MX2008014958A - Nuevos derivados de benzotiazinona y su uso como agentes antibacterianos. - Google Patents
Nuevos derivados de benzotiazinona y su uso como agentes antibacterianos.Info
- Publication number
- MX2008014958A MX2008014958A MX2008014958A MX2008014958A MX2008014958A MX 2008014958 A MX2008014958 A MX 2008014958A MX 2008014958 A MX2008014958 A MX 2008014958A MX 2008014958 A MX2008014958 A MX 2008014958A MX 2008014958 A MX2008014958 A MX 2008014958A
- Authority
- MX
- Mexico
- Prior art keywords
- saturated
- independently
- unsaturated
- antibacterial agents
- cycloalkyl
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- MJNPHLBKHKJDEF-UHFFFAOYSA-N 2h-1$l^{4},2-benzothiazine 1-oxide Chemical class C1=CC=C2S(=O)NC=CC2=C1 MJNPHLBKHKJDEF-UHFFFAOYSA-N 0.000 title 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 201000008827 tuberculosis Diseases 0.000 abstract 2
- UJVBZCCNLAAMOV-UHFFFAOYSA-N 2h-1,2-benzothiazine Chemical class C1=CC=C2C=CNSC2=C1 UJVBZCCNLAAMOV-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 206010024229 Leprosy Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Abstract
Derivados novedosos de benzotiazina de la fórmula (I) y su uso como agentes antibacterianos en enfermedades infecciosas producidas por bacterias, especialmente tuberculosis (TB) y lepra producida por micobacterias, en donde R1 y R2 son, independientemente uno del otro, NO2, CN, CONR7R8, COOR9, CHO, halógeno, NR7R8, SO2NR7R8, SR9, OCF3, mono-, di- o trifluorometilo; R3 y R4 son, independientemente uno del otro, H, un radical alifático lineal o ramificado, saturado o insaturado, que tiene de 1 a 7 miembros en la cadena, cicloalquilo que tiene de 3 a 6 átomos de carbono, bencilo, SR9, OR9; R5 y R6 son, independientemente uno del otro, un radical alifático lineal o ramificado, saturado o insaturado, halogenado o no halogenado, que tiene de 1 a 8 miembros en la cadena, cicloalquilo que tiene de 3 a 6 átomos de carbono, fenilo; o R5 y R6 representan juntos un radical bivalente -(CR92)m-, o R5 y R6 juntos representan radicales bivalentes: fórmula (II) o (III), en donde m es de 1 a 4, o representa radicales bivalentes, un mono o poliheterociclo saturado o insaturado con heteroátomos N, S, O y sustituido por (R10)x, en donde x es de 1 a 4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2006/004942 WO2007134625A1 (en) | 2006-05-24 | 2006-05-24 | New benzothiazinone derivatives and their use as antibacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2008014958A true MX2008014958A (es) | 2009-04-15 |
Family
ID=37595033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008014958A MX2008014958A (es) | 2006-05-24 | 2006-05-24 | Nuevos derivados de benzotiazinona y su uso como agentes antibacterianos. |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7863268B2 (es) |
| EP (1) | EP2029583B1 (es) |
| JP (1) | JP5068813B2 (es) |
| KR (1) | KR101314999B1 (es) |
| CN (1) | CN101472922B (es) |
| AP (1) | AP2444A (es) |
| AT (1) | ATE470667T1 (es) |
| AU (1) | AU2006343832B2 (es) |
| BR (1) | BRPI0621693B8 (es) |
| CA (1) | CA2652841C (es) |
| CR (1) | CR10519A (es) |
| CY (1) | CY1110769T1 (es) |
| DE (1) | DE602006014885D1 (es) |
| DK (1) | DK2029583T3 (es) |
