CA2650553C - 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial - Google Patents
2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial Download PDFInfo
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- CA2650553C CA2650553C CA2650553A CA2650553A CA2650553C CA 2650553 C CA2650553 C CA 2650553C CA 2650553 A CA2650553 A CA 2650553A CA 2650553 A CA2650553 A CA 2650553A CA 2650553 C CA2650553 C CA 2650553C
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- Prior art keywords
- phenyl
- alkyl
- compound
- ring
- oxo
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 29
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- HUTNOYOBQPAKIA-UHFFFAOYSA-N 1h-pyrazin-2-one Chemical class OC1=CN=CC=N1 HUTNOYOBQPAKIA-UHFFFAOYSA-N 0.000 title claims description 8
- 230000009286 beneficial effect Effects 0.000 title claims description 7
- 108010028275 Leukocyte Elastase Proteins 0.000 title claims description 6
- 102000016799 Leukocyte elastase Human genes 0.000 title claims description 6
- 230000005764 inhibitory process Effects 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 146
- 150000003839 salts Chemical class 0.000 claims abstract description 74
- 238000000034 method Methods 0.000 claims abstract description 24
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- 125000001424 substituent group Chemical group 0.000 claims description 48
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 33
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 24
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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Landscapes
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- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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| US79878406P | 2006-05-08 | 2006-05-08 | |
| US60/798,784 | 2006-05-08 | ||
| PCT/SE2007/000442 WO2007129963A1 (en) | 2006-05-08 | 2007-05-07 | 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial. |
Publications (2)
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| CA2650553A1 CA2650553A1 (en) | 2007-11-15 |
| CA2650553C true CA2650553C (en) | 2014-07-08 |
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| CA2650553A Expired - Fee Related CA2650553C (en) | 2006-05-08 | 2007-05-07 | 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial |
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| EC (1) | ECSP088869A (enExample) |
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| TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| HRP20141174T1 (hr) | 2007-06-27 | 2015-02-13 | Astrazeneca Ab | Derivati pirazinona i njihova uporaba za lijeäśenje bolesti pluä†a |
| WO2009058076A1 (en) * | 2007-11-02 | 2009-05-07 | Astrazeneca Ab | 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| AU2008325288B2 (en) | 2007-11-06 | 2011-12-22 | Astrazeneca Ab | Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| AR073711A1 (es) | 2008-10-01 | 2010-11-24 | Astrazeneca Ab | Derivados de isoquinolina |
| TW201036957A (en) * | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| CA2773618A1 (en) * | 2009-10-02 | 2011-04-07 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| US20110224229A1 (en) | 2010-03-10 | 2011-09-15 | Astrazeneca Ab | Novel Crystalline Form |
| DE102010030187A1 (de) | 2010-06-16 | 2011-12-22 | Bayer Schering Pharma Aktiengesellschaft | 4-Cyan-2-sulfonylphenyl)pyrazolyl-substituierte Pyridinone und Pyrazinone und ihre Verwendung |
| JP2013177318A (ja) * | 2010-06-30 | 2013-09-09 | Dainippon Sumitomo Pharma Co Ltd | ジヒドロピリミジノン誘導体およびその医薬用途 |
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| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| TW201247631A (en) | 2011-04-28 | 2012-12-01 | Du Pont | Herbicidal pyrazinones |
| US9102624B2 (en) | 2012-08-23 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057926A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057920A1 (en) * | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
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2007
- 2007-04-27 TW TW096115050A patent/TW200808771A/zh unknown
- 2007-05-07 AU AU2007248951A patent/AU2007248951B2/en not_active Ceased
- 2007-05-07 CN CN2007800259264A patent/CN101490040B/zh not_active Expired - Fee Related
- 2007-05-07 UY UY30327A patent/UY30327A1/es unknown
- 2007-05-07 EP EP07748106A patent/EP2018377A4/en not_active Withdrawn
- 2007-05-07 BR BRPI0711362-5A patent/BRPI0711362A2/pt not_active IP Right Cessation
- 2007-05-07 CL CL2007001283A patent/CL2007001283A1/es unknown
- 2007-05-07 US US12/299,878 patent/US8114881B2/en not_active Expired - Fee Related
- 2007-05-07 RU RU2008143457/04A patent/RU2448098C2/ru not_active IP Right Cessation
- 2007-05-07 KR KR1020087029813A patent/KR101429303B1/ko not_active Expired - Fee Related
- 2007-05-07 WO PCT/SE2007/000442 patent/WO2007129963A1/en not_active Ceased
- 2007-05-07 MX MX2008013837A patent/MX2008013837A/es active IP Right Grant
- 2007-05-07 JP JP2009509486A patent/JP5527739B2/ja not_active Expired - Fee Related
- 2007-05-07 SG SG201101743-1A patent/SG170101A1/en unknown
- 2007-05-07 CA CA2650553A patent/CA2650553C/en not_active Expired - Fee Related
- 2007-05-08 AR ARP070101993A patent/AR060874A1/es not_active Application Discontinuation
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- 2008-10-27 IL IL194949A patent/IL194949A0/en unknown
- 2008-10-28 CO CO08115221A patent/CO6140058A2/es unknown
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| KR20090009956A (ko) | 2009-01-23 |
| EP2018377A4 (en) | 2011-03-30 |
| AU2007248951B2 (en) | 2011-05-19 |
| IL194949A0 (en) | 2009-08-03 |
| AU2007248951A1 (en) | 2007-11-15 |
| CO6140058A2 (es) | 2010-03-19 |
| RU2011131170A (ru) | 2013-02-10 |
| AU2010236027A1 (en) | 2010-11-18 |
| SG170101A1 (en) | 2011-04-29 |
| ECSP088869A (es) | 2008-12-30 |
| US20090209555A1 (en) | 2009-08-20 |
| US20120108610A1 (en) | 2012-05-03 |
| CN101490040A (zh) | 2009-07-22 |
| AR060874A1 (es) | 2008-07-16 |
| AU2010236027B2 (en) | 2011-08-18 |
| EP2018377A1 (en) | 2009-01-28 |
| CN101490040B (zh) | 2013-06-12 |
| TW200808771A (en) | 2008-02-16 |
| CL2007001283A1 (es) | 2008-01-18 |
| MX2008013837A (es) | 2008-11-10 |
| JP2009536197A (ja) | 2009-10-08 |
| CA2650553A1 (en) | 2007-11-15 |
| KR101429303B1 (ko) | 2014-08-12 |
| UY30327A1 (es) | 2008-01-02 |
| RU2448098C2 (ru) | 2012-04-20 |
| JP5527739B2 (ja) | 2014-06-25 |
| WO2007129963A1 (en) | 2007-11-15 |
| US8114881B2 (en) | 2012-02-14 |
| RU2008143457A (ru) | 2010-06-20 |
| US8410114B2 (en) | 2013-04-02 |
| BRPI0711362A2 (pt) | 2011-12-06 |
| NO20084845L (no) | 2009-02-03 |
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