MX2009004053A - 1,5-difenil-3-piridinilamino-1,5-dihidropirrolidin-2-ona como modulador de receptor de cb1. - Google Patents

1,5-difenil-3-piridinilamino-1,5-dihidropirrolidin-2-ona como modulador de receptor de cb1.

Info

Publication number
MX2009004053A
MX2009004053A MX2009004053A MX2009004053A MX2009004053A MX 2009004053 A MX2009004053 A MX 2009004053A MX 2009004053 A MX2009004053 A MX 2009004053A MX 2009004053 A MX2009004053 A MX 2009004053A MX 2009004053 A MX2009004053 A MX 2009004053A
Authority
MX
Mexico
Prior art keywords
forumla
antipsychotics
blockade
schizophrenia
mammals
Prior art date
Application number
MX2009004053A
Other languages
English (en)
Spanish (es)
Inventor
Perry Clark Heath
John Mehnert Schaus
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2009004053A publication Critical patent/MX2009004053A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MX2009004053A 2006-10-23 2007-10-22 1,5-difenil-3-piridinilamino-1,5-dihidropirrolidin-2-ona como modulador de receptor de cb1. MX2009004053A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86254006P 2006-10-23 2006-10-23
PCT/US2007/082041 WO2008070305A2 (en) 2006-10-23 2007-10-22 1, 5-diphenyl-3-pyridinylamino-1, 5-dihydropyrrolidin-2-one as cbl' receptor modulator

Publications (1)

Publication Number Publication Date
MX2009004053A true MX2009004053A (es) 2009-04-27

Family

ID=39386481

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2009004054A MX2009004054A (es) 2006-10-23 2007-10-22 1,5-difenil-3-bencilamino-1,5-dihidropirrolidin-2-ona como moduladores de receptor de cb1.
MX2009004053A MX2009004053A (es) 2006-10-23 2007-10-22 1,5-difenil-3-piridinilamino-1,5-dihidropirrolidin-2-ona como modulador de receptor de cb1.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2009004054A MX2009004054A (es) 2006-10-23 2007-10-22 1,5-difenil-3-bencilamino-1,5-dihidropirrolidin-2-ona como moduladores de receptor de cb1.

Country Status (23)

Country Link
US (2) US7998985B2 (OSRAM)
EP (2) EP2099784B1 (OSRAM)
JP (2) JP5331002B2 (OSRAM)
KR (2) KR101088229B1 (OSRAM)
CN (2) CN101528733B (OSRAM)
AR (1) AR063497A1 (OSRAM)
AT (1) ATE492543T1 (OSRAM)
AU (1) AU2007329808B2 (OSRAM)
BR (1) BRPI0717347A2 (OSRAM)
CA (2) CA2667372C (OSRAM)
CL (1) CL2007003002A1 (OSRAM)
CY (1) CY1111140T1 (OSRAM)
DE (1) DE602007011495D1 (OSRAM)
DK (2) DK2099784T3 (OSRAM)
EA (2) EA015175B1 (OSRAM)
ES (2) ES2356025T3 (OSRAM)
MX (2) MX2009004054A (OSRAM)
PE (1) PE20080926A1 (OSRAM)
PL (2) PL2099784T3 (OSRAM)
PT (2) PT2099784E (OSRAM)
SI (2) SI2099784T1 (OSRAM)
TW (1) TW200825067A (OSRAM)
WO (2) WO2008070306A2 (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20080926A1 (es) * 2006-10-23 2008-07-19 Lilly Co Eli Compuestos cb1
EA201071222A1 (ru) * 2008-04-22 2011-12-30 Эли Лилли Энд Компани Соединения 1,5-дифенилпирролидин-2-она в качестве лигандов cb-1
PL2280961T3 (pl) 2008-04-22 2012-12-31 Lilly Co Eli Związki 1,5-difenylo-pirolidyn-2-onu jako ligandy CB-1
US20110280813A1 (en) * 2008-11-13 2011-11-17 Alice Prince Neuraminidase inhibitors and uses thereof
DE112011102349T5 (de) * 2010-07-15 2013-04-18 Oleg Iliich Epshtein Pharmazeutische Zusammensetzung und Behandlungsverfahren
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2022132803A1 (en) * 2020-12-14 2022-06-23 The Board Of Trustees Of The Leland Stanford Junior University Cb2 receptor agonists
WO2023205180A1 (en) 2022-04-19 2023-10-26 Nurix Therapeutics, Inc. Biomarkers for cbl, and compositions and methods for their use
US20230414598A1 (en) 2022-06-22 2023-12-28 Nurix Therapeutics, Inc. Combination therapies with cbl-b inhibitor compounds and antiemetic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200533657A (en) 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
KR20060131908A (ko) * 2004-02-19 2006-12-20 솔베이 파마슈티칼스 비. 브이 Ｃｂ1-길항 활성을 갖는 이미다졸린 유도체
US20060035245A1 (en) * 2004-04-20 2006-02-16 Ason Brandon L Modulators of enzymatic nucleic acid elements mobilization
WO2007020502A2 (en) * 2005-08-16 2007-02-22 Pharmacia & Upjohn Company Llc Cannabinoid receptor ligands and uses thereof
PE20080926A1 (es) * 2006-10-23 2008-07-19 Lilly Co Eli Compuestos cb1