| EA (1) | EA015910B1 (es) |
| ES (1) | ES2345902T3 (es) |
| IL (1) | IL195453A (es) |
| MX (1) | MX2008014958A (es) |
| NZ (1) | NZ573833A (es) |
| PL (1) | PL2029583T3 (es) |
| PT (1) | PT2029583E (es) |
| SI (1) | SI2029583T1 (es) |
| TN (1) | TNSN08474A1 (es) |
| WO (1) | WO2007134625A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006343832B2 (en) | 2006-05-24 | 2011-07-21 | Leibniz Institute For Natural Product Research And Infection Biology E.V. Hans-Knoll-Institut (Hki) | New benzothiazinone derivatives and their use as antibacterial agents |
| EP2020406A1 (en) * | 2007-07-16 | 2009-02-04 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knöll-Institut | New antimicrobial compounds, their synthesis and their use for treatment of mammalian infection |
| RU2474621C2 (ru) * | 2008-02-13 | 2013-02-10 | Сентинель Сх С.П.А. | Новая эффективная лекарственная мишень для лечения туберкулеза |
| EP2380886A1 (en) | 2010-04-23 | 2011-10-26 | Vadim A. Makarov | Process for the preparation of 2-aminosubstituted 1,3-benzothiazine-4-ones |
| KR101851774B1 (ko) * | 2010-11-19 | 2018-04-25 | 에꼴 뽈리떼끄닉 뻬데랄 드 로잔느 (으뻬에프엘) | 2-피페라진-1-일-4h-1,3-벤조티아진-4-온 유도체 및 포유동물 감염을 치료하기 위한 이의 용도 |
| EP2468746A1 (en) | 2010-12-23 | 2012-06-27 | The University of Queensland | Benzothiazinone compounds and their use as anti-tuberculosis agents |
| US8486717B2 (en) | 2011-01-18 | 2013-07-16 | Symbolics, Llc | Lateral flow assays using two dimensional features |
| CN102276598B (zh) * | 2011-05-27 | 2014-11-05 | 四川大学 | 苯并噻嗪硫酮衍生物及其制备方法和用途 |
| CN102367239B (zh) * | 2011-07-20 | 2015-10-28 | 沈阳药科大学 | 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途 |
| EP2570413A1 (en) | 2011-09-15 | 2013-03-20 | The University Of Queensland | Benzothiazinone derivatives as anti-tuberculosis agents |
| CN103508980B (zh) * | 2012-06-14 | 2016-07-06 | 四川大学 | 苯并噻嗪-4-酮衍生物及其制备方法和用途 |
| US9874556B2 (en) | 2012-07-18 | 2018-01-23 | Symbolics, Llc | Lateral flow assays using two dimensional features |
| CN104211708B (zh) * | 2013-05-29 | 2018-08-24 | 中国医学科学院药物研究所 | 苯并噁嗪酮衍生物及其作为抗菌剂的应用 |
| CN108051590B (zh) | 2013-09-13 | 2020-12-11 | Symbolics有限责任公司 | 运用二维试验和对照信号读出模式的侧向层析检测 |
| EP3071549B1 (en) | 2013-11-18 | 2017-10-18 | Grillo-Werke AG | Novel initiator for preparing alkanesulfonic acids from alkane and oleum |
| DE102014012546A1 (de) * | 2014-09-26 | 2016-03-31 | Martin-Luther-Universität Halle-Wittenberg | Antimykobakteriell wirksame Substanzen, Verfahren zu ihrer Herstellung und deren Verwendung |
| EP3072889A1 (en) * | 2015-03-23 | 2016-09-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | 2-Homopiperazine-1-yl-4H-1,3-benzothiazine-4-one derivatives and process for the preparation of 2-(homo)piperazine 1,3-benzothiazine-4-one hydrochlorides |
| CN105669664B (zh) * | 2016-02-19 | 2019-05-10 | 浙江司太立制药股份有限公司 | 含有碱性氮杂环片段的苯并噻嗪-4-酮类化合物及其制备方法 |
| CN105622596B (zh) * | 2016-02-19 | 2018-10-30 | 浙江司太立制药股份有限公司 | 含有烷氧亚胺基氮杂环片段的苯并噻嗪-4-酮类化合物及其制备方法 |
| US11155542B2 (en) | 2016-09-22 | 2021-10-26 | University Of Notre Dame Du Lac | Antimicrobial compounds, their use for the treatment of mammalian infections and a new metabolic mechanism |
