NO20060114L - Naphthylene derivatives as cytochrome P450 inhibitors - Google Patents

Naphthylene derivatives as cytochrome P450 inhibitors

Info

Publication number
NO20060114L
NO20060114L NO20060114A NO20060114A NO20060114L NO 20060114 L NO20060114 L NO 20060114L NO 20060114 A NO20060114 A NO 20060114A NO 20060114 A NO20060114 A NO 20060114A NO 20060114 L NO20060114 L NO 20060114L
Authority
NO
Norway
Prior art keywords
cytochrome
inhibitors
treatment
naphthylene
derivatives
Prior art date
Application number
NO20060114A
Other languages
Norwegian (no)
Inventor
Vanessa Smith
Anthony Nigro
Mark Mulvihill
Cara Cesario
Patrica Anne Beck
Arlindo L Castelhano
Original Assignee
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc
Publication of NO20060114L publication Critical patent/NO20060114L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles

Abstract

Forbindelser med formel og farmasøytisk akseptable salter derav, hvor ni, n2, n3, n4, G\ Q\ Z, R\ R', R', R'^ R'', R'^ og R'" er definert her, hemmer cytokrom P450RAI-enzymet og er anvendehge for behandling og/eller forebygging av forskjellige sykdommer og hdelser som responderer på behandling med retinoider og med naturlig forekommende retinsyre.Compounds of formula and pharmaceutically acceptable salts thereof, wherein ni, n2, n3, n4, G \ Q \ Z, R \ R ', R', R ', R' ', R' 'and R' 'are defined herein, inhibits the cytochrome P450RAI enzyme and is useful for the treatment and / or prevention of various diseases and diseases that respond to treatment with retinoids and with naturally occurring retinoic acid.

NO20060114A 2003-07-10 2006-01-06 Naphthylene derivatives as cytochrome P450 inhibitors NO20060114L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48638203P 2003-07-10 2003-07-10
PCT/US2004/022282 WO2005007631A1 (en) 2003-07-10 2004-07-12 Naphthylene derivatives as cytochrome p450 inhibitors

Publications (1)

Publication Number Publication Date
NO20060114L true NO20060114L (en) 2006-02-09

Family

ID=34079229

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060114A NO20060114L (en) 2003-07-10 2006-01-06 Naphthylene derivatives as cytochrome P450 inhibitors

Country Status (15)