Also Published As

Publication number Publication date
ES2356025T3 (es) 2011-04-04
EP2094684A2 (en) 2009-09-02
ATE492543T1 (de) 2011-01-15
JP2010507590A (ja) 2010-03-11
DK2094684T3 (da) 2011-03-14
EP2094684B1 (en) 2010-12-22
PL2099784T3 (pl) 2013-05-31
DK2099784T3 (da) 2013-01-14
WO2008070305A2 (en) 2008-06-12
TW200825067A (en) 2008-06-16
KR101088229B1 (ko) 2011-11-30
US7998985B2 (en) 2011-08-16
KR101088236B1 (ko) 2011-11-30
JP5331001B2 (ja) 2013-10-30
CA2667372A1 (en) 2008-06-12
PL2094684T3 (pl) 2011-05-31
PT2099784E (pt) 2013-01-04
SI2099784T1 (sl) 2013-02-28
AR063497A1 (es) 2009-01-28
CN101528733A (zh) 2009-09-09
PE20080926A1 (es) 2008-07-19
WO2008070305A3 (en) 2008-08-28
MX2009004054A (es) 2009-04-27
KR20090069316A (ko) 2009-06-30
PT2094684E (pt) 2011-01-28
US20100016375A1 (en) 2010-01-21
KR20090071613A (ko) 2009-07-01
EP2099784B1 (en) 2012-12-12
CN101528733B (zh) 2013-10-16
CA2667372C (en) 2013-09-03
WO2008070306A2 (en) 2008-06-12
JP2010507589A (ja) 2010-03-11
CL2007003002A1 (es) 2008-06-06
AU2007329807A1 (en) 2008-06-12
EP2099784A2 (en) 2009-09-16
CA2667210A1 (en) 2008-06-12
EA200970404A1 (ru) 2009-10-30
WO2008070306A3 (en) 2008-07-31
AU2007329808A1 (en) 2008-06-12
CN101528732A (zh) 2009-09-09
DE602007011495D1 (de) 2011-02-03
US8168659B2 (en) 2012-05-01
EA015175B1 (ru) 2011-06-30
EA015745B1 (ru) 2011-10-31
BRPI0717347A2 (pt) 2014-01-14
US20090275618A1 (en) 2009-11-05
JP5331002B2 (ja) 2013-10-30
CA2667210C (en) 2013-09-24
AU2007329808B2 (en) 2013-11-07
SI2094684T1 (sl) 2011-04-29
ES2398388T3 (es) 2013-03-15
CY1111140T1 (el) 2015-06-11
EA200970405A1 (ru) 2009-12-30
CN101528732B (zh) 2013-04-03

Similar Documents

Publication Publication Date Title
MX2009004053A (es) 1,5-difenil-3-piridinilamino-1,5-dihidropirrolidin-2-ona como modulador de receptor de cb1.
MX2010010407A (es) Derivados de 4-aminociclohexanos sustituidos.
CL2012000707A1 (es) Compuestos derivados de [5-(pirrolo[1,2-c][1.2.3]triazin-7-il)tetrahidrofuran-2-il]metanol; composición farmacéutica; y su uso para el tratamiento de la hepatitis c.
ME01532B (me) Jedinjenja
UA103616C2 (ru) Замещенные гамма-лактамы как терапевтические агенты
MY154909A (en) Novel thiophene derivatives
MX2009005252A (es) Aminopirrolidinas como antagonistas del receptor de quimiocina.
WO2007133802A3 (en) Pharmaceutical formulations of pimavanserin
TW200640867A (en) Pyridine-3-carboxamide derivatives as CB1 inverse agonists
MY181898A (en) Heterocyclic compounds and uses thereof
PL1979355T3 (pl) Pochodne spiro imidazoli jako modulatory PPAR
EP3542629A3 (en) Dithiol compounds, derivatives, and uses therefor
GB0812642D0 (en) Compounds
IL192948A0 (en) Novel pyridine derivatives
IL195256A0 (en) Compositions of r(+)and s(-)pramipexole and methods of using the same
EA201071234A1 (ru) Производные изохинолинона в качестве nk3 антагонистов
MX2009003129A (es) Derivados de oxadiazol con propiedades anti-inflamatorias e inmunosupresoras.
MX2008013196A (es) 5-amido-2-carboxiamida-indoles.
WO2008113559A3 (en) Indolizines and aza-analog derivatives thereof as cns active compounds
IL193479A0 (en) Modulators of muscarinic receptors
TW200736233A (en) Cyclohexyl piperazinyl methanone derivatives
IN2012DN02556A (OSRAM)
TW200942534A (en) Organic compounds
TW200942535A (en) Novel compounds as cannabinoid receptor ligands
MX2012004264A (es) Derivados de sulfoxidos para el tratamiento de tumores.

Legal Events

Date Code Title Description
FG Grant or registration