| RU2663848C1 (ru) * | 2018-03-23 | 2018-08-10 | Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук (ИОС УрО РАН) | 5-Фтор-2-(4-этоксикарбонилпиперазин-1-ил)-1,3-бензотиазин-4-он, обладающий противотуберкулезной активностью |
| CN111269197A (zh) * | 2020-04-08 | 2020-06-12 | 苏州大学 | 苯并噻嗪酮化合物及其制备方法与作为抗结核药物的应用 |
| CN113121521B (zh) * | 2021-03-26 | 2022-11-04 | 苏州大学 | 6-位三氟甲基取代的苯并噻嗪酮衍生物及其制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3470168A (en) * | 1967-03-31 | 1969-09-30 | American Home Prod | 2-substituted-4h-1,3-benzothiazin-4-one derivatives |
| US3522247A (en) * | 1967-11-07 | 1970-07-28 | Pfizer & Co C | 2-amino-6,7-disubstituted-4h-1,3-benzothiazine-4-ones as bronchodilators |
| GB8611617D0 (en) | 1986-05-13 | 1986-06-18 | Shell Int Research | Fungicides |
| WO2000051992A1 (en) | 1999-03-04 | 2000-09-08 | E.I. Du Pont De Nemours And Company | Fused bicyclic oxazinone and thiazinone fungicides |
| EP1312607A1 (en) | 2001-11-17 | 2003-05-21 | MEDAC GmbH | Dithiocarbamate derivatives and their use as antibacterial agents |
| US7659267B2 (en) | 2002-12-05 | 2010-02-09 | Takeda Pharmaceutical Company Limited | 1,3-Benzothiazinone derivatives, process for producing the same use thereof |
| EP1732907A1 (en) * | 2004-03-26 | 2006-12-20 | Arpida A/S | Peptide deformylase inhibitors |
| AU2006343832B2 (en) | 2006-05-24 | 2011-07-21 | Leibniz Institute For Natural Product Research And Infection Biology E.V. Hans-Knoll-Institut (Hki) | New benzothiazinone derivatives and their use as antibacterial agents |
-
2006
- 2006-05-24 AU AU2006343832A patent/AU2006343832B2/en not_active Ceased
- 2006-05-24 PT PT06743049T patent/PT2029583E/pt unknown
- 2006-05-24 AP AP2008004723A patent/AP2444A/xx active
- 2006-05-24 US US12/227,655 patent/US7863268B2/en active Active
- 2006-05-24 DE DE602006014885T patent/DE602006014885D1/de active Active
- 2006-05-24 MX MX2008014958A patent/MX2008014958A/es active IP Right Grant
- 2006-05-24 JP JP2009511341A patent/JP5068813B2/ja active Active
- 2006-05-24 SI SI200630745T patent/SI2029583T1/sl unknown
- 2006-05-24 DK DK06743049.6T patent/DK2029583T3/da active
- 2006-05-24 WO PCT/EP2006/004942 patent/WO2007134625A1/en active Application Filing
- 2006-05-24 BR BRPI0621693A patent/BRPI0621693B8/pt active IP Right Grant
- 2006-05-24 PL PL06743049T patent/PL2029583T3/pl unknown
- 2006-05-24 EA EA200870564A patent/EA015910B1/ru not_active IP Right Cessation
- 2006-05-24 CA CA2652841A patent/CA2652841C/en not_active Expired - Fee Related
- 2006-05-24 KR KR1020087031308A patent/KR101314999B1/ko active IP Right Grant
- 2006-05-24 EP EP06743049A patent/EP2029583B1/en active Active
- 2006-05-24 CN CN2006800551120A patent/CN101472922B/zh active Active
- 2006-05-24 ES ES06743049T patent/ES2345902T3/es active Active
- 2006-05-24 AT AT06743049T patent/ATE470667T1/de active
- 2006-05-24 NZ NZ573833A patent/NZ573833A/en not_active IP Right Cessation
-
2008
- 2008-11-21 TN TNP2008000474A patent/TNSN08474A1/en unknown
- 2008-11-23 IL IL195453A patent/IL195453A/en active IP Right Grant
- 2008-12-17 CR CR10519A patent/CR10519A/es unknown
-
2010
- 2010-09-07 CY CY20101100815T patent/CY1110769T1/el unknown
- 2010-12-22 US US12/976,905 patent/US20110160193A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |