MX2008013837A - Derivados de 2-pirazinona para el tratamiento de una enfermedad o condicion en la cual es benefica la inhibicion de la actividad de elastasa de neutrofilos. - Google Patents
Derivados de 2-pirazinona para el tratamiento de una enfermedad o condicion en la cual es benefica la inhibicion de la actividad de elastasa de neutrofilos.Info
- Publication number
- MX2008013837A MX2008013837A MX2008013837A MX2008013837A MX2008013837A MX 2008013837 A MX2008013837 A MX 2008013837A MX 2008013837 A MX2008013837 A MX 2008013837A MX 2008013837 A MX2008013837 A MX 2008013837A MX 2008013837 A MX2008013837 A MX 2008013837A
- Authority
- MX
- Mexico
- Prior art keywords
- carbon atoms
- phenyl
- alkyl
- compound
- ring
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims description 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 24
- 201000010099 disease Diseases 0.000 title claims description 21
- 230000000694 effects Effects 0.000 title claims description 13
- HUTNOYOBQPAKIA-UHFFFAOYSA-N 1h-pyrazin-2-one Chemical class OC1=CN=CC=N1 HUTNOYOBQPAKIA-UHFFFAOYSA-N 0.000 title claims description 7
- 230000009286 beneficial effect Effects 0.000 title claims description 6
- 108010028275 Leukocyte Elastase Proteins 0.000 title claims description 4
- 102000016799 Leukocyte elastase Human genes 0.000 title claims description 4
- 230000005764 inhibitory process Effects 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 144
- 150000003839 salts Chemical class 0.000 claims abstract description 73
- 238000000034 method Methods 0.000 claims abstract description 36
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 168
- 125000000217 alkyl group Chemical group 0.000 claims description 83
- -1 nitro, methylcarbonyl Chemical group 0.000 claims description 76
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 60
- 125000001424 substituent group Chemical group 0.000 claims description 48
- 239000001257 hydrogen Substances 0.000 claims description 45
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- 229910052760 oxygen Inorganic materials 0.000 claims description 32
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 31
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 31
- 125000001153 fluoro group Chemical group F* 0.000 claims description 29
- 125000005842 heteroatom Chemical group 0.000 claims description 26
- 229910052736 halogen Inorganic materials 0.000 claims description 24
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- 125000002947 alkylene group Chemical group 0.000 claims description 22
- 239000011737 fluorine Substances 0.000 claims description 22
- 229910052731 fluorine Inorganic materials 0.000 claims description 22
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 22
- 239000000460 chlorine Substances 0.000 claims description 21
- 229910052757 nitrogen Inorganic materials 0.000 claims description 21
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 20
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 20
- 229910052801 chlorine Inorganic materials 0.000 claims description 20
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 19
- 125000001072 heteroaryl group Chemical group 0.000 claims description 19
- 239000011593 sulfur Chemical group 0.000 claims description 19
- 229910052717 sulfur Chemical group 0.000 claims description 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 17
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 16
- 125000004076 pyridyl group Chemical group 0.000 claims description 16
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- 238000006243 chemical reaction Methods 0.000 claims description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 14
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims description 13
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims description 13
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims description 13
- 229920006395 saturated elastomer Polymers 0.000 claims description 13
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- 125000001589 carboacyl group Chemical group 0.000 claims description 12
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 12
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 10
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- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims description 9
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- 229910052799 carbon Inorganic materials 0.000 claims description 7
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- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims description 6
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- 239000002671 adjuvant Substances 0.000 claims description 6
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- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 6
- 125000002971 oxazolyl group Chemical group 0.000 claims description 6
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- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 5
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
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- LMWQVAJRBJDDOE-UHFFFAOYSA-N 6-[2-(6-cyanopyridin-3-yl)pyrazol-3-yl]-n-cyclopropyl-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide Chemical compound O=C1N(C=2C=C(C=CC=2)C(F)(F)F)C(C)=C(C=2N(N=CC=2)C=2C=NC(=CC=2)C#N)N=C1C(=O)NC1CC1 LMWQVAJRBJDDOE-UHFFFAOYSA-N 0.000 claims description 4
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims description 4
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 4
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- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 claims description 4
- 125000002950 monocyclic group Chemical group 0.000 claims description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 4
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 4
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- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 4
- 125000004414 alkyl thio group Chemical group 0.000 claims description 3
- LCUYXVNEQVXZIJ-UHFFFAOYSA-N 6-[2-(4-cyanophenyl)pyrazol-3-yl]-n-(1-hydroxy-2-methylpropan-2-yl)-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide Chemical compound CC1=C(C=2N(N=CC=2)C=2C=CC(=CC=2)C#N)N=C(C(=O)NC(C)(C)CO)C(=O)N1C1=CC=CC(C(F)(F)F)=C1 LCUYXVNEQVXZIJ-UHFFFAOYSA-N 0.000 claims description 2
- VLGZLMJRSIBGPH-UHFFFAOYSA-N 6-[2-(4-cyanophenyl)pyrazol-3-yl]-n-(2-methoxyethyl)-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide Chemical compound CC=1N(C=2C=C(C=CC=2)C(F)(F)F)C(=O)C(C(=O)NCCOC)=NC=1C1=CC=NN1C1=CC=C(C#N)C=C1 VLGZLMJRSIBGPH-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US79878406P | 2006-05-08 | 2006-05-08 | |
| PCT/SE2007/000442 WO2007129963A1 (en) | 2006-05-08 | 2007-05-07 | 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2008013837A true MX2008013837A (es) | 2008-11-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008013837A MX2008013837A (es) | 2006-05-08 | 2007-05-07 | Derivados de 2-pirazinona para el tratamiento de una enfermedad o condicion en la cual es benefica la inhibicion de la actividad de elastasa de neutrofilos. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8114881B2 (enExample) |
| EP (1) | EP2018377A4 (enExample) |
| JP (1) | JP5527739B2 (enExample) |
| KR (1) | KR101429303B1 (enExample) |
| CN (1) | CN101490040B (enExample) |
| AR (1) | AR060874A1 (enExample) |
| AU (2) | AU2007248951B2 (enExample) |
| BR (1) | BRPI0711362A2 (enExample) |
| CA (1) | CA2650553C (enExample) |
| CL (1) | CL2007001283A1 (enExample) |
| CO (1) | CO6140058A2 (enExample) |
| EC (1) | ECSP088869A (enExample) |
| IL (1) | IL194949A0 (enExample) |
| MX (1) | MX2008013837A (enExample) |
| NO (1) | NO20084845L (enExample) |
| RU (2) | RU2448098C2 (enExample) |
| SG (1) | SG170101A1 (enExample) |
| TW (1) | TW200808771A (enExample) |
| UY (1) | UY30327A1 (enExample) |
| WO (1) | WO2007129963A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| TW200808763A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| DK2170848T3 (en) * | 2007-06-27 | 2015-01-05 | Astrazeneca Ab | Pyrazinonderivater and their use to treat lung diseases |
| WO2009058076A1 (en) * | 2007-11-02 | 2009-05-07 | Astrazeneca Ab | 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| BRPI0819258A2 (pt) * | 2007-11-06 | 2017-05-02 | Astrazeneca Ab | alguns derivados de 2-pirazinona e seu uso como inibidores da elastase neutrófila |
| AR073711A1 (es) | 2008-10-01 | 2010-11-24 | Astrazeneca Ab | Derivados de isoquinolina |
| TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| MX2012003644A (es) | 2009-10-02 | 2012-04-30 | Astrazeneca Ab | Compuestos de 2-piridona empleados como inhibidores de la elastasa neutrofila. |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| US20110224229A1 (en) | 2010-03-10 | 2011-09-15 | Astrazeneca Ab | Novel Crystalline Form |
| DE102010030187A1 (de) | 2010-06-16 | 2011-12-22 | Bayer Schering Pharma Aktiengesellschaft | 4-Cyan-2-sulfonylphenyl)pyrazolyl-substituierte Pyridinone und Pyrazinone und ihre Verwendung |
| JP2013177318A (ja) * | 2010-06-30 | 2013-09-09 | Dainippon Sumitomo Pharma Co Ltd | ジヒドロピリミジノン誘導体およびその医薬用途 |
| GB201016912D0 (en) | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| TW201247631A (en) | 2011-04-28 | 2012-12-01 | Du Pont | Herbicidal pyrazinones |
| US20140057920A1 (en) * | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US9102624B2 (en) | 2012-08-23 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057926A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| EP3373936A1 (en) * | 2015-11-13 | 2018-09-19 | Bayer Pharma Aktiengesellschaft | 4-(4-cyano-2-thioaryl)dihydropyrimidinones for treating chronic wounds |
| JP6990663B2 (ja) * | 2016-05-31 | 2022-01-13 | シエッシ ファーマスーティシ エス．ピー．エー． | ヒト好中球エラスターゼ阻害剤としてのイミダゾロン化合物 |
| EP3749697A4 (en) | 2018-02-05 | 2021-11-03 | Bio-Rad Laboratories, Inc. | CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE |
| CN108440508B (zh) * | 2018-04-04 | 2020-03-20 | 河南科技大学第一附属医院 | 吡嗪药物及其制备方法、组合物及在胃肠病人护理的应用 |
| WO2021053058A1 (en) | 2019-09-17 | 2021-03-25 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| DK4106757T3 (da) | 2020-04-16 | 2023-10-23 | Mereo Biopharma 4 Ltd | Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel |
| AU2022373971A1 (en) | 2021-10-20 | 2024-04-04 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
| WO2023115043A1 (en) * | 2021-12-16 | 2023-06-22 | Orixa Therapeutics Llc | Small molecule inhibitors of pr3 and hne and uses thereof |
| CN118724801B (zh) * | 2024-09-03 | 2024-12-03 | 中节能万润股份有限公司 | 一种甲苯磺酸艾多沙班中间体的制备方法 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2358891A1 (fr) | 1976-07-22 | 1978-02-17 | Yamanouchi Pharma Co Ltd | Composes heterocycliques contenant un azote, utilise comme agents analgesiques et anti-inflammatoires |
| DE2706977A1 (de) | 1977-02-18 | 1978-08-24 | Hoechst Ag | Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung |
| EP0008864A1 (en) | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
| JPH02152966A (ja) | 1988-12-05 | 1990-06-12 | Otsuka Pharmaceut Co Ltd | ４−ヒドロキシカルボスチリル誘導体 |
| US5521179A (en) | 1991-04-18 | 1996-05-28 | Zeneca Limited | Heterocyclic amides |
| US5441960A (en) | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| CN1328277C (zh) | 1996-12-05 | 2007-07-25 | 安姆根有限公司 | 取代的嘧啶酮和吡啶酮化合物和它们的应用 |
| JPH1171351A (ja) | 1997-08-29 | 1999-03-16 | Ss Pharmaceut Co Ltd | 置換キノロン誘導体及びこれを含有する医薬 |
| CN1245386C (zh) | 2000-06-12 | 2006-03-15 | 卫材株式会社 | 1,2－二氢吡啶化合物及其制备方法和用途 |
| ATE438624T1 (de) | 2000-12-28 | 2009-08-15 | Shionogi & Co | 2-pyridonderivate mit affinität für den cannabinoid-typ-2-rezeptor |
| CA2456292A1 (en) | 2001-08-14 | 2003-02-27 | Toyama Chemical Co., Ltd. | Novel virus growth inhibitor and/or virucidal method, and novel pyrazine nucleotide or pirazine nucleoside analog |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| GB2383326A (en) | 2001-12-20 | 2003-06-25 | Bayer Ag | Antiinflammatory dihydropyridines |
| MXPA03000145A (es) | 2002-01-07 | 2003-07-15 | Pfizer | Compuestos de oxo u oxi-piridina como moduladores de receptores 5-ht4. |
| PT1477186E (pt) | 2002-02-19 | 2010-02-11 | Shionogi & Co | Antipruriginosos |
| US7230017B2 (en) | 2002-08-27 | 2007-06-12 | Bayer Healthcare Ag | Dihydropyridinone derivatives |
| GB2392910A (en) | 2002-09-10 | 2004-03-17 | Bayer Ag | 2-Oxopyrimidine derivatives and their use as human leukocyte elastase inhibitors |
| TW200500341A (en) | 2002-11-12 | 2005-01-01 | Astrazeneca Ab | Novel compounds |
| SE0302324D0 (sv) | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| SE0302323D0 (sv) | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| SE0302487D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| WO2005080372A1 (en) | 2004-02-19 | 2005-09-01 | Bayer Healthcare Ag | Dihydropyridinone derivatives |
| ES2394177T3 (es) | 2004-02-26 | 2013-01-23 | Bayer Intellectual Property Gmbh | 1,4-diaril-dihidropirimidin-2-onas y su uso como inhibidores de elastasa de neutrófilos humanos |