Country Link
EP (1) EP1654236A1 (en)
JP (1) JP4832295B2 (en)
KR (1) KR20060052799A (en)
CN (1) CN1819996B (en)
AU (1) AU2004257257B2 (en)
BR (1) BRPI0412424A (en)
CA (1) CA2532078A1 (en)
IL (1) IL172812A0 (en)
IS (1) IS8223A (en)
MX (1) MXPA06000401A (en)
NO (1) NO20060114L (en)
RU (1) RU2363696C2 (en)
SG (1) SG144941A1 (en)
UA (1) UA87822C2 (en)
WO (1) WO2005007631A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007515433A (en) * 2003-12-17 2007-06-14 アラーガン　インコーポレイテッド Methods of treating retinoid responsive disorders using selective inhibitors of CYP26A and CYP26B
US7662844B2 (en) 2004-07-12 2010-02-16 Osi Pharmaceuticals, Inc. Naphthylene derivatives as cytochrome P450 inhibitors
EP2576544A4 (en) * 2010-06-01 2013-09-11 Angion Biomedica Corp Cytochrome p450 inhibitors and uses thereof
US10414760B2 (en) 2016-11-29 2019-09-17 Angion Biomedica Corp. Cytochrome P450 inhibitors and uses thereof
WO2012064943A2 (en) * 2010-11-13 2012-05-18 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
CN103328452A (en) * 2010-12-13 2013-09-25 威尔金制药有限公司 Metalloenzyme inhibitor compounds
CN102586187A (en) * 2012-02-23 2012-07-18 深圳市中美康士生物科技有限公司 In vitro preservation method and culture medium for neutrophils
WO2014015137A2 (en) * 2012-07-18 2014-01-23 Angion Biomedica Corp. Compositions and methods for treating dysproliferative diseases
JP6578349B2 (en) 2014-08-11 2019-09-18 アンジオン バイオメディカ コーポレーション Cytochrome P450 inhibitors and uses thereof
CN104523967B (en) * 2014-12-12 2017-08-01 扬子江药业集团北京海燕药业有限公司 A kind of Bai Ai capsules as CYP enzyme inhibitors application
EP3240778A4 (en) 2014-12-31 2018-07-11 Angion Biomedica Corp. Methods and agents for treating disease
GB201602572D0 (en) * 2016-02-12 2016-03-30 Eriksson Leif And Strid Ake And Sirsjö Allan New compound and uses
WO2018065288A1 (en) 2016-10-07 2018-04-12 Bayer Cropscience Aktiengesellschaft 2-[2-phenyl-1-(sulfonyl-methyl)-vinyl]-imidazo-[4,5-b] pyridine derivatives and related compounds as pesticides in plant protection
WO2018130437A1 (en) 2017-01-10 2018-07-19 Bayer Aktiengesellschaft Heterocyclene derivatives as pest control agents
AU2018208422B2 (en) 2017-01-10 2021-11-11 Bayer Aktiengesellschaft Heterocyclene derivatives as pest control agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL291944A (en) * 1960-05-04
NL131915C (en) * 1966-07-27
DE3508903A1 (en) * 1985-03-13 1986-09-18 Hoechst Ag, 6230 Frankfurt NEW 3-PYRIDYLMETHYLNAPHTYL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DE3628545A1 (en) * 1985-09-23 1987-04-23 Hoechst Ag ARYLMETHYLAZOLES AND THEIR SALTS, METHOD FOR THE PRODUCTION THEREOF, MEANS CONTAINING THEM AND THEIR USE
AU5285593A (en) * 1992-10-21 1994-05-09 Sankyo Company Limited Azole compound
ATE293102T1 (en) * 1998-04-23 2005-04-15 Takeda Pharmaceutical NAPHTHALENE DERIVATIVES, THEIR PRODUCTION AND USE
JP4546589B2 (en) * 1998-04-23 2010-09-15 武田薬品工業株式会社 Naphthalene derivatives
FR2796070B1 (en) * 1999-07-06 2003-02-21 Lipha BENZODIAZEPINES DERIVATIVES FOR USE IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS OF PREPARATION
PE20010781A1 (en) * 1999-10-22 2001-08-08 Takeda Chemical Industries Ltd COMPOUNDS 1- (1H-IMIDAZOL-4-IL) -1- (NAFTIL-2-SUBSTITUTED) ETHANOL, ITS PRODUCTION AND USE
JP4520012B2 (en) * 1999-10-22 2010-08-04 武田薬品工業株式会社 1-Substituted-1- (1H-imidazol-4-yl) methanols

Also Published As

Publication number Publication date
CN1819996A (en) 2006-08-16
UA87822C2 (en) 2009-08-25
CA2532078A1 (en) 2005-01-27
JP4832295B2 (en) 2011-12-07
MXPA06000401A (en) 2006-03-17
WO2005007631A1 (en) 2005-01-27
IS8223A (en) 2006-01-10
CN1819996B (en) 2010-10-27
AU2004257257A1 (en) 2005-01-27
KR20060052799A (en) 2006-05-19
AU2004257257B2 (en) 2011-05-12
RU2363696C2 (en) 2009-08-10
SG144941A1 (en) 2008-08-28
JP2007523866A (en) 2007-08-23
IL172812A0 (en) 2006-06-11
BRPI0412424A (en) 2006-09-05
RU2006103996A (en) 2006-07-10
EP1654236A1 (en) 2006-05-10

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application