | 2002-03-21 | 2005-03-01 | Chiron Corporation | Immunological adjuvant compositions |
GB0428394D0 (en) * | 2004-12-24 | 2005-02-02 | Chiron Srl | Saccharide conjugate vaccines |
AR053833A1 (es) * | 2005-03-23 | 2007-05-23 | Glaxosmithkline Biolog Sa | Composicion inmunogenetica |
AR054822A1 (es) * | 2005-07-07 | 2007-07-18 | Sanofi Pasteur | Emulsion inmuno adyuvante |
GB0622282D0 (en) * | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
-
2006
- 2006-11-08 GB GBGB0622282.2A patent/GB0622282D0/en not_active Ceased
-
2007
- 2007-11-06 DK DK07859275.5T patent/DK2029170T3/da active
- 2007-11-06 KR KR1020097011625A patent/KR20090083448A/ko not_active Application Discontinuation
- 2007-11-06 EA EA200900665A patent/EA200900665A1/ru unknown
- 2007-11-06 CN CNA2007800411435A patent/CN101534856A/zh active Pending
- 2007-11-06 ES ES07859275T patent/ES2335160T3/es active Active
- 2007-11-06 BR BRPI0718858-7A2A patent/BRPI0718858A2/pt not_active IP Right Cessation
- 2007-11-06 SI SI200730094T patent/SI2029170T1/sl unknown
- 2007-11-06 PT PT07859275T patent/PT2029170E/pt unknown
- 2007-11-06 EP EP07859275A patent/EP2029170B1/en not_active Revoked
- 2007-11-06 RS RSP-2010/0022A patent/RS51214B/sr unknown
- 2007-11-06 US US12/312,629 patent/US8562943B2/en active Active
- 2007-11-06 EP EP09075409A patent/EP2218460A3/en not_active Withdrawn
- 2007-11-06 WO PCT/IB2007/004229 patent/WO2008056263A2/en active Application Filing
- 2007-11-06 PL PL07859275T patent/PL2029170T3/pl unknown
- 2007-11-06 JP JP2009535148A patent/JP2010509202A/ja active Pending
- 2007-11-06 DE DE602007003021T patent/DE602007003021D1/de active Active
- 2007-11-06 AU AU2007319006A patent/AU2007319006B2/en not_active Ceased
- 2007-11-06 AT AT07859275T patent/ATE446770T1/de active
- 2007-11-06 CA CA2668854A patent/CA2668854C/en active Active
- 2007-11-06 MX MX2009004697A patent/MX2009004697A/es active IP Right Grant
-
2009
- 2009-04-07 IL IL198084A patent/IL198084A0/en unknown
- 2009-04-24 ZA ZA200902870A patent/ZA200902870B/xx unknown
- 2009-06-02 HK HK09104924.4A patent/HK1126148A1/xx not_active IP Right Cessation
- 2009-06-03 NO NO20092137A patent/NO20092137L/no not_active Application Discontinuation
- 2009-12-21 CY CY20091101322T patent/CY1110248T1/el unknown
-
2010
- 2010-01-27 HR HR20100046T patent/HRP20100046T1/hr unknown
-
2013
- 2013-08-27 US US14/011,258 patent/US9744231B2/en active Active
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Legal Events
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FG | Grant or registration |