| US20050288290A1 (en) | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| GB0502258D0 (en) | 2005-02-03 | 2005-03-09 | Argenta Discovery Ltd | Compounds and their use |
| TW200700392A (en) | 2005-03-16 | 2007-01-01 | Astrazeneca Ab | Novel compounds |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| GB0512940D0 (en) | 2005-06-24 | 2005-08-03 | Argenta Discovery Ltd | Compounds and their use |
| GB0605469D0 (en) | 2006-03-17 | 2006-04-26 | Argenta Discovery Ltd | Multimers of heterocyclic compounds and their use |
| JP4999920B2 (ja) | 2006-05-04 | 2012-08-15 | プルマジェン セラピューティクス （インフラメーション） リミテッド | テトラヒドロピロロピリミジンジオン類およびヒト好中球エラスターゼ阻害薬としてのそれらの使用 |
| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| EP2064184A1 (en) | 2006-09-04 | 2009-06-03 | AstraZeneca AB | Multimeric heterocyclic compounds useful as neutrophil elastase inhibitors |
| WO2008104752A1 (en) | 2007-02-26 | 2008-09-04 | Astrazeneca Ab | Dihydropyridones as elastase inhibitors |
| WO2009058076A1 (en) | 2007-11-02 | 2009-05-07 | Astrazeneca Ab | 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| BRPI0819258A2 (pt) | 2007-11-06 | 2017-05-02 | Astrazeneca Ab | alguns derivados de 2-pirazinona e seu uso como inibidores da elastase neutrófila |
| TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| MX2012003644A (es) | 2009-10-02 | 2012-04-30 | Astrazeneca Ab | Compuestos de 2-piridona empleados como inhibidores de la elastasa neutrofila. |
-
2007
- 2007-04-27 TW TW096115050A patent/TW200808771A/zh unknown
- 2007-05-07 BR BRPI0711362-5A patent/BRPI0711362A2/pt not_active IP Right Cessation
- 2007-05-07 SG SG201101743-1A patent/SG170101A1/en unknown
- 2007-05-07 JP JP2009509486A patent/JP5527739B2/ja not_active Expired - Fee Related
- 2007-05-07 CL CL2007001283A patent/CL2007001283A1/es unknown
- 2007-05-07 MX MX2008013837A patent/MX2008013837A/es active IP Right Grant
- 2007-05-07 RU RU2008143457/04A patent/RU2448098C2/ru not_active IP Right Cessation
- 2007-05-07 US US12/299,878 patent/US8114881B2/en not_active Expired - Fee Related
- 2007-05-07 AU AU2007248951A patent/AU2007248951B2/en not_active Ceased
- 2007-05-07 WO PCT/SE2007/000442 patent/WO2007129963A1/en not_active Ceased
- 2007-05-07 UY UY30327A patent/UY30327A1/es unknown
- 2007-05-07 CN CN2007800259264A patent/CN101490040B/zh not_active Expired - Fee Related
- 2007-05-07 EP EP07748106A patent/EP2018377A4/en not_active Withdrawn
- 2007-05-07 CA CA2650553A patent/CA2650553C/en not_active Expired - Fee Related
- 2007-05-07 KR KR1020087029813A patent/KR101429303B1/ko not_active Expired - Fee Related
- 2007-05-08 AR ARP070101993A patent/AR060874A1/es not_active Application Discontinuation
-
2008
- 2008-10-27 IL IL194949A patent/IL194949A0/en unknown
- 2008-10-28 CO CO08115221A patent/CO6140058A2/es unknown
- 2008-11-06 EC EC2008008869A patent/ECSP088869A/es unknown
- 2008-11-18 NO NO20084845A patent/NO20084845L/no not_active Application Discontinuation
-
2010
- 2010-10-26 AU AU2010236027A patent/AU2010236027B2/en not_active Ceased
-
2011
- 2011-07-27 RU RU2011131170/04A patent/RU2011131170A/ru not_active Application Discontinuation
-
2012
- 2012-01-06 US US13/344,658 patent/US8410114B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009536197A (ja) | 2009-10-08 |
| EP2018377A4 (en) | 2011-03-30 |
| KR20090009956A (ko) | 2009-01-23 |
| AU2007248951B2 (en) | 2011-05-19 |
| AU2007248951A1 (en) | 2007-11-15 |
| CN101490040B (zh) | 2013-06-12 |
| TW200808771A (en) | 2008-02-16 |
| CA2650553A1 (en) | 2007-11-15 |
| CA2650553C (en) | 2014-07-08 |
| RU2011131170A (ru) | 2013-02-10 |
| RU2008143457A (ru) | 2010-06-20 |
| RU2448098C2 (ru) | 2012-04-20 |
| CN101490040A (zh) | 2009-07-22 |
| US8410114B2 (en) | 2013-04-02 |
| AU2010236027B2 (en) | 2011-08-18 |
| NO20084845L (no) | 2009-02-03 |
| ECSP088869A (es) | 2008-12-30 |
| UY30327A1 (es) | 2008-01-02 |
| JP5527739B2 (ja) | 2014-06-25 |
| EP2018377A1 (en) | 2009-01-28 |
| KR101429303B1 (ko) | 2014-08-12 |
| IL194949A0 (en) | 2009-08-03 |
| US8114881B2 (en) | 2012-02-14 |
| AR060874A1 (es) | 2008-07-16 |
| US20090209555A1 (en) | 2009-08-20 |
| US20120108610A1 (en) | 2012-05-03 |
| AU2010236027A1 (en) | 2010-11-18 |
| BRPI0711362A2 (pt) | 2011-12-06 |
| CL2007001283A1 (es) | 2008-01-18 |
| WO2007129963A1 (en) | 2007-11-15 |
| CO6140058A2 (es) | 2010-03-19 |
| SG170101A1 (en) | 2011-04-29 |
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