AU2002215932A1 - Nitroderivatives as drugs for diseases having an inflammatory basis - Google Patents

Nitroderivatives as drugs for diseases having an inflammatory basis

Info

Publication number
AU2002215932A1
AU2002215932A1 AU2002215932A AU1593202A AU2002215932A1 AU 2002215932 A1 AU2002215932 A1 AU 2002215932A1 AU 2002215932 A AU2002215932 A AU 2002215932A AU 1593202 A AU1593202 A AU 1593202A AU 2002215932 A1 AU2002215932 A1 AU 2002215932A1
Authority
AU
Australia
Prior art keywords
diseases
nitroderivatives
drugs
inflammatory basis
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002215932A
Inventor
Patrizia Antognazza
Francesca Benedini
Piero Del Soldato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox SA filed Critical Nicox SA
Publication of AU2002215932A1 publication Critical patent/AU2002215932A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Abstract

Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, Having the following general formula (I): A-X1-L-(W)p-NO2 wherein A contains the radical of a drug, X1 and W are bivalent radicals, L is a covalent bond or oxygen, sulphur, NR1e wherein R1e is H or a C1-C5 linear or branched alkyl.
AU2002215932A 2000-10-12 2001-10-09 Nitroderivatives as drugs for diseases having an inflammatory basis Abandoned AU2002215932A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI200A002202 2000-10-12
IT2000MI002202A IT1319202B1 (en) 2000-10-12 2000-10-12 DRUGS FOR INFLAMMATORY-BASED DISEASES.
PCT/EP2001/011664 WO2002030866A1 (en) 2000-10-12 2001-10-09 Nitroderivatives as drugs for diseases having an inflammatory basis

Publications (1)

Publication Number Publication Date
AU2002215932A1 true AU2002215932A1 (en) 2002-04-22

Family

ID=11445950

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002215932A Abandoned AU2002215932A1 (en) 2000-10-12 2001-10-09 Nitroderivatives as drugs for diseases having an inflammatory basis

Country Status (10)

Country Link
US (3) US7465803B2 (en)
EP (1) EP1339665B1 (en)
JP (1) JP4451595B2 (en)
AT (1) ATE381531T1 (en)
AU (1) AU2002215932A1 (en)
CA (1) CA2425649A1 (en)
DE (1) DE60132011T2 (en)
ES (1) ES2298280T3 (en)
IT (1) IT1319202B1 (en)
WO (1) WO2002030866A1 (en)

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ITMI20011240A1 (en) * 2001-06-13 2002-12-13 Nicox Sa DRUGS FOR VASCULOPATHIES
ITMI20011308A1 (en) 2001-06-21 2002-12-21 Nicox Sa DRUGS FOR CHRONIC PAIN
ITMI20011307A1 (en) * 2001-06-21 2002-12-21 Nicox Sa DRUGS FOR EPILEPSY
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
CA2487414A1 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021391A1 (en) * 2002-06-25 2003-12-29 Nicox Sa NITRO-DERIVATIVES OF CYCLOOXYGENASE-2 INHIBITORS
ITMI20021399A1 (en) * 2002-06-25 2003-12-29 Nicox Sa CYCLOOXYGENASE INHIBITORS 2
JP2005535642A (en) * 2002-06-28 2005-11-24 ニトロメッド インコーポレーティッド Nitrosated and / or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use containing oximes and / or hydrazones
WO2004004648A2 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en) 2002-07-29 2007-07-17 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
DE602004014822D1 (en) 2003-11-20 2008-08-14 Nicox Sa NEW METHOD FOR THE PRODUCTION OF NITROOXY DERIVATIVES OF PARACETAMOL
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
KR20070053214A (en) 2004-08-26 2007-05-23 니콜라스 피라말 인디아 리미티드 Prodrugs containing novel bio-cleavable linkers
WO2008062466A2 (en) * 2006-10-13 2008-05-29 Reliance Life Sciences Pvt. Ltd. Cinnamic acid, vanillic acid and benzofuran derivatives for use in the treatment of inflammation and cancer
ES2441263T3 (en) 2007-08-17 2014-02-03 Council Of Scientific & Industrial Research Paracetamol derivatives that release nitric oxide
US20100286264A1 (en) * 2008-01-10 2010-11-11 Nicox S.A. Composition comprising a nitrooxyderivative of acetaminophen and a anticonvulsant drug for the treatment of neuropathic pain
MX2010012647A (en) 2008-05-20 2010-12-14 Neurogesx Inc Hepatoprotectant acetaminophen mutual prodrugs.
US8062653B2 (en) 2009-02-18 2011-11-22 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
WO2010108843A1 (en) 2009-03-27 2010-09-30 Nicox S.A. Use of nitrooxyderivative of paracetamol for the treatment of muscular dystrophies
WO2011133385A2 (en) * 2010-04-16 2011-10-27 The Research Foundation Of State University Of New York Novel ether-based compounds and their use
CN111087301B (en) * 2019-12-23 2022-05-20 河南中医药大学 Synthesis method of ibuprofen caffeate and application of ibuprofen caffeate in preparation of immunosuppressive drugs
CN111087302B (en) * 2019-12-23 2022-05-20 河南中医药大学 Synthesis method of ibuprofen ferulate and application of ibuprofen ferulate in preparation of immunosuppressive drugs

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Also Published As

Publication number Publication date
IT1319202B1 (en) 2003-09-26
US20080194651A1 (en) 2008-08-14
US7465803B2 (en) 2008-12-16
JP4451595B2 (en) 2010-04-14
WO2002030866A1 (en) 2002-04-18
ES2298280T3 (en) 2008-05-16
ATE381531T1 (en) 2008-01-15
EP1339665B1 (en) 2007-12-19
DE60132011D1 (en) 2008-01-31
ITMI20002202A1 (en) 2002-04-12
EP1339665A1 (en) 2003-09-03
US20090075952A1 (en) 2009-03-19
US20040023933A1 (en) 2004-02-05
CA2425649A1 (en) 2002-04-18
US7629368B2 (en) 2009-12-08
DE60132011T2 (en) 2009-01-22
JP2004511455A (en) 2004-04-15

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